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The map label for this gene is yngE [H]

Identifier: 187927228

GI number: 187927228

Start: 139955

End: 141562

Strand: Reverse

Name: yngE [H]

Synonym: Rpic_0120

Alternate gene names: 187927228

Gene position: 141562-139955 (Counterclockwise)

Preceding gene: 187927229

Following gene: 187927227

Centisome position: 3.59

GC content: 65.36

Gene sequence:

>1608_bases
ATGCCGACGCTAGAGACCAAGCTGAACCCCCGCGCTGAAGACTTCAAGGCCAACGCCGATGCCATGCGCGCACTCGTCGC
CGACTTGCGCGACAAGGTTGCGCGCATCGCCCAGGGCGGCGGTGACGACGCCCGTGCCAAACACCTCGCCCGCGGCAAGT
TGCTGCCGCGCGACCGCGTGCAGCAACTGCTCGATCCTGGCACGCCGTTCCTGGAGTTCTCGCAACTGGCGGCGTATGGC
ATGTACGACAACGCCGCGCCCGGCGCCGGCATCATCACCGGTATCGGCCGCATCTCGGGGCAGGAATGCGTGATCGTCTG
CAACGACGCCACGGTCAAGGGCGGCACCTACTACCCGATGACCGTGAAGAAGCACCTGCGCGCGCAGGAGATCGCCGAGC
AGAACCACCTGCCCTGCGTCTATCTGGTCGATTCCGGCGGCGCCAACCTGCCGAACCAGGACGACGTGTTCCCCGATCGA
GATCACTTCGGTCGCATCTTCTACAACCAGGCCAACCTGTCATCGAAGGGCATTCCACAGATCGCGGTGGTGATGGGCTC
GTGCACGGCGGGCGGCGCGTATGTGCCGGCCATGAGTGATGAGTCGATCATCGTCAAGGAACAGGGGACGATCTTCCTGG
CAGGCCCGCCGCTGGTGAAGGCCGCGACCGGCGAAGTGGTGAGCGCCGAAGACCTCGGTGGCGCCGATGTGCACACGCGG
CTGTCGGGCGTGGCGGATTACTTCGCCAACAACGATTCGCACGCGTTGGCGCAAGCCCGCAGCATCGTCGCGCACCTGAA
CCGCCGCAAGCCGGAGCAGGTGCAGATTCATGCGCCCGTCGAGCCGCGCTTTCCCGCAGAAGAACTCTACGGCGTGATCC
CGACCGACACGCGCAAGCCGTTCGACGTGCGCGAGGTCATCGCCCGCATCGTCGACGATTCCGCCTTCGATGAATTCAAG
GCGCGCTACGGCACGACGCTGGTCTGCGGCTTTGCGCGCATCTGGGGTTACCCGGTCGGCATCATCGCCAACAACGGCAT
TCTTTTTTCAGAGGCGGCACTCAAGGGCGCGCACTTCATCGAGCTGTGCTGTCAGCGCAAGATCCCGCTGGTGTTCCTGC
AGAACATCACCGGCTTCATGGTGGGCCGCAAGTACGAAAACGAAGGCATCGCCAAGAACGGCGCGAAAATGGTGACGGCC
GTGGCAACGGCGCAGGTGCCCAAGTTCACGGTCATCATCGGCGGCTCGTTCGGCGCGGGCAATTACGGCATGTGCGGCCG
GGCGTATTCGCCGCGCTTCCTGTGGATGTGGCCGAACGCGCGCATCTCTGTGATGGGCGGCGAACAGGCCGCAAGCGTGC
TCGCCACCGTGCGCCGCGACGGCATCGAAGCCAAGGGCGGCCAGTGGAGCGCCGATGAAGAGGCCGCGTTCAAGGCGCCG
ATCCGCGACCAATATGAGCGCCAGGGCCATCCGTACTACGCCAGCGCACGCCTGTGGGACGACGGCGTGATCGACCCCGC
CGACACGCGCAGCGTGCTGGGCCTCGGCCTGTCGGCGAGCCTGAACGCGCCCATTGGCGACATGAACTTCGGCGTGTTCC
GCATGTAA

Upstream 100 bases:

>100_bases
CGCCTGGACGCAAGCGGCGCCGAATCCGCCGAAGGCCGTTGGCTGTACGTCGACGGCACCTTCCCTGACTGAACCGCACC
GACCTTCCCGCACTGCTGCC

Downstream 100 bases:

>100_bases
GCGGGCCGTCAATCGAACAGGAATATTTGCAGTGAACAGCAACACCGCGCGAACGTGGCGCAGCGCCTTGGCAGCCGTTG
GCTGCGCGCTGCTGCTTGCG

Product: Propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MPTLETKLNPRAEDFKANADAMRALVADLRDKVARIAQGGGDDARAKHLARGKLLPRDRVQQLLDPGTPFLEFSQLAAYG
MYDNAAPGAGIITGIGRISGQECVIVCNDATVKGGTYYPMTVKKHLRAQEIAEQNHLPCVYLVDSGGANLPNQDDVFPDR
DHFGRIFYNQANLSSKGIPQIAVVMGSCTAGGAYVPAMSDESIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGADVHTR
LSGVADYFANNDSHALAQARSIVAHLNRRKPEQVQIHAPVEPRFPAEELYGVIPTDTRKPFDVREVIARIVDDSAFDEFK
ARYGTTLVCGFARIWGYPVGIIANNGILFSEAALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIAKNGAKMVTA
VATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGQWSADEEAAFKAP
IRDQYERQGHPYYASARLWDDGVIDPADTRSVLGLGLSASLNAPIGDMNFGVFRM

Sequences:

>Translated_535_residues
MPTLETKLNPRAEDFKANADAMRALVADLRDKVARIAQGGGDDARAKHLARGKLLPRDRVQQLLDPGTPFLEFSQLAAYG
MYDNAAPGAGIITGIGRISGQECVIVCNDATVKGGTYYPMTVKKHLRAQEIAEQNHLPCVYLVDSGGANLPNQDDVFPDR
DHFGRIFYNQANLSSKGIPQIAVVMGSCTAGGAYVPAMSDESIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGADVHTR
LSGVADYFANNDSHALAQARSIVAHLNRRKPEQVQIHAPVEPRFPAEELYGVIPTDTRKPFDVREVIARIVDDSAFDEFK
ARYGTTLVCGFARIWGYPVGIIANNGILFSEAALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIAKNGAKMVTA
VATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGQWSADEEAAFKAP
IRDQYERQGHPYYASARLWDDGVIDPADTRSVLGLGLSASLNAPIGDMNFGVFRM
>Mature_534_residues
PTLETKLNPRAEDFKANADAMRALVADLRDKVARIAQGGGDDARAKHLARGKLLPRDRVQQLLDPGTPFLEFSQLAAYGM
YDNAAPGAGIITGIGRISGQECVIVCNDATVKGGTYYPMTVKKHLRAQEIAEQNHLPCVYLVDSGGANLPNQDDVFPDRD
HFGRIFYNQANLSSKGIPQIAVVMGSCTAGGAYVPAMSDESIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGADVHTRL
SGVADYFANNDSHALAQARSIVAHLNRRKPEQVQIHAPVEPRFPAEELYGVIPTDTRKPFDVREVIARIVDDSAFDEFKA
RYGTTLVCGFARIWGYPVGIIANNGILFSEAALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIAKNGAKMVTAV
ATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGQWSADEEAAFKAPI
RDQYERQGHPYYASARLWDDGVIDPADTRSVLGLGLSASLNAPIGDMNFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=522, Percent_Identity=69.5402298850575, Blast_Score=739, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=495, Percent_Identity=32.7272727272727, Blast_Score=233, Evalue=5e-61,
Organism=Homo sapiens, GI295821216, Length=509, Percent_Identity=31.041257367387, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=62.8787878787879, Blast_Score=158, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=63.0393996247655, Blast_Score=719, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=524, Percent_Identity=32.824427480916, Blast_Score=240, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI25147362, Length=485, Percent_Identity=33.4020618556701, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24586065, Length=550, Percent_Identity=63.6363636363636, Blast_Score=729, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57812; Mature: 57681

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLETKLNPRAEDFKANADAMRALVADLRDKVARIAQGGGDDARAKHLARGKLLPRDRV
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHH
QQLLDPGTPFLEFSQLAAYGMYDNAAPGAGIITGIGRISGQECVIVCNDATVKGGTYYPM
HHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHEEHHHCCCCCEEEEEECCCEECCCEECCH
TVKKHLRAQEIAEQNHLPCVYLVDSGGANLPNQDDVFPDRDHFGRIFYNQANLSSKGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEEECCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDESIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGADVHTR
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCEEECCCCCCCHHHHH
LSGVADYFANNDSHALAQARSIVAHLNRRKPEQVQIHAPVEPRFPAEELYGVIPTDTRKP
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHCCCCCCCCCCC
FDVREVIARIVDDSAFDEFKARYGTTLVCGFARIWGYPVGIIANNGILFSEAALKGAHFI
CCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCEEEEHHHHCCHHHH
ELCCQRKIPLVFLQNITGFMVGRKYENEGIAKNGAKMVTAVATAQVPKFTVIIGGSFGAG
HHHHCCCCCEEEECCCHHHHCCCEECCCCCCCCCCCEEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGQWSADEEAAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCC
IRDQYERQGHPYYASARLWDDGVIDPADTRSVLGLGLSASLNAPIGDMNFGVFRM
CHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEC
>Mature Secondary Structure 
PTLETKLNPRAEDFKANADAMRALVADLRDKVARIAQGGGDDARAKHLARGKLLPRDRV
CCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHH
QQLLDPGTPFLEFSQLAAYGMYDNAAPGAGIITGIGRISGQECVIVCNDATVKGGTYYPM
HHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHEEHHHCCCCCEEEEEECCCEECCCEECCH
TVKKHLRAQEIAEQNHLPCVYLVDSGGANLPNQDDVFPDRDHFGRIFYNQANLSSKGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEEECCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDESIIVKEQGTIFLAGPPLVKAATGEVVSAEDLGGADVHTR
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCEEECCCCCCCHHHHH
LSGVADYFANNDSHALAQARSIVAHLNRRKPEQVQIHAPVEPRFPAEELYGVIPTDTRKP
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHCCCCCCCCCCC
FDVREVIARIVDDSAFDEFKARYGTTLVCGFARIWGYPVGIIANNGILFSEAALKGAHFI
CCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCEEEEHHHHCCHHHH
ELCCQRKIPLVFLQNITGFMVGRKYENEGIAKNGAKMVTAVATAQVPKFTVIIGGSFGAG
HHHHCCCCCEEEECCCHHHHCCCEECCCCCCCCCCCEEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGQWSADEEAAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCC
IRDQYERQGHPYYASARLWDDGVIDPADTRSVLGLGLSASLNAPIGDMNFGVFRM
CHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]