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The map label for this gene is lysN [H]

Identifier: 187927183

GI number: 187927183

Start: 86034

End: 87242

Strand: Direct

Name: lysN [H]

Synonym: Rpic_0073

Alternate gene names: 187927183

Gene position: 86034-87242 (Clockwise)

Preceding gene: 187927181

Following gene: 187927184

Centisome position: 2.18

GC content: 66.83

Gene sequence:

>1209_bases
ATGGAATTCCTGCAATCGCTGCTGGCACCCCGCCTGCAAAACGTTGAAACCTCCGCCATCCGCGAACTGTTCAAGGTGCT
CGGCAAGCCGGGCCTGATCTCGTTTGCCGGCGGCTTTCCTGACGCCGCCCTGTTTGACGTGGAAGGCCTGAAGGCCGCGG
CCGACAGCGCGCTCACCACCGACGCCGCCCGCGCGTTGCAATATGGCGCCACCGAGGGCTTCGAGCCGCTGCGCGAGGCT
ATCGTCACGCTGATGAAGGCGCGCGGCGCCAACGTCGCCAACACCGACATCCTCGTCACCACCGGTTCGCAGCAGGGGCT
GGATCTGCTGGGCAAGGTGCTGATCGGCGAAGGCGATACGGTGCTGACAGAAGCCCCCACCTTCCTCGCCGCCATTCAGG
CGTTCAAGCTGTATGGCGCCAAGGTGGCCGGCGTGCCGACCGATGGCGACGGCCTGGACGTCGACGCGCTGGAAAAGGTG
CTGTCCACCGCGCGCCCCAAATTCCTCTACGTGATTCCCAACTTCGGCAACCCGAGCGGCGCGCTGATGAGCCTGGAGCG
CCGCAAGCGCCTGCTGGACGTGGCCGTGCGCCACAACCTGCTGATCGTGGAAGACGACCCCTATGGCGATCTGTATTTCG
ACGCACCCCCGCCGCCGTCGCTGTACGCGCTGTCGCAGCAGACCGACGGCGCACAGGGGCGCGTGATCTACCTGGGCAGC
CTGTCGAAGGTGGTGGCGCCGGGCCTGCGCGTGGGCTGGATGATCGCTTCGCAGCCGGTGCTGGGCAACGCGGTGATGGT
CAAGCAGTTTGCCGATGCGCATACCTCCACGTTTGCGCAGGCCACGGCCGCTGCGTATCTGCGCAGTAATCGCCTCGAGA
CCGTGCTGCCGCGCACGCGCGCTGCCTATGCCGAACGCGCACACGCCATGGCCAACGGGCTGCGTGCGCTGCTGCCCGAC
ACCGAACTGACCTTCAACCGCCCGCGCGGCGGCATGTTCCTGTGGTGCACCTTGCCGGGCCGCAATGCCGGCGATGTAGC
CAAGATGGCCATCGAACGCGGTGTGGCGTTCGTGCCGGGTGCGGCGTTCTACCCCGTAGACCCGGATCGCTCGACGCTGC
GTCTGTCATACGCGACCTCGTCGCTGGCGCAGGTGGAAGAGGGTGTGCGCAAGCTTGCGCACGCCATCGGCGAGTTCAAG
CTGGGCTGA

Upstream 100 bases:

>100_bases
TGCCGGCATTCTAGTCACGGCTGTGACGCCCTGTTGGCATGCGCACGCGGCGCACATCACGTAAAGTGGCGGGCACTCGA
ACAACAGAGACACGCACGCC

Downstream 100 bases:

>100_bases
CCGCACCGGCGCAGGCCGCGGTGGCACAGGCACACACCGACGCGCAGCAAGACCCCGCGCTGCTGCGCCGCCTGCTGCGC
GCCAAAGACCGCATGGACGC

Product: putative GntR family transcriptional regulator

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MEFLQSLLAPRLQNVETSAIRELFKVLGKPGLISFAGGFPDAALFDVEGLKAAADSALTTDAARALQYGATEGFEPLREA
IVTLMKARGANVANTDILVTTGSQQGLDLLGKVLIGEGDTVLTEAPTFLAAIQAFKLYGAKVAGVPTDGDGLDVDALEKV
LSTARPKFLYVIPNFGNPSGALMSLERRKRLLDVAVRHNLLIVEDDPYGDLYFDAPPPPSLYALSQQTDGAQGRVIYLGS
LSKVVAPGLRVGWMIASQPVLGNAVMVKQFADAHTSTFAQATAAAYLRSNRLETVLPRTRAAYAERAHAMANGLRALLPD
TELTFNRPRGGMFLWCTLPGRNAGDVAKMAIERGVAFVPGAAFYPVDPDRSTLRLSYATSSLAQVEEGVRKLAHAIGEFK
LG

Sequences:

>Translated_402_residues
MEFLQSLLAPRLQNVETSAIRELFKVLGKPGLISFAGGFPDAALFDVEGLKAAADSALTTDAARALQYGATEGFEPLREA
IVTLMKARGANVANTDILVTTGSQQGLDLLGKVLIGEGDTVLTEAPTFLAAIQAFKLYGAKVAGVPTDGDGLDVDALEKV
LSTARPKFLYVIPNFGNPSGALMSLERRKRLLDVAVRHNLLIVEDDPYGDLYFDAPPPPSLYALSQQTDGAQGRVIYLGS
LSKVVAPGLRVGWMIASQPVLGNAVMVKQFADAHTSTFAQATAAAYLRSNRLETVLPRTRAAYAERAHAMANGLRALLPD
TELTFNRPRGGMFLWCTLPGRNAGDVAKMAIERGVAFVPGAAFYPVDPDRSTLRLSYATSSLAQVEEGVRKLAHAIGEFK
LG
>Mature_402_residues
MEFLQSLLAPRLQNVETSAIRELFKVLGKPGLISFAGGFPDAALFDVEGLKAAADSALTTDAARALQYGATEGFEPLREA
IVTLMKARGANVANTDILVTTGSQQGLDLLGKVLIGEGDTVLTEAPTFLAAIQAFKLYGAKVAGVPTDGDGLDVDALEKV
LSTARPKFLYVIPNFGNPSGALMSLERRKRLLDVAVRHNLLIVEDDPYGDLYFDAPPPPSLYALSQQTDGAQGRVIYLGS
LSKVVAPGLRVGWMIASQPVLGNAVMVKQFADAHTSTFAQATAAAYLRSNRLETVLPRTRAAYAERAHAMANGLRALLPD
TELTFNRPRGGMFLWCTLPGRNAGDVAKMAIERGVAFVPGAAFYPVDPDRSTLRLSYATSSLAQVEEGVRKLAHAIGEFK
LG

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=420, Percent_Identity=30.952380952381, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI33469970, Length=420, Percent_Identity=30.952380952381, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4507369, Length=381, Percent_Identity=23.6220472440945, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790797, Length=372, Percent_Identity=27.6881720430108, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1787710, Length=381, Percent_Identity=27.5590551181102, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1788722, Length=344, Percent_Identity=26.7441860465116, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788627, Length=369, Percent_Identity=23.8482384823848, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321236, Length=400, Percent_Identity=26.25, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6321929, Length=320, Percent_Identity=25, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321000, Length=440, Percent_Identity=25.6818181818182, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322401, Length=226, Percent_Identity=26.9911504424779, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21356535, Length=382, Percent_Identity=25.6544502617801, Blast_Score=124, Evalue=9e-29,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 42906; Mature: 42906

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFLQSLLAPRLQNVETSAIRELFKVLGKPGLISFAGGFPDAALFDVEGLKAAADSALTT
CHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHH
DAARALQYGATEGFEPLREAIVTLMKARGANVANTDILVTTGSQQGLDLLGKVLIGEGDT
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCE
VLTEAPTFLAAIQAFKLYGAKVAGVPTDGDGLDVDALEKVLSTARPKFLYVIPNFGNPSG
EEECCHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCH
ALMSLERRKRLLDVAVRHNLLIVEDDPYGDLYFDAPPPPSLYALSQQTDGAQGRVIYLGS
HHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEECCCCCCCEEEECCCCCCCCCEEEEECC
LSKVVAPGLRVGWMIASQPVLGNAVMVKQFADAHTSTFAQATAAAYLRSNRLETVLPRTR
CHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHH
AAYAERAHAMANGLRALLPDTELTFNRPRGGMFLWCTLPGRNAGDVAKMAIERGVAFVPG
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCEECCC
AAFYPVDPDRSTLRLSYATSSLAQVEEGVRKLAHAIGEFKLG
CEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEFLQSLLAPRLQNVETSAIRELFKVLGKPGLISFAGGFPDAALFDVEGLKAAADSALTT
CHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHH
DAARALQYGATEGFEPLREAIVTLMKARGANVANTDILVTTGSQQGLDLLGKVLIGEGDT
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCE
VLTEAPTFLAAIQAFKLYGAKVAGVPTDGDGLDVDALEKVLSTARPKFLYVIPNFGNPSG
EEECCHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCH
ALMSLERRKRLLDVAVRHNLLIVEDDPYGDLYFDAPPPPSLYALSQQTDGAQGRVIYLGS
HHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEECCCCCCCEEEECCCCCCCCCEEEEECC
LSKVVAPGLRVGWMIASQPVLGNAVMVKQFADAHTSTFAQATAAAYLRSNRLETVLPRTR
CHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHH
AAYAERAHAMANGLRALLPDTELTFNRPRGGMFLWCTLPGRNAGDVAKMAIERGVAFVPG
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCEECCC
AAFYPVDPDRSTLRLSYATSSLAQVEEGVRKLAHAIGEFKLG
CEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA