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The map label for this gene is rnc [H]

Identifier: 187918561

GI number: 187918561

Start: 748006

End: 748737

Strand: Direct

Name: rnc [H]

Synonym: BH0705

Alternate gene names: 187918561

Gene position: 748006-748737 (Clockwise)

Preceding gene: 187918560

Following gene: 187918563

Centisome position: 81.1

GC content: 32.65

Gene sequence:

>732_bases
ATGGGTTCTGCTATAGTGAAGTTGGATGTGGATCGGAGAAGAAAGTTAGATGAGTTCTTAATGGGTTTACATATTGATTT
TAATGATATTGATTTGTTAAATATGTCTTTAAGTCATTCATCATATGCAAATGAATTTGATCAAAAATATGCTAATAATG
AGAGATTAGAGTTTTTAGGAGACTCTGTTCTTAATCTTATTATTACAGATTATTTGTATAAATTTTATCCTGAAAAGAGC
GAAGGTGAACTTAGCAAGGCCAGATCTTATATTGTTAGTGAAGAGTCTCTCTCTAGTATTGCCCGGGAACTTAACCTTGG
TAACTATATTTTGCTTGGTAGGGGCGAGGAGAATAATGATGGCCGCAATAAAAAGGGTATTATTGCAGATGCTATTGAGG
CTTTTGTTGGTGCACTTTATCTTGATGGTGGGTTTTTAAAAGCCTCAGCTTTCGTGGTAGAGCTTTTTGAAGTTCACATA
AGGTTGATGTTTAATCGTGGTGACTTTAAAGATTATAAAAGCCTTCTGCAGGAATATGTTCAAAAGAAATATAAGATTTC
GCCAAATTATAGGTTGGCTAAAGAGTTAGGTCCTGATCATAATAAAATTTTTTGTGTTGAACTTTATGTTAATGATAAAT
TTATATCTAATGGCAAAGGAAAATCTAAAAAAGAGGCTGAAATGATAGCAGCTGAAATGGCACTTAAGACTATTGCAAAT
ATTGATCTTTAA

Upstream 100 bases:

>100_bases
AGGAAGCATTTGATGATAAGATCCCAGAAAATGAGGCTAGTGAATTTGAGACTATAGGTGATGTTGTTGCTTTTATTGAG
AAAAAAAAGGGTTAGATATA

Downstream 100 bases:

>100_bases
TTTTTTTAATTAAGATCTCTTTTTTGTTTAATTTGGGATTAGTTAGTACTTCTCTTAATAGATAGTTGAGGATTTCTCCA
ATGTTTTTGTTGTCTGTTAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MGSAIVKLDVDRRRKLDEFLMGLHIDFNDIDLLNMSLSHSSYANEFDQKYANNERLEFLGDSVLNLIITDYLYKFYPEKS
EGELSKARSYIVSEESLSSIARELNLGNYILLGRGEENNDGRNKKGIIADAIEAFVGALYLDGGFLKASAFVVELFEVHI
RLMFNRGDFKDYKSLLQEYVQKKYKISPNYRLAKELGPDHNKIFCVELYVNDKFISNGKGKSKKEAEMIAAEMALKTIAN
IDL

Sequences:

>Translated_243_residues
MGSAIVKLDVDRRRKLDEFLMGLHIDFNDIDLLNMSLSHSSYANEFDQKYANNERLEFLGDSVLNLIITDYLYKFYPEKS
EGELSKARSYIVSEESLSSIARELNLGNYILLGRGEENNDGRNKKGIIADAIEAFVGALYLDGGFLKASAFVVELFEVHI
RLMFNRGDFKDYKSLLQEYVQKKYKISPNYRLAKELGPDHNKIFCVELYVNDKFISNGKGKSKKEAEMIAAEMALKTIAN
IDL
>Mature_242_residues
GSAIVKLDVDRRRKLDEFLMGLHIDFNDIDLLNMSLSHSSYANEFDQKYANNERLEFLGDSVLNLIITDYLYKFYPEKSE
GELSKARSYIVSEESLSSIARELNLGNYILLGRGEENNDGRNKKGIIADAIEAFVGALYLDGGFLKASAFVVELFEVHIR
LMFNRGDFKDYKSLLQEYVQKKYKISPNYRLAKELGPDHNKIFCVELYVNDKFISNGKGKSKKEAEMIAAEMALKTIANI
DL

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=229, Percent_Identity=29.6943231441048, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI155030236, Length=229, Percent_Identity=29.6943231441048, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1788920, Length=200, Percent_Identity=31, Blast_Score=117, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=30.3964757709251, Blast_Score=106, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=30.3964757709251, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17137682, Length=230, Percent_Identity=30.8695652173913, Blast_Score=107, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27726; Mature: 27595

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSAIVKLDVDRRRKLDEFLMGLHIDFNDIDLLNMSLSHSSYANEFDQKYANNERLEFLG
CCCEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCHHHHHH
DSVLNLIITDYLYKFYPEKSEGELSKARSYIVSEESLSSIARELNLGNYILLGRGEENND
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECCCCCCC
GRNKKGIIADAIEAFVGALYLDGGFLKASAFVVELFEVHIRLMFNRGDFKDYKSLLQEYV
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHH
QKKYKISPNYRLAKELGPDHNKIFCVELYVNDKFISNGKGKSKKEAEMIAAEMALKTIAN
HHHHCCCCCEEEHHHCCCCCCEEEEEEEEECCEEECCCCCCCHHHHHHHHHHHHHHHHHH
IDL
CCC
>Mature Secondary Structure 
GSAIVKLDVDRRRKLDEFLMGLHIDFNDIDLLNMSLSHSSYANEFDQKYANNERLEFLG
CCEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCHHHHHH
DSVLNLIITDYLYKFYPEKSEGELSKARSYIVSEESLSSIARELNLGNYILLGRGEENND
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECCCCCCC
GRNKKGIIADAIEAFVGALYLDGGFLKASAFVVELFEVHIRLMFNRGDFKDYKSLLQEYV
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHH
QKKYKISPNYRLAKELGPDHNKIFCVELYVNDKFISNGKGKSKKEAEMIAAEMALKTIAN
HHHHCCCCCEEEHHHCCCCCCEEEEEEEEECCEEECCCCCCCHHHHHHHHHHHHHHHHHH
IDL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]