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The map label for this gene is lspA

Identifier: 187918336

GI number: 187918336

Start: 494772

End: 495284

Strand: Direct

Name: lspA

Synonym: BH0469

Alternate gene names: 187918336

Gene position: 494772-495284 (Clockwise)

Preceding gene: 187918335

Following gene: 187918337

Centisome position: 53.65

GC content: 25.54

Gene sequence:

>513_bases
ATGAATATAGATAGAAACAGATTAATTGGCAGTGTTATATTTATCTTTATTTTAGTTTTTATTGATCAATGGTCTAAGTA
TTTGGTTGTTAAATATATCAGCATTGGAACTGAATATTTATCTTTTTTTGGCGATTTTTTTAAAATAATACATGTGAGAA
ATACTGGGATTTTATTCTCAATAGGTGCTAATATTAATTCTAGCTTGAAAAATTTGTTTTTTCTTGTAATTCCTATTATT
ATTTTGGTTTTTGTTTTTTGTTTTATTTTAAAAGAAACTAATAAAATAGCTAGAATTGCTCTTATATTGATTTTATCTGG
TGGTATTGGGAATATTATTGATAGGCTTTTTAGACCCTTAGGAGTTGTGGATTTCTTGGACGTGAAATTTTTTGGTATTT
TTGGCCTTCAAAGATGGCCAACTTTTAACTTTGCAGACAGCTATGTTGTTATTGGAATAACTTTATTTATAATTTATGAT
TTGTTTGCCAAAAATAAAAGTACTGATTTATGA

Upstream 100 bases:

>100_bases
CGAAACATTTGGTTTAATCAAATTAATGGAATATTTTAAGATTCAAAAAGAATTAGAGGTTAATTTTATTTTAAAAGATA
CTAATTTATAAGGATTTTAT

Downstream 100 bases:

>100_bases
ATATTTTATACTTTATTTTATGTTCATTAATTAATTTAGCTTTAATGTTTTTGGTTTTTTTTATTGAATTTCTTGTTATT
GCTAAACTAAATATTATTGT

Product: signal peptidase II

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MNIDRNRLIGSVIFIFILVFIDQWSKYLVVKYISIGTEYLSFFGDFFKIIHVRNTGILFSIGANINSSLKNLFFLVIPII
ILVFVFCFILKETNKIARIALILILSGGIGNIIDRLFRPLGVVDFLDVKFFGIFGLQRWPTFNFADSYVVIGITLFIIYD
LFAKNKSTDL

Sequences:

>Translated_170_residues
MNIDRNRLIGSVIFIFILVFIDQWSKYLVVKYISIGTEYLSFFGDFFKIIHVRNTGILFSIGANINSSLKNLFFLVIPII
ILVFVFCFILKETNKIARIALILILSGGIGNIIDRLFRPLGVVDFLDVKFFGIFGLQRWPTFNFADSYVVIGITLFIIYD
LFAKNKSTDL
>Mature_170_residues
MNIDRNRLIGSVIFIFILVFIDQWSKYLVVKYISIGTEYLSFFGDFFKIIHVRNTGILFSIGANINSSLKNLFFLVIPII
ILVFVFCFILKETNKIARIALILILSGGIGNIIDRLFRPLGVVDFLDVKFFGIFGLQRWPTFNFADSYVVIGITLFIIYD
LFAKNKSTDL

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_BORHD (B2S0H3)

Other databases:

- EMBL:   CP000048
- RefSeq:   YP_001883899.1
- EnsemblBacteria:   EBBORT00000006435
- GeneID:   6276788
- GenomeReviews:   CP000048_GR
- KEGG:   bhr:BH0469
- GeneTree:   EBGT00050000007459
- HOGENOM:   HBG724422
- OMA:   LARRYVI
- ProtClustDB:   PRK01574
- BioCyc:   BHER314723:BH0469-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 19510; Mature: 19510

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 114-114 ACT_SITE 146-146

Signals:

None

Transmembrane regions:

HASH(0x1fdc4bcc)-; HASH(0x1f87c7ec)-; HASH(0x1f2db29c)-; HASH(0x1c950168)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDRNRLIGSVIFIFILVFIDQWSKYLVVKYISIGTEYLSFFGDFFKIIHVRNTGILFS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEE
IGANINSSLKNLFFLVIPIIILVFVFCFILKETNKIARIALILILSGGIGNIIDRLFRPL
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHH
GVVDFLDVKFFGIFGLQRWPTFNFADSYVVIGITLFIIYDLFAKNKSTDL
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MNIDRNRLIGSVIFIFILVFIDQWSKYLVVKYISIGTEYLSFFGDFFKIIHVRNTGILFS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEE
IGANINSSLKNLFFLVIPIIILVFVFCFILKETNKIARIALILILSGGIGNIIDRLFRPL
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHH
GVVDFLDVKFFGIFGLQRWPTFNFADSYVVIGITLFIIYDLFAKNKSTDL
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA