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The map label for this gene is ndk [H]

Identifier: 187918329

GI number: 187918329

Start: 489744

End: 490253

Strand: Direct

Name: ndk [H]

Synonym: BH0463

Alternate gene names: 187918329

Gene position: 489744-490253 (Clockwise)

Preceding gene: 187918328

Following gene: 187918330

Centisome position: 53.1

GC content: 32.75

Gene sequence:

>510_bases
ATGTCTACTTTAATACAAAAAACTTTATGTATTATTAAACCTGATGGTGTTAGAAGGGGTTTGATTGGTAATGTAATTTC
TAGATTTGAGAAGGCAGGATTGAAAATTGTAGCTGCTAAGATGACTTTAGTTAATAGAGCAATGGCCGAGATTCATTATC
TTTATGATGATATTGCTGTAAGGCATGGCGAGTTTGTTTGGCGATCTTTAATTGATTTTATAATTAGTTCACCAGTTTTT
GTGTTTGTTATTGAAGGTGTTGAAGCTGTTGAGGTTGTTAGAAAATTTTGTGGTTCTACAGAACCAAAAGTAGCTGCTCT
TGGGACAATAAGGGGTGATTTTGCTTATCATAGTTTTAACTATGCGAATGAGAAAAAGTTTGCAGTTTATAATGTGATTC
ATGCTTCCGCTAGTGTTGATGATGCTCTTCGTGAAATACCCATTTGGTTTAAAGAAGATGAAATTTTAACTTATAAAAGG
AATGATGAGCTTGAACATTATTATGGTTAA

Upstream 100 bases:

>100_bases
TCTTATTTTTTATTTATTCTTTTGAAGCAGATGTTTATAAAGTCAATAACTTATATCTTATAATTAACTTGAATTGTAAT
GAAAACATTGGGAGGTTTTT

Downstream 100 bases:

>100_bases
AATATTAATATGAGCGTTGCAATACGGCCTGTTTTGAAATGGGCTGGTGGTAAGAAAAATTTATTGAAAGTTATTTTAAA
TAATATTCCCCTTTCTTTTA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MSTLIQKTLCIIKPDGVRRGLIGNVISRFEKAGLKIVAAKMTLVNRAMAEIHYLYDDIAVRHGEFVWRSLIDFIISSPVF
VFVIEGVEAVEVVRKFCGSTEPKVAALGTIRGDFAYHSFNYANEKKFAVYNVIHASASVDDALREIPIWFKEDEILTYKR
NDELEHYYG

Sequences:

>Translated_169_residues
MSTLIQKTLCIIKPDGVRRGLIGNVISRFEKAGLKIVAAKMTLVNRAMAEIHYLYDDIAVRHGEFVWRSLIDFIISSPVF
VFVIEGVEAVEVVRKFCGSTEPKVAALGTIRGDFAYHSFNYANEKKFAVYNVIHASASVDDALREIPIWFKEDEILTYKR
NDELEHYYG
>Mature_168_residues
STLIQKTLCIIKPDGVRRGLIGNVISRFEKAGLKIVAAKMTLVNRAMAEIHYLYDDIAVRHGEFVWRSLIDFIISSPVFV
FVIEGVEAVEVVRKFCGSTEPKVAALGTIRGDFAYHSFNYANEKKFAVYNVIHASASVDDALREIPIWFKEDEILTYKRN
DELEHYYG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI4826862, Length=153, Percent_Identity=39.8692810457516, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI37693993, Length=162, Percent_Identity=35.8024691358025, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI66392227, Length=155, Percent_Identity=36.7741935483871, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI66392205, Length=155, Percent_Identity=36.7741935483871, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI4505409, Length=155, Percent_Identity=36.7741935483871, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI66392192, Length=155, Percent_Identity=36.7741935483871, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI66392203, Length=155, Percent_Identity=36.7741935483871, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI4557797, Length=153, Percent_Identity=35.2941176470588, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI38045913, Length=153, Percent_Identity=35.2941176470588, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1788866, Length=156, Percent_Identity=36.5384615384615, Blast_Score=95, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17506807, Length=153, Percent_Identity=39.8692810457516, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322783, Length=161, Percent_Identity=37.888198757764, Blast_Score=110, Evalue=8e-26,
Organism=Drosophila melanogaster, GI45549037, Length=158, Percent_Identity=36.7088607594937, Blast_Score=109, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 19221; Mature: 19090

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLIQKTLCIIKPDGVRRGLIGNVISRFEKAGLKIVAAKMTLVNRAMAEIHYLYDDIAV
CCHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
RHGEFVWRSLIDFIISSPVFVFVIEGVEAVEVVRKFCGSTEPKVAALGTIRGDFAYHSFN
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCHHCCCCC
YANEKKFAVYNVIHASASVDDALREIPIWFKEDEILTYKRNDELEHYYG
CCCCCHHHHHHHHHCCCCHHHHHHHCCCEECCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
STLIQKTLCIIKPDGVRRGLIGNVISRFEKAGLKIVAAKMTLVNRAMAEIHYLYDDIAV
CHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
RHGEFVWRSLIDFIISSPVFVFVIEGVEAVEVVRKFCGSTEPKVAALGTIRGDFAYHSFN
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCHHCCCCC
YANEKKFAVYNVIHASASVDDALREIPIWFKEDEILTYKRNDELEHYYG
CCCCCHHHHHHHHHCCCCHHHHHHHCCCEECCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]