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The map label for this gene is hpt [H]

Identifier: 187918287

GI number: 187918287

Start: 442692

End: 443216

Strand: Direct

Name: hpt [H]

Synonym: BH0421A

Alternate gene names: 187918287

Gene position: 442692-443216 (Clockwise)

Preceding gene: 187918283

Following gene: 187918288

Centisome position: 48.0

GC content: 26.48

Gene sequence:

>525_bases
ATGGATGAGGAAATTTCAACTTTATTCACAGAAGAAAAAATAAAAAGTAAAATTAAAGAATTAGCCCAAAAGATTAGAAA
CTACTATAAAGATAAAAGTAATGTGGTTTTTATATCACTTCTTAAAGGCTCTTTCATGTTTTTTGCAGATATTACAAGAG
AGATTGGATTAAACGTAAAAATCGATTTTCTACAAGTCTCAAGTTATAAAAATAAAACTCATTCTTCACTAAACGTACTA
ATCAAGAAAGATATTGATATTGATATAAAGGACAGTTACGTAATAATCTTTGATGACATCATAGATACTGGACTTACATA
TGATAAAATAATTACTTACTTAAAAACCAAGAATCCTAAAGAAATTAAAATTTGTACTCTTTTTAATAAACCATCCAGAA
GGCTGATAGAACTAAAGATAGACTATGCGGGCTTTGAAATTGAAAATGATTTCATAGTCGGATATGGTATTGATTTTAAT
GAAAAACACAGAACTTTAAAGGATGTAGCAAAAATAAACAAATAG

Upstream 100 bases:

>100_bases
ATTAAATTTATGACCTGTAACCTTGACTTGAATTAAATCAATAAAAAAAATATAATGATGATATCAAAGGGTGAAAATAA
AGAGTTAAATGTAGCGATGA

Downstream 100 bases:

>100_bases
GAGATATGAATGTCAATTTACGCAGTTATTGGAACTCAATGGGGTGATGAAGGTAAGGGAAAAATTATAGATTTTCTCTC
ATCAAAGGCGGATTATGTTG

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MDEEISTLFTEEKIKSKIKELAQKIRNYYKDKSNVVFISLLKGSFMFFADITREIGLNVKIDFLQVSSYKNKTHSSLNVL
IKKDIDIDIKDSYVIIFDDIIDTGLTYDKIITYLKTKNPKEIKICTLFNKPSRRLIELKIDYAGFEIENDFIVGYGIDFN
EKHRTLKDVAKINK

Sequences:

>Translated_174_residues
MDEEISTLFTEEKIKSKIKELAQKIRNYYKDKSNVVFISLLKGSFMFFADITREIGLNVKIDFLQVSSYKNKTHSSLNVL
IKKDIDIDIKDSYVIIFDDIIDTGLTYDKIITYLKTKNPKEIKICTLFNKPSRRLIELKIDYAGFEIENDFIVGYGIDFN
EKHRTLKDVAKINK
>Mature_174_residues
MDEEISTLFTEEKIKSKIKELAQKIRNYYKDKSNVVFISLLKGSFMFFADITREIGLNVKIDFLQVSSYKNKTHSSLNVL
IKKDIDIDIKDSYVIIFDDIIDTGLTYDKIITYLKTKNPKEIKICTLFNKPSRRLIELKIDYAGFEIENDFIVGYGIDFN
EKHRTLKDVAKINK

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=150, Percent_Identity=32.6666666666667, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI9910262, Length=151, Percent_Identity=30.4635761589404, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI87081689, Length=173, Percent_Identity=40.4624277456647, Blast_Score=151, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17510817, Length=177, Percent_Identity=26.5536723163842, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20336; Mature: 20336

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEEISTLFTEEKIKSKIKELAQKIRNYYKDKSNVVFISLLKGSFMFFADITREIGLNVK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEHEEHHHHHCCCCEE
IDFLQVSSYKNKTHSSLNVLIKKDIDIDIKDSYVIIFDDIIDTGLTYDKIITYLKTKNPK
EEEEEECCCCCCCCCCEEEEEEECCCEEECCCEEEEEECHHHCCCCHHHHHHHHCCCCCC
EIKICTLFNKPSRRLIELKIDYAGFEIENDFIVGYGIDFNEKHRTLKDVAKINK
EEEEEEEECCCCCEEEEEEEEEECEEECCCEEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDEEISTLFTEEKIKSKIKELAQKIRNYYKDKSNVVFISLLKGSFMFFADITREIGLNVK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEHEEHHHHHCCCCEE
IDFLQVSSYKNKTHSSLNVLIKKDIDIDIKDSYVIIFDDIIDTGLTYDKIITYLKTKNPK
EEEEEECCCCCCCCCCEEEEEEECCCEEECCCEEEEEECHHHCCCCHHHHHHHHCCCCCC
EIKICTLFNKPSRRLIELKIDYAGFEIENDFIVGYGIDFNEKHRTLKDVAKINK
EEEEEEEECCCCCEEEEEEEEEECEEECCCEEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]