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The map label for this gene is nanH [H]

Identifier: 187736322

GI number: 187736322

Start: 2229943

End: 2231967

Strand: Direct

Name: nanH [H]

Synonym: Amuc_1835

Alternate gene names: 187736322

Gene position: 2229943-2231967 (Clockwise)

Preceding gene: 187736321

Following gene: 187736324

Centisome position: 83.7

GC content: 56.94

Gene sequence:

>2025_bases
ATGGGGCTTGGCCTGTTGTGCGCACTGGGCCTGTCTATTCCCTCCGTTCTCGGCAAGGAAAGCTTTGAGCAGGCCAGGCG
TGGCAAATTTACAACGCTTTCCACCAAATACGGCCTTATGTCCTGCCGGAACGGTGTGGCGGAAATCGGAGGAGGGGGAA
AATCCGGAGAAGCCTCCCTGCGGATGTTCGGCGGACAGGATGCTGAATTGAAACTGGACTTGAAGGATACGCCTTCCAGG
GAAGTCCGGCTTTCTGCCTGGGCGGAGCGATGGACCGGGCAGGCCCCTTTTGAATTTTCCATTGTGGCCATAGGGCCGAA
TGGAGAAAAGAAAATTTATGACGGCAAGGATATCAGGACGGGCGGGTTTCATACCAGGATAGAAGCCAGTGTTCCTGCCG
GAACGCGTTCCCTGGTGTTCAGGCTTACTTCTCCGGAAAACAAGGGAATGAAGCTGGACGACCTGTTTCTTGTTCCCTGT
ATTCCCATGAAAGTGAATCCGCAGGTGGAGATGGCCTCTTCCGCTTACCCGGTGATGGTGCGTATCCCGTGCAGCCCCGT
TCTTTCTCTGAATGTCCGGACGGACGGCTGCCTTAATCCTCAGTTCCTGACAGCTGTCAATCTGGATTTTACGGGTACGA
CGAAGCTTTCCGACATTGAGTCCGTGGCTGTAATACGGGGGGAAGAGGCCCCTATCATCCATCATGGGGAAGAGCCGTTC
CCGAAAGACTCTTCCCAGGTTCTTGGTACAGTAAAGCTTGCCGGTTCCGCCAGACCCCAGATTTCTGTGAAGGGGAAAAT
GGAGCTGGAGCCCGGAGACAATTACCTGTGGGCTTGCGTGACGATGAAAGAAGGAGCCTCCCTGGACGGCAGGGTGGTGG
TGCGTCCGGCCAGCGTTGTGGCGGGCAATAAACCGGTGAGGGTTGCCAATGCGGCTCCCGTGGCGCAGCGCATCGGCGTG
GCCGTAGTCAGGCATGGGGATTTCAAATCAAAATTCTACCGTATTCCCGGTCTGGCCCGTTCCAGGAAGGGGACCCTGCT
GGCCGTGTACGATATCCGGTACAACCATTCCGGAGACCTTCCGGCCAACATTGATGTGGGCGTAAGCCGCTCTACGGACG
GAGGCCGCACCTGGTCTGATGTCAAAATCGCCATTGATGATTCCAAGATTGACCCCTCTCTGGGGGCTACCAGGGGCGTA
GGGGATCCGGCCATTCTGGTGGATGAAAAGACGGGGCGCATCTGGGTGGCCGCCATATGGAGCCACAGGCATTCCATCTG
GGGCAGCAAGTCCGGAGACAATTCTCCGGAGGCCTGCGGACAGCTGGTGCTGGCCTACAGCGATGACGATGGCCTGACCT
GGTCCAGTCCGATCAATATCACGGAACAAACCAAGAACAAGGATTGGCGCATTTTATTTAATGGCCCCGGCAATGGCATT
TGCATGAAAGACGGCACGCTGGTCTTCGCCGCCCAGTACTGGGACGGCAAAGGGGTGCCGTGGTCCACCATTGTTTATTC
CAAAGACCGGGGAAAAACCTGGCACTGCGGCACGGGCGTCAACCAGCAGACGACGGAAGCCCAGGTGATTGAGCTGGAAG
ACGGCTCCGTCATGATCAACGCCCGATGCAACTGGGGCGGTTCCCGCATCGTGGGCGTTACGAAAGACCTGGGCCAAACG
TGGGAAAAACACCCCACCAACCGCACTGCCCAGCTGAAGGAACCGGTCTGCCAGGGCAGCCTGCTTGCCGTGGACGGCGT
TCCGGGCGCGGGCAGAGTGGTTCTGTTTTCCAATCCCAATACCACATCCGGACGTTCCCACATGACGTTGAAAGCTTCTA
CGAATGATGCCGGGTCATGGCCGGAAGACAAATGGCTTCTTTATGATGCCCGCAAAGGCTGGGGATATTCCTGCCTGGCG
CCGGTAGATAAGAACCATGTGGGCGTGCTGTACGAATCCCAGGGGGCGCTGAACTTCCTGAAAATTCCCTATAAGGATGT
TCTTAACGCAAAAAATGCGCGCTGA

Upstream 100 bases:

>100_bases
CGGCAAATAACGCTGCTCCGGGCAAGATTGCCGCGGGGGGCGGCGTATATATCCCGCGAAACACACCATAAATACGATGC
GTTTATCTTTGAATAAATTA

Downstream 100 bases:

>100_bases
TTTCGTTTTCCGGTAACATGTTCAATGGGCCGTTTTCGTTGGAGAACGGCCCGTTTTTTTTGTTTCCGGGTGTTTTTGTG
AAAGGACTTGGCCGCTGCGC

Product: Exo-alpha-sialidase

Products: NA

Alternate protein names: Neuraminidase [H]

Number of amino acids: Translated: 674; Mature: 673

Protein sequence:

>674_residues
MGLGLLCALGLSIPSVLGKESFEQARRGKFTTLSTKYGLMSCRNGVAEIGGGGKSGEASLRMFGGQDAELKLDLKDTPSR
EVRLSAWAERWTGQAPFEFSIVAIGPNGEKKIYDGKDIRTGGFHTRIEASVPAGTRSLVFRLTSPENKGMKLDDLFLVPC
IPMKVNPQVEMASSAYPVMVRIPCSPVLSLNVRTDGCLNPQFLTAVNLDFTGTTKLSDIESVAVIRGEEAPIIHHGEEPF
PKDSSQVLGTVKLAGSARPQISVKGKMELEPGDNYLWACVTMKEGASLDGRVVVRPASVVAGNKPVRVANAAPVAQRIGV
AVVRHGDFKSKFYRIPGLARSRKGTLLAVYDIRYNHSGDLPANIDVGVSRSTDGGRTWSDVKIAIDDSKIDPSLGATRGV
GDPAILVDEKTGRIWVAAIWSHRHSIWGSKSGDNSPEACGQLVLAYSDDDGLTWSSPINITEQTKNKDWRILFNGPGNGI
CMKDGTLVFAAQYWDGKGVPWSTIVYSKDRGKTWHCGTGVNQQTTEAQVIELEDGSVMINARCNWGGSRIVGVTKDLGQT
WEKHPTNRTAQLKEPVCQGSLLAVDGVPGAGRVVLFSNPNTTSGRSHMTLKASTNDAGSWPEDKWLLYDARKGWGYSCLA
PVDKNHVGVLYESQGALNFLKIPYKDVLNAKNAR

Sequences:

>Translated_674_residues
MGLGLLCALGLSIPSVLGKESFEQARRGKFTTLSTKYGLMSCRNGVAEIGGGGKSGEASLRMFGGQDAELKLDLKDTPSR
EVRLSAWAERWTGQAPFEFSIVAIGPNGEKKIYDGKDIRTGGFHTRIEASVPAGTRSLVFRLTSPENKGMKLDDLFLVPC
IPMKVNPQVEMASSAYPVMVRIPCSPVLSLNVRTDGCLNPQFLTAVNLDFTGTTKLSDIESVAVIRGEEAPIIHHGEEPF
PKDSSQVLGTVKLAGSARPQISVKGKMELEPGDNYLWACVTMKEGASLDGRVVVRPASVVAGNKPVRVANAAPVAQRIGV
AVVRHGDFKSKFYRIPGLARSRKGTLLAVYDIRYNHSGDLPANIDVGVSRSTDGGRTWSDVKIAIDDSKIDPSLGATRGV
GDPAILVDEKTGRIWVAAIWSHRHSIWGSKSGDNSPEACGQLVLAYSDDDGLTWSSPINITEQTKNKDWRILFNGPGNGI
CMKDGTLVFAAQYWDGKGVPWSTIVYSKDRGKTWHCGTGVNQQTTEAQVIELEDGSVMINARCNWGGSRIVGVTKDLGQT
WEKHPTNRTAQLKEPVCQGSLLAVDGVPGAGRVVLFSNPNTTSGRSHMTLKASTNDAGSWPEDKWLLYDARKGWGYSCLA
PVDKNHVGVLYESQGALNFLKIPYKDVLNAKNAR
>Mature_673_residues
GLGLLCALGLSIPSVLGKESFEQARRGKFTTLSTKYGLMSCRNGVAEIGGGGKSGEASLRMFGGQDAELKLDLKDTPSRE
VRLSAWAERWTGQAPFEFSIVAIGPNGEKKIYDGKDIRTGGFHTRIEASVPAGTRSLVFRLTSPENKGMKLDDLFLVPCI
PMKVNPQVEMASSAYPVMVRIPCSPVLSLNVRTDGCLNPQFLTAVNLDFTGTTKLSDIESVAVIRGEEAPIIHHGEEPFP
KDSSQVLGTVKLAGSARPQISVKGKMELEPGDNYLWACVTMKEGASLDGRVVVRPASVVAGNKPVRVANAAPVAQRIGVA
VVRHGDFKSKFYRIPGLARSRKGTLLAVYDIRYNHSGDLPANIDVGVSRSTDGGRTWSDVKIAIDDSKIDPSLGATRGVG
DPAILVDEKTGRIWVAAIWSHRHSIWGSKSGDNSPEACGQLVLAYSDDDGLTWSSPINITEQTKNKDWRILFNGPGNGIC
MKDGTLVFAAQYWDGKGVPWSTIVYSKDRGKTWHCGTGVNQQTTEAQVIELEDGSVMINARCNWGGSRIVGVTKDLGQTW
EKHPTNRTAQLKEPVCQGSLLAVDGVPGAGRVVLFSNPNTTSGRSHMTLKASTNDAGSWPEDKWLLYDARKGWGYSCLAP
VDKNHVGVLYESQGALNFLKIPYKDVLNAKNAR

Specific function: Sialidases have been suggested to be pathogenic factors in microbial infections [H]

COG id: COG4409

COG function: function code G; Neuraminidase (sialidase)

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 5 BNR repeats [H]

Homologues:

Organism=Homo sapiens, GI4557791, Length=351, Percent_Identity=27.9202279202279, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002860
- InterPro:   IPR011040
- InterPro:   IPR008377 [H]

Pfam domain/function: PF02012 BNR [H]

EC number: =3.2.1.18 [H]

Molecular weight: Translated: 72841; Mature: 72709

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLGLLCALGLSIPSVLGKESFEQARRGKFTTLSTKYGLMSCRNGVAEIGGGGKSGEASL
CCHHHHHHHHCCCHHHHCHHHHHHHHCCCEEEEECCCCHHHHCCCHHHCCCCCCCCCCEE
RMFGGQDAELKLDLKDTPSREVRLSAWAERWTGQAPFEFSIVAIGPNGEKKIYDGKDIRT
EEECCCCCEEEEEECCCCCCEEEEEEHHHHCCCCCCEEEEEEEECCCCCCEEECCCCEEC
GGFHTRIEASVPAGTRSLVFRLTSPENKGMKLDDLFLVPCIPMKVNPQVEMASSAYPVMV
CCCEEEEEECCCCCCEEEEEEEECCCCCCCEECCEEEEEEECEEECCCEEECCCCCCEEE
RIPCSPVLSLNVRTDGCLNPQFLTAVNLDFTGTTKLSDIESVAVIRGEEAPIIHHGEEPF
EECCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEECCCCCC
PKDSSQVLGTVKLAGSARPQISVKGKMELEPGDNYLWACVTMKEGASLDGRVVVRPASVV
CCCCCCEEEEEEECCCCCCEEEEEEEEEECCCCCEEEEEEEECCCCCCCCEEEEEECCEE
AGNKPVRVANAAPVAQRIGVAVVRHGDFKSKFYRIPGLARSRKGTLLAVYDIRYNHSGDL
CCCCCEEEECCCCHHHHCCEEEEECCCCCHHEEECCCCCCCCCCCEEEEEEEEECCCCCC
PANIDVGVSRSTDGGRTWSDVKIAIDDSKIDPSLGATRGVGDPAILVDEKTGRIWVAAIW
CCEEEEEEECCCCCCCEECEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEE
SHRHSIWGSKSGDNSPEACGQLVLAYSDDDGLTWSSPINITEQTKNKDWRILFNGPGNGI
CCHHHCCCCCCCCCCHHHCCEEEEEEECCCCCEECCCCCEEECCCCCCEEEEEECCCCEE
CMKDGTLVFAAQYWDGKGVPWSTIVYSKDRGKTWHCGTGVNQQTTEAQVIELEDGSVMIN
EEECCCEEEEEEEECCCCCCEEEEEEECCCCCEEEECCCCCCCCCCEEEEEEECCCEEEE
ARCNWGGSRIVGVTKDLGQTWEKHPTNRTAQLKEPVCQGSLLAVDGVPGAGRVVLFSNPN
EEECCCCCEEEEECHHHHHHHHHCCCCCCHHHHCCCCCCCEEEEECCCCCCEEEEECCCC
TTSGRSHMTLKASTNDAGSWPEDKWLLYDARKGWGYSCLAPVDKNHVGVLYESQGALNFL
CCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCCEEEEEECCCCEEEE
KIPYKDVLNAKNAR
ECCHHHHCCCCCCC
>Mature Secondary Structure 
GLGLLCALGLSIPSVLGKESFEQARRGKFTTLSTKYGLMSCRNGVAEIGGGGKSGEASL
CHHHHHHHHCCCHHHHCHHHHHHHHCCCEEEEECCCCHHHHCCCHHHCCCCCCCCCCEE
RMFGGQDAELKLDLKDTPSREVRLSAWAERWTGQAPFEFSIVAIGPNGEKKIYDGKDIRT
EEECCCCCEEEEEECCCCCCEEEEEEHHHHCCCCCCEEEEEEEECCCCCCEEECCCCEEC
GGFHTRIEASVPAGTRSLVFRLTSPENKGMKLDDLFLVPCIPMKVNPQVEMASSAYPVMV
CCCEEEEEECCCCCCEEEEEEEECCCCCCCEECCEEEEEEECEEECCCEEECCCCCCEEE
RIPCSPVLSLNVRTDGCLNPQFLTAVNLDFTGTTKLSDIESVAVIRGEEAPIIHHGEEPF
EECCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEECCCCCC
PKDSSQVLGTVKLAGSARPQISVKGKMELEPGDNYLWACVTMKEGASLDGRVVVRPASVV
CCCCCCEEEEEEECCCCCCEEEEEEEEEECCCCCEEEEEEEECCCCCCCCEEEEEECCEE
AGNKPVRVANAAPVAQRIGVAVVRHGDFKSKFYRIPGLARSRKGTLLAVYDIRYNHSGDL
CCCCCEEEECCCCHHHHCCEEEEECCCCCHHEEECCCCCCCCCCCEEEEEEEEECCCCCC
PANIDVGVSRSTDGGRTWSDVKIAIDDSKIDPSLGATRGVGDPAILVDEKTGRIWVAAIW
CCEEEEEEECCCCCCCEECEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEE
SHRHSIWGSKSGDNSPEACGQLVLAYSDDDGLTWSSPINITEQTKNKDWRILFNGPGNGI
CCHHHCCCCCCCCCCHHHCCEEEEEEECCCCCEECCCCCEEECCCCCCEEEEEECCCCEE
CMKDGTLVFAAQYWDGKGVPWSTIVYSKDRGKTWHCGTGVNQQTTEAQVIELEDGSVMIN
EEECCCEEEEEEEECCCCCCEEEEEEECCCCCEEEECCCCCCCCCCEEEEEEECCCEEEE
ARCNWGGSRIVGVTKDLGQTWEKHPTNRTAQLKEPVCQGSLLAVDGVPGAGRVVLFSNPN
EEECCCCCEEEEECHHHHHHHHHCCCCCCHHHHCCCCCCCEEEEECCCCCCEEEEECCCC
TTSGRSHMTLKASTNDAGSWPEDKWLLYDARKGWGYSCLAPVDKNHVGVLYESQGALNFL
CCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCCEEEEEECCCCEEEE
KIPYKDVLNAKNAR
ECCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8093075; 2158974 [H]