| Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
|---|---|
| Accession | NC_010655 |
| Length | 2,664,102 |
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The map label for this gene is yqhE [C]
Identifier: 187736287
GI number: 187736287
Start: 2187372
End: 2188220
Strand: Direct
Name: yqhE [C]
Synonym: Amuc_1800
Alternate gene names: 187736287
Gene position: 2187372-2188220 (Clockwise)
Preceding gene: 187736286
Following gene: 187736288
Centisome position: 82.11
GC content: 55.12
Gene sequence:
>849_bases ATGGAAAAAGTGATGTTGAACAATGGCGTTACGATGCCTGTCCTGGGATTTGGCGTTTTTCAGATTCCGGACGCTAAGGA GTGCGAACGCTGCGTGCTGGATGCGATTGAGGTCGGCTACCGTTCTATTGATACCGCGCAGATTTACGGCAATGAGGAAG CCGTAGGCCGCGCAGCGGAGAAGAGCGGGGTTCCGCGGGAAGAGTTGTTCCTTACCACGAAGGTGTGGATTTCCAACGGC GGGTATGAGAAGGCGAAGGCGTCCATTGACGAATCCCTGCGCAGGCTGCGCACGGATTATCTGGATCTGCTGCTCATCCA CCAGCCTTTCAACGATTACTACGGCACTTACCGGGCCATGGAAGAAGCGAACCGGGCCGGAAAGGTACGCGCCATTGGCG TGAGCAATTTTTATCCGGACCGTTTTGTGGACCTGGCGGAGTTCTGCGAGATCAGACCCGCCGTCAACCAGGTGGAAACG CATGTGTTCCACCAGCAGGAAAAAGTCCGGGAGGTGATGGAAAAGTACGGTACCAGAATGGAATCCTGGGGGCCTTTTGC GGAAGGTCGCAATGGGTTTTTCTCCAACCCCGTGTTGAAGGGCATTGGAGAGAAATACGGCAAGACCCCGGCGCAAACAG CCCTGAGGTTCCTGATTCAGCGTGGAATTATCGCCATTCCGAAGACGACCCACCGGGAAAGGATGGAGGAGAATTTCAAC GTCTTTGATTTTGCCCTTTCCCAGGAGGATATGGGCGCTATTGCCAGGCTGGACCGCGGAGAGAGCCTTTTCCTGTGCCA CCGGGATCCGGAATCGGTCCTGTACCTGATCAATTACGGGAAGCAGTAA
Upstream 100 bases:
>100_bases TCTTGGCAGCAGGAAGTATGAACTGAAAGAGCTGAAACCGCAGCAGGCCGTTTAGTCGGTCATTTCCTTTTTAGTATCAA AAACAATAGAAAAAACTGTG
Downstream 100 bases:
>100_bases TTCGCATGAAGTTCCAGAAAGATGACACGATACTCATTTAAAATATTTTGCGTGGCTTTTTCCGCCTGCTTTTGCTGTGC GGGGAGCCTGTTGGCAGAAG
Product: 2,5-didehydrogluconate reductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 282; Mature: 282
Protein sequence:
>282_residues MEKVMLNNGVTMPVLGFGVFQIPDAKECERCVLDAIEVGYRSIDTAQIYGNEEAVGRAAEKSGVPREELFLTTKVWISNG GYEKAKASIDESLRRLRTDYLDLLLIHQPFNDYYGTYRAMEEANRAGKVRAIGVSNFYPDRFVDLAEFCEIRPAVNQVET HVFHQQEKVREVMEKYGTRMESWGPFAEGRNGFFSNPVLKGIGEKYGKTPAQTALRFLIQRGIIAIPKTTHRERMEENFN VFDFALSQEDMGAIARLDRGESLFLCHRDPESVLYLINYGKQ
Sequences:
>Translated_282_residues MEKVMLNNGVTMPVLGFGVFQIPDAKECERCVLDAIEVGYRSIDTAQIYGNEEAVGRAAEKSGVPREELFLTTKVWISNG GYEKAKASIDESLRRLRTDYLDLLLIHQPFNDYYGTYRAMEEANRAGKVRAIGVSNFYPDRFVDLAEFCEIRPAVNQVET HVFHQQEKVREVMEKYGTRMESWGPFAEGRNGFFSNPVLKGIGEKYGKTPAQTALRFLIQRGIIAIPKTTHRERMEENFN VFDFALSQEDMGAIARLDRGESLFLCHRDPESVLYLINYGKQ >Mature_282_residues MEKVMLNNGVTMPVLGFGVFQIPDAKECERCVLDAIEVGYRSIDTAQIYGNEEAVGRAAEKSGVPREELFLTTKVWISNG GYEKAKASIDESLRRLRTDYLDLLLIHQPFNDYYGTYRAMEEANRAGKVRAIGVSNFYPDRFVDLAEFCEIRPAVNQVET HVFHQQEKVREVMEKYGTRMESWGPFAEGRNGFFSNPVLKGIGEKYGKTPAQTALRFLIQRGIIAIPKTTHRERMEENFN VFDFALSQEDMGAIARLDRGESLFLCHRDPESVLYLINYGKQ
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=290, Percent_Identity=32.0689655172414, Blast_Score=165, Evalue=5e-41, Organism=Homo sapiens, GI5174391, Length=290, Percent_Identity=32.0689655172414, Blast_Score=165, Evalue=5e-41, Organism=Homo sapiens, GI310109922, Length=276, Percent_Identity=34.7826086956522, Blast_Score=163, Evalue=2e-40, Organism=Homo sapiens, GI5174695, Length=299, Percent_Identity=32.7759197324415, Blast_Score=162, Evalue=4e-40, Organism=Homo sapiens, GI310109920, Length=297, Percent_Identity=32.996632996633, Blast_Score=160, Evalue=1e-39, Organism=Homo sapiens, GI24497583, Length=300, Percent_Identity=32.6666666666667, Blast_Score=160, Evalue=2e-39, Organism=Homo sapiens, GI45446745, Length=297, Percent_Identity=32.6599326599327, Blast_Score=158, Evalue=5e-39, Organism=Homo sapiens, GI4503285, Length=297, Percent_Identity=32.6599326599327, Blast_Score=158, Evalue=5e-39, Organism=Homo sapiens, GI5453543, Length=296, Percent_Identity=32.4324324324324, Blast_Score=157, Evalue=1e-38, Organism=Homo sapiens, GI24497585, Length=298, Percent_Identity=31.2080536912752, Blast_Score=152, Evalue=4e-37, Organism=Homo sapiens, GI4502049, Length=307, Percent_Identity=34.2019543973941, Blast_Score=147, Evalue=9e-36, Organism=Homo sapiens, GI223468663, Length=292, Percent_Identity=32.1917808219178, Blast_Score=145, Evalue=4e-35, Organism=Homo sapiens, GI300116273, Length=280, Percent_Identity=32.5, Blast_Score=145, Evalue=5e-35, Organism=Homo sapiens, GI93277124, Length=300, Percent_Identity=31.3333333333333, Blast_Score=139, Evalue=3e-33, Organism=Homo sapiens, GI300116271, Length=274, Percent_Identity=31.7518248175182, Blast_Score=138, Evalue=6e-33, Organism=Homo sapiens, GI291291012, Length=266, Percent_Identity=31.9548872180451, Blast_Score=124, Evalue=9e-29, Organism=Homo sapiens, GI310109926, Length=115, Percent_Identity=42.6086956521739, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI207028673, Length=115, Percent_Identity=41.7391304347826, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI310109924, Length=153, Percent_Identity=30.0653594771242, Blast_Score=83, Evalue=3e-16, Organism=Escherichia coli, GI87082198, Length=263, Percent_Identity=39.1634980988593, Blast_Score=214, Evalue=7e-57, Organism=Escherichia coli, GI1786400, Length=260, Percent_Identity=39.2307692307692, Blast_Score=172, Evalue=3e-44, Organism=Escherichia coli, GI1788081, Length=276, Percent_Identity=31.5217391304348, Blast_Score=108, Evalue=5e-25, Organism=Escherichia coli, GI87081735, Length=292, Percent_Identity=28.7671232876712, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI48994888, Length=186, Percent_Identity=29.5698924731183, Blast_Score=71, Evalue=1e-13, Organism=Escherichia coli, GI1787674, Length=271, Percent_Identity=23.9852398523985, Blast_Score=67, Evalue=9e-13, Organism=Caenorhabditis elegans, GI17537075, Length=297, Percent_Identity=35.016835016835, Blast_Score=171, Evalue=3e-43, Organism=Caenorhabditis elegans, GI71998625, Length=265, Percent_Identity=38.4905660377359, Blast_Score=171, Evalue=4e-43, Organism=Caenorhabditis elegans, GI17564128, Length=303, Percent_Identity=31.6831683168317, Blast_Score=171, Evalue=5e-43, Organism=Caenorhabditis elegans, GI17537077, Length=304, Percent_Identity=33.8815789473684, Blast_Score=169, Evalue=1e-42, Organism=Caenorhabditis elegans, GI17550248, Length=295, Percent_Identity=34.5762711864407, Blast_Score=158, Evalue=3e-39, Organism=Caenorhabditis elegans, GI17552492, Length=286, Percent_Identity=35.3146853146853, Blast_Score=150, Evalue=9e-37, Organism=Caenorhabditis elegans, GI17537079, Length=298, Percent_Identity=31.2080536912752, Blast_Score=148, Evalue=2e-36, Organism=Caenorhabditis elegans, GI17566692, Length=295, Percent_Identity=32.2033898305085, Blast_Score=148, Evalue=4e-36, Organism=Caenorhabditis elegans, GI17561298, Length=278, Percent_Identity=29.4964028776978, Blast_Score=139, Evalue=1e-33, Organism=Caenorhabditis elegans, GI17562292, Length=278, Percent_Identity=28.4172661870504, Blast_Score=132, Evalue=3e-31, Organism=Caenorhabditis elegans, GI17561300, Length=273, Percent_Identity=30.03663003663, Blast_Score=124, Evalue=6e-29, Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=29.4117647058824, Blast_Score=120, Evalue=8e-28, Organism=Saccharomyces cerevisiae, GI6320576, Length=287, Percent_Identity=33.4494773519164, Blast_Score=164, Evalue=2e-41, Organism=Saccharomyces cerevisiae, GI6324694, Length=287, Percent_Identity=32.404181184669, Blast_Score=162, Evalue=8e-41, Organism=Saccharomyces cerevisiae, GI6322556, Length=268, Percent_Identity=33.955223880597, Blast_Score=153, Evalue=3e-38, Organism=Saccharomyces cerevisiae, GI6321896, Length=304, Percent_Identity=31.25, Blast_Score=143, Evalue=3e-35, Organism=Saccharomyces cerevisiae, GI6319625, Length=273, Percent_Identity=32.2344322344322, Blast_Score=126, Evalue=5e-30, Organism=Saccharomyces cerevisiae, GI6320079, Length=236, Percent_Identity=28.8135593220339, Blast_Score=108, Evalue=1e-24, Organism=Drosophila melanogaster, GI24644950, Length=299, Percent_Identity=35.4515050167224, Blast_Score=179, Evalue=2e-45, Organism=Drosophila melanogaster, GI24657054, Length=304, Percent_Identity=34.8684210526316, Blast_Score=175, Evalue=3e-44, Organism=Drosophila melanogaster, GI45553081, Length=292, Percent_Identity=33.2191780821918, Blast_Score=174, Evalue=8e-44, Organism=Drosophila melanogaster, GI24663317, Length=290, Percent_Identity=35.5172413793103, Blast_Score=172, Evalue=2e-43, Organism=Drosophila melanogaster, GI221378297, Length=319, Percent_Identity=33.2288401253918, Blast_Score=171, Evalue=4e-43, Organism=Drosophila melanogaster, GI20129731, Length=291, Percent_Identity=36.7697594501718, Blast_Score=164, Evalue=5e-41, Organism=Drosophila melanogaster, GI21356425, Length=293, Percent_Identity=32.4232081911263, Blast_Score=164, Evalue=7e-41, Organism=Drosophila melanogaster, GI24662789, Length=290, Percent_Identity=32.4137931034483, Blast_Score=157, Evalue=6e-39, Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=31.7829457364341, Blast_Score=144, Evalue=4e-35, Organism=Drosophila melanogaster, GI24662785, Length=278, Percent_Identity=34.1726618705036, Blast_Score=127, Evalue=1e-29, Organism=Drosophila melanogaster, GI24662781, Length=280, Percent_Identity=33.5714285714286, Blast_Score=127, Evalue=1e-29,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 32172; Mature: 32172
Theoretical pI: Translated: 5.76; Mature: 5.76
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEKVMLNNGVTMPVLGFGVFQIPDAKECERCVLDAIEVGYRSIDTAQIYGNEEAVGRAAE CCCEEECCCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCHHEECCCHHHHHHHHH KSGVPREELFLTTKVWISNGGYEKAKASIDESLRRLRTDYLDLLLIHQPFNDYYGTYRAM HCCCCHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHH EEANRAGKVRAIGVSNFYPDRFVDLAEFCEIRPAVNQVETHVFHQQEKVREVMEKYGTRM HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH ESWGPFAEGRNGFFSNPVLKGIGEKYGKTPAQTALRFLIQRGIIAIPKTTHRERMEENFN HHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCCCHHHHHHHCCCC VFDFALSQEDMGAIARLDRGESLFLCHRDPESVLYLINYGKQ EEEEEECHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCC >Mature Secondary Structure MEKVMLNNGVTMPVLGFGVFQIPDAKECERCVLDAIEVGYRSIDTAQIYGNEEAVGRAAE CCCEEECCCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCHHEECCCHHHHHHHHH KSGVPREELFLTTKVWISNGGYEKAKASIDESLRRLRTDYLDLLLIHQPFNDYYGTYRAM HCCCCHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHH EEANRAGKVRAIGVSNFYPDRFVDLAEFCEIRPAVNQVETHVFHQQEKVREVMEKYGTRM HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH ESWGPFAEGRNGFFSNPVLKGIGEKYGKTPAQTALRFLIQRGIIAIPKTTHRERMEENFN HHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCCCHHHHHHHCCCC VFDFALSQEDMGAIARLDRGESLFLCHRDPESVLYLINYGKQ EEEEEECHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA