Click here to switch to the map view.

The map label for this gene is cobU [H]

Identifier: 187736165

GI number: 187736165

Start: 2036580

End: 2037128

Strand: Reverse

Name: cobU [H]

Synonym: Amuc_1678

Alternate gene names: 187736165

Gene position: 2037128-2036580 (Counterclockwise)

Preceding gene: 187736166

Following gene: 187736162

Centisome position: 76.47

GC content: 57.92

Gene sequence:

>549_bases
ATGACGCTCGTCCTGGGCGGCATCAGAAGCGGCAAAAGCCAATACGCTGAACAAATAGCCGCCGGATTCGGGAAAAAAAT
CCTGTACGTCGCCACGGCGGAAGTCTGGCCCGGAGCCGGCTCCATGGAATACCGCGTGCGCAAGCACCAGGAACGCCGTC
CTAAAAGCTGGCTCACGCTGGAATGTCCCCGTCATGTAGCTTCTGCCGTCGGGGAATCCGGCTTGCTGGACCAGGTGGAC
GGCGTCATTCTGGAATGCGTCACCCTGCTCTCCTCCAATACCCTGTACGCCCAGAAGGACCCCACGGACTACGAGCCGTT
CCAGGAAGCGCTGATTGAGGAAATAGAAGCTTTGAAAAAGCTCATCCGCCAATCCCCTGTGCCATGGGTGCTTGTTTCTT
CTGAAACCGGCATGGGCATCAGCCAGTCAGATGCGGAAACGCGCCACTACTGCGACGGGCTGGGCATTGCCAACCAACTC
CTTGCCAAAAGCGCGGATGAAGTCTACTTCATGGTGGCGGGACTACCCCTGACCGTGAAAAAAGGCTGA

Upstream 100 bases:

>100_bases
CTGGAAGTCTTCAGCCTGGATGACTTCCTGAACTCCCACCAGGCCATGCTGGAATCCCATGAACGCTACATCACCAAACA
CTGACGCCAATACCGCACGC

Downstream 100 bases:

>100_bases
AACGCCAACCATGAATTTTCATCGGCTTGCGCACATGAAACACAAAGAAACATGCCGGAAATTAAGCCGCGCCACTCATT
CAACGGGAGCGGCGCAAGAC

Product: cobalbumin biosynthesis protein

Products: NA

Alternate protein names: Adenosylcobinamide kinase; Adenosylcobinamide-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MTLVLGGIRSGKSQYAEQIAAGFGKKILYVATAEVWPGAGSMEYRVRKHQERRPKSWLTLECPRHVASAVGESGLLDQVD
GVILECVTLLSSNTLYAQKDPTDYEPFQEALIEEIEALKKLIRQSPVPWVLVSSETGMGISQSDAETRHYCDGLGIANQL
LAKSADEVYFMVAGLPLTVKKG

Sequences:

>Translated_182_residues
MTLVLGGIRSGKSQYAEQIAAGFGKKILYVATAEVWPGAGSMEYRVRKHQERRPKSWLTLECPRHVASAVGESGLLDQVD
GVILECVTLLSSNTLYAQKDPTDYEPFQEALIEEIEALKKLIRQSPVPWVLVSSETGMGISQSDAETRHYCDGLGIANQL
LAKSADEVYFMVAGLPLTVKKG
>Mature_181_residues
TLVLGGIRSGKSQYAEQIAAGFGKKILYVATAEVWPGAGSMEYRVRKHQERRPKSWLTLECPRHVASAVGESGLLDQVDG
VILECVTLLSSNTLYAQKDPTDYEPFQEALIEEIEALKKLIRQSPVPWVLVSSETGMGISQSDAETRHYCDGLGIANQLL
AKSADEVYFMVAGLPLTVKKG

Specific function: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate [H]

COG id: COG2087

COG function: function code H; Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788302, Length=185, Percent_Identity=36.2162162162162, Blast_Score=111, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003203 [H]

Pfam domain/function: PF02283 CobU [H]

EC number: =2.7.1.156; =2.7.7.62 [H]

Molecular weight: Translated: 19914; Mature: 19783

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVLGGIRSGKSQYAEQIAAGFGKKILYVATAEVWPGAGSMEYRVRKHQERRPKSWLTL
CEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEE
ECPRHVASAVGESGLLDQVDGVILECVTLLSSNTLYAQKDPTDYEPFQEALIEEIEALKK
ECHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHH
LIRQSPVPWVLVSSETGMGISQSDAETRHYCDGLGIANQLLAKSADEVYFMVAGLPLTVK
HHHHCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCEEEEE
KG
CC
>Mature Secondary Structure 
TLVLGGIRSGKSQYAEQIAAGFGKKILYVATAEVWPGAGSMEYRVRKHQERRPKSWLTL
EEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEE
ECPRHVASAVGESGLLDQVDGVILECVTLLSSNTLYAQKDPTDYEPFQEALIEEIEALKK
ECHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHH
LIRQSPVPWVLVSSETGMGISQSDAETRHYCDGLGIANQLLAKSADEVYFMVAGLPLTVK
HHHHCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCEEEEE
KG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8501034; 11677609; 9601028; 10529169 [H]