Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is hppA [H]

Identifier: 187736018

GI number: 187736018

Start: 1827934

End: 1830162

Strand: Direct

Name: hppA [H]

Synonym: Amuc_1528

Alternate gene names: 187736018

Gene position: 1827934-1830162 (Clockwise)

Preceding gene: 187736017

Following gene: 187736019

Centisome position: 68.61

GC content: 58.68

Gene sequence:

>2229_bases
ATGATAACCATCCAGGATTTATTTTGGCTCATCCCATCGGCTTCCGTGCTGGCCCTCATTTTTGCGGGCATCTTTTTTTA
CCGCATGAAAGCGCAGGATGAGGGGAACGAGGTCATGAAAATGATCGCCCGGCATGTCCGCAGCGGCGCCATGGCCTACC
TGCGGCAGCAGTATAAGATTGTCGCCATTTTCTTTGTGCTCATTACTGTTGTCTTCGCTTTTCTGGCCTACTGCCTCCAC
ATTCAGAACCCCTGGGTTCCCTTCGCTTTCATTTCAGGCGGCTTTTTCTCCGGTCTGGCCGGCTACATCGGAATGAAGAC
GGCTACGTATGCTTCCGGCCGCGTGGCGAATGCCTGCCGCCATTCCCTGGATGCCGGGCTGCAAATAGCTTTCCGCTCGG
GCGCCGTGCTAGGCCTGACCGTCGTGGGCCTTGCCATGCTTGATATCGGTGCCTGGTACTGGGTTCTGGATTGGTTTTAC
GGGGACATGGAGCTTTCCATGCGCCTGGTCGTCATTACTACCACCATGCTGACGTTCGGCATGGGGGCTTCCCTCCAGGC
GCTGTTTGCCCGTGTGGGCGGCGGCATTTTTACCAAGGCGGCGGATGTAGGGGCCGACCTGGTGGGGAAGGTGGAGGCCG
GCATTCCGGAGGACGACCCCCGCAACCCAGCCACCATTGCGGATAACGTGGGCGATAACGTGGGGGATGTGGCCGGCATG
GGGGCGGACCTTTACGAATCTTACTGCGGTTCCATTCTTGCTTCCGCCGCTTTGGGTGCGGCAGCTTACATGGCCGTTCC
TGAAATGGCGATCAAGGCCGTCCTTACGCCCATGCTGATCGCCGCCCTCGGCACCATTCTTTCCCTGTTGGGCGTGTACG
CGGTGCGCGTGAAGCGCGGCGCTTCCCAAACGGAGCTGATGGCAGCCCTGAACCGCGGCATCAACTTGAGTTCCTTTCTG
ATTGCCATTGCTTCCGCATTCCTGCTCCAGCTCATCGGCCTGGATAACTGGGCCGGCATCTGGGGGGCCATCGTCACCGG
CCTGGCGGTGGGCATCGTCATCGGCAAGAGCACGGAGCATTACACTTCCCATGATTCCTATCCCTGCCGTAAAATCGCCC
ACAGCGCGAAGACGGGGCCGGCCACCGTCATTATTTCCGGCATCGGCATCGGCATGATTTCCACCTGCATTCCCGTAATT
ACTGTCGTCGTTGGCACTGTGCTGGCTTACGGCCTGGCTTCCGGAGACTGGCATTTCACCGGGGCGGAAATGAGCAAGGG
GCTGTATGGCATCGGCATTGCCGCCGTCGGCATGCTTTCCACGCTGGGCCTGACATTGGCGACGGACGCTTACGGCCCCA
TTTCCGACAACGCCGGGGGTAATGCGGAGATGAGCAAGCTGGACCCGGAAGTGCGCCGCCGCACGGATGCCCTGGATGCC
CTGGGCAACACGACCGCCGCCACGGGCAAGGGATTTGCCATCGGTTCCGCCGCTCTGACGGCATTGGCGCTTCTGGCCTC
CTATATTGAAGAATTGAAGATTTCCATCCTTCACTGGAGTGAGGCCACGGGCAATACCATTTACAAAATTAATGATGCCG
TGAGTGTGGAGGTTTCCAAAATCTCCACTGCTTCCCTGTCTGATTTCATGGGCTATTTCCAGGTAACCCTGATGAACCCG
AAGGTGCTCATGGGGCTCTTCGTGGGGGCCATGATGTCCTTCATGTTTTGCGGGCTGACCATGAATGCCGTCGGCCGCGC
CGCGGAAAAAATGGTTAAGGAAGTGCGCCGCCAGTTTAAGGAAATCAAGGGAATCCTGACCGGAGAGGCAGAACCGGATT
ACGTGCGCTGCGTGGAAATTTCCACGGCGGGAGCGCAGCATGAGATGATCTGGCCGTCCGTACTGGCGGTCATCACCCCC
ATCTGCATGGGTATCGTTTTCGGTGTTCCCGGCGTGTTCGGCCTGCTGGCCGGCGGCCTGGCTTCCGGCTTTGTGTTGGC
CGTATTCATGGCTAATTCCGGCGGAGCGTGGGACAATGCCAAGAAATATATTGAGCAGGGCCATGTGGGCGGCAAAGGCT
CGGAAAGCCATAAGGCAGCCGTTATCGGCGATACGGTGGGCGACCCCTTCAAGGATACGTCCGGCCCGTCCCTGAACATC
CTGATCAAGCTCATGAGCATGGTGGCTATCGTCACCGCCGGCGTGAATATAGCCGTGACCCTGTTCTAA

Upstream 100 bases:

>100_bases
TGCTGGAAGGGGCATTTCCTGTTCCGGACACAGGTTTTTTCTTGGAGTAAAGTAGAGCTGGTGTTATGTTTTTACTACTT
TAATTTAAAGTGTACTGACA

Downstream 100 bases:

>100_bases
ACAGAAAGATTCTTTCACGGAAAACGGAGGGAGTCCGCAAGATTGGCGGACTCCCTTTTTTTTCTGGCTGAAGGGAACCG
TCCACTGGTGAGCGGTTTTT

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound sodium-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; Na(+)-PPase [H]

Number of amino acids: Translated: 742; Mature: 742

Protein sequence:

>742_residues
MITIQDLFWLIPSASVLALIFAGIFFYRMKAQDEGNEVMKMIARHVRSGAMAYLRQQYKIVAIFFVLITVVFAFLAYCLH
IQNPWVPFAFISGGFFSGLAGYIGMKTATYASGRVANACRHSLDAGLQIAFRSGAVLGLTVVGLAMLDIGAWYWVLDWFY
GDMELSMRLVVITTTMLTFGMGASLQALFARVGGGIFTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDVAGM
GADLYESYCGSILASAALGAAAYMAVPEMAIKAVLTPMLIAALGTILSLLGVYAVRVKRGASQTELMAALNRGINLSSFL
IAIASAFLLQLIGLDNWAGIWGAIVTGLAVGIVIGKSTEHYTSHDSYPCRKIAHSAKTGPATVIISGIGIGMISTCIPVI
TVVVGTVLAYGLASGDWHFTGAEMSKGLYGIGIAAVGMLSTLGLTLATDAYGPISDNAGGNAEMSKLDPEVRRRTDALDA
LGNTTAATGKGFAIGSAALTALALLASYIEELKISILHWSEATGNTIYKINDAVSVEVSKISTASLSDFMGYFQVTLMNP
KVLMGLFVGAMMSFMFCGLTMNAVGRAAEKMVKEVRRQFKEIKGILTGEAEPDYVRCVEISTAGAQHEMIWPSVLAVITP
ICMGIVFGVPGVFGLLAGGLASGFVLAVFMANSGGAWDNAKKYIEQGHVGGKGSESHKAAVIGDTVGDPFKDTSGPSLNI
LIKLMSMVAIVTAGVNIAVTLF

Sequences:

>Translated_742_residues
MITIQDLFWLIPSASVLALIFAGIFFYRMKAQDEGNEVMKMIARHVRSGAMAYLRQQYKIVAIFFVLITVVFAFLAYCLH
IQNPWVPFAFISGGFFSGLAGYIGMKTATYASGRVANACRHSLDAGLQIAFRSGAVLGLTVVGLAMLDIGAWYWVLDWFY
GDMELSMRLVVITTTMLTFGMGASLQALFARVGGGIFTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDVAGM
GADLYESYCGSILASAALGAAAYMAVPEMAIKAVLTPMLIAALGTILSLLGVYAVRVKRGASQTELMAALNRGINLSSFL
IAIASAFLLQLIGLDNWAGIWGAIVTGLAVGIVIGKSTEHYTSHDSYPCRKIAHSAKTGPATVIISGIGIGMISTCIPVI
TVVVGTVLAYGLASGDWHFTGAEMSKGLYGIGIAAVGMLSTLGLTLATDAYGPISDNAGGNAEMSKLDPEVRRRTDALDA
LGNTTAATGKGFAIGSAALTALALLASYIEELKISILHWSEATGNTIYKINDAVSVEVSKISTASLSDFMGYFQVTLMNP
KVLMGLFVGAMMSFMFCGLTMNAVGRAAEKMVKEVRRQFKEIKGILTGEAEPDYVRCVEISTAGAQHEMIWPSVLAVITP
ICMGIVFGVPGVFGLLAGGLASGFVLAVFMANSGGAWDNAKKYIEQGHVGGKGSESHKAAVIGDTVGDPFKDTSGPSLNI
LIKLMSMVAIVTAGVNIAVTLF
>Mature_742_residues
MITIQDLFWLIPSASVLALIFAGIFFYRMKAQDEGNEVMKMIARHVRSGAMAYLRQQYKIVAIFFVLITVVFAFLAYCLH
IQNPWVPFAFISGGFFSGLAGYIGMKTATYASGRVANACRHSLDAGLQIAFRSGAVLGLTVVGLAMLDIGAWYWVLDWFY
GDMELSMRLVVITTTMLTFGMGASLQALFARVGGGIFTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDVAGM
GADLYESYCGSILASAALGAAAYMAVPEMAIKAVLTPMLIAALGTILSLLGVYAVRVKRGASQTELMAALNRGINLSSFL
IAIASAFLLQLIGLDNWAGIWGAIVTGLAVGIVIGKSTEHYTSHDSYPCRKIAHSAKTGPATVIISGIGIGMISTCIPVI
TVVVGTVLAYGLASGDWHFTGAEMSKGLYGIGIAAVGMLSTLGLTLATDAYGPISDNAGGNAEMSKLDPEVRRRTDALDA
LGNTTAATGKGFAIGSAALTALALLASYIEELKISILHWSEATGNTIYKINDAVSVEVSKISTASLSDFMGYFQVTLMNP
KVLMGLFVGAMMSFMFCGLTMNAVGRAAEKMVKEVRRQFKEIKGILTGEAEPDYVRCVEISTAGAQHEMIWPSVLAVITP
ICMGIVFGVPGVFGLLAGGLASGFVLAVFMANSGGAWDNAKKYIEQGHVGGKGSESHKAAVIGDTVGDPFKDTSGPSLNI
LIKLMSMVAIVTAGVNIAVTLF

Specific function: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 77955; Mature: 77955

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure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HHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]