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The map label for this gene is gmk [H]

Identifier: 187735980

GI number: 187735980

Start: 1779046

End: 1779648

Strand: Direct

Name: gmk [H]

Synonym: Amuc_1489

Alternate gene names: 187735980

Gene position: 1779046-1779648 (Clockwise)

Preceding gene: 187735979

Following gene: 187735982

Centisome position: 66.78

GC content: 57.88

Gene sequence:

>603_bases
ATGACAGCCATGAAACAGCCATTGGGAACATTGCTGGTGGTATCCGGGCCTTCCGGTTCCGGGAAGACGACGTTGTGCCG
CCGCGCGACGGAAAACGGTCTGTGTGTGTACAGCATTTCCTGCACGACGCGCCAGCCCAGACCCGGGGAAGTCAATGGAG
TGGATTACCATTTCCTGACTCCCGCCGAATTTGACGCCAGGGTGGAGCGGGGAGACTTTCTGGAATATGCGGAGGTGCAC
GGCAACCGCTACGGTACGCTGAAAGCGGATATTTTGACTCTTCTGGAACAGGGGAAAAACGTGGTGATGGATATTGACGT
GCAGGGGGCTGGGCAAGTCCGTTCCTGCCGGGAGGGCATTCTACCCCTCTGCTATGTGGACGTTTACATTTATGTGCCGC
AGGCGGAGCTTAAAAACCGCCTTTGCGGACGGCAGACGGATGGCGCTGAAACCATTGCCCTGCGTCTTCGCAATGCGGAA
CAGGAAGACGCCTGCCTGCCGCAGTACCAGTACTGCCTGGTTTCCTCCGACCGCGAGACGGATTATGCTTCCTTTTGCGC
CCTGCTCAAATGCCAGTCCATGCGGGTGGGACTGATGCGGTGA

Upstream 100 bases:

>100_bases
ACACCATCGGCTCCAAGGCGAACGATTCCACGCTGGCCCATCTGGTTGTGGCTGCCAAGACGGAGCTGGAGAAAATCAGG
GAACAGGTTCAGAACATCGA

Downstream 100 bases:

>100_bases
TAAGGTCTTGCCTGTTTATCGAGAGACTGCGTTCTCTCGTTTCGTCCCCCGTCACATGGCATCCGGGATGGCGGCTCCGG
TTCCGAGACATTTGGAATTG

Product: Guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MTAMKQPLGTLLVVSGPSGSGKTTLCRRATENGLCVYSISCTTRQPRPGEVNGVDYHFLTPAEFDARVERGDFLEYAEVH
GNRYGTLKADILTLLEQGKNVVMDIDVQGAGQVRSCREGILPLCYVDVYIYVPQAELKNRLCGRQTDGAETIALRLRNAE
QEDACLPQYQYCLVSSDRETDYASFCALLKCQSMRVGLMR

Sequences:

>Translated_200_residues
MTAMKQPLGTLLVVSGPSGSGKTTLCRRATENGLCVYSISCTTRQPRPGEVNGVDYHFLTPAEFDARVERGDFLEYAEVH
GNRYGTLKADILTLLEQGKNVVMDIDVQGAGQVRSCREGILPLCYVDVYIYVPQAELKNRLCGRQTDGAETIALRLRNAE
QEDACLPQYQYCLVSSDRETDYASFCALLKCQSMRVGLMR
>Mature_199_residues
TAMKQPLGTLLVVSGPSGSGKTTLCRRATENGLCVYSISCTTRQPRPGEVNGVDYHFLTPAEFDARVERGDFLEYAEVHG
NRYGTLKADILTLLEQGKNVVMDIDVQGAGQVRSCREGILPLCYVDVYIYVPQAELKNRLCGRQTDGAETIALRLRNAEQ
EDACLPQYQYCLVSSDRETDYASFCALLKCQSMRVGLMR

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=154, Percent_Identity=38.961038961039, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI4504221, Length=154, Percent_Identity=38.961038961039, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI226874831, Length=154, Percent_Identity=38.961038961039, Blast_Score=100, Evalue=7e-22,
Organism=Escherichia coli, GI1790080, Length=194, Percent_Identity=39.1752577319588, Blast_Score=126, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI193203132, Length=186, Percent_Identity=34.4086021505376, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17508835, Length=186, Percent_Identity=34.4086021505376, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17557440, Length=182, Percent_Identity=28.021978021978, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320662, Length=154, Percent_Identity=40.2597402597403, Blast_Score=112, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21356141, Length=162, Percent_Identity=37.6543209876543, Blast_Score=93, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 22189; Mature: 22057

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
5.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAMKQPLGTLLVVSGPSGSGKTTLCRRATENGLCVYSISCTTRQPRPGEVNGVDYHFLT
CCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCEEEEEEEECCCCCCCCCCCCEEEEEEC
PAEFDARVERGDFLEYAEVHGNRYGTLKADILTLLEQGKNVVMDIDVQGAGQVRSCREGI
CCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCC
LPLCYVDVYIYVPQAELKNRLCGRQTDGAETIALRLRNAEQEDACLPQYQYCLVSSDRET
CEEEEEEEEEEECCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCC
DYASFCALLKCQSMRVGLMR
CHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TAMKQPLGTLLVVSGPSGSGKTTLCRRATENGLCVYSISCTTRQPRPGEVNGVDYHFLT
CCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCEEEEEEEECCCCCCCCCCCCEEEEEEC
PAEFDARVERGDFLEYAEVHGNRYGTLKADILTLLEQGKNVVMDIDVQGAGQVRSCREGI
CCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCC
LPLCYVDVYIYVPQAELKNRLCGRQTDGAETIALRLRNAEQEDACLPQYQYCLVSSDRET
CEEEEEEEEEEECCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCC
DYASFCALLKCQSMRVGLMR
CHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]