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The map label for this gene is tuaD [H]

Identifier: 187735926

GI number: 187735926

Start: 1720797

End: 1722119

Strand: Reverse

Name: tuaD [H]

Synonym: Amuc_1435

Alternate gene names: 187735926

Gene position: 1722119-1720797 (Counterclockwise)

Preceding gene: 187735932

Following gene: 187735923

Centisome position: 64.64

GC content: 54.65

Gene sequence:

>1323_bases
ATGAATTTAACAATTATCGGCAGTGGTTACGTGGGGCTGACCACAGGCACCTGTTTTGCCGAAATGGGCCATCACGTCAT
TTGCGTGGATAATAATACGGAAAAAATACGTACTCTTCAATCCGGGGCCATCCCCATTTACGAGCCCAAGCTGGAAGAGC
TCGTGAAAAAAAACGTAGCCGTGGGGCGGCTGGAATTTTCCCCTTCCATCGCCGCTTCCATTGCGGAAAGCGAAGTCATC
TTCATCGCCGTGCCCACGCCGCCCAATACGGATGGTTCCGTGGACCTGACCTACATTGAAAAAGTGGCCAGGGAAATCGC
CCAGGCGCTCCAACCAGAAATGGGATACAAGGTCATTGTGGACAAATCCACCGTACCCGTCAAAACCGGGGAAAAAGTCA
GCCAGACCATCAAGCACTATGCGGGGCCGAATGTTCAGTTCGACATTGTCTCCAATCCAGAATTCCTGAGGGAAGGATGC
GCCGTGGACGACCTGCTGCACCCTGACCGCATTGTCATTGGAGCCAACTCGGAACAGGCCATGAACGTCATCAAGCGCGT
TTACCAGCCCATTCATGCCCCCATTCTGGAAACGGACGTCAACTCCGCGGAACTCATCAAGCACGCAGCCAACTCCTTCT
TGGCTCTGAAAATTTCCTACATTAACGCTGTCGCCAAGGTCTGTGAAAAAACGGGCGCAGACGTGGAACTGGTGGCGGAA
GGCATCGGCATGGACAAACGCATCTCACGCCACTTTCTCAACGCGGGGCTGGGCTACGGCGGGTCCTGCTTCCCGAAAGA
CGTCAAAGCCTTCATCAACATCAGCCGCACGCTGGGCATTCCCTTCACCCTGTTGGAGGAAGTGGAACACATCAATGATA
CCCAGCATATCCACTTCCTGGACAGAATTCGGGACCGCCTGTGGGTCCTCAAGGACAAAAAGATAGCCGTTTGGGGCCTT
GCCTTCAAACAGAACACGGACGACGTCCGGGAATCCATCGCCCTGAAACTATGTGAAAAACTCTGCGGGGAAGGAGCCAT
TGTCACCGCTACGGACCCCAAAGCCATGCACACGGCGGCCCCCATTCTGAACCCTATGGGGGTCAAACTGGTGGAAGACA
TGTACGAATGCGCCCGGGATGCGGAAGTTCTGGTCATCGCCACGGAATGGAGCGAATATGCGAATGCGGATCTGCAGAAA
CTCGCCGGAGTCATGCGCAACCGCATCATCTTTGACGGAAGAAACATCCTCTCCCCGGCAAACCTCCGGGCCGTAGGATT
TGAATACCACTCCGTGGGCAGACCCTCCGTTGAAGAAGCCTGA

Upstream 100 bases:

>100_bases
TTATTTTGACAGAAAAAATTCCCTATCCCATAATGCTCAGGGGTTGACTGCTCTTACTTTTCCATACAGTTAAGTTTTTA
CCAATATTTACGCTAACACT

Downstream 100 bases:

>100_bases
CTGCCTCCGGGAACCGTCCCGGCTTCAAACGTCCCCATATGTAAAAGGCCTCCGGCACATTCAACGCACCGGAGGCCTTT
GTCATGTATTCGCTAATCCT

Product: nucleotide sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MNLTIIGSGYVGLTTGTCFAEMGHHVICVDNNTEKIRTLQSGAIPIYEPKLEELVKKNVAVGRLEFSPSIAASIAESEVI
FIAVPTPPNTDGSVDLTYIEKVAREIAQALQPEMGYKVIVDKSTVPVKTGEKVSQTIKHYAGPNVQFDIVSNPEFLREGC
AVDDLLHPDRIVIGANSEQAMNVIKRVYQPIHAPILETDVNSAELIKHAANSFLALKISYINAVAKVCEKTGADVELVAE
GIGMDKRISRHFLNAGLGYGGSCFPKDVKAFINISRTLGIPFTLLEEVEHINDTQHIHFLDRIRDRLWVLKDKKIAVWGL
AFKQNTDDVRESIALKLCEKLCGEGAIVTATDPKAMHTAAPILNPMGVKLVEDMYECARDAEVLVIATEWSEYANADLQK
LAGVMRNRIIFDGRNILSPANLRAVGFEYHSVGRPSVEEA

Sequences:

>Translated_440_residues
MNLTIIGSGYVGLTTGTCFAEMGHHVICVDNNTEKIRTLQSGAIPIYEPKLEELVKKNVAVGRLEFSPSIAASIAESEVI
FIAVPTPPNTDGSVDLTYIEKVAREIAQALQPEMGYKVIVDKSTVPVKTGEKVSQTIKHYAGPNVQFDIVSNPEFLREGC
AVDDLLHPDRIVIGANSEQAMNVIKRVYQPIHAPILETDVNSAELIKHAANSFLALKISYINAVAKVCEKTGADVELVAE
GIGMDKRISRHFLNAGLGYGGSCFPKDVKAFINISRTLGIPFTLLEEVEHINDTQHIHFLDRIRDRLWVLKDKKIAVWGL
AFKQNTDDVRESIALKLCEKLCGEGAIVTATDPKAMHTAAPILNPMGVKLVEDMYECARDAEVLVIATEWSEYANADLQK
LAGVMRNRIIFDGRNILSPANLRAVGFEYHSVGRPSVEEA
>Mature_440_residues
MNLTIIGSGYVGLTTGTCFAEMGHHVICVDNNTEKIRTLQSGAIPIYEPKLEELVKKNVAVGRLEFSPSIAASIAESEVI
FIAVPTPPNTDGSVDLTYIEKVAREIAQALQPEMGYKVIVDKSTVPVKTGEKVSQTIKHYAGPNVQFDIVSNPEFLREGC
AVDDLLHPDRIVIGANSEQAMNVIKRVYQPIHAPILETDVNSAELIKHAANSFLALKISYINAVAKVCEKTGADVELVAE
GIGMDKRISRHFLNAGLGYGGSCFPKDVKAFINISRTLGIPFTLLEEVEHINDTQHIHFLDRIRDRLWVLKDKKIAVWGL
AFKQNTDDVRESIALKLCEKLCGEGAIVTATDPKAMHTAAPILNPMGVKLVEDMYECARDAEVLVIATEWSEYANADLQK
LAGVMRNRIIFDGRNILSPANLRAVGFEYHSVGRPSVEEA

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=462, Percent_Identity=38.0952380952381, Blast_Score=279, Evalue=5e-75,
Organism=Homo sapiens, GI296040438, Length=365, Percent_Identity=38.3561643835616, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI296040443, Length=309, Percent_Identity=38.5113268608414, Blast_Score=195, Evalue=6e-50,
Organism=Escherichia coli, GI1788340, Length=359, Percent_Identity=29.5264623955432, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI48994968, Length=410, Percent_Identity=28.780487804878, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17560350, Length=459, Percent_Identity=39.2156862745098, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17136908, Length=463, Percent_Identity=38.8768898488121, Blast_Score=298, Evalue=7e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48288; Mature: 48288

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTIIGSGYVGLTTGTCFAEMGHHVICVDNNTEKIRTLQSGAIPIYEPKLEELVKKNVA
CEEEEEECCCEEECCCHHHHHHCCEEEEEECCHHHHHHHHCCCCCCCCHHHHHHHHCCCE
VGRLEFSPSIAASIAESEVIFIAVPTPPNTDGSVDLTYIEKVAREIAQALQPEMGYKVIV
EEEEECCCHHHHHHCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCEEEE
DKSTVPVKTGEKVSQTIKHYAGPNVQFDIVSNPEFLREGCAVDDLLHPDRIVIGANSEQA
ECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHCCCCHHHCCCCCEEEEECCCHHH
MNVIKRVYQPIHAPILETDVNSAELIKHAANSFLALKISYINAVAKVCEKTGADVELVAE
HHHHHHHHHHHCCCHHHCCCCHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCCCCEEHHH
GIGMDKRISRHFLNAGLGYGGSCFPKDVKAFINISRTLGIPFTLLEEVEHINDTQHIHFL
HCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHH
DRIRDRLWVLKDKKIAVWGLAFKQNTDDVRESIALKLCEKLCGEGAIVTATDPKAMHTAA
HHHHHHHEEEECCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHH
PILNPMGVKLVEDMYECARDAEVLVIATEWSEYANADLQKLAGVMRNRIIFDGRNILSPA
HCCCCCHHHHHHHHHHHCCCCEEEEEEECCHHHHCCHHHHHHHHHHCCEEECCCCCCCCC
NLRAVGFEYHSVGRPSVEEA
CCEEEEEEHHCCCCCCCCCC
>Mature Secondary Structure
MNLTIIGSGYVGLTTGTCFAEMGHHVICVDNNTEKIRTLQSGAIPIYEPKLEELVKKNVA
CEEEEEECCCEEECCCHHHHHHCCEEEEEECCHHHHHHHHCCCCCCCCHHHHHHHHCCCE
VGRLEFSPSIAASIAESEVIFIAVPTPPNTDGSVDLTYIEKVAREIAQALQPEMGYKVIV
EEEEECCCHHHHHHCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCEEEE
DKSTVPVKTGEKVSQTIKHYAGPNVQFDIVSNPEFLREGCAVDDLLHPDRIVIGANSEQA
ECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHCCCCHHHCCCCCEEEEECCCHHH
MNVIKRVYQPIHAPILETDVNSAELIKHAANSFLALKISYINAVAKVCEKTGADVELVAE
HHHHHHHHHHHCCCHHHCCCCHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCCCCEEHHH
GIGMDKRISRHFLNAGLGYGGSCFPKDVKAFINISRTLGIPFTLLEEVEHINDTQHIHFL
HCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHH
DRIRDRLWVLKDKKIAVWGLAFKQNTDDVRESIALKLCEKLCGEGAIVTATDPKAMHTAA
HHHHHHHEEEECCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHH
PILNPMGVKLVEDMYECARDAEVLVIATEWSEYANADLQKLAGVMRNRIIFDGRNILSPA
HCCCCCHHHHHHHHHHHCCCCEEEEEEECCHHHHCCHHHHHHHHHHCCEEECCCCCCCCC
NLRAVGFEYHSVGRPSVEEA
CCEEEEEEHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]