Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is bioF [H]

Identifier: 187735886

GI number: 187735886

Start: 1663872

End: 1665035

Strand: Direct

Name: bioF [H]

Synonym: Amuc_1393

Alternate gene names: 187735886

Gene position: 1663872-1665035 (Clockwise)

Preceding gene: 187735885

Following gene: 187735887

Centisome position: 62.46

GC content: 60.4

Gene sequence:

>1164_bases
ATGAAGAATCCTGAACAGTTTTTGTCAGAGTTGAAGTCTGCGGGGCTGCTGCGCGTCCTGCGGGATGTGGAATGCCTGCC
CGGAGGAATGGCCCGTCTGGCGGATGGCCGGGAAGCGGTCAATCTGGCAAGCAACGATTATCTGGGGCTGGCCCACCATC
CGTCCCTGGCGGAGGCTTTTTCCCGTGCGGTGCGGGATGAAGGGGTCGGAGCCATGGCATCCCGCCTGGTGACGGGGACG
CGGCGGGAACATTCCTGTCTGGAAGAGGCCCTGGCCGCTTTGAAGGGGACTGAAGCGGCGGTCAGTTTTTCCTCCGGTTA
TGCTACCTCCCTGGGAGTGATTGCTTCTATTGCGGACCGGGAGGATACGGTGCTGATGGATAAGTTGTCCCATGCCAGCC
TGATTGACGGGGCGCGTTTGTCCGGGGCGCGTTTGTCTACGTTCCTGCATAACGATATGGAGTCATTAAGGAAAAAACTG
CAGCATTTGCGGGACGCGAATCCTTCCGGCGGGATTCTGGTAGTGACCGAATCCGTTTTCAGCATGGATGGAGACCGTGC
CCCCCTTCGGGAAATTGTGCGTCTGAAGGATGAATTCGGCGCGTTGCTGCTGGTGGATGAAGCTCACGGATTCGGTGTGC
TGGGAGAACACGGGGCCGGACTGGCGGAAGAGCTGGGTGTTTCCTCCCGGATAGATTTTCAAATGGGGACTTTGAGCAAG
GCTGCCGGGGTAAGTGGTGGATATGTGGCCTGTTCCCGCGCCTGGGCGGATGTAATGGTTAATTCCGCCCGGTCCCTGAT
TTATTCCACGGCTCCGCCTCCCGCTTTGGCCGCCGCCGCCCTGGCCGCGGTGGAAGTGATCCGCAGCGGGGAGGGAAAGG
AATTGCGCCGCCGTGTTTCCGTGCTGGCAAACAGTTTGTCCGCCGCACTGGGGATGCCGGGAAGGCCTCTTTCTTCCATT
TTCCCTGTTGTGGTGGGAGAAAACGATGCTGCCCTGGCTGCGGCGGATGCCCTGCTGGAACAGGGCTTTCTGGCTCCCGC
CATCCGTTATCCTACGGTTCCCCGCGGAACGGCCCGGTTGCGCATTACGGTAACGGCTGCGCATGAATCCGGGCAGGTCA
CGCGGCTGGGGACGGCGTTGAAGGAGCTGCTGCATGGGAAGTAA

Upstream 100 bases:

>100_bases
GGGGGCGGATGCTGGTCAAATCCGCCGCTTCCATGGGCGGCCATAATGTGGTGCTGAGTCTGGCTGTGGACGGTTGAATA
TTGTTGAATAGTGAACGCTT

Downstream 100 bases:

>100_bases
CGCAGGCGTTGTTTTTGGTTCTCCGCATTGGAGCCGGTTCCTGTTTTTATGCGGGGCCTGCCGGAAATGGGATTATCCTC
ATTGATGCCGCCATAAAAAA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKNPEQFLSELKSAGLLRVLRDVECLPGGMARLADGREAVNLASNDYLGLAHHPSLAEAFSRAVRDEGVGAMASRLVTGT
RREHSCLEEALAALKGTEAAVSFSSGYATSLGVIASIADREDTVLMDKLSHASLIDGARLSGARLSTFLHNDMESLRKKL
QHLRDANPSGGILVVTESVFSMDGDRAPLREIVRLKDEFGALLLVDEAHGFGVLGEHGAGLAEELGVSSRIDFQMGTLSK
AAGVSGGYVACSRAWADVMVNSARSLIYSTAPPPALAAAALAAVEVIRSGEGKELRRRVSVLANSLSAALGMPGRPLSSI
FPVVVGENDAALAAADALLEQGFLAPAIRYPTVPRGTARLRITVTAAHESGQVTRLGTALKELLHGK

Sequences:

>Translated_387_residues
MKNPEQFLSELKSAGLLRVLRDVECLPGGMARLADGREAVNLASNDYLGLAHHPSLAEAFSRAVRDEGVGAMASRLVTGT
RREHSCLEEALAALKGTEAAVSFSSGYATSLGVIASIADREDTVLMDKLSHASLIDGARLSGARLSTFLHNDMESLRKKL
QHLRDANPSGGILVVTESVFSMDGDRAPLREIVRLKDEFGALLLVDEAHGFGVLGEHGAGLAEELGVSSRIDFQMGTLSK
AAGVSGGYVACSRAWADVMVNSARSLIYSTAPPPALAAAALAAVEVIRSGEGKELRRRVSVLANSLSAALGMPGRPLSSI
FPVVVGENDAALAAADALLEQGFLAPAIRYPTVPRGTARLRITVTAAHESGQVTRLGTALKELLHGK
>Mature_387_residues
MKNPEQFLSELKSAGLLRVLRDVECLPGGMARLADGREAVNLASNDYLGLAHHPSLAEAFSRAVRDEGVGAMASRLVTGT
RREHSCLEEALAALKGTEAAVSFSSGYATSLGVIASIADREDTVLMDKLSHASLIDGARLSGARLSTFLHNDMESLRKKL
QHLRDANPSGGILVVTESVFSMDGDRAPLREIVRLKDEFGALLLVDEAHGFGVLGEHGAGLAEELGVSSRIDFQMGTLSK
AAGVSGGYVACSRAWADVMVNSARSLIYSTAPPPALAAAALAAVEVIRSGEGKELRRRVSVLANSLSAALGMPGRPLSSI
FPVVVGENDAALAAADALLEQGFLAPAIRYPTVPRGTARLRITVTAAHESGQVTRLGTALKELLHGK

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI83977444, Length=335, Percent_Identity=36.7164179104478, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI83977442, Length=337, Percent_Identity=37.3887240356083, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI83977440, Length=335, Percent_Identity=36.7164179104478, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI7657118, Length=357, Percent_Identity=35.0140056022409, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI284448556, Length=357, Percent_Identity=35.0140056022409, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI4502025, Length=333, Percent_Identity=36.6366366366366, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI40316939, Length=333, Percent_Identity=36.6366366366366, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI4758668, Length=368, Percent_Identity=30.9782608695652, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=30.5405405405405, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI5454084, Length=385, Percent_Identity=27.7922077922078, Blast_Score=125, Evalue=8e-29,
Organism=Escherichia coli, GI1786993, Length=366, Percent_Identity=43.4426229508197, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1790046, Length=379, Percent_Identity=34.5646437994723, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71994529, Length=375, Percent_Identity=31.7333333333333, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI32566772, Length=397, Percent_Identity=28.463476070529, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17560914, Length=360, Percent_Identity=30, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17560912, Length=360, Percent_Identity=30, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71982625, Length=305, Percent_Identity=28.1967213114754, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71982617, Length=305, Percent_Identity=28.1967213114754, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320438, Length=356, Percent_Identity=34.5505617977528, Blast_Score=185, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6320267, Length=346, Percent_Identity=28.9017341040462, Blast_Score=146, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=217, Percent_Identity=31.3364055299539, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24662918, Length=352, Percent_Identity=32.3863636363636, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17137420, Length=350, Percent_Identity=34.2857142857143, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17136286, Length=363, Percent_Identity=29.4765840220386, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24653280, Length=260, Percent_Identity=29.6153846153846, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24653276, Length=260, Percent_Identity=29.6153846153846, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24653278, Length=260, Percent_Identity=29.6153846153846, Blast_Score=118, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 40621; Mature: 40621

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNPEQFLSELKSAGLLRVLRDVECLPGGMARLADGREAVNLASNDYLGLAHHPSLAEAF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCCCCCCCCCCCCHHHHHH
SRAVRDEGVGAMASRLVTGTRREHSCLEEALAALKGTEAAVSFSSGYATSLGVIASIADR
HHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHCCC
EDTVLMDKLSHASLIDGARLSGARLSTFLHNDMESLRKKLQHLRDANPSGGILVVTESVF
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHH
SMDGDRAPLREIVRLKDEFGALLLVDEAHGFGVLGEHGAGLAEELGVSSRIDFQMGTLSK
HCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCEECCCCHH
AAGVSGGYVACSRAWADVMVNSARSLIYSTAPPPALAAAALAAVEVIRSGEGKELRRRVS
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
VLANSLSAALGMPGRPLSSIFPVVVGENDAALAAADALLEQGFLAPAIRYPTVPRGTARL
HHHHHHHHHHCCCCCCHHHCCCEEECCCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCEEE
RITVTAAHESGQVTRLGTALKELLHGK
EEEEEEECCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNPEQFLSELKSAGLLRVLRDVECLPGGMARLADGREAVNLASNDYLGLAHHPSLAEAF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHCCCCCCCCCCCCCHHHHHH
SRAVRDEGVGAMASRLVTGTRREHSCLEEALAALKGTEAAVSFSSGYATSLGVIASIADR
HHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHCCC
EDTVLMDKLSHASLIDGARLSGARLSTFLHNDMESLRKKLQHLRDANPSGGILVVTESVF
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHH
SMDGDRAPLREIVRLKDEFGALLLVDEAHGFGVLGEHGAGLAEELGVSSRIDFQMGTLSK
HCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCEECCCCHH
AAGVSGGYVACSRAWADVMVNSARSLIYSTAPPPALAAAALAAVEVIRSGEGKELRRRVS
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
VLANSLSAALGMPGRPLSSIFPVVVGENDAALAAADALLEQGFLAPAIRYPTVPRGTARL
HHHHHHHHHHCCCCCCHHHCCCEEECCCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCEEE
RITVTAAHESGQVTRLGTALKELLHGK
EEEEEEECCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA