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The map label for this gene is ilvD

Identifier: 187735606

GI number: 187735606

Start: 1326464

End: 1328140

Strand: Direct

Name: ilvD

Synonym: Amuc_1111

Alternate gene names: 187735606

Gene position: 1326464-1328140 (Clockwise)

Preceding gene: 187735603

Following gene: 187735607

Centisome position: 49.79

GC content: 58.32

Gene sequence:

>1677_bases
ATGCGAAGCGATAGAGTTAAAGCAGGGTTCGAGCGTGCGCCGCACCGCAGTTTGATGCGTGCCACCGGAATGACGGATGA
GGATTTAAGCCGTCCTTTCATTGCCATTTGCAATTCTTTTAATGAAGTGATTCCGGGCCATGTCCACCTGAACAGGGTGG
CCGCCCTCATCAAGGAGGAGGTACGCAAGGCCGGAGGAACTCCCGTGGAATTCAACCTTCCCGGCGTTTGTGACGGCATT
GCCATGGGCCACGGCGGCATGAAGTTTTCCCTGGCCAGCCGTGAGCTGATCGCGGACAGCGTAGAGACGATGCTGAGCGC
CCATGCGTTTGATGCTATGATCTGCATCCCTAATTGCGACAAGATTGTTCCCGGCATGATTATGGGCGCCCTGCGCTGCA
ATATTCCCACTATTTTCTGCAGCGGCGGTCCGATGGCCGCCGGCATGGCGGAGGACGGCACGGTGCTGGACCTGAACAGC
GTGTTTGAGGCTGTCGCCCGCTTTAAGGCAGGCAAGATTAATGAGGAGGAACTTCATTCCCTGGAATGCCGCGCCTGCCC
CGGCGCCGGTTCCTGCTCCGGCATGTTTACAGCCAATTCCATGAATTGCCTGAGCGAGGTGATCGGCCTGGCCCTTCCCG
GCAACGGTTCCCTGCTGGCTACTTCAGAGGAACGAAAGGAGTTCTGGAAGCAGACTGCCCGCCGCGCCGTGGAGATGGCG
AAGGCGGACGGCCCCCTGCCGCGAGACATCGTAACCCGTGACGCTATCGACAATGCTTTCACAATTGATATGGCCATGGG
CGGCAGTTCCAATACCGTGCTCCATACGCTGGCTATCGCCAGGGAAGCCGGCGTGGAGTATGACCTCCAGCGCATCAATG
ATATTTCTAGGCGAACCCCGAATATTTGCAAGGTGGCTCCTTCCTCCCGCTTCCACATGCAGGATGTTCTGCGTGCAGGC
GGGGTGAGTGCCATCATTCATGAAATTGCCAGAATTCCCGGAGCCCTTCATCTGGACGCCATGACCGTCAGCGGGAAAAC
GCTGGGTGAAACAGTGGAGGGATGCGGCATTGCGGATGAAACCGTGATTCATCCGTTGGAAAATGCCTATTCCCGTGATG
GCGGCCTGGCGATTCTGTTCGGCAATCTGGCTGAGGAGGGCGCTGTGGTGAAAAAGGCGGGTGTGCATCCGAATATGATG
AGTTTCCGCGGGCCCGCCGTGATTTTCGAGTCTCAGGAAGAGGCCTGCGAAGGCATCCTTGCCGGGAAGGTGAAATCAGG
CGATGTGGTTGTCATACGCAATGAAGGCCCCAAGGGCGGCCCCGGCATGCAGGAAATGCTGGCTCCCACTTCCTATATTA
TGGGGCAGGGCCTTGGCGCGGAAGTGGCGCTTATTACGGACGGCCGTTTTTCCGGAGCCACGCACGGAGCCTGTATTGGC
CATATTTCCCCGGAAGCGGCGGAAGGCGGCCTGATCGGCCTGCTGAGGAACGGGGATATTATTGAGTATTCCATTCCGGA
CCGCACGCTGAACGTCTGTTTGAGCGAGGAGGAGATCGCACGCCGCCGTGCGGATTGGAAACCTACCTATAACAGGGTTT
CCTCCTCCTGGCTGAGCCGTTACCGCCAGCTTGCCACGAATGCCAGCAAGGGGGCAGTCCTCCGGCGCGGGGAATAA

Upstream 100 bases:

>100_bases
ATACTGTAACGGAAGCGTTTCCGTTTTGCAAGGCTGGCCCAGATTCAACTTCTCTTCCCTGCGTCATGTGATACACTTGC
CCCGCAACAGTTGTATTGTT

Downstream 100 bases:

>100_bases
TAGTTTCCCTTTTAACAGCAGCCGCTTCCCGTGATAGCCGGGAAGCGGTTTTTTATGCCTGTTTTCCTTGCTCTGTAGTC
TGGCAGGCTGCATGGTCGGA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MRSDRVKAGFERAPHRSLMRATGMTDEDLSRPFIAICNSFNEVIPGHVHLNRVAALIKEEVRKAGGTPVEFNLPGVCDGI
AMGHGGMKFSLASRELIADSVETMLSAHAFDAMICIPNCDKIVPGMIMGALRCNIPTIFCSGGPMAAGMAEDGTVLDLNS
VFEAVARFKAGKINEEELHSLECRACPGAGSCSGMFTANSMNCLSEVIGLALPGNGSLLATSEERKEFWKQTARRAVEMA
KADGPLPRDIVTRDAIDNAFTIDMAMGGSSNTVLHTLAIAREAGVEYDLQRINDISRRTPNICKVAPSSRFHMQDVLRAG
GVSAIIHEIARIPGALHLDAMTVSGKTLGETVEGCGIADETVIHPLENAYSRDGGLAILFGNLAEEGAVVKKAGVHPNMM
SFRGPAVIFESQEEACEGILAGKVKSGDVVVIRNEGPKGGPGMQEMLAPTSYIMGQGLGAEVALITDGRFSGATHGACIG
HISPEAAEGGLIGLLRNGDIIEYSIPDRTLNVCLSEEEIARRRADWKPTYNRVSSSWLSRYRQLATNASKGAVLRRGE

Sequences:

>Translated_558_residues
MRSDRVKAGFERAPHRSLMRATGMTDEDLSRPFIAICNSFNEVIPGHVHLNRVAALIKEEVRKAGGTPVEFNLPGVCDGI
AMGHGGMKFSLASRELIADSVETMLSAHAFDAMICIPNCDKIVPGMIMGALRCNIPTIFCSGGPMAAGMAEDGTVLDLNS
VFEAVARFKAGKINEEELHSLECRACPGAGSCSGMFTANSMNCLSEVIGLALPGNGSLLATSEERKEFWKQTARRAVEMA
KADGPLPRDIVTRDAIDNAFTIDMAMGGSSNTVLHTLAIAREAGVEYDLQRINDISRRTPNICKVAPSSRFHMQDVLRAG
GVSAIIHEIARIPGALHLDAMTVSGKTLGETVEGCGIADETVIHPLENAYSRDGGLAILFGNLAEEGAVVKKAGVHPNMM
SFRGPAVIFESQEEACEGILAGKVKSGDVVVIRNEGPKGGPGMQEMLAPTSYIMGQGLGAEVALITDGRFSGATHGACIG
HISPEAAEGGLIGLLRNGDIIEYSIPDRTLNVCLSEEEIARRRADWKPTYNRVSSSWLSRYRQLATNASKGAVLRRGE
>Mature_558_residues
MRSDRVKAGFERAPHRSLMRATGMTDEDLSRPFIAICNSFNEVIPGHVHLNRVAALIKEEVRKAGGTPVEFNLPGVCDGI
AMGHGGMKFSLASRELIADSVETMLSAHAFDAMICIPNCDKIVPGMIMGALRCNIPTIFCSGGPMAAGMAEDGTVLDLNS
VFEAVARFKAGKINEEELHSLECRACPGAGSCSGMFTANSMNCLSEVIGLALPGNGSLLATSEERKEFWKQTARRAVEMA
KADGPLPRDIVTRDAIDNAFTIDMAMGGSSNTVLHTLAIAREAGVEYDLQRINDISRRTPNICKVAPSSRFHMQDVLRAG
GVSAIIHEIARIPGALHLDAMTVSGKTLGETVEGCGIADETVIHPLENAYSRDGGLAILFGNLAEEGAVVKKAGVHPNMM
SFRGPAVIFESQEEACEGILAGKVKSGDVVVIRNEGPKGGPGMQEMLAPTSYIMGQGLGAEVALITDGRFSGATHGACIG
HISPEAAEGGLIGLLRNGDIIEYSIPDRTLNVCLSEEEIARRRADWKPTYNRVSSSWLSRYRQLATNASKGAVLRRGE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=605, Percent_Identity=48.9256198347107, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1788157, Length=539, Percent_Identity=30.2411873840445, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1786464, Length=501, Percent_Identity=33.9321357285429, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI2367371, Length=504, Percent_Identity=34.5238095238095, Blast_Score=209, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6322476, Length=558, Percent_Identity=40.3225806451613, Blast_Score=387, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_AKKM8 (B2UR52)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001877718.1
- GeneID:   6273966
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_1111
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 59477; Mature: 59477

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDRVKAGFERAPHRSLMRATGMTDEDLSRPFIAICNSFNEVIPGHVHLNRVAALIKEE
CCCCCCCCCHHHCCHHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VRKAGGTPVEFNLPGVCDGIAMGHGGMKFSLASRELIADSVETMLSAHAFDAMICIPNCD
HHHCCCCCEEECCCCCCCHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
KIVPGMIMGALRCNIPTIFCSGGPMAAGMAEDGTVLDLNSVFEAVARFKAGKINEEELHS
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHC
LECRACPGAGSCSGMFTANSMNCLSEVIGLALPGNGSLLATSEERKEFWKQTARRAVEMA
CCCCCCCCCCCCCCEEECCHHHHHHHHHCEECCCCCCEEECCHHHHHHHHHHHHHHHHHH
KADGPLPRDIVTRDAIDNAFTIDMAMGGSSNTVLHTLAIAREAGVEYDLQRINDISRRTP
HCCCCCCHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
NICKVAPSSRFHMQDVLRAGGVSAIIHEIARIPGALHLDAMTVSGKTLGETVEGCGIADE
CEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHCCCCCHH
TVIHPLENAYSRDGGLAILFGNLAEEGAVVKKAGVHPNMMSFRGPAVIFESQEEACEGIL
HHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCCCEEEECCHHHHHCHHH
AGKVKSGDVVVIRNEGPKGGPGMQEMLAPTSYIMGQGLGAEVALITDGRFSGATHGACIG
HCCCCCCCEEEEECCCCCCCCCHHHHHCCHHHHHCCCCCCEEEEEECCCCCCCCCCEEEE
HISPEAAEGGLIGLLRNGDIIEYSIPDRTLNVCLSEEEIARRRADWKPTYNRVSSSWLSR
CCCCCCCCCCEEEEEECCCEEEEECCCCHHHEEECHHHHHHHCCCCCHHHHHHHHHHHHH
YRQLATNASKGAVLRRGE
HHHHHCCCCCCCEEECCC
>Mature Secondary Structure
MRSDRVKAGFERAPHRSLMRATGMTDEDLSRPFIAICNSFNEVIPGHVHLNRVAALIKEE
CCCCCCCCCHHHCCHHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VRKAGGTPVEFNLPGVCDGIAMGHGGMKFSLASRELIADSVETMLSAHAFDAMICIPNCD
HHHCCCCCEEECCCCCCCHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
KIVPGMIMGALRCNIPTIFCSGGPMAAGMAEDGTVLDLNSVFEAVARFKAGKINEEELHS
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHC
LECRACPGAGSCSGMFTANSMNCLSEVIGLALPGNGSLLATSEERKEFWKQTARRAVEMA
CCCCCCCCCCCCCCEEECCHHHHHHHHHCEECCCCCCEEECCHHHHHHHHHHHHHHHHHH
KADGPLPRDIVTRDAIDNAFTIDMAMGGSSNTVLHTLAIAREAGVEYDLQRINDISRRTP
HCCCCCCHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
NICKVAPSSRFHMQDVLRAGGVSAIIHEIARIPGALHLDAMTVSGKTLGETVEGCGIADE
CEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHCCCCCHH
TVIHPLENAYSRDGGLAILFGNLAEEGAVVKKAGVHPNMMSFRGPAVIFESQEEACEGIL
HHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCCCEEEECCHHHHHCHHH
AGKVKSGDVVVIRNEGPKGGPGMQEMLAPTSYIMGQGLGAEVALITDGRFSGATHGACIG
HCCCCCCCEEEEECCCCCCCCCHHHHHCCHHHHHCCCCCCEEEEEECCCCCCCCCCEEEE
HISPEAAEGGLIGLLRNGDIIEYSIPDRTLNVCLSEEEIARRRADWKPTYNRVSSSWLSR
CCCCCCCCCCEEEEEECCCEEEEECCCCHHHEEECHHHHHHHCCCCCHHHHHHHHHHHHH
YRQLATNASKGAVLRRGE
HHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA