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The map label for this gene is msrAB [H]

Identifier: 187735407

GI number: 187735407

Start: 1081425

End: 1082552

Strand: Reverse

Name: msrAB [H]

Synonym: Amuc_0906

Alternate gene names: 187735407

Gene position: 1082552-1081425 (Counterclockwise)

Preceding gene: 187735408

Following gene: 187735405

Centisome position: 40.63

GC content: 52.39

Gene sequence:

>1128_bases
ATGAAGCGTATTTACCACGGACCATGGACACTGGCCGGACTGGCATGCGCCATTTTGGCCGCAGTCGCCATGCTCTCCTT
TTTTTCCTGCGGGGAAAAAGGCCAGTCAAGCAGTAATGACAAACCTCATATGGACAACAAGGATTTAAAAACGATTTACC
TGGCGGGAGGCTGTTTCTGGGGAGTGGAAAAGTACTTCTCCCTGATGCCCGGCGTTAAGGAAACGGAAGCGGGATATGCC
AACGGCTCCACGGCTTCTCCCACGTATGAAGAAGTATGCAGCGGGAAAACGGGCCATGCGGAAACGGTAAAAGTAGTATT
TGACCCGGAAGAACTCAGTCTGCCCTTTCTTCTGGAACGGTATTACTCCATTATTGATCCTGTTTCCGTCAACAAACAGG
GAAACGACAGGGGAATTCAATACCGCACGGGCATCTATTACGCGGATGAGAAGGACAAACCTGTTATAGAAACGTCCCTG
AAAAGGCTCCAGCAGCACTTCAGGCAGCCTCTGGCAATTGAAGTTCAGCCCCTCCGCCAATTTTCACGGGCGGAAAAATA
TCATCAGCGCTATCTGGATAAAAACCCTGGCGGATACTGCCATATTCCACCCGCCAAATTCCGGGAAGCGTCCCAGGCCC
GCGAAAACGAACCTGTTTACCGGAAAAAATCGGACGAAGAGCTGCGCCGCGTCCTGACACGCGAGCAATTTGCCGTCACG
CGGAATAATGCGACGGAACCTCCCTTCCGCAATGAATATTTCAATAACGACAGACCTGGCATTTATGTGGACGTCACGAC
AGGCGAACCTTTATTCCTGTCCACGGACAAGTTTGATTCAGGCTGCGGCTGGCCCAGCTTCTCCCGCCCCATCAAAGAAG
AACTGATTCAGGAAAAACAGGATTTCTCCCACGGCATGAGGCGCACGGAAGTCCGCAGCAAAACGGGAGACGCCCACCTG
GGCCACGTTTTCACAGACGGCCCGAAGGAACAGGGCGGACTGCGCTACTGCATCAACAGCGCCTCCCTGAAATTCATTCC
TGAACAGGACATGGAAGCACAGGGTTATGGAAAATACCTTCCCCTGCTGCACCGGGAAGGAACAGACAGGAAAGCTGCGG
AAAAATAA

Upstream 100 bases:

>100_bases
TTGTCTAATCATTTACCTTTCCGGAAAAGCCGGGGGACAGCAGTTCCCCGGCCCAGGGAGCCGCTGCTCCCGCACCGGAA
GGCGACTCCATACAGCGTTT

Downstream 100 bases:

>100_bases
TCCGGAGAAAAAGCAGGGGAGGCCAATCCTTCTTCTCCATTAATCTTTTACAACACGGAGGAACAAATGCGGCCCCGGGA
GAACAAGCACCATGTCCTCT

Product: methionine-R-sulfoxide reductase

Products: NA

Alternate protein names: Thioredoxin; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MKRIYHGPWTLAGLACAILAAVAMLSFFSCGEKGQSSSNDKPHMDNKDLKTIYLAGGCFWGVEKYFSLMPGVKETEAGYA
NGSTASPTYEEVCSGKTGHAETVKVVFDPEELSLPFLLERYYSIIDPVSVNKQGNDRGIQYRTGIYYADEKDKPVIETSL
KRLQQHFRQPLAIEVQPLRQFSRAEKYHQRYLDKNPGGYCHIPPAKFREASQARENEPVYRKKSDEELRRVLTREQFAVT
RNNATEPPFRNEYFNNDRPGIYVDVTTGEPLFLSTDKFDSGCGWPSFSRPIKEELIQEKQDFSHGMRRTEVRSKTGDAHL
GHVFTDGPKEQGGLRYCINSASLKFIPEQDMEAQGYGKYLPLLHREGTDRKAAEK

Sequences:

>Translated_375_residues
MKRIYHGPWTLAGLACAILAAVAMLSFFSCGEKGQSSSNDKPHMDNKDLKTIYLAGGCFWGVEKYFSLMPGVKETEAGYA
NGSTASPTYEEVCSGKTGHAETVKVVFDPEELSLPFLLERYYSIIDPVSVNKQGNDRGIQYRTGIYYADEKDKPVIETSL
KRLQQHFRQPLAIEVQPLRQFSRAEKYHQRYLDKNPGGYCHIPPAKFREASQARENEPVYRKKSDEELRRVLTREQFAVT
RNNATEPPFRNEYFNNDRPGIYVDVTTGEPLFLSTDKFDSGCGWPSFSRPIKEELIQEKQDFSHGMRRTEVRSKTGDAHL
GHVFTDGPKEQGGLRYCINSASLKFIPEQDMEAQGYGKYLPLLHREGTDRKAAEK
>Mature_375_residues
MKRIYHGPWTLAGLACAILAAVAMLSFFSCGEKGQSSSNDKPHMDNKDLKTIYLAGGCFWGVEKYFSLMPGVKETEAGYA
NGSTASPTYEEVCSGKTGHAETVKVVFDPEELSLPFLLERYYSIIDPVSVNKQGNDRGIQYRTGIYYADEKDKPVIETSL
KRLQQHFRQPLAIEVQPLRQFSRAEKYHQRYLDKNPGGYCHIPPAKFREASQARENEPVYRKKSDEELRRVLTREQFAVT
RNNATEPPFRNEYFNNDRPGIYVDVTTGEPLFLSTDKFDSGCGWPSFSRPIKEELIQEKQDFSHGMRRTEVRSKTGDAHL
GHVFTDGPKEQGGLRYCINSASLKFIPEQDMEAQGYGKYLPLLHREGTDRKAAEK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=150, Percent_Identity=44.6666666666667, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI208609995, Length=150, Percent_Identity=44.6666666666667, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI301336164, Length=124, Percent_Identity=51.6129032258064, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI301336162, Length=124, Percent_Identity=51.6129032258064, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI73089054, Length=124, Percent_Identity=51.6129032258064, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI37620216, Length=124, Percent_Identity=51.6129032258064, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI117606353, Length=133, Percent_Identity=46.6165413533835, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI208609993, Length=109, Percent_Identity=42.2018348623853, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1788077, Length=131, Percent_Identity=51.9083969465649, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=42.483660130719, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17553450, Length=120, Percent_Identity=49.1666666666667, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI115532676, Length=120, Percent_Identity=49.1666666666667, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=30.0699300699301, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320881, Length=168, Percent_Identity=36.9047619047619, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319816, Length=127, Percent_Identity=35.4330708661417, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45553335, Length=122, Percent_Identity=45.0819672131148, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356369, Length=122, Percent_Identity=45.0819672131148, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221378664, Length=122, Percent_Identity=44.2622950819672, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24645799, Length=122, Percent_Identity=45.0819672131148, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221378662, Length=129, Percent_Identity=41.8604651162791, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24645804, Length=133, Percent_Identity=42.1052631578947, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24645801, Length=133, Percent_Identity=42.1052631578947, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24664627, Length=165, Percent_Identity=32.1212121212121, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45553131, Length=142, Percent_Identity=33.0985915492958, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01625 PMSR; PF08534 Redoxin; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 42623; Mature: 42623

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIYHGPWTLAGLACAILAAVAMLSFFSCGEKGQSSSNDKPHMDNKDLKTIYLAGGCFW
CCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCHHH
GVEKYFSLMPGVKETEAGYANGSTASPTYEEVCSGKTGHAETVKVVFDPEELSLPFLLER
HHHHHHHHCCCCCHHCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECHHHCCHHHHHHH
YYSIIDPVSVNKQGNDRGIQYRTGIYYADEKDKPVIETSLKRLQQHFRQPLAIEVQPLRQ
HHHHHCCCCCCCCCCCCCEEEECCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHH
FSRAEKYHQRYLDKNPGGYCHIPPAKFREASQARENEPVYRKKSDEELRRVLTREQFAVT
HHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHEE
RNNATEPPFRNEYFNNDRPGIYVDVTTGEPLFLSTDKFDSGCGWPSFSRPIKEELIQEKQ
CCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
DFSHGMRRTEVRSKTGDAHLGHVFTDGPKEQGGLRYCINSASLKFIPEQDMEAQGYGKYL
HHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCC
PLLHREGTDRKAAEK
CHHHCCCCCHHCCCC
>Mature Secondary Structure
MKRIYHGPWTLAGLACAILAAVAMLSFFSCGEKGQSSSNDKPHMDNKDLKTIYLAGGCFW
CCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCHHH
GVEKYFSLMPGVKETEAGYANGSTASPTYEEVCSGKTGHAETVKVVFDPEELSLPFLLER
HHHHHHHHCCCCCHHCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECHHHCCHHHHHHH
YYSIIDPVSVNKQGNDRGIQYRTGIYYADEKDKPVIETSLKRLQQHFRQPLAIEVQPLRQ
HHHHHCCCCCCCCCCCCCEEEECCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHH
FSRAEKYHQRYLDKNPGGYCHIPPAKFREASQARENEPVYRKKSDEELRRVLTREQFAVT
HHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHEE
RNNATEPPFRNEYFNNDRPGIYVDVTTGEPLFLSTDKFDSGCGWPSFSRPIKEELIQEKQ
CCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
DFSHGMRRTEVRSKTGDAHLGHVFTDGPKEQGGLRYCINSASLKFIPEQDMEAQGYGKYL
HHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCEEEEECCCCEEECCCCCCCCCCCCCCC
PLLHREGTDRKAAEK
CHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2854063; 8755589 [H]