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The map label for this gene is lacZ [H]

Identifier: 187735326

GI number: 187735326

Start: 969353

End: 973147

Strand: Direct

Name: lacZ [H]

Synonym: Amuc_0824

Alternate gene names: 187735326

Gene position: 969353-973147 (Clockwise)

Preceding gene: 187735325

Following gene: 187735329

Centisome position: 36.39

GC content: 55.73

Gene sequence:

>3795_bases
ATGAGAACGACCAGATCCTGGCTTTTATCCTGTACCGCGCTGGCGGTAAGTTCCGCCATGTGCGGCCTGGGAGCACCGGG
CGATTCCGCCCCCGCGCCAGCCCCCACAGGGCTGGAATGGGAACAGGAACAAAACCTGCATTTGAATAAGGAAGCTCCAA
CCGCCTTTTTCGCGTCTTTCAGCGATTTGCAGTCCGCCTTGAAAGTGCTGCCTGAAAACAGTAAATGGCGCAGGTCCCTG
AACGGTCAGTGGAAGTTCCACTGGGCGAAGGATCCCCAGAGCCGCCCGGCCGATTTTTACAAGCCGGATTACGACGTAAA
GGACTGGAAGGAGATTAAGGTGCCTTCCTCCTGGCAGACTCAGGGTTACGGCACCCCCATTTATTCCAATCAGCCGTATC
CCTTTGAACGCTCCTGGCCTTATGTAATGAAGGAGCCTTCCAACAAGAATTATACGTCCTACAAGGAACGGAACCCCGTA
GGTTCCTACCGCCGCACTTTTGAAGTACCTGCGGACTGGGACGGCAGGGAAGTGTACATGCAGTTTGACGGAGTGGATTC
CTTCTTCTACCTCTGGATCAACGGGCAGTATGTAGGTTTTTCCAAAGATTCCCGGAATCCGGCCCGTTTTGACATCAGCC
CCTACCTTAAGAAGGGGGAGAATGTGGTGGCCGCAGAGGTGTACCGCCATTCCGACGGAGCATATCTGGAATGCCAGGAC
ATGTTCCGCCTGTCCGGCATTTTCCGCAATGTTTCCATCTTTGCGCTGCCGAAAGTTCACATCCGCGACTTTTTCGCACA
GGCCAATCCGGTGGACCAGAGGGATTGGGCTTTGAATATTGACCATGCCAAACCGGGGACCGTGGACGGCGATTGGCGCC
TTCAGGTGGATGTGGATGTTCGCAATCTGTTTCCGGCAACGGAAAAGCTGGACGGCTGCACGGTTTCCATGGCCCTGTAT
GACGCTGCCGGAAAACTGGTAGAACCTGTCAAGCCCAAGGATGCGCCATATGACGGCGTGTTGGAAAAGCCCTTGCGCAT
TACCGGCATGAAGGATTTTAAAACTTCCCTGCTGGGCATTTATTCCAAACCCAGACTATGGTCTGCGGAGGATCCCAACC
TGTACACCCTGGTACTGACGCTGAAGCGTGACGGGAAGACGGAAGAAATGGTTTCCTCCCGCGTGGGTTTCCGCAATGTG
GTGATTAAGGACAGCGTGTTCCTGGTAAACGGCCAGCCGGTGAAGGTAAAGGGCGTGAACCGCCATGAAAGCCATCCGGA
AACAGGGCATTACGTGACTCCGGAGCAGATGGAGGAAGAAGTGCGGATGATGAAACGCGCCAATATCAACCACGTGCGCT
GTTCCCATTATCCCGCGGATCCTTATTTTTATTACCTCTGTGACAAGTACGGCATTTACGTGCAGGATGAGGCCAACATC
GAGTCCCACGGCTATTACTATGGCAAGGAGTCCCTTTCCCATCCCATTGAGTGGATGCCGGCCCACGTGGACCGCATCAT
GGCGATGGTGGAGCGCAACAAGAACCATCCCTGCGTGATTATGTGGTCCCTGGGGAATGAAGCCGGCCCCGGCCAGAATT
TCCGCAGTGCGGAAAAGATGGTGAAGGCCAGGGATATGTCCCGCCCCACCCACTACGAACGCAATAATGACATTGTGGAC
TTGGGGTCCAACCAGTATCCGTCCGTGGACTGGACGCGTTCCATGGCGGGCAACAAGGATTTCCCCAAGCCCTACTATAT
TTCCGAGTACGCACACAACATGATGAATGCCATGGGCAACCTGGCGGATTACTGGGAGGCCATCGAGTCTTCCGACCGCA
TTATGGGCGGCGCCATCTGGGACTGGGTGGACCAGGGCTTGTACAAGACCCTGCCGAATGGAGAAAAGATGCTCTGCTAT
GGCGGCGATTTCAACGACCATCCCAATAGCGGCCAGTTTGTGTTCAACGGCACCATCCTGTCGGATCGTACGCCGGAACC
GGGTTATTTTGAAGTCAAGCACGTCTATCAGAATATTTCCACATCTTTGACGGACGACGGCAGGATTTCCATTTTCAACA
AGAATTTCTTTACGGACCTTTCTTCATACGACATTACCTGGACCCTCACGGAAAACGGCAATGCAGTGGCTGAAGGCAGG
TTGGACACGCCTCCGGCCGGTCCCAGAGAAAAGATTGTGGTTCCCATTCCGGACATTCCCCAGTTGAAAAACCGGAAACC
GGGGGTGGAGTATGCCTTGCGCATAAGTTACAAGCTGAAGAAGGACAGGGGGTGGGCCAAGAAGGGATATGAATTGGCCT
TTGACCAGCTCCAGCTTCCCGTGCAGGGAGATCTGCCTGTGTTCAAGGCTCCTGCGGGCAAAGTCAGCCTCAGCACGGAC
AAGCATACCGTTTCCGGCAAGGATTTTTCCGTGCAGTTTGACGCGTCCACCGGGGAACTGGCCCAGTTCACGGTAAACGG
CAAGCCTCTGTTTAAAACGCCCATGGCGGTGAACGCCCTGCGCGCCGCCTCCAGCAATGAGCCGGGCGTCATGGCCAAGA
GCATGGCTAACGGCCTCCGTGAACTGAAGCATGAACTGCTCAGTTACGAAGCCATTGATAACGGCAATAGCGTCACCGTC
AAGCAATCCATCAAGGTAAGCGGCAAACAGGCTGAAAACATCAGCGGCTACGGCGATACCAAGACCACCATCACGGCCAG
GAAGCAACCCCTGAACGATACGAACACCCATTTCATCAATAATTTGGAATGGACCATCTATGCGGATGGAACTGTCGTCT
GCCAGTCCGTACTGCTTCCGCGCGGCAATCCCCTGGAACTGCTGCGCCTGGGATACGAACTCCAGTTGCCGGCGAATATG
GACAACGTAGCCTATTACGGGCGCGGGCCGGAAGAAAACTATGCGGACCGCAAGAGCGGCATGCCTCTGGGCGTGTATAA
AACGACAGCCTGGGATTCTTTCTTCCCGTACGGCAGACCGCAGGATTGCGGCAACCATGAGGATACCCGCTGGGTGGCCG
TTACGGACGACAAGGGGAACGGCCTGCTTTTCGGTTCCGTGGGCGCACCGTTCGCTTTCTCCGCCCTTCCGTATACCACC
ACGGATTTGATCCTGGCAAACCACCCCGTGGAACTGCCGAAGACGACGGATAAGACCGTTCTGGTTCTCTCTTCCGCCAC
GCGCGGCCTGGGGGGTGCTTCCTGCGGTCCCGGCCCTATGGGCAGGGACATCATCAAGGCCAACAAGCCCTACCCGATGT
CCTTCTTTATGCGGCCCATTACCGCCAAGTCCTACAAGGGGGAAATCCGCGTGCCTGCGGCCCGGCTGGATATGACCATG
CTGACCCGCACGGACAAGTATACGGTCAAGAGTGTAACCAGCCAGGAGCAGGGCGAAGCGGACGCCGAATTCGCCATTGA
CGGTGATCCCGGCACCTTCTGGCACTCTGAATACAATAAAACCGTGACCAAACATCCGCATGTACTGGCCGTGGACCTGG
GTAAGGAGCGGGAATTCTCCGGAATCACTTATCTTCCACGTCAGGATGGCAGCAGCAATGGCCGCGTGAAAGATTATTCC
GTGGACGTGAGCACGGACGGAGAGAAATGGCAGCCTGCCGCCAAGGGCTCCTTCCCGGACAGTGCTGACCTGCAGGAAGT
GAAATTCCAAGCTCCCGTCAAGGCGCGTTATTTCCGCTTCTCCGCCCTTAGTGAGGCGCAGGGGCGGGATTACGCCGCCG
TAGCGGAACTGGATATCATTCCCGTTAAGAAATAA

Upstream 100 bases:

>100_bases
AGCTTGCAAAGGGCAAGTTTGCTGTTAGAATTAGAATTGCGGATTCGTATGTAACAGGACAATCCGTTTGTGCATATCAA
CTCCGACACATATTGATTTC

Downstream 100 bases:

>100_bases
CTCCTGCGGTTTTTACCGTTTGAACAGGCGCCCCGCCGCTCTTTCCGAGTGCGCGGGGCGTTTTATTGCCGGGCTCCATG
GGTTTCCTGGAGGGAAAATG

Product: glycoside hydrolase family 2 TIM barrel

Products: NA

Alternate protein names: Beta-gal; Lactase [H]

Number of amino acids: Translated: 1264; Mature: 1264

Protein sequence:

>1264_residues
MRTTRSWLLSCTALAVSSAMCGLGAPGDSAPAPAPTGLEWEQEQNLHLNKEAPTAFFASFSDLQSALKVLPENSKWRRSL
NGQWKFHWAKDPQSRPADFYKPDYDVKDWKEIKVPSSWQTQGYGTPIYSNQPYPFERSWPYVMKEPSNKNYTSYKERNPV
GSYRRTFEVPADWDGREVYMQFDGVDSFFYLWINGQYVGFSKDSRNPARFDISPYLKKGENVVAAEVYRHSDGAYLECQD
MFRLSGIFRNVSIFALPKVHIRDFFAQANPVDQRDWALNIDHAKPGTVDGDWRLQVDVDVRNLFPATEKLDGCTVSMALY
DAAGKLVEPVKPKDAPYDGVLEKPLRITGMKDFKTSLLGIYSKPRLWSAEDPNLYTLVLTLKRDGKTEEMVSSRVGFRNV
VIKDSVFLVNGQPVKVKGVNRHESHPETGHYVTPEQMEEEVRMMKRANINHVRCSHYPADPYFYYLCDKYGIYVQDEANI
ESHGYYYGKESLSHPIEWMPAHVDRIMAMVERNKNHPCVIMWSLGNEAGPGQNFRSAEKMVKARDMSRPTHYERNNDIVD
LGSNQYPSVDWTRSMAGNKDFPKPYYISEYAHNMMNAMGNLADYWEAIESSDRIMGGAIWDWVDQGLYKTLPNGEKMLCY
GGDFNDHPNSGQFVFNGTILSDRTPEPGYFEVKHVYQNISTSLTDDGRISIFNKNFFTDLSSYDITWTLTENGNAVAEGR
LDTPPAGPREKIVVPIPDIPQLKNRKPGVEYALRISYKLKKDRGWAKKGYELAFDQLQLPVQGDLPVFKAPAGKVSLSTD
KHTVSGKDFSVQFDASTGELAQFTVNGKPLFKTPMAVNALRAASSNEPGVMAKSMANGLRELKHELLSYEAIDNGNSVTV
KQSIKVSGKQAENISGYGDTKTTITARKQPLNDTNTHFINNLEWTIYADGTVVCQSVLLPRGNPLELLRLGYELQLPANM
DNVAYYGRGPEENYADRKSGMPLGVYKTTAWDSFFPYGRPQDCGNHEDTRWVAVTDDKGNGLLFGSVGAPFAFSALPYTT
TDLILANHPVELPKTTDKTVLVLSSATRGLGGASCGPGPMGRDIIKANKPYPMSFFMRPITAKSYKGEIRVPAARLDMTM
LTRTDKYTVKSVTSQEQGEADAEFAIDGDPGTFWHSEYNKTVTKHPHVLAVDLGKEREFSGITYLPRQDGSSNGRVKDYS
VDVSTDGEKWQPAAKGSFPDSADLQEVKFQAPVKARYFRFSALSEAQGRDYAAVAELDIIPVKK

Sequences:

>Translated_1264_residues
MRTTRSWLLSCTALAVSSAMCGLGAPGDSAPAPAPTGLEWEQEQNLHLNKEAPTAFFASFSDLQSALKVLPENSKWRRSL
NGQWKFHWAKDPQSRPADFYKPDYDVKDWKEIKVPSSWQTQGYGTPIYSNQPYPFERSWPYVMKEPSNKNYTSYKERNPV
GSYRRTFEVPADWDGREVYMQFDGVDSFFYLWINGQYVGFSKDSRNPARFDISPYLKKGENVVAAEVYRHSDGAYLECQD
MFRLSGIFRNVSIFALPKVHIRDFFAQANPVDQRDWALNIDHAKPGTVDGDWRLQVDVDVRNLFPATEKLDGCTVSMALY
DAAGKLVEPVKPKDAPYDGVLEKPLRITGMKDFKTSLLGIYSKPRLWSAEDPNLYTLVLTLKRDGKTEEMVSSRVGFRNV
VIKDSVFLVNGQPVKVKGVNRHESHPETGHYVTPEQMEEEVRMMKRANINHVRCSHYPADPYFYYLCDKYGIYVQDEANI
ESHGYYYGKESLSHPIEWMPAHVDRIMAMVERNKNHPCVIMWSLGNEAGPGQNFRSAEKMVKARDMSRPTHYERNNDIVD
LGSNQYPSVDWTRSMAGNKDFPKPYYISEYAHNMMNAMGNLADYWEAIESSDRIMGGAIWDWVDQGLYKTLPNGEKMLCY
GGDFNDHPNSGQFVFNGTILSDRTPEPGYFEVKHVYQNISTSLTDDGRISIFNKNFFTDLSSYDITWTLTENGNAVAEGR
LDTPPAGPREKIVVPIPDIPQLKNRKPGVEYALRISYKLKKDRGWAKKGYELAFDQLQLPVQGDLPVFKAPAGKVSLSTD
KHTVSGKDFSVQFDASTGELAQFTVNGKPLFKTPMAVNALRAASSNEPGVMAKSMANGLRELKHELLSYEAIDNGNSVTV
KQSIKVSGKQAENISGYGDTKTTITARKQPLNDTNTHFINNLEWTIYADGTVVCQSVLLPRGNPLELLRLGYELQLPANM
DNVAYYGRGPEENYADRKSGMPLGVYKTTAWDSFFPYGRPQDCGNHEDTRWVAVTDDKGNGLLFGSVGAPFAFSALPYTT
TDLILANHPVELPKTTDKTVLVLSSATRGLGGASCGPGPMGRDIIKANKPYPMSFFMRPITAKSYKGEIRVPAARLDMTM
LTRTDKYTVKSVTSQEQGEADAEFAIDGDPGTFWHSEYNKTVTKHPHVLAVDLGKEREFSGITYLPRQDGSSNGRVKDYS
VDVSTDGEKWQPAAKGSFPDSADLQEVKFQAPVKARYFRFSALSEAQGRDYAAVAELDIIPVKK
>Mature_1264_residues
MRTTRSWLLSCTALAVSSAMCGLGAPGDSAPAPAPTGLEWEQEQNLHLNKEAPTAFFASFSDLQSALKVLPENSKWRRSL
NGQWKFHWAKDPQSRPADFYKPDYDVKDWKEIKVPSSWQTQGYGTPIYSNQPYPFERSWPYVMKEPSNKNYTSYKERNPV
GSYRRTFEVPADWDGREVYMQFDGVDSFFYLWINGQYVGFSKDSRNPARFDISPYLKKGENVVAAEVYRHSDGAYLECQD
MFRLSGIFRNVSIFALPKVHIRDFFAQANPVDQRDWALNIDHAKPGTVDGDWRLQVDVDVRNLFPATEKLDGCTVSMALY
DAAGKLVEPVKPKDAPYDGVLEKPLRITGMKDFKTSLLGIYSKPRLWSAEDPNLYTLVLTLKRDGKTEEMVSSRVGFRNV
VIKDSVFLVNGQPVKVKGVNRHESHPETGHYVTPEQMEEEVRMMKRANINHVRCSHYPADPYFYYLCDKYGIYVQDEANI
ESHGYYYGKESLSHPIEWMPAHVDRIMAMVERNKNHPCVIMWSLGNEAGPGQNFRSAEKMVKARDMSRPTHYERNNDIVD
LGSNQYPSVDWTRSMAGNKDFPKPYYISEYAHNMMNAMGNLADYWEAIESSDRIMGGAIWDWVDQGLYKTLPNGEKMLCY
GGDFNDHPNSGQFVFNGTILSDRTPEPGYFEVKHVYQNISTSLTDDGRISIFNKNFFTDLSSYDITWTLTENGNAVAEGR
LDTPPAGPREKIVVPIPDIPQLKNRKPGVEYALRISYKLKKDRGWAKKGYELAFDQLQLPVQGDLPVFKAPAGKVSLSTD
KHTVSGKDFSVQFDASTGELAQFTVNGKPLFKTPMAVNALRAASSNEPGVMAKSMANGLRELKHELLSYEAIDNGNSVTV
KQSIKVSGKQAENISGYGDTKTTITARKQPLNDTNTHFINNLEWTIYADGTVVCQSVLLPRGNPLELLRLGYELQLPANM
DNVAYYGRGPEENYADRKSGMPLGVYKTTAWDSFFPYGRPQDCGNHEDTRWVAVTDDKGNGLLFGSVGAPFAFSALPYTT
TDLILANHPVELPKTTDKTVLVLSSATRGLGGASCGPGPMGRDIIKANKPYPMSFFMRPITAKSYKGEIRVPAARLDMTM
LTRTDKYTVKSVTSQEQGEADAEFAIDGDPGTFWHSEYNKTVTKHPHVLAVDLGKEREFSGITYLPRQDGSSNGRVKDYS
VDVSTDGEKWQPAAKGSFPDSADLQEVKFQAPVKARYFRFSALSEAQGRDYAAVAELDIIPVKK

Specific function: The Wild-Type Enzyme Is An Ineffective Lactase. Two Classes Of Point Mutations Dramatically Improve Activity Of The Enzyme. [C]

COG id: COG3250

COG function: function code G; Beta-galactosidase/beta-glucuronidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI268834192, Length=471, Percent_Identity=25.9023354564756, Blast_Score=97, Evalue=1e-19,
Organism=Escherichia coli, GI48994920, Length=1052, Percent_Identity=33.0798479087452, Blast_Score=490, Evalue=1e-139,
Organism=Escherichia coli, GI1786539, Length=1060, Percent_Identity=31.8867924528302, Blast_Score=460, Evalue=1e-130,
Organism=Escherichia coli, GI1787903, Length=460, Percent_Identity=23.695652173913, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17510825, Length=292, Percent_Identity=26.3698630136986, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922582, Length=611, Percent_Identity=24.2225859247136, Blast_Score=104, Evalue=4e-22,
Organism=Drosophila melanogaster, GI62471735, Length=611, Percent_Identity=24.2225859247136, Blast_Score=104, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24655438, Length=611, Percent_Identity=24.2225859247136, Blast_Score=103, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24651745, Length=425, Percent_Identity=23.7647058823529, Blast_Score=87, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008979
- InterPro:   IPR011013
- InterPro:   IPR014718
- InterPro:   IPR006101
- InterPro:   IPR013812
- InterPro:   IPR006104
- InterPro:   IPR004199
- InterPro:   IPR006102
- InterPro:   IPR006103
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF02929 Bgal_small_N; PF00703 Glyco_hydro_2; PF02836 Glyco_hydro_2_C; PF02837 Glyco_hydro_2_N [H]

EC number: =3.2.1.23 [H]

Molecular weight: Translated: 142052; Mature: 142052

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50022 FA58C_3 ; PS00608 GLYCOSYL_HYDROL_F2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTTRSWLLSCTALAVSSAMCGLGAPGDSAPAPAPTGLEWEQEQNLHLNKEAPTAFFASF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHH
SDLQSALKVLPENSKWRRSLNGQWKFHWAKDPQSRPADFYKPDYDVKDWKEIKVPSSWQT
HHHHHHHHHCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHEEECCCCCCC
QGYGTPIYSNQPYPFERSWPYVMKEPSNKNYTSYKERNPVGSYRRTFEVPADWDGREVYM
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHCCCCCCCCEEEECCCCCCCCEEEE
QFDGVDSFFYLWINGQYVGFSKDSRNPARFDISPYLKKGENVVAAEVYRHSDGAYLECQD
EECCCCEEEEEEEECEEEEECCCCCCCCEEECCHHHHCCCCEEEEEEEECCCCCEEEHHH
MFRLSGIFRNVSIFALPKVHIRDFFAQANPVDQRDWALNIDHAKPGTVDGDWRLQVDVDV
HHHHHHHHHCEEEEEECCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCEEEEEEEEH
RNLFPATEKLDGCTVSMALYDAAGKLVEPVKPKDAPYDGVLEKPLRITGMKDFKTSLLGI
HHCCCCCCCCCCCEEEEEEEHHCCHHCCCCCCCCCCCCCHHCCCEEEECCHHHHHHHHHH
YSKPRLWSAEDPNLYTLVLTLKRDGKTEEMVSSRVGFRNVVIKDSVFLVNGQPVKVKGVN
CCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCEEEECCCEEEEECCC
RHESHPETGHYVTPEQMEEEVRMMKRANINHVRCSHYPADPYFYYLCDKYGIYVQDEANI
CCCCCCCCCCEECHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCEEEEECCCC
ESHGYYYGKESLSHPIEWMPAHVDRIMAMVERNKNHPCVIMWSLGNEAGPGQNFRSAEKM
CCCCEEECHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHH
VKARDMSRPTHYERNNDIVDLGSNQYPSVDWTRSMAGNKDFPKPYYISEYAHNMMNAMGN
HHHHHCCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCC
LADYWEAIESSDRIMGGAIWDWVDQGLYKTLPNGEKMLCYGGDFNDHPNSGQFVFNGTIL
HHHHHHHHCCCCCEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEEEE
SDRTPEPGYFEVKHVYQNISTSLTDDGRISIFNKNFFTDLSSYDITWTLTENGNAVAEGR
CCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHCCCCCCEEEEEEECCCCEEECCC
LDTPPAGPREKIVVPIPDIPQLKNRKPGVEYALRISYKLKKDRGWAKKGYELAFDQLQLP
CCCCCCCCCCEEEECCCCCCHHCCCCCCCEEEEEEEEEEECCCCCCCCCCCEEHHHEECC
VQGDLPVFKAPAGKVSLSTDKHTVSGKDFSVQFDASTGELAQFTVNGKPLFKTPMAVNAL
CCCCCCEEECCCCEEEECCCCEEECCCCEEEEECCCCCCEEEEEECCCCEEECCHHHHHH
RAASSNEPGVMAKSMANGLRELKHELLSYEAIDNGNSVTVKQSIKVSGKQAENISGYGDT
HHCCCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCCEEEEEEEEEECCCCCCCCCCCCCC
KTTITARKQPLNDTNTHFINNLEWTIYADGTVVCQSVLLPRGNPLELLRLGYELQLPANM
CEEEEECCCCCCCCCCEEECCEEEEEEECCHHHHHHHHCCCCCCHHHHHCCEEEECCCCC
DNVAYYGRGPEENYADRKSGMPLGVYKTTAWDSFFPYGRPQDCGNHEDTRWVAVTDDKGN
CCEEEECCCCCCCCCHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
GLLFGSVGAPFAFSALPYTTTDLILANHPVELPKTTDKTVLVLSSATRGLGGASCGPGPM
EEEEECCCCCCEECCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
GRDIIKANKPYPMSFFMRPITAKSYKGEIRVPAARLDMTMLTRTDKYTVKSVTSQEQGEA
CCHHHHCCCCCCHHHHCCCCCCCCCCCEEECCHHHHCEEEEECCCCEEEHHHCCCCCCCC
DAEFAIDGDPGTFWHSEYNKTVTKHPHVLAVDLGKEREFSGITYLPRQDGSSNGRVKDYS
CCEEEEECCCCCEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCEEEEE
VDVSTDGEKWQPAAKGSFPDSADLQEVKFQAPVKARYFRFSALSEAQGRDYAAVAELDII
EEECCCCCCCCCCCCCCCCCCCCHHHHEECCCCCEEEEEEEHHHHCCCCCEEEEEEEEEE
PVKK
ECCC
>Mature Secondary Structure
MRTTRSWLLSCTALAVSSAMCGLGAPGDSAPAPAPTGLEWEQEQNLHLNKEAPTAFFASF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHH
SDLQSALKVLPENSKWRRSLNGQWKFHWAKDPQSRPADFYKPDYDVKDWKEIKVPSSWQT
HHHHHHHHHCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHEEECCCCCCC
QGYGTPIYSNQPYPFERSWPYVMKEPSNKNYTSYKERNPVGSYRRTFEVPADWDGREVYM
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHCCCCCCCCEEEECCCCCCCCEEEE
QFDGVDSFFYLWINGQYVGFSKDSRNPARFDISPYLKKGENVVAAEVYRHSDGAYLECQD
EECCCCEEEEEEEECEEEEECCCCCCCCEEECCHHHHCCCCEEEEEEEECCCCCEEEHHH
MFRLSGIFRNVSIFALPKVHIRDFFAQANPVDQRDWALNIDHAKPGTVDGDWRLQVDVDV
HHHHHHHHHCEEEEEECCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCEEEEEEEEH
RNLFPATEKLDGCTVSMALYDAAGKLVEPVKPKDAPYDGVLEKPLRITGMKDFKTSLLGI
HHCCCCCCCCCCCEEEEEEEHHCCHHCCCCCCCCCCCCCHHCCCEEEECCHHHHHHHHHH
YSKPRLWSAEDPNLYTLVLTLKRDGKTEEMVSSRVGFRNVVIKDSVFLVNGQPVKVKGVN
CCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCEEEECCCEEEEECCC
RHESHPETGHYVTPEQMEEEVRMMKRANINHVRCSHYPADPYFYYLCDKYGIYVQDEANI
CCCCCCCCCCEECHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCEEEEECCCC
ESHGYYYGKESLSHPIEWMPAHVDRIMAMVERNKNHPCVIMWSLGNEAGPGQNFRSAEKM
CCCCEEECHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHH
VKARDMSRPTHYERNNDIVDLGSNQYPSVDWTRSMAGNKDFPKPYYISEYAHNMMNAMGN
HHHHHCCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCC
LADYWEAIESSDRIMGGAIWDWVDQGLYKTLPNGEKMLCYGGDFNDHPNSGQFVFNGTIL
HHHHHHHHCCCCCEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEEEE
SDRTPEPGYFEVKHVYQNISTSLTDDGRISIFNKNFFTDLSSYDITWTLTENGNAVAEGR
CCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHCCCCCCEEEEEEECCCCEEECCC
LDTPPAGPREKIVVPIPDIPQLKNRKPGVEYALRISYKLKKDRGWAKKGYELAFDQLQLP
CCCCCCCCCCEEEECCCCCCHHCCCCCCCEEEEEEEEEEECCCCCCCCCCCEEHHHEECC
VQGDLPVFKAPAGKVSLSTDKHTVSGKDFSVQFDASTGELAQFTVNGKPLFKTPMAVNAL
CCCCCCEEECCCCEEEECCCCEEECCCCEEEEECCCCCCEEEEEECCCCEEECCHHHHHH
RAASSNEPGVMAKSMANGLRELKHELLSYEAIDNGNSVTVKQSIKVSGKQAENISGYGDT
HHCCCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCCEEEEEEEEEECCCCCCCCCCCCCC
KTTITARKQPLNDTNTHFINNLEWTIYADGTVVCQSVLLPRGNPLELLRLGYELQLPANM
CEEEEECCCCCCCCCCEEECCEEEEEEECCHHHHHHHHCCCCCCHHHHHCCEEEECCCCC
DNVAYYGRGPEENYADRKSGMPLGVYKTTAWDSFFPYGRPQDCGNHEDTRWVAVTDDKGN
CCEEEECCCCCCCCCHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
GLLFGSVGAPFAFSALPYTTTDLILANHPVELPKTTDKTVLVLSSATRGLGGASCGPGPM
EEEEECCCCCCEECCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
GRDIIKANKPYPMSFFMRPITAKSYKGEIRVPAARLDMTMLTRTDKYTVKSVTSQEQGEA
CCHHHHCCCCCCHHHHCCCCCCCCCCCEEECCHHHHCEEEEECCCCEEEHHHCCCCCCCC
DAEFAIDGDPGTFWHSEYNKTVTKHPHVLAVDLGKEREFSGITYLPRQDGSSNGRVKDYS
CCEEEEECCCCCEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCEEEEE
VDVSTDGEKWQPAAKGSFPDSADLQEVKFQAPVKARYFRFSALSEAQGRDYAAVAELDII
EEECCCCCCCCCCCCCCCCCCCCHHHHEECCCCCEEEEEEEHHHHCCCCCEEEEEEEEEE
PVKK
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8088532; 10360571; 9741105 [H]