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The map label for this gene is gpmA [H]

Identifier: 187735276

GI number: 187735276

Start: 908842

End: 910647

Strand: Direct

Name: gpmA [H]

Synonym: Amuc_0772

Alternate gene names: 187735276

Gene position: 908842-910647 (Clockwise)

Preceding gene: 187735274

Following gene: 187735277

Centisome position: 34.11

GC content: 52.44

Gene sequence:

>1806_bases
ATGAAAACAATTGTTCTTCTTCGCCATGGAGAAAGCACGTGGAACCGTGAAAACAGATTCACCGGATGGACGGACGTGGA
TCTGACGGAATTGGGAATACAGGAAGCCAACCACGCGGGCGACCTTCTGAAAGACAGGGGAATGGCCTTTGACCATGCCT
ACACCTCTTATCTCAAGAGGGCCGTGAAAACGCTCAACTGCGTGCTGGACCATTTGGACCAGGACTGGCTGCCCGTCTCC
AAAAGCTGGAGGTTGAATGAAAAGCACTACGGCATGCTCCAGGGCCTGAATAAAAGTGAAACGGCTCAAAAATACGGAGA
CGAACAGGTACTGATCTGGAGGCGCAGTTATGACGTGGCGCCTCCTCCCCTGGCGGAGGACGATCCCGCCAACCCCAAAT
GGGATCCCCGCTACAAGGGAGTGCCGGACAGCGAACTTCCGCGAACGGAATCACTGAAAGAAACTATTGCCCGCATGATG
CCCTACTGGGAAGGAACAGTTCTCCCTTCTCTACGGACGCTGGACAATATCCTAATCGTAGCCCACGGCAACACATTGCG
GGGCATGATCAAGTATTTGAAAAACATTCCTGACGAACAGCTGCTTTCCCTTAATCTTCCTACCGCCACCCCCTATGTAT
TTGAATTTGACGACTCCCTAAACCTGGAAAAAGACTACTTTCTTGGGGATCCGGAAGAAATCCGCAAACGCATGGCGGCC
GTCGCCGGCCAGGGAAGCGCAAAGAAAAAAAACGCCTGCGGAATAACCTCATTATCCTTTCCTATGACCGCCCATTCCTG
CCGCATTGCGTTCTTTGACGCCAAGCCCTACGACCGGGATTCCTTCAATTCTGTCAATGAACGCGAATTCCATTACGACA
TCCGTTACTTCAAAGGGCACCTCACTCCGGACAGCGTGCCCCTGACCCGCGGTACGGACGTAGCGTGCATTTTCGTCAAT
GACACGGCAAACCGGGAAGTAATACGGAACCTGAAGGAAAATGGCGTCAAATTGCTGGCTCTGCGTTGCGCCGGATTCAA
TAATGTGGATCTGAAAGCTGCGGAAGAAGCGGAACTGCCCGTCGTGCGGGTGCCCCAATATTCTCCCTATGCGGTGGCGG
AACATGCCGTAGCCCTGATGCTTTCCCTGAACCGCAAAATACACCGCGCCTACTGGCGCACCAGGGACGGCAATTTTTCC
CTTCACGGCCTGATGGGCTTTGACATGAATGGAAAAACGGCCGGCATCATCGGAACGGGAAAAATCGCCAGAATCCTCAT
CCGCATTCTCAAAGGCTTCGGGATGAACATCCTGGCCTATGACCTGCACCCTGACCAGCGCTTTGCGGAAGAAGCCGGCA
TTACGTACACCACCCTGGACGATCTGTACGCCCGGTCCGATATCATCTCCCTGCACTGTCCCCTTACTCCGGAAACGGAA
CACCTGATTAATACGGATTCCATTGGAAAAATGAAGGATGGAGTGATGATCATCAACACGGGACGCGGCAAGCTGATTAA
CACGGAAATGCTGATTGACGGCCTGAAATCAAAAAAAGTGGGAGCTGCCGGACTGGACGTGTACGAAGAAGAGGGAGAAT
ATTTCTACGAAGACAAATCCGACAGGATTATTGATGATGATACTCTGGCTCGTCTCCTTTCCTTCAACAACGTCATCCTG
ACTTCCCACCAGGGCTTTTTCACGAAAGAAGCCCTGCACAATATTGCGGAAGTCACCCTGCACAACATCCGGGACTTTCT
GGAAAGCAAACCTCTGATCAACCGAGTCTCGCTTCAGTCACGCTGA

Upstream 100 bases:

>100_bases
CGGACGGAACGGAGGCCTTCCGTTCCGTGGAATGTGATCATGTCATATATCTTCATCCCTTTGTATGAAAACCGGAGGAC
GCCTGTCTAAATTGATCAAT

Downstream 100 bases:

>100_bases
ACGTGCCCGGCGGGCGCTCTACGGAAATCCGGGACTTTCTCATCCGCCTTCTGCCGGACAGAAGGCGGAATTCGGGGAAA
GGCGGCAGCTTTTTTATGCA

Product: phosphoglycerate mutase 1 family

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MKTIVLLRHGESTWNRENRFTGWTDVDLTELGIQEANHAGDLLKDRGMAFDHAYTSYLKRAVKTLNCVLDHLDQDWLPVS
KSWRLNEKHYGMLQGLNKSETAQKYGDEQVLIWRRSYDVAPPPLAEDDPANPKWDPRYKGVPDSELPRTESLKETIARMM
PYWEGTVLPSLRTLDNILIVAHGNTLRGMIKYLKNIPDEQLLSLNLPTATPYVFEFDDSLNLEKDYFLGDPEEIRKRMAA
VAGQGSAKKKNACGITSLSFPMTAHSCRIAFFDAKPYDRDSFNSVNEREFHYDIRYFKGHLTPDSVPLTRGTDVACIFVN
DTANREVIRNLKENGVKLLALRCAGFNNVDLKAAEEAELPVVRVPQYSPYAVAEHAVALMLSLNRKIHRAYWRTRDGNFS
LHGLMGFDMNGKTAGIIGTGKIARILIRILKGFGMNILAYDLHPDQRFAEEAGITYTTLDDLYARSDIISLHCPLTPETE
HLINTDSIGKMKDGVMIINTGRGKLINTEMLIDGLKSKKVGAAGLDVYEEEGEYFYEDKSDRIIDDDTLARLLSFNNVIL
TSHQGFFTKEALHNIAEVTLHNIRDFLESKPLINRVSLQSR

Sequences:

>Translated_601_residues
MKTIVLLRHGESTWNRENRFTGWTDVDLTELGIQEANHAGDLLKDRGMAFDHAYTSYLKRAVKTLNCVLDHLDQDWLPVS
KSWRLNEKHYGMLQGLNKSETAQKYGDEQVLIWRRSYDVAPPPLAEDDPANPKWDPRYKGVPDSELPRTESLKETIARMM
PYWEGTVLPSLRTLDNILIVAHGNTLRGMIKYLKNIPDEQLLSLNLPTATPYVFEFDDSLNLEKDYFLGDPEEIRKRMAA
VAGQGSAKKKNACGITSLSFPMTAHSCRIAFFDAKPYDRDSFNSVNEREFHYDIRYFKGHLTPDSVPLTRGTDVACIFVN
DTANREVIRNLKENGVKLLALRCAGFNNVDLKAAEEAELPVVRVPQYSPYAVAEHAVALMLSLNRKIHRAYWRTRDGNFS
LHGLMGFDMNGKTAGIIGTGKIARILIRILKGFGMNILAYDLHPDQRFAEEAGITYTTLDDLYARSDIISLHCPLTPETE
HLINTDSIGKMKDGVMIINTGRGKLINTEMLIDGLKSKKVGAAGLDVYEEEGEYFYEDKSDRIIDDDTLARLLSFNNVIL
TSHQGFFTKEALHNIAEVTLHNIRDFLESKPLINRVSLQSR
>Mature_601_residues
MKTIVLLRHGESTWNRENRFTGWTDVDLTELGIQEANHAGDLLKDRGMAFDHAYTSYLKRAVKTLNCVLDHLDQDWLPVS
KSWRLNEKHYGMLQGLNKSETAQKYGDEQVLIWRRSYDVAPPPLAEDDPANPKWDPRYKGVPDSELPRTESLKETIARMM
PYWEGTVLPSLRTLDNILIVAHGNTLRGMIKYLKNIPDEQLLSLNLPTATPYVFEFDDSLNLEKDYFLGDPEEIRKRMAA
VAGQGSAKKKNACGITSLSFPMTAHSCRIAFFDAKPYDRDSFNSVNEREFHYDIRYFKGHLTPDSVPLTRGTDVACIFVN
DTANREVIRNLKENGVKLLALRCAGFNNVDLKAAEEAELPVVRVPQYSPYAVAEHAVALMLSLNRKIHRAYWRTRDGNFS
LHGLMGFDMNGKTAGIIGTGKIARILIRILKGFGMNILAYDLHPDQRFAEEAGITYTTLDDLYARSDIISLHCPLTPETE
HLINTDSIGKMKDGVMIINTGRGKLINTEMLIDGLKSKKVGAAGLDVYEEEGEYFYEDKSDRIIDDDTLARLLSFNNVIL
TSHQGFFTKEALHNIAEVTLHNIRDFLESKPLINRVSLQSR

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily [H]

Homologues:

Organism=Homo sapiens, GI50593010, Length=248, Percent_Identity=52.0161290322581, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI4505753, Length=249, Percent_Identity=52.6104417670683, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI71274132, Length=249, Percent_Identity=50.2008032128514, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4502445, Length=251, Percent_Identity=43.8247011952191, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI40353764, Length=251, Percent_Identity=43.8247011952191, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI310129614, Length=160, Percent_Identity=56.875, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI23308577, Length=256, Percent_Identity=30.46875, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI61743967, Length=278, Percent_Identity=27.6978417266187, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4557497, Length=278, Percent_Identity=27.6978417266187, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI145580575, Length=284, Percent_Identity=26.7605633802817, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI145580578, Length=284, Percent_Identity=26.7605633802817, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI4557499, Length=284, Percent_Identity=26.7605633802817, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI6912396, Length=285, Percent_Identity=27.3684210526316, Blast_Score=105, Evalue=9e-23,
Organism=Escherichia coli, GI1787645, Length=319, Percent_Identity=52.3510971786834, Blast_Score=352, Evalue=5e-98,
Organism=Escherichia coli, GI1786970, Length=245, Percent_Identity=58.3673469387755, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI87082289, Length=251, Percent_Identity=32.6693227091633, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789279, Length=242, Percent_Identity=32.2314049586777, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17532191, Length=251, Percent_Identity=29.8804780876494, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI25147481, Length=256, Percent_Identity=29.6875, Blast_Score=102, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6322697, Length=245, Percent_Identity=47.7551020408163, Blast_Score=234, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6324055, Length=249, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324516, Length=296, Percent_Identity=30.0675675675676, Blast_Score=134, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6320183, Length=300, Percent_Identity=28.6666666666667, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=295, Percent_Identity=29.8305084745763, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322116, Length=290, Percent_Identity=31.0344827586207, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=213, Percent_Identity=28.6384976525822, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=128, Percent_Identity=38.28125, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324857, Length=191, Percent_Identity=24.0837696335079, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321253, Length=178, Percent_Identity=28.0898876404494, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324980, Length=140, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646216, Length=249, Percent_Identity=51.004016064257, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI85725270, Length=249, Percent_Identity=48.995983935743, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI85725272, Length=249, Percent_Identity=48.995983935743, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24650981, Length=249, Percent_Identity=48.995983935743, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI28571815, Length=251, Percent_Identity=37.4501992031873, Blast_Score=173, Evalue=4e-43,
Organism=Drosophila melanogaster, GI28571817, Length=251, Percent_Identity=37.4501992031873, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24648979, Length=251, Percent_Identity=37.4501992031873, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI19921140, Length=262, Percent_Identity=30.5343511450382, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI62472511, Length=271, Percent_Identity=32.4723247232472, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646446, Length=271, Percent_Identity=32.4723247232472, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646448, Length=271, Percent_Identity=32.4723247232472, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646452, Length=271, Percent_Identity=32.4723247232472, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646450, Length=271, Percent_Identity=32.4723247232472, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45552429, Length=265, Percent_Identity=27.9245283018868, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24585514, Length=265, Percent_Identity=27.9245283018868, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574282, Length=265, Percent_Identity=27.9245283018868, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574284, Length=265, Percent_Identity=27.9245283018868, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45551003, Length=265, Percent_Identity=27.9245283018868, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574286, Length=264, Percent_Identity=27.2727272727273, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28571528, Length=294, Percent_Identity=27.2108843537415, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24585516, Length=265, Percent_Identity=24.5283018867925, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =5.4.2.1 [H]

Molecular weight: Translated: 68089; Mature: 68089

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3 ; PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIVLLRHGESTWNRENRFTGWTDVDLTELGIQEANHAGDLLKDRGMAFDHAYTSYLKR
CCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHH
AVKTLNCVLDHLDQDWLPVSKSWRLNEKHYGMLQGLNKSETAQKYGDEQVLIWRRSYDVA
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEEEEEECCCCC
PPPLAEDDPANPKWDPRYKGVPDSELPRTESLKETIARMMPYWEGTVLPSLRTLDNILIV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEEE
AHGNTLRGMIKYLKNIPDEQLLSLNLPTATPYVFEFDDSLNLEKDYFLGDPEEIRKRMAA
ECCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHH
VAGQGSAKKKNACGITSLSFPMTAHSCRIAFFDAKPYDRDSFNSVNEREFHYDIRYFKGH
HHCCCCCCCCCCCCEEEECCCCEECCEEEEEEECCCCCCCCCCCCCCCEEEEEEEEEECC
LTPDSVPLTRGTDVACIFVNDTANREVIRNLKENGVKLLALRCAGFNNVDLKAAEEAELP
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCC
VVRVPQYSPYAVAEHAVALMLSLNRKIHRAYWRTRDGNFSLHGLMGFDMNGKTAGIIGTG
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCEEEEEECH
KIARILIRILKGFGMNILAYDLHPDQRFAEEAGITYTTLDDLYARSDIISLHCPLTPETE
HHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCEEEEHHHHHHCCCEEEEECCCCCCHH
HLINTDSIGKMKDGVMIINTGRGKLINTEMLIDGLKSKKVGAAGLDVYEEEGEYFYEDKS
HHCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHCHHCCCCCCCCCCEEECCCCEEEECCC
DRIIDDDTLARLLSFNNVILTSHQGFFTKEALHNIAEVTLHNIRDFLESKPLINRVSLQS
CCEECHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCC
R
C
>Mature Secondary Structure
MKTIVLLRHGESTWNRENRFTGWTDVDLTELGIQEANHAGDLLKDRGMAFDHAYTSYLKR
CCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHH
AVKTLNCVLDHLDQDWLPVSKSWRLNEKHYGMLQGLNKSETAQKYGDEQVLIWRRSYDVA
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEEEEEECCCCC
PPPLAEDDPANPKWDPRYKGVPDSELPRTESLKETIARMMPYWEGTVLPSLRTLDNILIV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEEE
AHGNTLRGMIKYLKNIPDEQLLSLNLPTATPYVFEFDDSLNLEKDYFLGDPEEIRKRMAA
ECCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHH
VAGQGSAKKKNACGITSLSFPMTAHSCRIAFFDAKPYDRDSFNSVNEREFHYDIRYFKGH
HHCCCCCCCCCCCCEEEECCCCEECCEEEEEEECCCCCCCCCCCCCCCEEEEEEEEEECC
LTPDSVPLTRGTDVACIFVNDTANREVIRNLKENGVKLLALRCAGFNNVDLKAAEEAELP
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCC
VVRVPQYSPYAVAEHAVALMLSLNRKIHRAYWRTRDGNFSLHGLMGFDMNGKTAGIIGTG
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCEEEEEECH
KIARILIRILKGFGMNILAYDLHPDQRFAEEAGITYTTLDDLYARSDIISLHCPLTPETE
HHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCEEEEHHHHHHCCCEEEEECCCCCCHH
HLINTDSIGKMKDGVMIINTGRGKLINTEMLIDGLKSKKVGAAGLDVYEEEGEYFYEDKS
HHCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHCHHCCCCCCCCCCEEECCCCEEEECCC
DRIIDDDTLARLLSFNNVILTSHQGFFTKEALHNIAEVTLHNIRDFLESKPLINRVSLQS
CCEECHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA