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The map label for this gene is hldD [H]

Identifier: 187735261

GI number: 187735261

Start: 889451

End: 890437

Strand: Reverse

Name: hldD [H]

Synonym: Amuc_0756

Alternate gene names: 187735261

Gene position: 890437-889451 (Counterclockwise)

Preceding gene: 187735268

Following gene: 187735260

Centisome position: 33.42

GC content: 56.74

Gene sequence:

>987_bases
ATGATTATTGTCACGGGTGGGGCCGGGTTTATCGGCTCAAACATTGTCGCCGCTCTGGAAAAAGCCGGTAAAAAGGATCT
TGTGGTGGTGGACGAGCTGGGCTCTTCCGACAAGTGGAGGAACATTGCCAAGAGAGAGCTGTGCGCCGTGGTTTCTCCGG
AAGGCATGTTTGATTATATGAAGGCGCATGCGGATGAGGTGGAGGCGGTCATTCACATGGGGGCCATTTCCGCCACCACG
GAGACGGACGCCGATTTGATTATCCGGACGAATTTCACGTTGAGCTGGCATTTGTGGGAGTTTTGTTCCCTGTACGGCAA
ACGGTTTATTTACGCCTCCTCCGCAGCCACGTACGGGGACGGTTCCATGGGGTTTGACGATGACGCCTCCCTGGAGCACG
TCAATGCGCTGCGCCCCCTGAACGCATACGGCTGGAGCAAGGCCCTGTTTGACCGCAAGGTGGCCCGGGAAGTGAAAGAA
GGGCGTCCGGTTCCCCCCCAATACGCCGGGCTTAAATTTTTCAACGTGTACGGCCCTAATGAATACCATAAGGGCGGGCA
GAAAAGCGTGGTGGCCCATATATTCCCCCAAGTGAAGGCCAATGAAACGGTGAAGCTGTTCAAATCTTACCATCCCGACT
ACCGTGACGGATGGCAGCTCCGGGATTTCGTGTGGGTGGGCGACTGCGTGGACGTGGTGCTTTGGCTGCTGGAGCATCCG
GAGGTGAGCGGCCTGTTCAACGTAGGTTCCGGGAAGGCACGCTCTTTCCACGATCTGGCGAAGGCGGCATTCCATGCGCT
GGGCCTTCAGGAAAAGATTGCCTACCGGGAGATGCCTGAAGAGCTCAGGGGGAAATATCAGTATTATACGCAGGCGGACC
TTTCCAGGCTGCGCGTTGCCGGTTATGCAGCGCCCATGACTTCCCTGGAGGATGGCGTGCGCCGGTACGTGCAGGAGTAT
CTGGACAGGGAAGACAGTTACGTTTAA

Upstream 100 bases:

>100_bases
TTGAAAATTGGGAGCCGGGGAACGCCTCAAATGGCAGTTGCCTAGGGACGGGTGGATGTGGTATAAAAGGCCGTACAACT
TTTTTATTGATTCTTTTCTT

Downstream 100 bases:

>100_bases
CCCGCATTCCTTTTTTCTCCCATGCCCGCACAGCGCATTCTGATCATCAAGCATGGAGCCCTTGGCGATGTGGTGCTCGC
CATGGGGACGATGAAGCGGC

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MIIVTGGAGFIGSNIVAALEKAGKKDLVVVDELGSSDKWRNIAKRELCAVVSPEGMFDYMKAHADEVEAVIHMGAISATT
ETDADLIIRTNFTLSWHLWEFCSLYGKRFIYASSAATYGDGSMGFDDDASLEHVNALRPLNAYGWSKALFDRKVAREVKE
GRPVPPQYAGLKFFNVYGPNEYHKGGQKSVVAHIFPQVKANETVKLFKSYHPDYRDGWQLRDFVWVGDCVDVVLWLLEHP
EVSGLFNVGSGKARSFHDLAKAAFHALGLQEKIAYREMPEELRGKYQYYTQADLSRLRVAGYAAPMTSLEDGVRRYVQEY
LDREDSYV

Sequences:

>Translated_328_residues
MIIVTGGAGFIGSNIVAALEKAGKKDLVVVDELGSSDKWRNIAKRELCAVVSPEGMFDYMKAHADEVEAVIHMGAISATT
ETDADLIIRTNFTLSWHLWEFCSLYGKRFIYASSAATYGDGSMGFDDDASLEHVNALRPLNAYGWSKALFDRKVAREVKE
GRPVPPQYAGLKFFNVYGPNEYHKGGQKSVVAHIFPQVKANETVKLFKSYHPDYRDGWQLRDFVWVGDCVDVVLWLLEHP
EVSGLFNVGSGKARSFHDLAKAAFHALGLQEKIAYREMPEELRGKYQYYTQADLSRLRVAGYAAPMTSLEDGVRRYVQEY
LDREDSYV
>Mature_328_residues
MIIVTGGAGFIGSNIVAALEKAGKKDLVVVDELGSSDKWRNIAKRELCAVVSPEGMFDYMKAHADEVEAVIHMGAISATT
ETDADLIIRTNFTLSWHLWEFCSLYGKRFIYASSAATYGDGSMGFDDDASLEHVNALRPLNAYGWSKALFDRKVAREVKE
GRPVPPQYAGLKFFNVYGPNEYHKGGQKSVVAHIFPQVKANETVKLFKSYHPDYRDGWQLRDFVWVGDCVDVVLWLLEHP
EVSGLFNVGSGKARSFHDLAKAAFHALGLQEKIAYREMPEELRGKYQYYTQADLSRLRVAGYAAPMTSLEDGVRRYVQEY
LDREDSYV

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790049, Length=328, Percent_Identity=42.0731707317073, Blast_Score=227, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6319493, Length=359, Percent_Identity=26.1838440111421, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 36860; Mature: 36860

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVTGGAGFIGSNIVAALEKAGKKDLVVVDELGSSDKWRNIAKRELCAVVSPEGMFDYM
CEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHH
KAHADEVEAVIHMGAISATTETDADLIIRTNFTLSWHLWEFCSLYGKRFIYASSAATYGD
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEHHHHHHHHHHCCCEEEECCCCCCCC
GSMGFDDDASLEHVNALRPLNAYGWSKALFDRKVAREVKEGRPVPPQYAGLKFFNVYGPN
CCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCC
EYHKGGQKSVVAHIFPQVKANETVKLFKSYHPDYRDGWQLRDFVWVGDCVDVVLWLLEHP
HHCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHEEEEHHHHHHHHHHHCCC
EVSGLFNVGSGKARSFHDLAKAAFHALGLQEKIAYREMPEELRGKYQYYTQADLSRLRVA
CCCCEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHH
GYAAPMTSLEDGVRRYVQEYLDREDSYV
HHHCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIIVTGGAGFIGSNIVAALEKAGKKDLVVVDELGSSDKWRNIAKRELCAVVSPEGMFDYM
CEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHH
KAHADEVEAVIHMGAISATTETDADLIIRTNFTLSWHLWEFCSLYGKRFIYASSAATYGD
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEHHHHHHHHHHCCCEEEECCCCCCCC
GSMGFDDDASLEHVNALRPLNAYGWSKALFDRKVAREVKEGRPVPPQYAGLKFFNVYGPN
CCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCC
EYHKGGQKSVVAHIFPQVKANETVKLFKSYHPDYRDGWQLRDFVWVGDCVDVVLWLLEHP
HHCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHEEEEHHHHHHHHHHHCCC
EVSGLFNVGSGKARSFHDLAKAAFHALGLQEKIAYREMPEELRGKYQYYTQADLSRLRVA
CCCCEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHH
GYAAPMTSLEDGVRRYVQEYLDREDSYV
HHHCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]