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The map label for this gene is gph [H]

Identifier: 187735245

GI number: 187735245

Start: 876068

End: 876706

Strand: Direct

Name: gph [H]

Synonym: Amuc_0740

Alternate gene names: 187735245

Gene position: 876068-876706 (Clockwise)

Preceding gene: 187735244

Following gene: 187735246

Centisome position: 32.88

GC content: 48.67

Gene sequence:

>639_bases
ATGATCAAGCTGATCGCTTTTGATCTGGACGGAACCATTGGGGACACGGTCCCTATGTGCATCAGGGCATTTGAAAAAGC
AGTTTCTCCCTATGCCGGACACACGCTGAGCGAACGGGAAATCACGCAGACTTTCGGCCTGAATGAAGTAGGAATGATCA
AGAAAGTTGCTGGAGAAAAATGGCGGGAAGCTCTCCATGATTTCTACCCGGTTTATGAAGAAATGCATCAATCATGCCCG
TCTCCGTATGAAGGTATACGTGAATTGATAAAAACCTTGCAAAAGGCTGGCGTGCTTGTCGCCCTGATTACCGGGAAGGG
AGACAAAAGCTGCCGCATCACGCTTGAGCAATTCGGCATGCGGAATTTGTTCTGTTCCATCAAGACCGGAACGGAAGACA
AACCAAACAAGGCGGAAGCCATTGAAGAACTTCTGCATGACTTCCGCTTGAACAAAGATGAATTTTACTATATCGGGGAT
GCGGTTTCGGATGTGGCCGCCTGCAACAAAGCGGGGGTGACCTGCCTGTCCGCCGCCTGGGCAACGACCGCAGATGTCAA
CGGATTGAAAAAAGCCAACCCCTCAAAGGTTTTTCCCAGCATAAAGGAATTGACATTATTCCTGTCCATTGAGAAATAA

Upstream 100 bases:

>100_bases
TCGGAGCCGGCAGCGTGGTCACCAAAAATATTCCTCCCGACAGCCTGGCGGCGGGGAACCCCTGCAAGGTTATTCGTAAA
ATCAACGGAAGTCGGGAACA

Downstream 100 bases:

>100_bases
TTAGGAGGTCTTTTCCGACTAATAAAAACATTATGAAATTTCATAGGATAGTTGTTCTCATTGATGCTGATAATACCAAT
CTAGCTAATCTTGAAAAACT

Product: Haloacid dehalogenase domain protein hydrolase

Products: NA

Alternate protein names: PGP; PGPase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MIKLIAFDLDGTIGDTVPMCIRAFEKAVSPYAGHTLSEREITQTFGLNEVGMIKKVAGEKWREALHDFYPVYEEMHQSCP
SPYEGIRELIKTLQKAGVLVALITGKGDKSCRITLEQFGMRNLFCSIKTGTEDKPNKAEAIEELLHDFRLNKDEFYYIGD
AVSDVAACNKAGVTCLSAAWATTADVNGLKKANPSKVFPSIKELTLFLSIEK

Sequences:

>Translated_212_residues
MIKLIAFDLDGTIGDTVPMCIRAFEKAVSPYAGHTLSEREITQTFGLNEVGMIKKVAGEKWREALHDFYPVYEEMHQSCP
SPYEGIRELIKTLQKAGVLVALITGKGDKSCRITLEQFGMRNLFCSIKTGTEDKPNKAEAIEELLHDFRLNKDEFYYIGD
AVSDVAACNKAGVTCLSAAWATTADVNGLKKANPSKVFPSIKELTLFLSIEK
>Mature_212_residues
MIKLIAFDLDGTIGDTVPMCIRAFEKAVSPYAGHTLSEREITQTFGLNEVGMIKKVAGEKWREALHDFYPVYEEMHQSCP
SPYEGIRELIKTLQKAGVLVALITGKGDKSCRITLEQFGMRNLFCSIKTGTEDKPNKAEAIEELLHDFRLNKDEFYYIGD
AVSDVAACNKAGVTCLSAAWATTADVNGLKKANPSKVFPSIKELTLFLSIEK

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR006346
- InterPro:   IPR023198 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.18 [H]

Molecular weight: Translated: 23488; Mature: 23488

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLIAFDLDGTIGDTVPMCIRAFEKAVSPYAGHTLSEREITQTFGLNEVGMIKKVAGEK
CEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHH
WREALHDFYPVYEEMHQSCPSPYEGIRELIKTLQKAGVLVALITGKGDKSCRITLEQFGM
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEHHHCCC
RNLFCSIKTGTEDKPNKAEAIEELLHDFRLNKDEFYYIGDAVSDVAACNKAGVTCLSAAW
HHEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCHHHHHHH
ATTADVNGLKKANPSKVFPSIKELTLFLSIEK
HHHHCCCCCCCCCCHHHCCCHHHEEEEEEECC
>Mature Secondary Structure
MIKLIAFDLDGTIGDTVPMCIRAFEKAVSPYAGHTLSEREITQTFGLNEVGMIKKVAGEK
CEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHH
WREALHDFYPVYEEMHQSCPSPYEGIRELIKTLQKAGVLVALITGKGDKSCRITLEQFGM
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEHHHCCC
RNLFCSIKTGTEDKPNKAEAIEELLHDFRLNKDEFYYIGDAVSDVAACNKAGVTCLSAAW
HHEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCHHHHHHH
ATTADVNGLKKANPSKVFPSIKELTLFLSIEK
HHHHCCCCCCCCCCHHHCCCHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]