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The map label for this gene is panC

Identifier: 186476948

GI number: 186476948

Start: 2472125

End: 2472958

Strand: Direct

Name: panC

Synonym: Bphy_2197

Alternate gene names: 186476948

Gene position: 2472125-2472958 (Clockwise)

Preceding gene: 186476947

Following gene: 186476949

Centisome position: 71.05

GC content: 64.15

Gene sequence:

>834_bases
ATGAAAGTCATCAGTTCGATCCAGGAATTGCGCGATCAGTTGCGCGGCCAGAACCGCACCGCCTTCGTGCCGACGATGGG
TAACCTGCACGAGGGCCATCTGTCGCTGATGCGCCTCGCGCGCCAGCACGGCGACCCGGTCGTGGCGAGCATCTTCGTGA
ACCGGCTGCAGTTCGGCCCGAACGAAGACTTCGACAAATACCCGCGCACACTCGAAGCGGACATCGAGAAGCTGCAGAAG
GAAAACGTCTACGTGCTGTTCGCGCCGACGGAGCGAGACATGTACCCGCAACCGCAGGAATACCGCGTACACCCGCCACA
CGATCTCGGTGACATTCTGGAAGGCGAATTCCGCCCCGGGTTCTTCACGGGCGTATGCACGGTCGTGATGAAGCTGATGT
CGTGCGTGCAGCCGCGCGTCGCCGTGTTCGGCAAGAAGGACTACCAGCAGTTGATGATCGTGCGCGCGATGACCGAGCAG
TTTGCGCTGCCCACCGACATCGTCGCCGCCGAGACCGTGCGCGACACCGACGGTCTCGCGCTCAGCTCGCGCAACCGCTA
TCTGACTCAAACCGAGCGCGCCGAAGCGCCAATGCTCGCGGCAACGCTGCAAGGCGTACGTCAGGCCGTGCTGTCGGGCA
ACCGCGACTTCGCGAAACTCGAACGGGACGCGATGGCGTCGCTGGCAGCACGCGGCTGGAAGCCGGATTACATCGCGATT
CGCAAGCGCTCGAACCTGATCGCGCCCGCCGCGCAGGACCTGGATGCGCCGCTCGTCGTGCTGGCGGCGGCCAAGCTCGG
CGCGACGCGCCTCATCGACAACCTCGAAATCTGA

Upstream 100 bases:

>100_bases
GCCGCCCCCGTTTCGCGGATATCACGAAACCGCGCGCTGCGTCGCGCGACCGAGACAACCACGAGCCACGCGCACGCGTG
ACTCCCAACATCGCCCGACC

Downstream 100 bases:

>100_bases
CGGCCGGAAGGACAAGCCATGCAACGCAACATGCTGAAGTCGAAGATTCACCGCGCGGTGGTCACGCACTGCGAATTGCA
CTACGAAGGGTCGTGTGCGA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MKVISSIQELRDQLRGQNRTAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLEADIEKLQK
ENVYVLFAPTERDMYPQPQEYRVHPPHDLGDILEGEFRPGFFTGVCTVVMKLMSCVQPRVAVFGKKDYQQLMIVRAMTEQ
FALPTDIVAAETVRDTDGLALSSRNRYLTQTERAEAPMLAATLQGVRQAVLSGNRDFAKLERDAMASLAARGWKPDYIAI
RKRSNLIAPAAQDLDAPLVVLAAAKLGATRLIDNLEI

Sequences:

>Translated_277_residues
MKVISSIQELRDQLRGQNRTAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLEADIEKLQK
ENVYVLFAPTERDMYPQPQEYRVHPPHDLGDILEGEFRPGFFTGVCTVVMKLMSCVQPRVAVFGKKDYQQLMIVRAMTEQ
FALPTDIVAAETVRDTDGLALSSRNRYLTQTERAEAPMLAATLQGVRQAVLSGNRDFAKLERDAMASLAARGWKPDYIAI
RKRSNLIAPAAQDLDAPLVVLAAAKLGATRLIDNLEI
>Mature_277_residues
MKVISSIQELRDQLRGQNRTAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLEADIEKLQK
ENVYVLFAPTERDMYPQPQEYRVHPPHDLGDILEGEFRPGFFTGVCTVVMKLMSCVQPRVAVFGKKDYQQLMIVRAMTEQ
FALPTDIVAAETVRDTDGLALSSRNRYLTQTERAEAPMLAATLQGVRQAVLSGNRDFAKLERDAMASLAARGWKPDYIAI
RKRSNLIAPAAQDLDAPLVVLAAAKLGATRLIDNLEI

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=279, Percent_Identity=42.6523297491039, Blast_Score=206, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6322046, Length=299, Percent_Identity=35.4515050167224, Blast_Score=152, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_BURP8 (B2JEQ7)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001858418.1
- ProteinModelPortal:   B2JEQ7
- SMR:   B2JEQ7
- GeneID:   6243683
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_2197
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31049; Mature: 31049

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: ACT_SITE 33-33 BINDING 57-57 BINDING 57-57 BINDING 150-150 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVISSIQELRDQLRGQNRTAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGP
CHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
NEDFDKYPRTLEADIEKLQKENVYVLFAPTERDMYPQPQEYRVHPPHDLGDILEGEFRPG
CCCHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCC
FFTGVCTVVMKLMSCVQPRVAVFGKKDYQQLMIVRAMTEQFALPTDIVAAETVRDTDGLA
HHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCE
LSSRNRYLTQTERAEAPMLAATLQGVRQAVLSGNRDFAKLERDAMASLAARGWKPDYIAI
ECCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEE
RKRSNLIAPAAQDLDAPLVVLAAAKLGATRLIDNLEI
ECCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVISSIQELRDQLRGQNRTAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGP
CHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
NEDFDKYPRTLEADIEKLQKENVYVLFAPTERDMYPQPQEYRVHPPHDLGDILEGEFRPG
CCCHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCC
FFTGVCTVVMKLMSCVQPRVAVFGKKDYQQLMIVRAMTEQFALPTDIVAAETVRDTDGLA
HHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCE
LSSRNRYLTQTERAEAPMLAATLQGVRQAVLSGNRDFAKLERDAMASLAARGWKPDYIAI
ECCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEE
RKRSNLIAPAAQDLDAPLVVLAAAKLGATRLIDNLEI
ECCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA