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The map label for this gene is ttuB [H]

Identifier: 186476927

GI number: 186476927

Start: 2438693

End: 2440012

Strand: Direct

Name: ttuB [H]

Synonym: Bphy_2176

Alternate gene names: 186476927

Gene position: 2438693-2440012 (Clockwise)

Preceding gene: 186476926

Following gene: 186476931

Centisome position: 70.09

GC content: 60.45

Gene sequence:

>1320_bases
GTGTCCAGTCCTGCGAATCCGCTCCACCATCCCGGCGCAGGGGCGCCGCCTTCGACCTTTGAAGAGGCGACATACAGAAA
GGTCGCCTGGCGTCTAACGCCACTTTTGATGCTCAGCTATGTCGTCGCATATCTGGACCGCGTGAATGTCGGCTTCGCGA
AGCTCGGCATGAGCACCGACCTGGGATTGTCGGATGCTGTCTATGGTTTTGGCGCGGGGGTTTTCTTCATCGGCTATTTC
ATCTTCGAGGTGCCGAGCAACATCATCCTGCACCGGGTCGGCGCGCGGGTCTGGATTGCACGGATCATGGTGACATGGGG
CGTCGTCTCGATGCTGACGATGTTCGTCACTACGCCCACCATGTTCTATGTGATGCGTTTTCTGCTCGGTCTTGCCGAAG
CGGGCTTTTTCCCCGGCATCATTCTCTACCTGACCTACTGGTATCCGGCGCAGCGGCGCGGCCGCATGACGACGTGGTTC
ATGACCGCTATCGCAATTTCGGGCGTGGTGGGCGGACCGATCTCGGGCTACATCCTGAAGGCGTTCGACGGCGCAAACGG
CTGGCACGGCTGGCAGTGGCTGTTCCTGCTCGAAGGCGTGCCTTCCGTGATCGTCGGGATACTGGTGTTCATCGTGCTCG
ATGACCGCATCTCGAAGGCGAAGTGGCTCACGAAGGAAGAGCGCGAACTGCTCGAACGCAATATCGCCGCTGAAGATGCA
ACGAAGGAAGATCACGCGGTGGGCAAGGTGATGCTGAGCCCGCGCGTGCTGATGATGAGCCTGATTTACTTTTCGTTCGT
GATGGGACTATATGGCGTGAGTTTCTGGCTGCCGACCATCATCAAGTCGACGGGCGTCACCGATGCGTTCGTGATCGGCC
TGCTGTCCGCCATTCCCTTTGCGGCCGCGGTGATCGCGATGGTGCTCGTTGCGCGCAGTGCCGACCGTACGCGCGAGCGC
CGCTGGCACGTCGCGGTGCCGGGCTTCGTTGGTGCTCTGGGTCTCGTGCTCTCCGTTATCTGGGCGAAGGATACGACGCT
GGCGATGGCTGGCCTCACGCTCGCGACGATGGGGATTCTCACAACTCTGCCGCTCTTTTGGAGTTTGCCTACGTCGTTCC
TGGCTGGCACAGGGGCGGCCGCCGGGATTGCCTTGATCAATTCGATCGGAAATCTGGCGGGGTTTCTGAGCCCCTATGCC
GTGGGCTGGCTCAAGCAGGCAACTTCGGCCAATGCCGCCGGTATGTATATGCTGGCCGGGTTTATGATCCTGGGCGGATT
GCTGGCCGTTTGTGTGCCTGCCCGGCTAGTGAATCGCTAG

Upstream 100 bases:

>100_bases
TAGAATCGCGAACGGCGGTACGACATTTCCACAAAAATCAGCTTCACATAGGATCAGTCTGATGCGCTCGCGCGCCGACG
CTGATCGATAGGAGACAAGC

Downstream 100 bases:

>100_bases
GGCGCCTGCGCGGCGCGGGCGGGTTTCTTGTTTCTGGTGCTGTCGATGCGCTGTGTTTTTTTGCGCGAAGGGCCAAAAAA
CCAGATCCCGACTGCGTCGC

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSSPANPLHHPGAGAPPSTFEEATYRKVAWRLTPLLMLSYVVAYLDRVNVGFAKLGMSTDLGLSDAVYGFGAGVFFIGYF
IFEVPSNIILHRVGARVWIARIMVTWGVVSMLTMFVTTPTMFYVMRFLLGLAEAGFFPGIILYLTYWYPAQRRGRMTTWF
MTAIAISGVVGGPISGYILKAFDGANGWHGWQWLFLLEGVPSVIVGILVFIVLDDRISKAKWLTKEERELLERNIAAEDA
TKEDHAVGKVMLSPRVLMMSLIYFSFVMGLYGVSFWLPTIIKSTGVTDAFVIGLLSAIPFAAAVIAMVLVARSADRTRER
RWHVAVPGFVGALGLVLSVIWAKDTTLAMAGLTLATMGILTTLPLFWSLPTSFLAGTGAAAGIALINSIGNLAGFLSPYA
VGWLKQATSANAAGMYMLAGFMILGGLLAVCVPARLVNR

Sequences:

>Translated_439_residues
MSSPANPLHHPGAGAPPSTFEEATYRKVAWRLTPLLMLSYVVAYLDRVNVGFAKLGMSTDLGLSDAVYGFGAGVFFIGYF
IFEVPSNIILHRVGARVWIARIMVTWGVVSMLTMFVTTPTMFYVMRFLLGLAEAGFFPGIILYLTYWYPAQRRGRMTTWF
MTAIAISGVVGGPISGYILKAFDGANGWHGWQWLFLLEGVPSVIVGILVFIVLDDRISKAKWLTKEERELLERNIAAEDA
TKEDHAVGKVMLSPRVLMMSLIYFSFVMGLYGVSFWLPTIIKSTGVTDAFVIGLLSAIPFAAAVIAMVLVARSADRTRER
RWHVAVPGFVGALGLVLSVIWAKDTTLAMAGLTLATMGILTTLPLFWSLPTSFLAGTGAAAGIALINSIGNLAGFLSPYA
VGWLKQATSANAAGMYMLAGFMILGGLLAVCVPARLVNR
>Mature_438_residues
SSPANPLHHPGAGAPPSTFEEATYRKVAWRLTPLLMLSYVVAYLDRVNVGFAKLGMSTDLGLSDAVYGFGAGVFFIGYFI
FEVPSNIILHRVGARVWIARIMVTWGVVSMLTMFVTTPTMFYVMRFLLGLAEAGFFPGIILYLTYWYPAQRRGRMTTWFM
TAIAISGVVGGPISGYILKAFDGANGWHGWQWLFLLEGVPSVIVGILVFIVLDDRISKAKWLTKEERELLERNIAAEDAT
KEDHAVGKVMLSPRVLMMSLIYFSFVMGLYGVSFWLPTIIKSTGVTDAFVIGLLSAIPFAAAVIAMVLVARSADRTRERR
WHVAVPGFVGALGLVLSVIWAKDTTLAMAGLTLATMGILTTLPLFWSLPTSFLAGTGAAAGIALINSIGNLAGFLSPYAV
GWLKQATSANAAGMYMLAGFMILGGLLAVCVPARLVNR

Specific function: Component of the tartrate utilization system and may allow entry of tartrate and tartrate dehydrogenase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI6912666, Length=300, Percent_Identity=22, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082071, Length=408, Percent_Identity=34.3137254901961, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI2367379, Length=294, Percent_Identity=25.1700680272109, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082320, Length=406, Percent_Identity=21.9211822660099, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789152, Length=399, Percent_Identity=23.5588972431078, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789515, Length=405, Percent_Identity=23.7037037037037, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32565914, Length=307, Percent_Identity=22.4755700325733, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI32565916, Length=254, Percent_Identity=22.0472440944882, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321698, Length=324, Percent_Identity=25.6172839506173, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322612, Length=243, Percent_Identity=27.9835390946502, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319876, Length=341, Percent_Identity=26.3929618768328, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322025, Length=306, Percent_Identity=24.8366013071895, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324410, Length=149, Percent_Identity=27.5167785234899, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319250, Length=234, Percent_Identity=24.3589743589744, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323032, Length=233, Percent_Identity=27.8969957081545, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24584153, Length=355, Percent_Identity=22.5352112676056, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45550460, Length=306, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24654215, Length=384, Percent_Identity=24.21875, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922400, Length=375, Percent_Identity=24.2666666666667, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24655255, Length=257, Percent_Identity=22.9571984435798, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24648416, Length=386, Percent_Identity=21.2435233160622, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21356189, Length=386, Percent_Identity=21.2435233160622, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24583789, Length=387, Percent_Identity=22.4806201550388, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24580790, Length=367, Percent_Identity=22.8882833787466, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47632; Mature: 47501

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPANPLHHPGAGAPPSTFEEATYRKVAWRLTPLLMLSYVVAYLDRVNVGFAKLGMSTD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC
LGLSDAVYGFGAGVFFIGYFIFEVPSNIILHRVGARVWIARIMVTWGVVSMLTMFVTTPT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFYVMRFLLGLAEAGFFPGIILYLTYWYPAQRRGRMTTWFMTAIAISGVVGGPISGYILK
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCCCCHHEE
AFDGANGWHGWQWLFLLEGVPSVIVGILVFIVLDDRISKAKWLTKEERELLERNIAAEDA
EECCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
TKEDHAVGKVMLSPRVLMMSLIYFSFVMGLYGVSFWLPTIIKSTGVTDAFVIGLLSAIPF
CCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AAAVIAMVLVARSADRTRERRWHVAVPGFVGALGLVLSVIWAKDTTLAMAGLTLATMGIL
HHHHHHHHHHHHCHHHHHHCCEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TTLPLFWSLPTSFLAGTGAAAGIALINSIGNLAGFLSPYAVGWLKQATSANAAGMYMLAG
HHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
FMILGGLLAVCVPARLVNR
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSPANPLHHPGAGAPPSTFEEATYRKVAWRLTPLLMLSYVVAYLDRVNVGFAKLGMSTD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC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HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]