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The map label for this gene is atoC [H]

Identifier: 186476903

GI number: 186476903

Start: 2412407

End: 2413462

Strand: Direct

Name: atoC [H]

Synonym: Bphy_2152

Alternate gene names: 186476903

Gene position: 2412407-2413462 (Clockwise)

Preceding gene: 186476902

Following gene: 186476904

Centisome position: 69.34

GC content: 64.3

Gene sequence:

>1056_bases
ATGTCGTCAACCGATCTGGACTCGCCCGCCGCCGAAGCCGACAGCGGCGGCGCATCGCAGGCGAGGCAACGCGCGGTCGA
CAACGTCCCGGGACTGAAGTCTTACGGCACGCTGTTCGGCTCGTCGCCCGTCATGCTGGATCTCTACGAACAGATCGACC
GCGTGGCCGCGACGGACGCGACCGCGCTCATCATCGGCGAATCGGGCACGGGCAAGGAGCTGATTGCCCGCACGATTCAC
GAGCACAGCGCACGCAAGGACGGCGCGTTCGTCGCCGTCAATTGCGGCGCGATCCCCGACGAACTGATCGAGGCCGAACT
GTTCGGCCATGAAAAAGGCAGCTTCACAGGTGCGGTCCAGGGTCGCGTCGGATATTTCGAGCACGCGAACGGCGGCACGC
TGTTTCTGGACGAAGTCACCGAAATGGCGCCCGTGCGCCAGGTGAAACTGCTGCGCGCGCTGGAGACGGGCACCTTCTAT
CGCGTCGGCGGCACCGAGCTGATTCGCGGCGACGTGCGTGTCATCGCCGCGACCAATCGCGACCCGGCTGTCGCAGTCAA
GGAAAACGGACTGCGCGAAGATCTGATGTACCGGCTCGCCGTGTTTCCGCTGCGCGCGCCGCCGCTGCGCGAACGCGAAG
GCGACCGGGAACTGCTCGCGCTGCATTTTCTCGACGAGCTCAATCGCCAGGAAGGCACGAACAAGGTCTTCAGCAAGCGC
TCGATGGAAACGCTGCGCACCTGGTCCTGGCCGGGCAACGTCCGCGAGCTGAAGAACGCCGTGTATCGCGCGTTCATCCT
GGCGGAGAAGGCGGTGGAGCTGCCACATCCGCACCTGATGTCGCGTGTGAAGAAGCCCGTGACAGTCGGCGACTCGATGA
GCGTGTGGATCGGTACACCGCTCGCCGATGCGCAGAAGCAGATCATCCTCGGCACGCTCAAGTATTGCGGCGGCGATAAG
CGCCGCGCGGCCAAAGCACTCGGCGTCAGCCTGAAGACGCTGTACAACAGGCTCAGCGCTTACGGCGACGAAGAGTCAAA
TCCCGACGATAACTGA

Upstream 100 bases:

>100_bases
TTTTGTGAGATAGTGGACCACTCTCAAGGCATTGCCACACTCGATACTGGCCTGCGCCATTCACGACACCTATCCGAAAT
TGCACAGGACACCCTTCGCT

Downstream 100 bases:

>100_bases
TCGGACACTCGCGCGCGCATGGCAGTGATGCGCGCGTCGCGGATGCGCCGTCCGGCGCGCCGCCCTTCCCCCGTCCCCGC
GCGGCTTCCAATCAAGCCGC

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSSTDLDSPAAEADSGGASQARQRAVDNVPGLKSYGTLFGSSPVMLDLYEQIDRVAATDATALIIGESGTGKELIARTIH
EHSARKDGAFVAVNCGAIPDELIEAELFGHEKGSFTGAVQGRVGYFEHANGGTLFLDEVTEMAPVRQVKLLRALETGTFY
RVGGTELIRGDVRVIAATNRDPAVAVKENGLREDLMYRLAVFPLRAPPLREREGDRELLALHFLDELNRQEGTNKVFSKR
SMETLRTWSWPGNVRELKNAVYRAFILAEKAVELPHPHLMSRVKKPVTVGDSMSVWIGTPLADAQKQIILGTLKYCGGDK
RRAAKALGVSLKTLYNRLSAYGDEESNPDDN

Sequences:

>Translated_351_residues
MSSTDLDSPAAEADSGGASQARQRAVDNVPGLKSYGTLFGSSPVMLDLYEQIDRVAATDATALIIGESGTGKELIARTIH
EHSARKDGAFVAVNCGAIPDELIEAELFGHEKGSFTGAVQGRVGYFEHANGGTLFLDEVTEMAPVRQVKLLRALETGTFY
RVGGTELIRGDVRVIAATNRDPAVAVKENGLREDLMYRLAVFPLRAPPLREREGDRELLALHFLDELNRQEGTNKVFSKR
SMETLRTWSWPGNVRELKNAVYRAFILAEKAVELPHPHLMSRVKKPVTVGDSMSVWIGTPLADAQKQIILGTLKYCGGDK
RRAAKALGVSLKTLYNRLSAYGDEESNPDDN
>Mature_350_residues
SSTDLDSPAAEADSGGASQARQRAVDNVPGLKSYGTLFGSSPVMLDLYEQIDRVAATDATALIIGESGTGKELIARTIHE
HSARKDGAFVAVNCGAIPDELIEAELFGHEKGSFTGAVQGRVGYFEHANGGTLFLDEVTEMAPVRQVKLLRALETGTFYR
VGGTELIRGDVRVIAATNRDPAVAVKENGLREDLMYRLAVFPLRAPPLREREGDRELLALHFLDELNRQEGTNKVFSKRS
METLRTWSWPGNVRELKNAVYRAFILAEKAVELPHPHLMSRVKKPVTVGDSMSVWIGTPLADAQKQIILGTLKYCGGDKR
RAAKALGVSLKTLYNRLSAYGDEESNPDDN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=316, Percent_Identity=43.6708860759494, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1790437, Length=309, Percent_Identity=45.3074433656958, Blast_Score=253, Evalue=9e-69,
Organism=Escherichia coli, GI87082117, Length=321, Percent_Identity=42.9906542056075, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI1789087, Length=319, Percent_Identity=42.6332288401254, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI87082152, Length=232, Percent_Identity=49.5689655172414, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1789233, Length=330, Percent_Identity=39.3939393939394, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1790299, Length=363, Percent_Identity=38.0165289256198, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788905, Length=232, Percent_Identity=47.4137931034483, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI87081872, Length=230, Percent_Identity=45.6521739130435, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787583, Length=323, Percent_Identity=36.5325077399381, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1786524, Length=322, Percent_Identity=40.3726708074534, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI1789828, Length=278, Percent_Identity=36.3309352517986, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI87081858, Length=284, Percent_Identity=29.9295774647887, Blast_Score=125, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 38354; Mature: 38223

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTDLDSPAAEADSGGASQARQRAVDNVPGLKSYGTLFGSSPVMLDLYEQIDRVAATDA
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCC
TALIIGESGTGKELIARTIHEHSARKDGAFVAVNCGAIPDELIEAELFGHEKGSFTGAVQ
EEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEEC
GRVGYFEHANGGTLFLDEVTEMAPVRQVKLLRALETGTFYRVGGTELIRGDVRVIAATNR
CCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCEEEEEECCC
DPAVAVKENGLREDLMYRLAVFPLRAPPLREREGDRELLALHFLDELNRQEGTNKVFSKR
CCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
SMETLRTWSWPGNVRELKNAVYRAFILAEKAVELPHPHLMSRVKKPVTVGDSMSVWIGTP
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEECCC
LADAQKQIILGTLKYCGGDKRRAAKALGVSLKTLYNRLSAYGDEESNPDDN
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SSTDLDSPAAEADSGGASQARQRAVDNVPGLKSYGTLFGSSPVMLDLYEQIDRVAATDA
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCC
TALIIGESGTGKELIARTIHEHSARKDGAFVAVNCGAIPDELIEAELFGHEKGSFTGAVQ
EEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEEC
GRVGYFEHANGGTLFLDEVTEMAPVRQVKLLRALETGTFYRVGGTELIRGDVRVIAATNR
CCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCEEEEEECCC
DPAVAVKENGLREDLMYRLAVFPLRAPPLREREGDRELLALHFLDELNRQEGTNKVFSKR
CCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
SMETLRTWSWPGNVRELKNAVYRAFILAEKAVELPHPHLMSRVKKPVTVGDSMSVWIGTP
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEECCC
LADAQKQIILGTLKYCGGDKRRAAKALGVSLKTLYNRLSAYGDEESNPDDN
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]