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The map label for this gene is hemF [H]

Identifier: 186476820

GI number: 186476820

Start: 2318306

End: 2319238

Strand: Direct

Name: hemF [H]

Synonym: Bphy_2066

Alternate gene names: 186476820

Gene position: 2318306-2319238 (Clockwise)

Preceding gene: 186476819

Following gene: 186476821

Centisome position: 66.63

GC content: 64.31

Gene sequence:

>933_bases
ATGACCGATTCGATTCACGACGCCCACGACACCCAGACCGTCCGGGCCTGGATGCAAGGCTTGCAGACGCGGATCGCCGA
CGCGCTCGGCGGGTTTGACGGCACACCGCTCGCGACCGACGCGTGGCAACGTGCGCCCGGCGAGAAGTTGCGCGGCGGCG
GCTGCACGCGCATTCTGGAAAACGGTGCATTCTTTGAACGCGCGGGCATCGGCTTCTCGGATGTGCAAGGCGACGCGCTG
CCCGGCTCGGCGAGCGCGCTGCGCCCGCAACTGGCGGGGCGAGGCTTCGAAGCGATGGGGGTGTCGCTCGTATTGCATCC
GCGCAATCCGTACTGTCCGACCGTTCATATGAACGTGCGCCTCCTGGTCGCGACGAAAGCAGGCGAAGCGCCCGTGTTCT
GGTTCGGCGGCGGTATGGACCTGACGCCATACTACGGGTTTGAAGAAGATGCGCGGCATTTCCACCGTGTCTGCCGCGAC
GCGCTGCAGCCATATGGCGACGACCTCTACCCGCGCTTCAAGCGTTGGTGCGACGACTACTTCTTCCTGAAACACCGCAA
CGAGCCGCGCGGCATCGGCGGGATTTTCTTCGACGATTTCGCGGAGCCCGGTTTCGAAAAGTCGTTTGCGATGGTGAAGA
GCGTCGGCGATGCGTTCCTGAATGCCTATCTGCCTATCATCGAGAGACGCCGCGGCATGCCATACGGCGAAGCCCAGCGC
GACTTCCAGGCGTACCGGCGCGGCCGCTACGTCGAATTCAACCTCGTGTTCGACCGTGGCACGCTGTTCGGGCTGCAAAG
CGGCGGACGTACGGAGTCGATCCTGATGTCGATGCCGCCCGTCGTGAACTGGCGCTATAACTGGCAGCCCGAGCCGGGCA
CGCCGGAAGCGCGCCTCTACAGTGACTTTCTCGTGCAGCGCGAGTGGGTCTGA

Upstream 100 bases:

>100_bases
GCAACCGTCCGAACATGTGCCGTGAAGGGCGCATCGCGCCCAATCCGTCCCATTGAAACCCGACCGCGCCAGCGTTTTTC
CGTGCCGCGCCTCACATATC

Downstream 100 bases:

>100_bases
CGCGCTTTGCCGCGCCGCTCCCTCTCCAACCGACAGGCAAAGGAACCGCAACTGAATCCGACCGCTCACTCCGTCGCGCC
GAAACAGGCATTGCGCCGTA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTDSIHDAHDTQTVRAWMQGLQTRIADALGGFDGTPLATDAWQRAPGEKLRGGGCTRILENGAFFERAGIGFSDVQGDAL
PGSASALRPQLAGRGFEAMGVSLVLHPRNPYCPTVHMNVRLLVATKAGEAPVFWFGGGMDLTPYYGFEEDARHFHRVCRD
ALQPYGDDLYPRFKRWCDDYFFLKHRNEPRGIGGIFFDDFAEPGFEKSFAMVKSVGDAFLNAYLPIIERRRGMPYGEAQR
DFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVVNWRYNWQPEPGTPEARLYSDFLVQREWV

Sequences:

>Translated_310_residues
MTDSIHDAHDTQTVRAWMQGLQTRIADALGGFDGTPLATDAWQRAPGEKLRGGGCTRILENGAFFERAGIGFSDVQGDAL
PGSASALRPQLAGRGFEAMGVSLVLHPRNPYCPTVHMNVRLLVATKAGEAPVFWFGGGMDLTPYYGFEEDARHFHRVCRD
ALQPYGDDLYPRFKRWCDDYFFLKHRNEPRGIGGIFFDDFAEPGFEKSFAMVKSVGDAFLNAYLPIIERRRGMPYGEAQR
DFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVVNWRYNWQPEPGTPEARLYSDFLVQREWV
>Mature_309_residues
TDSIHDAHDTQTVRAWMQGLQTRIADALGGFDGTPLATDAWQRAPGEKLRGGGCTRILENGAFFERAGIGFSDVQGDALP
GSASALRPQLAGRGFEAMGVSLVLHPRNPYCPTVHMNVRLLVATKAGEAPVFWFGGGMDLTPYYGFEEDARHFHRVCRDA
LQPYGDDLYPRFKRWCDDYFFLKHRNEPRGIGGIFFDDFAEPGFEKSFAMVKSVGDAFLNAYLPIIERRRGMPYGEAQRD
FQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVVNWRYNWQPEPGTPEARLYSDFLVQREWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=298, Percent_Identity=43.2885906040268, Blast_Score=247, Evalue=9e-66,
Organism=Escherichia coli, GI1788777, Length=301, Percent_Identity=60.4651162790698, Blast_Score=389, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=43.217665615142, Blast_Score=266, Evalue=3e-72,
Organism=Drosophila melanogaster, GI17864388, Length=323, Percent_Identity=42.4148606811146, Blast_Score=255, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 35058; Mature: 34927

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSIHDAHDTQTVRAWMQGLQTRIADALGGFDGTPLATDAWQRAPGEKLRGGGCTRILE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHH
NGAFFERAGIGFSDVQGDALPGSASALRPQLAGRGFEAMGVSLVLHPRNPYCPTVHMNVR
CCCEEHHCCCCHHHCCCCCCCCCHHHHCHHHHCCCCCCCCEEEEEECCCCCCCEEEEEEE
LLVATKAGEAPVFWFGGGMDLTPYYGFEEDARHFHRVCRDALQPYGDDLYPRFKRWCDDY
EEEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHH
FFLKHRNEPRGIGGIFFDDFAEPGFEKSFAMVKSVGDAFLNAYLPIIERRRGMPYGEAQR
EEEEECCCCCCCCCEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVVNWRYNWQPEPGTPEARLY
HHHHHHCCCEEEEEEEEECCEEEEECCCCCCHHHEEECCCEEEEEEECCCCCCCCHHHHH
SDFLVQREWV
HHHHHHHCCC
>Mature Secondary Structure 
TDSIHDAHDTQTVRAWMQGLQTRIADALGGFDGTPLATDAWQRAPGEKLRGGGCTRILE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHH
NGAFFERAGIGFSDVQGDALPGSASALRPQLAGRGFEAMGVSLVLHPRNPYCPTVHMNVR
CCCEEHHCCCCHHHCCCCCCCCCHHHHCHHHHCCCCCCCCEEEEEECCCCCCCEEEEEEE
LLVATKAGEAPVFWFGGGMDLTPYYGFEEDARHFHRVCRDALQPYGDDLYPRFKRWCDDY
EEEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHH
FFLKHRNEPRGIGGIFFDDFAEPGFEKSFAMVKSVGDAFLNAYLPIIERRRGMPYGEAQR
EEEEECCCCCCCCCEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVVNWRYNWQPEPGTPEARLY
HHHHHHCCCEEEEEEEEECCEEEEECCCCCCHHHEEECCCEEEEEEECCCCCCCCHHHHH
SDFLVQREWV
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA