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The map label for this gene is irgA [H]

Identifier: 183222773

GI number: 183222773

Start: 3552062

End: 3554218

Strand: Direct

Name: irgA [H]

Synonym: LEPBI_I3432

Alternate gene names: 183222773

Gene position: 3552062-3554218 (Clockwise)

Preceding gene: 183222772

Following gene: 183222774

Centisome position: 98.68

GC content: 40.7

Gene sequence:

>2157_bases
ATGACACTGAATCTACAATTTTGTATTCCAATCCTTTGTTTGTTTCTTTTATTTTTTGGAGAACTCCATGCACAAACACG
TACAAATGGAAAAATAACAAAACCAATTCCCAAAACTGAAACAACACCTGCTGATCCAAAAAACGAAACTACCCAAGACC
CAACAAATTTAAAACCAAATTCACAACCGGGAACAGAAGAATCTAAACCAGAAGAAACGGCTGAAGAAGATCGTTTCAAA
GATTTGGACAATAAAAATGGAATTGTTGTAACTGGATCACGAGGAGAACGCCGTCTCAAAGACTCCGCCGTGGCTACAGA
AGTCATCTCACGAAAAAGGATCGAACAAACGGGTGCACGTAACTTAGGTGAGGTGCTGGATACACAAATTGGAATCAATG
TTACACCTTTTTTTGGTGGATCCCAAGTACAAATGTTGGGACTCGATTCGAAGTATGTCTTATTTTTAGTTGATGGCCAA
CGTGTGGCAGGAAGGCTCAACAACACCATTGATTTAACTCGTTTTAAGGTACAAAACATTGAACGGATTGAAATTGTAAA
AGGAAGTTCTTCTTCCCTTTACGGAGCAGATGCCATTGGCGGTGTGATCAATATCATCACAAAACAAGCTGAAAAACCAG
AACATTATCAATTCCGCACTTCTTACGGTAACGGTCGCCAAATGAACTTTGGATCCCAAGGCGAAAAAAACATGATCGCC
GATGTTGGATTCAAAAATGATTTTGTGGCGACTAATTTTTTTGGTGGGTTTAACCAAGCAGGTGCTTATGACCTAGATCC
AAGAACGCCAGCCACAACGGGAAACTCTTTCCAAGACAATAACCTTGGAGGGAATATGACGTTTAATCCCGATGGACAAT
TTAAAGTCAAAACTGGAATCAATTATCTGAACCGCAACCAAGCTGGTATTGACTCACGTTCCACTGGCGGTGTTTTTGAT
CGGTCGAACATGACGAACGACTTTTTAGCGTTAGGTGCACTTGAATACACTTATGGAAAACGAAATATGGTTTCTCTTCG
TGGAAACTTTTCACGTTGGGAAAATCATTATAAATTAGACCAAAGAAATTCCAACGAACTCGATGTAAAAGAAATCACAA
ACGAATTTTCCTCGCAAGGTGTGGCCCAAATCGATCATGAAATTCACAAAGACCACATGATCACTGCTGGATTTGAATCA
TTTTCAGAAGAACTACAAACAGATCGTTTGGAACGAAGGAACGCTTACCGTACAAGAAGAGCTGCATTCTTACAAGATGA
ATGGGTGGTATGGCGCCAAGGTATTGTTTGGCGATTAGTTCCTGGAGTTCGCCATGATGTAGATTCACAATTTGGAGGAC
AAACCACTCCCAAAATTGCGACCAAAGTCGATATCACAAGTAACTTAGTCTTTCGAGCCAGTTACGGAAAAGGATTTCGC
CCACCTTCCTTTCGCGAATTGTACTTACGATTTGAAAACCCTGGCGTTGGTTATGTCGTGGAAGGAAACGACAAACTTCG
TCCTGAAAAATCAACAACAGTCAATGCTGATATCGAATACTCACCGTTTAAGTATTGGACTTTGTCTTTGAGTGTGTTCC
GGAATGATATTACGGATCTCATCCAATATACTTTTGGAACAAGGACAAGTGAATTTGCCAATTTCCAATTAAAGAACGTA
CAACGTGCATATACGAGAGGAGTGGAAGCTGGCTCCCGTGTTCGTTTTTGGAAATACTTTGCACTTGAACTTGGCTACAA
CCAAACCGACACAAGGGACCTAACAACGGATAGACCTCTAGAAGGGCGTGCACTCCACCAAGGTACGATGAATTTTTTTG
TGAATGCACCTGGTGGTTGGGAATTTGCCCTTCGTGCCAAACGTTTAGACAAACGGCCTTTTTATAGTACAACCAATGAG
TTTACAACAGGAACTAGTACTGCCCTCATTGACCAACAAACACGAAGTGTAGAAGAAAACAATAAAGTCGTTTATGGAAA
ACCATTCACTCTTCTAAACGTTCGGATGGAGAAAAAATTTTTTGAAGGGAGGATGTCGCTATTTTTAGGAGTAGACAATG
TTTTGGACCAATACGAGCTTACTTACAATCCTATTCGTCCAAGGTTTTACTATGGCGGACTCCAAGCTACATTCTAA

Upstream 100 bases:

>100_bases
CTGGTACAGGAACTTCGGTATACGCCGTACATATTGAAAATTATTATAGTGATGCAGGTACCTCTGGTTACCCAACCATC
CGATGGAAAAAACTTCCATA

Downstream 100 bases:

>100_bases
ATCCAATGCCATCAAAATAGTATTCTCTGGAGTTTTGTTCTTATTTTTTTCCATTCAAATTCTATTTGCCGATGAATCGA
AGTTAACTGCCAAACAAAAC

Product: TonB-dependent receptor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 718; Mature: 717

Protein sequence:

>718_residues
MTLNLQFCIPILCLFLLFFGELHAQTRTNGKITKPIPKTETTPADPKNETTQDPTNLKPNSQPGTEESKPEETAEEDRFK
DLDNKNGIVVTGSRGERRLKDSAVATEVISRKRIEQTGARNLGEVLDTQIGINVTPFFGGSQVQMLGLDSKYVLFLVDGQ
RVAGRLNNTIDLTRFKVQNIERIEIVKGSSSSLYGADAIGGVINIITKQAEKPEHYQFRTSYGNGRQMNFGSQGEKNMIA
DVGFKNDFVATNFFGGFNQAGAYDLDPRTPATTGNSFQDNNLGGNMTFNPDGQFKVKTGINYLNRNQAGIDSRSTGGVFD
RSNMTNDFLALGALEYTYGKRNMVSLRGNFSRWENHYKLDQRNSNELDVKEITNEFSSQGVAQIDHEIHKDHMITAGFES
FSEELQTDRLERRNAYRTRRAAFLQDEWVVWRQGIVWRLVPGVRHDVDSQFGGQTTPKIATKVDITSNLVFRASYGKGFR
PPSFRELYLRFENPGVGYVVEGNDKLRPEKSTTVNADIEYSPFKYWTLSLSVFRNDITDLIQYTFGTRTSEFANFQLKNV
QRAYTRGVEAGSRVRFWKYFALELGYNQTDTRDLTTDRPLEGRALHQGTMNFFVNAPGGWEFALRAKRLDKRPFYSTTNE
FTTGTSTALIDQQTRSVEENNKVVYGKPFTLLNVRMEKKFFEGRMSLFLGVDNVLDQYELTYNPIRPRFYYGGLQATF

Sequences:

>Translated_718_residues
MTLNLQFCIPILCLFLLFFGELHAQTRTNGKITKPIPKTETTPADPKNETTQDPTNLKPNSQPGTEESKPEETAEEDRFK
DLDNKNGIVVTGSRGERRLKDSAVATEVISRKRIEQTGARNLGEVLDTQIGINVTPFFGGSQVQMLGLDSKYVLFLVDGQ
RVAGRLNNTIDLTRFKVQNIERIEIVKGSSSSLYGADAIGGVINIITKQAEKPEHYQFRTSYGNGRQMNFGSQGEKNMIA
DVGFKNDFVATNFFGGFNQAGAYDLDPRTPATTGNSFQDNNLGGNMTFNPDGQFKVKTGINYLNRNQAGIDSRSTGGVFD
RSNMTNDFLALGALEYTYGKRNMVSLRGNFSRWENHYKLDQRNSNELDVKEITNEFSSQGVAQIDHEIHKDHMITAGFES
FSEELQTDRLERRNAYRTRRAAFLQDEWVVWRQGIVWRLVPGVRHDVDSQFGGQTTPKIATKVDITSNLVFRASYGKGFR
PPSFRELYLRFENPGVGYVVEGNDKLRPEKSTTVNADIEYSPFKYWTLSLSVFRNDITDLIQYTFGTRTSEFANFQLKNV
QRAYTRGVEAGSRVRFWKYFALELGYNQTDTRDLTTDRPLEGRALHQGTMNFFVNAPGGWEFALRAKRLDKRPFYSTTNE
FTTGTSTALIDQQTRSVEENNKVVYGKPFTLLNVRMEKKFFEGRMSLFLGVDNVLDQYELTYNPIRPRFYYGGLQATF
>Mature_717_residues
TLNLQFCIPILCLFLLFFGELHAQTRTNGKITKPIPKTETTPADPKNETTQDPTNLKPNSQPGTEESKPEETAEEDRFKD
LDNKNGIVVTGSRGERRLKDSAVATEVISRKRIEQTGARNLGEVLDTQIGINVTPFFGGSQVQMLGLDSKYVLFLVDGQR
VAGRLNNTIDLTRFKVQNIERIEIVKGSSSSLYGADAIGGVINIITKQAEKPEHYQFRTSYGNGRQMNFGSQGEKNMIAD
VGFKNDFVATNFFGGFNQAGAYDLDPRTPATTGNSFQDNNLGGNMTFNPDGQFKVKTGINYLNRNQAGIDSRSTGGVFDR
SNMTNDFLALGALEYTYGKRNMVSLRGNFSRWENHYKLDQRNSNELDVKEITNEFSSQGVAQIDHEIHKDHMITAGFESF
SEELQTDRLERRNAYRTRRAAFLQDEWVVWRQGIVWRLVPGVRHDVDSQFGGQTTPKIATKVDITSNLVFRASYGKGFRP
PSFRELYLRFENPGVGYVVEGNDKLRPEKSTTVNADIEYSPFKYWTLSLSVFRNDITDLIQYTFGTRTSEFANFQLKNVQ
RAYTRGVEAGSRVRFWKYFALELGYNQTDTRDLTTDRPLEGRALHQGTMNFFVNAPGGWEFALRAKRLDKRPFYSTTNEF
TTGTSTALIDQQTRSVEENNKVVYGKPFTLLNVRMEKKFFEGRMSLFLGVDNVLDQYELTYNPIRPRFYYGGLQATF

Specific function: Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=596, Percent_Identity=26.006711409396, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1790405, Length=129, Percent_Identity=34.1085271317829, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 81514; Mature: 81383

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNLQFCIPILCLFLLFFGELHAQTRTNGKITKPIPKTETTPADPKNETTQDPTNLKPN
CEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
SQPGTEESKPEETAEEDRFKDLDNKNGIVVTGSRGERRLKDSAVATEVISRKRIEQTGAR
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NLGEVLDTQIGINVTPFFGGSQVQMLGLDSKYVLFLVDGQRVAGRLNNTIDLTRFKVQNI
HHHHHHHHHCCCEEEECCCCCEEEEEECCCCEEEEEECCHHHHHHCCCCEEEEEEECCCC
ERIEIVKGSSSSLYGADAIGGVINIITKQAEKPEHYQFRTSYGNGRQMNFGSQGEKNMIA
CEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEE
DVGFKNDFVATNFFGGFNQAGAYDLDPRTPATTGNSFQDNNLGGNMTFNPDGQFKVKTGI
ECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCC
NYLNRNQAGIDSRSTGGVFDRSNMTNDFLALGALEYTYGKRNMVSLRGNFSRWENHYKLD
CHHCCCCCCCCCCCCCCEEECCCCCCHHHHHCEEEEECCCCEEEEECCCHHHHHCCEECC
QRNSNELDVKEITNEFSSQGVAQIDHEIHKDHMITAGFESFSEELQTDRLERRNAYRTRR
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
AAFLQDEWVVWRQGIVWRLVPGVRHDVDSQFGGQTTPKIATKVDITSNLVFRASYGKGFR
HHHHCCCHHHHHCCCEEEECCCHHHCCCHHCCCCCCCCEEEEEEECCCEEEEECCCCCCC
PPSFRELYLRFENPGVGYVVEGNDKLRPEKSTTVNADIEYSPFKYWTLSLSVFRNDITDL
CCCCEEEEEEECCCCEEEEECCCCCCCCCCCCEEECCEEECCCEEEEEEHHHHHHHHHHH
IQYTFGTRTSEFANFQLKNVQRAYTRGVEAGSRVRFWKYFALELGYNQTDTRDLTTDRPL
HHHHHCCCCCHHHCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCC
EGRALHQGTMNFFVNAPGGWEFALRAKRLDKRPFYSTTNEFTTGTSTALIDQQTRSVEEN
CCCCEECCCEEEEEECCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHC
NKVVYGKPFTLLNVRMEKKFFEGRMSLFLGVDNVLDQYELTYNPIRPRFYYGGLQATF
CCEEEECCEEEEEEHHHHHHHHHHHHEEEEHHHHHHHHCCEECCCCCEEEECCEEECC
>Mature Secondary Structure 
TLNLQFCIPILCLFLLFFGELHAQTRTNGKITKPIPKTETTPADPKNETTQDPTNLKPN
EEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
SQPGTEESKPEETAEEDRFKDLDNKNGIVVTGSRGERRLKDSAVATEVISRKRIEQTGAR
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NLGEVLDTQIGINVTPFFGGSQVQMLGLDSKYVLFLVDGQRVAGRLNNTIDLTRFKVQNI
HHHHHHHHHCCCEEEECCCCCEEEEEECCCCEEEEEECCHHHHHHCCCCEEEEEEECCCC
ERIEIVKGSSSSLYGADAIGGVINIITKQAEKPEHYQFRTSYGNGRQMNFGSQGEKNMIA
CEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEE
DVGFKNDFVATNFFGGFNQAGAYDLDPRTPATTGNSFQDNNLGGNMTFNPDGQFKVKTGI
ECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCC
NYLNRNQAGIDSRSTGGVFDRSNMTNDFLALGALEYTYGKRNMVSLRGNFSRWENHYKLD
CHHCCCCCCCCCCCCCCEEECCCCCCHHHHHCEEEEECCCCEEEEECCCHHHHHCCEECC
QRNSNELDVKEITNEFSSQGVAQIDHEIHKDHMITAGFESFSEELQTDRLERRNAYRTRR
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
AAFLQDEWVVWRQGIVWRLVPGVRHDVDSQFGGQTTPKIATKVDITSNLVFRASYGKGFR
HHHHCCCHHHHHCCCEEEECCCHHHCCCHHCCCCCCCCEEEEEEECCCEEEEECCCCCCC
PPSFRELYLRFENPGVGYVVEGNDKLRPEKSTTVNADIEYSPFKYWTLSLSVFRNDITDL
CCCCEEEEEEECCCCEEEEECCCCCCCCCCCCEEECCEEECCCEEEEEEHHHHHHHHHHH
IQYTFGTRTSEFANFQLKNVQRAYTRGVEAGSRVRFWKYFALELGYNQTDTRDLTTDRPL
HHHHHCCCCCHHHCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCC
EGRALHQGTMNFFVNAPGGWEFALRAKRLDKRPFYSTTNEFTTGTSTALIDQQTRSVEEN
CCCCEECCCEEEEEECCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHC
NKVVYGKPFTLLNVRMEKKFFEGRMSLFLGVDNVLDQYELTYNPIRPRFYYGGLQATF
CCEEEECCEEEEEEHHHHHHHHHHHHEEEEHHHHHHHHCCEECCCCCEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1406279; 2174861 [H]