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The map label for this gene is nudH [H]

Identifier: 183222671

GI number: 183222671

Start: 3437132

End: 3437650

Strand: Direct

Name: nudH [H]

Synonym: LEPBI_I3326

Alternate gene names: 183222671

Gene position: 3437132-3437650 (Clockwise)

Preceding gene: 183222669

Following gene: 183222672

Centisome position: 95.48

GC content: 37.38

Gene sequence:

>519_bases
ATGGATGAGAGAGACATTCTAACGTTTATGACAAACAAACCCTACCGCAAAAATGTAGGAATGGTAGTCTTCAACTCTTT
TGGAAAAGTCATTGTGGGCGAAAGAATTCAATTTCCTGGTTCTTGGCAATTCCCACAAGGTGGGATCGATGAAGAAGAAG
ATTATCTAGAAGCCGCTAAACGTGAATTATACGAGGAATTAGGGATCAAAAAGGCTACTTATGTTACGGAGTATCCAGAT
TGGATACCCTATGATTTTCCAAATTCGTTAGGACTCAATTCCCATTTACAGAAGTTTCGTGGTCAATTGCAAAGATGGAT
TTTGTTTTATTGGGATGGTGGGCTCGATGAATGTGATCTCATACATCATGAACAAGAGTTTTTGACCATCCGACATATGG
AAATTGAGGAAACTATCCAAGCAGTCGTTGAATTCAAACGACCTGTTTATGAAAAGTTTGTCCCTATTTTTAAAGCAGCA
ATTCAAAATTACATTGCAGAGAATGTAAAAACAAAGTAA

Upstream 100 bases:

>100_bases
CACCGTGACGAACCAAAATGATCTTCATACTATCTCCTAAACCCAAGATTGAAACCACGGATTTCCCAAGAAACAAAAAA
TTAAGGAATTTCTTGCGAAA

Downstream 100 bases:

>100_bases
GGTTAAAGAAGGAGACAATCTTTGGGAAAATCAGAAGAAGCAAGAGCTAGAATTATCATTCGGGGTACCGTACAGGGTGT
GGGATTTCGGTATTATATCC

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MDERDILTFMTNKPYRKNVGMVVFNSFGKVIVGERIQFPGSWQFPQGGIDEEEDYLEAAKRELYEELGIKKATYVTEYPD
WIPYDFPNSLGLNSHLQKFRGQLQRWILFYWDGGLDECDLIHHEQEFLTIRHMEIEETIQAVVEFKRPVYEKFVPIFKAA
IQNYIAENVKTK

Sequences:

>Translated_172_residues
MDERDILTFMTNKPYRKNVGMVVFNSFGKVIVGERIQFPGSWQFPQGGIDEEEDYLEAAKRELYEELGIKKATYVTEYPD
WIPYDFPNSLGLNSHLQKFRGQLQRWILFYWDGGLDECDLIHHEQEFLTIRHMEIEETIQAVVEFKRPVYEKFVPIFKAA
IQNYIAENVKTK
>Mature_172_residues
MDERDILTFMTNKPYRKNVGMVVFNSFGKVIVGERIQFPGSWQFPQGGIDEEEDYLEAAKRELYEELGIKKATYVTEYPD
WIPYDFPNSLGLNSHLQKFRGQLQRWILFYWDGGLDECDLIHHEQEFLTIRHMEIEETIQAVVEFKRPVYEKFVPIFKAA
IQNYIAENVKTK

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=158, Percent_Identity=32.9113924050633, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 20393; Mature: 20393

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDERDILTFMTNKPYRKNVGMVVFNSFGKVIVGERIQFPGSWQFPQGGIDEEEDYLEAAK
CCCCCEEHHHCCCCCHHCCCEEEECCCCCEEECCEECCCCCCCCCCCCCCCHHHHHHHHH
RELYEELGIKKATYVTEYPDWIPYDFPNSLGLNSHLQKFRGQLQRWILFYWDGGLDECDL
HHHHHHHCCCHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCHHHH
IHHEQEFLTIRHMEIEETIQAVVEFKRPVYEKFVPIFKAAIQNYIAENVKTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDERDILTFMTNKPYRKNVGMVVFNSFGKVIVGERIQFPGSWQFPQGGIDEEEDYLEAAK
CCCCCEEHHHCCCCCHHCCCEEEECCCCCEEECCEECCCCCCCCCCCCCCCHHHHHHHHH
RELYEELGIKKATYVTEYPDWIPYDFPNSLGLNSHLQKFRGQLQRWILFYWDGGLDECDL
HHHHHHHCCCHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCHHHH
IHHEQEFLTIRHMEIEETIQAVVEFKRPVYEKFVPIFKAAIQNYIAENVKTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA