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The map label for this gene is hpt [H]

Identifier: 183222502

GI number: 183222502

Start: 3271420

End: 3271932

Strand: Direct

Name: hpt [H]

Synonym: LEPBI_I3157

Alternate gene names: 183222502

Gene position: 3271420-3271932 (Clockwise)

Preceding gene: 183222501

Following gene: 183222503

Centisome position: 90.88

GC content: 40.55

Gene sequence:

>513_bases
ATGAAACCTTTATATTCAGAAGAACGAATCCACCAACGTGTAGAAGAATTAGCGCGTGAAATCTCTCGAGATTTTTTAAG
CAAAGATCTCGTTGTCATTGGGATCCTGAATGGAGGGTTCATTTTTACAGCGGACCTTTGCCGTAGCATCGCCATCCCAC
ATGAAGTCGATTTTATGGGTGCCTCTTCCTATGGTGATGGAACCTCCTCTGGAGATTTTAAAATCACAAAAGAATTGAAA
AAATCGATTCAAAACAAATCCGTTCTGTTAGTCGAAGACATCGTGGATACAGGGAAAACCTTGGAATACCTGCTGTTGGA
AGTCCAAAAACAAAATCCAAAGGATCTAAAAGTGGCCGCTCTTTTTTGGAAACAAAAAAAAGCCAATCCACACATCATCG
TAGATTACCCGGGCTTCATCATCGAAGATGATTTCCTCGTTGGATATGGTTTGGATTTCCAAGGTAAGTATCGCAATTTG
CCATACGTTGCAAAATTAGAAGGCACAGATTGA

Upstream 100 bases:

>100_bases
CCTTTCTCGGATTGTGTTTTTCTGGGGATTCTTGGAAAAATCTTAGTTGGGGAAGTTGCCAATTAGTAGTATTCTGGATC
CCTGGGCAAATAGGAAAAGA

Downstream 100 bases:

>100_bases
AAGATTCCATCATCAAACAAAAATTCGATACATTACGAACCTTTCCTACATTAAAACCTGAAATTTTACAAATTGCAGAA
AATTATGTAAACCATTCGGA

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MKPLYSEERIHQRVEELAREISRDFLSKDLVVIGILNGGFIFTADLCRSIAIPHEVDFMGASSYGDGTSSGDFKITKELK
KSIQNKSVLLVEDIVDTGKTLEYLLLEVQKQNPKDLKVAALFWKQKKANPHIIVDYPGFIIEDDFLVGYGLDFQGKYRNL
PYVAKLEGTD

Sequences:

>Translated_170_residues
MKPLYSEERIHQRVEELAREISRDFLSKDLVVIGILNGGFIFTADLCRSIAIPHEVDFMGASSYGDGTSSGDFKITKELK
KSIQNKSVLLVEDIVDTGKTLEYLLLEVQKQNPKDLKVAALFWKQKKANPHIIVDYPGFIIEDDFLVGYGLDFQGKYRNL
PYVAKLEGTD
>Mature_170_residues
MKPLYSEERIHQRVEELAREISRDFLSKDLVVIGILNGGFIFTADLCRSIAIPHEVDFMGASSYGDGTSSGDFKITKELK
KSIQNKSVLLVEDIVDTGKTLEYLLLEVQKQNPKDLKVAALFWKQKKANPHIIVDYPGFIIEDDFLVGYGLDFQGKYRNL
PYVAKLEGTD

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=170, Percent_Identity=38.2352941176471, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI9910262, Length=165, Percent_Identity=33.9393939393939, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=42.7710843373494, Blast_Score=144, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17510817, Length=166, Percent_Identity=32.5301204819277, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19230; Mature: 19230

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLYSEERIHQRVEELAREISRDFLSKDLVVIGILNGGFIFTADLCRSIAIPHEVDFMG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEHHHHHHHCCCCCCCCCC
ASSYGDGTSSGDFKITKELKKSIQNKSVLLVEDIVDTGKTLEYLLLEVQKQNPKDLKVAA
CCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHCCCCCCHHHHE
LFWKQKKANPHIIVDYPGFIIEDDFLVGYGLDFQGKYRNLPYVAKLEGTD
EEEHHCCCCCEEEEECCCEEEECCEEEEECCCCCCCCCCCCEEEEECCCC
>Mature Secondary Structure
MKPLYSEERIHQRVEELAREISRDFLSKDLVVIGILNGGFIFTADLCRSIAIPHEVDFMG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEHHHHHHHCCCCCCCCCC
ASSYGDGTSSGDFKITKELKKSIQNKSVLLVEDIVDTGKTLEYLLLEVQKQNPKDLKVAA
CCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHCCCCCCHHHHE
LFWKQKKANPHIIVDYPGFIIEDDFLVGYGLDFQGKYRNLPYVAKLEGTD
EEEHHCCCCCEEEEECCCEEEECCEEEEECCCCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]