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The map label for this gene is degU [H]

Identifier: 183222500

GI number: 183222500

Start: 3270269

End: 3270865

Strand: Direct

Name: degU [H]

Synonym: LEPBI_I3155

Alternate gene names: 183222500

Gene position: 3270269-3270865 (Clockwise)

Preceding gene: 183222498

Following gene: 183222501

Centisome position: 90.85

GC content: 40.2

Gene sequence:

>597_bases
GTGGAATCCGTTAAAATTGCCATCTTAGAAGACCATTCCGTTGTCACTGAAGGAATCATATCTATTCTGAAATCCAATCC
TTTCTTTTCTCTTGCCGGAGAATTTCGAACGGCCGCCGATTTGTTTGAATTCATCGCAACAAATCCCATTGACGTATTAA
TTCTCGACATTGATCTACCAGACCGAAATGGAATCGATGTATTAAGAGAAATCAAAGAAAAACACCAACCCACTAAGGTC
ATTATCTTCTCATTGCATGGTAGCCGGGTCTATGTTGAAGATGCACTCAAGTCCAAAGCAGACGGTTATATGCTAAAGTC
CGATCCGATCGCCAAACTCCCCGAAGTCATCCAACTTGTGATGAAAGGTGGTTCCTTTGTTTCGGATGGAGTGAGCAAAG
TACAACTTCCGTTTTCTCCTTTCCAAATGGAAATCCTAAACCTTCTCGTCCAAGGATTATCCCAAAATGAAGTGGCAGAC
CGGATCCAAAAATCAAGAAAAACAGTCGAGTACCACTTGAACCAAATGAGGACAAAATTTTCCTGCAAAAACAACAACGA
ACTCATTTCTAAATACGAAAAAGAAATACAAAAATAG

Upstream 100 bases:

>100_bases
GGAGGGCAAAGACCAAAATTAAGGGATAACGACAAAATTTTACTAAGGTAGAAAAAGATTTTTGGATAGATGAGATGGAG
ACTGTGAAAATCATAAGGCT

Downstream 100 bases:

>100_bases
CAATTTCGTGATTTCTAAGTCATATGTTTCGACTAATGTATATGTATGAAACATATCTACTTACTCAGGCATGCGAAGTC
CGAATGGGATGAACCGTATG

Product: putative regulatory protein

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MESVKIAILEDHSVVTEGIISILKSNPFFSLAGEFRTAADLFEFIATNPIDVLILDIDLPDRNGIDVLREIKEKHQPTKV
IIFSLHGSRVYVEDALKSKADGYMLKSDPIAKLPEVIQLVMKGGSFVSDGVSKVQLPFSPFQMEILNLLVQGLSQNEVAD
RIQKSRKTVEYHLNQMRTKFSCKNNNELISKYEKEIQK

Sequences:

>Translated_198_residues
MESVKIAILEDHSVVTEGIISILKSNPFFSLAGEFRTAADLFEFIATNPIDVLILDIDLPDRNGIDVLREIKEKHQPTKV
IIFSLHGSRVYVEDALKSKADGYMLKSDPIAKLPEVIQLVMKGGSFVSDGVSKVQLPFSPFQMEILNLLVQGLSQNEVAD
RIQKSRKTVEYHLNQMRTKFSCKNNNELISKYEKEIQK
>Mature_198_residues
MESVKIAILEDHSVVTEGIISILKSNPFFSLAGEFRTAADLFEFIATNPIDVLILDIDLPDRNGIDVLREIKEKHQPTKV
IIFSLHGSRVYVEDALKSKADGYMLKSDPIAKLPEVIQLVMKGGSFVSDGVSKVQLPFSPFQMEILNLLVQGLSQNEVAD
RIQKSRKTVEYHLNQMRTKFSCKNNNELISKYEKEIQK

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=193, Percent_Identity=25.3886010362694, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=26.8292682926829, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788222, Length=199, Percent_Identity=22.1105527638191, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1788521, Length=194, Percent_Identity=25.7731958762887, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787473, Length=187, Percent_Identity=24.5989304812834, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1788546, Length=203, Percent_Identity=23.1527093596059, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1788712, Length=189, Percent_Identity=23.2804232804233, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22365; Mature: 22365

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESVKIAILEDHSVVTEGIISILKSNPFFSLAGEFRTAADLFEFIATNPIDVLILDIDLP
CCCEEEEEEECCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
DRNGIDVLREIKEKHQPTKVIIFSLHGSRVYVEDALKSKADGYMLKSDPIAKLPEVIQLV
CCCCHHHHHHHHHHCCCCEEEEEEECCCEEEHHHHHHCCCCCEEECCCCHHHHHHHHHHH
MKGGSFVSDGVSKVQLPFSPFQMEILNLLVQGLSQNEVADRIQKSRKTVEYHLNQMRTKF
HHCCCHHHCCCCEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SCKNNNELISKYEKEIQK
CCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MESVKIAILEDHSVVTEGIISILKSNPFFSLAGEFRTAADLFEFIATNPIDVLILDIDLP
CCCEEEEEEECCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
DRNGIDVLREIKEKHQPTKVIIFSLHGSRVYVEDALKSKADGYMLKSDPIAKLPEVIQLV
CCCCHHHHHHHHHHCCCCEEEEEEECCCEEEHHHHHHCCCCCEEECCCCHHHHHHHHHHH
MKGGSFVSDGVSKVQLPFSPFQMEILNLLVQGLSQNEVADRIQKSRKTVEYHLNQMRTKF
HHCCCHHHCCCCEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SCKNNNELISKYEKEIQK
CCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]