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The map label for this gene is fumC [H]

Identifier: 183222476

GI number: 183222476

Start: 3242939

End: 3244327

Strand: Direct

Name: fumC [H]

Synonym: LEPBI_I3130

Alternate gene names: 183222476

Gene position: 3242939-3244327 (Clockwise)

Preceding gene: 183222475

Following gene: 183222480

Centisome position: 90.09

GC content: 41.54

Gene sequence:

>1389_bases
ATGGAACCAAAAAAAAGAAGAATCGAAACAGACTCTATGGGAGAAATCGAAGTAGATGCTTCACGTTATTGGGGAGCGCA
AACCGAACGTTCATTAAAGTACTTCCAAATCGGAAAGGACAAGTTCCCTAGAGAATTGATTCGCGCTTTAGGAATTGTCA
AAAAAACATCGGCAATCATCAATTCAGAACTTGGCCTACTTGAAGAATCCAAAAAAGATCTGATCCTAAAGGCAGCAGAA
GAAGTCATTGAAGGTTTGTTAGATGATCATTTTCCACTTTCAGTTTGGCAAACAGGTTCCGGAACACAAACCAATATGAA
TGCCAATGAAGTGATTGCCAACAGAGCAAACGAACTTGTTGGTGCTAAATTGGGATCCAAATCCCCCATCCATCCCAATG
ATGATGTCAACAAAGGCCAAAGTTCCAATGATGTCTTCCCCACTGCGATGCACATTGCGACTGCCGAATCCATTCACAAA
AACCTCATCCCAAATCTAAATTTACTCCAATCCAAACTGAATGAAAAATCAGAGAGCTTCCAAAACATCATTAAAATTGG
AAGGACACATTTACAAGATGCCACTCCCCTTACCTTGGGACAGGAATTTTCTGGTTATGCCGCGCAACTTTCCTACAGCT
TAGATCGAATTGAACGTGGATTACCTTCCCTTTACAGACTCGCGTTAGGTGGGACAGCGGTGGGAACTGGACTCAATACC
CATCCAGAATTCCCATTAAAAGTTGCGAGTGCCATTTCACAAGAGACAGGAATTCCATTTGTCACCGCTCCCAATAAATT
TGAGGCACTCGCCGCCAATGATTCGCTCGTGGAAGTGAGTGGAATTTTAAAAACCATCGCTGCATCGCTTATGAAAATTG
CCAATGATATCCGTTGGTTGTCTTCGGGACCGAGATCAGGGATCGGAGAAATTCAAATTCCTGAAAACGAACCTGGGTCC
TCCATCATGCCTGGAAAAGTGAATCCGACGCAATCGGAAGCCCTCACCATGATCTGTGCCCAAGTGATTGGAAACGATGT
TGCGGTCACGATTGGAGGTGCTTCTGGTAATTTTGAACTCAATGTATTTAAGCCTCTTATAATTTTTAATGTTCTTAATT
CAATTCGACTTCTATCTGATGGATGTCGTTCTTTTGCAAATCATTGTGTTGAAGGGATCAAAGCGAATGAATCGAAGATC
CAGTCAAATCTAAATCAATCATTGATGCTTGTGACAGCCTTAAACCCACATATTGGGTATGATAAAGCAGCAAAGATCGC
CAAACTGGCATTTAGCGATAATCTAACATTGAAAGAAGCCGGAATCAAACTAGGATTTTTGACAAAGGAAGAATTTGATA
AATGGGTAAACCCGAAGGATATGATTTAA

Upstream 100 bases:

>100_bases
CCACTGAGAAGTGATTGCCTTCCTCTTCCTTATCCTGTAATTTTAATCAACAAAACCCACCTGATCCGGCGCCGATGGAA
TCTAAGGATGGACAGATAAT

Downstream 100 bases:

>100_bases
AAGAATACCATTCTTTCTAGAATTCTTTGCGATCTAAAGTTCAAACTTGTTTGCGAATCCTTTCCCAAAAGTGTTTACGC
CAATTTTCTTCAACATCGGT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MEPKKRRIETDSMGEIEVDASRYWGAQTERSLKYFQIGKDKFPRELIRALGIVKKTSAIINSELGLLEESKKDLILKAAE
EVIEGLLDDHFPLSVWQTGSGTQTNMNANEVIANRANELVGAKLGSKSPIHPNDDVNKGQSSNDVFPTAMHIATAESIHK
NLIPNLNLLQSKLNEKSESFQNIIKIGRTHLQDATPLTLGQEFSGYAAQLSYSLDRIERGLPSLYRLALGGTAVGTGLNT
HPEFPLKVASAISQETGIPFVTAPNKFEALAANDSLVEVSGILKTIAASLMKIANDIRWLSSGPRSGIGEIQIPENEPGS
SIMPGKVNPTQSEALTMICAQVIGNDVAVTIGGASGNFELNVFKPLIIFNVLNSIRLLSDGCRSFANHCVEGIKANESKI
QSNLNQSLMLVTALNPHIGYDKAAKIAKLAFSDNLTLKEAGIKLGFLTKEEFDKWVNPKDMI

Sequences:

>Translated_462_residues
MEPKKRRIETDSMGEIEVDASRYWGAQTERSLKYFQIGKDKFPRELIRALGIVKKTSAIINSELGLLEESKKDLILKAAE
EVIEGLLDDHFPLSVWQTGSGTQTNMNANEVIANRANELVGAKLGSKSPIHPNDDVNKGQSSNDVFPTAMHIATAESIHK
NLIPNLNLLQSKLNEKSESFQNIIKIGRTHLQDATPLTLGQEFSGYAAQLSYSLDRIERGLPSLYRLALGGTAVGTGLNT
HPEFPLKVASAISQETGIPFVTAPNKFEALAANDSLVEVSGILKTIAASLMKIANDIRWLSSGPRSGIGEIQIPENEPGS
SIMPGKVNPTQSEALTMICAQVIGNDVAVTIGGASGNFELNVFKPLIIFNVLNSIRLLSDGCRSFANHCVEGIKANESKI
QSNLNQSLMLVTALNPHIGYDKAAKIAKLAFSDNLTLKEAGIKLGFLTKEEFDKWVNPKDMI
>Mature_462_residues
MEPKKRRIETDSMGEIEVDASRYWGAQTERSLKYFQIGKDKFPRELIRALGIVKKTSAIINSELGLLEESKKDLILKAAE
EVIEGLLDDHFPLSVWQTGSGTQTNMNANEVIANRANELVGAKLGSKSPIHPNDDVNKGQSSNDVFPTAMHIATAESIHK
NLIPNLNLLQSKLNEKSESFQNIIKIGRTHLQDATPLTLGQEFSGYAAQLSYSLDRIERGLPSLYRLALGGTAVGTGLNT
HPEFPLKVASAISQETGIPFVTAPNKFEALAANDSLVEVSGILKTIAASLMKIANDIRWLSSGPRSGIGEIQIPENEPGS
SIMPGKVNPTQSEALTMICAQVIGNDVAVTIGGASGNFELNVFKPLIIFNVLNSIRLLSDGCRSFANHCVEGIKANESKI
QSNLNQSLMLVTALNPHIGYDKAAKIAKLAFSDNLTLKEAGIKLGFLTKEEFDKWVNPKDMI

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=458, Percent_Identity=62.882096069869, Blast_Score=587, Evalue=1e-167,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=50.6493506493506, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=63.3771929824561, Blast_Score=596, Evalue=1e-172,
Organism=Escherichia coli, GI87082375, Length=459, Percent_Identity=39.2156862745098, Blast_Score=328, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=61.0869565217391, Blast_Score=587, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI32565146, Length=323, Percent_Identity=63.7770897832817, Blast_Score=435, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6324993, Length=458, Percent_Identity=60.2620087336244, Blast_Score=569, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24640179, Length=465, Percent_Identity=62.5806451612903, Blast_Score=598, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24640177, Length=459, Percent_Identity=63.1808278867102, Blast_Score=596, Evalue=1e-170,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=60.2173913043478, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24662684, Length=460, Percent_Identity=59.1304347826087, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24583245, Length=460, Percent_Identity=53.695652173913, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50188; Mature: 50188

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPKKRRIETDSMGEIEVDASRYWGAQTERSLKYFQIGKDKFPRELIRALGIVKKTSAII
CCCCCCCCCCCCCCCEEECHHHHCCCCHHCCCHHEECCCCCCHHHHHHHHHHHHHHHHHH
NSELGLLEESKKDLILKAAEEVIEGLLDDHFPLSVWQTGSGTQTNMNANEVIANRANELV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
GAKLGSKSPIHPNDDVNKGQSSNDVFPTAMHIATAESIHKNLIPNLNLLQSKLNEKSESF
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QNIIKIGRTHLQDATPLTLGQEFSGYAAQLSYSLDRIERGLPSLYRLALGGTAVGTGLNT
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCC
HPEFPLKVASAISQETGIPFVTAPNKFEALAANDSLVEVSGILKTIAASLMKIANDIRWL
CCCCCHHHHHHHHHHCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SSGPRSGIGEIQIPENEPGSSIMPGKVNPTQSEALTMICAQVIGNDVAVTIGGASGNFEL
HCCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEE
NVFKPLIIFNVLNSIRLLSDGCRSFANHCVEGIKANESKIQSNLNQSLMLVTALNPHIGY
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEEECCCCCCC
DKAAKIAKLAFSDNLTLKEAGIKLGFLTKEEFDKWVNPKDMI
HHHHHHHHHHHCCCCEEHHCCCEEEECCHHHHHHCCCCCCCC
>Mature Secondary Structure
MEPKKRRIETDSMGEIEVDASRYWGAQTERSLKYFQIGKDKFPRELIRALGIVKKTSAII
CCCCCCCCCCCCCCCEEECHHHHCCCCHHCCCHHEECCCCCCHHHHHHHHHHHHHHHHHH
NSELGLLEESKKDLILKAAEEVIEGLLDDHFPLSVWQTGSGTQTNMNANEVIANRANELV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
GAKLGSKSPIHPNDDVNKGQSSNDVFPTAMHIATAESIHKNLIPNLNLLQSKLNEKSESF
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QNIIKIGRTHLQDATPLTLGQEFSGYAAQLSYSLDRIERGLPSLYRLALGGTAVGTGLNT
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCC
HPEFPLKVASAISQETGIPFVTAPNKFEALAANDSLVEVSGILKTIAASLMKIANDIRWL
CCCCCHHHHHHHHHHCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SSGPRSGIGEIQIPENEPGSSIMPGKVNPTQSEALTMICAQVIGNDVAVTIGGASGNFEL
HCCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEE
NVFKPLIIFNVLNSIRLLSDGCRSFANHCVEGIKANESKIQSNLNQSLMLVTALNPHIGY
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEEECCCCCCC
DKAAKIAKLAFSDNLTLKEAGIKLGFLTKEEFDKWVNPKDMI
HHHHHHHHHHHCCCCEEHHCCCEEEECCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA