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The map label for this gene is norD [H]

Identifier: 183222300

GI number: 183222300

Start: 3056268

End: 3058076

Strand: Reverse

Name: norD [H]

Synonym: LEPBI_I2952

Alternate gene names: 183222300

Gene position: 3058076-3056268 (Counterclockwise)

Preceding gene: 183222301

Following gene: 183222293

Centisome position: 84.95

GC content: 37.76

Gene sequence:

>1809_bases
TTGGAATGGGATCAATTTGTATTTTACCAAGGCCACAAACTTTGGAAAAAGTTAAAAACTAAGTTAACTCCACCGAGTCC
TTACTTTCCATACCAAATGGAAACAGAGGAAATCAAAATCATCAAATACCTACAAACCTTACGTTTGGAAACGACCTCCA
TTGTTTATGGAGGGGTAGTGGTTTCGCTTGGCGAAAACTTTTTAAAATTTCCAGAAGTGATCCACTGGTATGAGAAGGAA
TTGGATACAAAAAAACAGGTTCGGATCCTACTTGCCTATTTATCTTACCTCTTTGATTTAAATTCACCTAACACGAACTT
AACAACTACTTTCTCCAAACAGGAAGTACCGCTAACGAATCTAAAAAAAACAGAAACACAAGAACGGAAAGCGATCGAAG
AACAAACTTTTTACCAAAACTTTCGTTCCTTTTTGAAAGTATTCCCTGGTGTTCGGAGTGATTGGAAAGAGATTCGAAAA
GAACGTTTGTTACTTCGAAAAAAAGATCCAAAACAGTATACAAACATTATCTCTCATTTTTACAAAGCCAAATTCTCTCT
CACCCATTCAAGAATGAACTTTCCCATAGGGAAAGACTTTGTTTCCGCAAAACAAAATCAAAAAATAGAATCCAAAGAAT
CCAAACAAAAATTGGATCCAAGTGATGCTGAAATTTTGGAAGTGGATGAGAAAAAAATCGAAGAATATACCTTAGGGCAT
AATTTTGAAAAGATTGAAACGGTAGAAGAGTTTGATGGGCAATGGCGAGACATCGATGGCGAAGAGGATATGGAAGAAGA
GGAGGCCCTAGAGGAACTCAATCTCAAACACATCATCCGAACCGAAGACCCGGTTCATACAACAAGAACTAGTGAATCAG
GATCTGGTACCTTACTTGAAATTTTAGAAGATACAAGTAATGAAAAACCATTTTTGTATCCAGAATGGGATTACAAACAA
AAGAAATACAAACCTAGTTACTGTTCTGTGGTAGAAGAGTTTCCCAAGTCAATGGATCATTCGTATACAGCGAATGTATT
AGAAAAACAACATCGTACACTTTTACTTTTAAAGAAAAAAATGACGGCACTTCTCAACCAAACACGGATCAAAAAAAGAT
TGGTATCTGGTGCTGATATCGACTTGGATGCACTTGTGGATCGTTATGCGGACTTAAAAGCGAAAAAAAGTCCGTCAGAA
GCCATTTATATGAATCCCATTCGTGATGTTTCAGACATTGCATTGTATTTTCTAATGGACCTTAGTTTGTCTACGGACTC
CTGGATTCATGATAAACGTGTGTTGGATGTCGAAAGGGAAAGTTTGTTACTCTTTTCGGAATGTTTGGATGAACTAAAAA
TTCCTTTCGGGATTGCTGGATTCTATTCTCGCACTAGAAATCACAATCAGTTCATTCACCTAAAACAAATGAATGAATCC
TGGATGGGAGTCCGGGATCGTTTGGGCCCATTGTCACCCATTGGATATACTAGGGTTGGACCATCGCTTAGGCACACCAA
TGAACTGCTCAAAAATTGTGGTTATAAACAAAAATGGATTATCTTAATCACAGATGCTAGGCCAAACGATTATGACCAGT
ATGAAGGAAAGTATGGCATTGAAGATGTCAATAAAGCCGTCGGTGAATGTCTGTTAAATGGAGTTCAAGTATACACGCTG
GCAATTGGTAAAGAAGAAAAACCAACAATTCCTGCCATGATGCGAAACGCAAGTTACCAAATGTTATTCCATCCGGAAAG
GCTACTCGATTCCTTACAGGAATTTTTTCGAAGAGCCATTCGCGTTTGA

Upstream 100 bases:

>100_bases
GTTAGCAGGTCGAACTGCCATTATCTTACCTTTAACAGATGATGATGACACTGTTACGGCCTTACAAGATAGTTTTGATT
TAATCTTTTAGGATCAAATT

Downstream 100 bases:

>100_bases
TTTAGATTTTTACCATCGTAACCATCGAATTCACATCTTGTGCTAAGATGGTTTTCCATCTGGACGTTTGGAAAATAGAA
TGAGTGAGTATTGGATCGAA

Product: NorD protein

Products: nitric oxide; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MEWDQFVFYQGHKLWKKLKTKLTPPSPYFPYQMETEEIKIIKYLQTLRLETTSIVYGGVVVSLGENFLKFPEVIHWYEKE
LDTKKQVRILLAYLSYLFDLNSPNTNLTTTFSKQEVPLTNLKKTETQERKAIEEQTFYQNFRSFLKVFPGVRSDWKEIRK
ERLLLRKKDPKQYTNIISHFYKAKFSLTHSRMNFPIGKDFVSAKQNQKIESKESKQKLDPSDAEILEVDEKKIEEYTLGH
NFEKIETVEEFDGQWRDIDGEEDMEEEEALEELNLKHIIRTEDPVHTTRTSESGSGTLLEILEDTSNEKPFLYPEWDYKQ
KKYKPSYCSVVEEFPKSMDHSYTANVLEKQHRTLLLLKKKMTALLNQTRIKKRLVSGADIDLDALVDRYADLKAKKSPSE
AIYMNPIRDVSDIALYFLMDLSLSTDSWIHDKRVLDVERESLLLFSECLDELKIPFGIAGFYSRTRNHNQFIHLKQMNES
WMGVRDRLGPLSPIGYTRVGPSLRHTNELLKNCGYKQKWIILITDARPNDYDQYEGKYGIEDVNKAVGECLLNGVQVYTL
AIGKEEKPTIPAMMRNASYQMLFHPERLLDSLQEFFRRAIRV

Sequences:

>Translated_602_residues
MEWDQFVFYQGHKLWKKLKTKLTPPSPYFPYQMETEEIKIIKYLQTLRLETTSIVYGGVVVSLGENFLKFPEVIHWYEKE
LDTKKQVRILLAYLSYLFDLNSPNTNLTTTFSKQEVPLTNLKKTETQERKAIEEQTFYQNFRSFLKVFPGVRSDWKEIRK
ERLLLRKKDPKQYTNIISHFYKAKFSLTHSRMNFPIGKDFVSAKQNQKIESKESKQKLDPSDAEILEVDEKKIEEYTLGH
NFEKIETVEEFDGQWRDIDGEEDMEEEEALEELNLKHIIRTEDPVHTTRTSESGSGTLLEILEDTSNEKPFLYPEWDYKQ
KKYKPSYCSVVEEFPKSMDHSYTANVLEKQHRTLLLLKKKMTALLNQTRIKKRLVSGADIDLDALVDRYADLKAKKSPSE
AIYMNPIRDVSDIALYFLMDLSLSTDSWIHDKRVLDVERESLLLFSECLDELKIPFGIAGFYSRTRNHNQFIHLKQMNES
WMGVRDRLGPLSPIGYTRVGPSLRHTNELLKNCGYKQKWIILITDARPNDYDQYEGKYGIEDVNKAVGECLLNGVQVYTL
AIGKEEKPTIPAMMRNASYQMLFHPERLLDSLQEFFRRAIRV
>Mature_602_residues
MEWDQFVFYQGHKLWKKLKTKLTPPSPYFPYQMETEEIKIIKYLQTLRLETTSIVYGGVVVSLGENFLKFPEVIHWYEKE
LDTKKQVRILLAYLSYLFDLNSPNTNLTTTFSKQEVPLTNLKKTETQERKAIEEQTFYQNFRSFLKVFPGVRSDWKEIRK
ERLLLRKKDPKQYTNIISHFYKAKFSLTHSRMNFPIGKDFVSAKQNQKIESKESKQKLDPSDAEILEVDEKKIEEYTLGH
NFEKIETVEEFDGQWRDIDGEEDMEEEEALEELNLKHIIRTEDPVHTTRTSESGSGTLLEILEDTSNEKPFLYPEWDYKQ
KKYKPSYCSVVEEFPKSMDHSYTANVLEKQHRTLLLLKKKMTALLNQTRIKKRLVSGADIDLDALVDRYADLKAKKSPSE
AIYMNPIRDVSDIALYFLMDLSLSTDSWIHDKRVLDVERESLLLFSECLDELKIPFGIAGFYSRTRNHNQFIHLKQMNES
WMGVRDRLGPLSPIGYTRVGPSLRHTNELLKNCGYKQKWIILITDARPNDYDQYEGKYGIEDVNKAVGECLLNGVQVYTL
AIGKEEKPTIPAMMRNASYQMLFHPERLLDSLQEFFRRAIRV

Specific function: Part of the operon norEFCBQD encoding nitric oxide reductase. Essential virulence factor, probably involved in the detoxification of nitric oxide (NO) produced in the macrophages during the innate response against infection [H]

COG id: COG4548

COG function: function code P; Nitric oxide reductase activation protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 VWFA domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002035 [H]

Pfam domain/function: PF00092 VWA [H]

EC number: 1.7.99.7

Molecular weight: Translated: 70748; Mature: 70748

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50234 VWFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWDQFVFYQGHKLWKKLKTKLTPPSPYFPYQMETEEIKIIKYLQTLRLETTSIVYGGVV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECHHH
VSLGENFLKFPEVIHWYEKELDTKKQVRILLAYLSYLFDLNSPNTNLTTTFSKQEVPLTN
HHHCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
LKKTETQERKAIEEQTFYQNFRSFLKVFPGVRSDWKEIRKERLLLRKKDPKQYTNIISHF
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YKAKFSLTHSRMNFPIGKDFVSAKQNQKIESKESKQKLDPSDAEILEVDEKKIEEYTLGH
HHHHHHEEHHHCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCEEECHHHHHHHHHCCC
NFEKIETVEEFDGQWRDIDGEEDMEEEEALEELNLKHIIRTEDPVHTTRTSESGSGTLLE
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCHHHH
ILEDTSNEKPFLYPEWDYKQKKYKPSYCSVVEEFPKSMDHSYTANVLEKQHRTLLLLKKK
HHHCCCCCCCEECCCCCCHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
MTALLNQTRIKKRLVSGADIDLDALVDRYADLKAKKSPSEAIYMNPIRDVSDIALYFLMD
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHH
LSLSTDSWIHDKRVLDVERESLLLFSECLDELKIPFGIAGFYSRTRNHNQFIHLKQMNES
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEECCCH
WMGVRDRLGPLSPIGYTRVGPSLRHTNELLKNCGYKQKWIILITDARPNDYDQYEGKYGI
HHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHCCCCCCH
EDVNKAVGECLLNGVQVYTLAIGKEEKPTIPAMMRNASYQMLFHPERLLDSLQEFFRRAI
HHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHCCCCEEEECHHHHHHHHHHHHHHHH
RV
CC
>Mature Secondary Structure
MEWDQFVFYQGHKLWKKLKTKLTPPSPYFPYQMETEEIKIIKYLQTLRLETTSIVYGGVV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECHHH
VSLGENFLKFPEVIHWYEKELDTKKQVRILLAYLSYLFDLNSPNTNLTTTFSKQEVPLTN
HHHCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
LKKTETQERKAIEEQTFYQNFRSFLKVFPGVRSDWKEIRKERLLLRKKDPKQYTNIISHF
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YKAKFSLTHSRMNFPIGKDFVSAKQNQKIESKESKQKLDPSDAEILEVDEKKIEEYTLGH
HHHHHHEEHHHCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCEEECHHHHHHHHHCCC
NFEKIETVEEFDGQWRDIDGEEDMEEEEALEELNLKHIIRTEDPVHTTRTSESGSGTLLE
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCHHHH
ILEDTSNEKPFLYPEWDYKQKKYKPSYCSVVEEFPKSMDHSYTANVLEKQHRTLLLLKKK
HHHCCCCCCCEECCCCCCHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
MTALLNQTRIKKRLVSGADIDLDALVDRYADLKAKKSPSEAIYMNPIRDVSDIALYFLMD
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHH
LSLSTDSWIHDKRVLDVERESLLLFSECLDELKIPFGIAGFYSRTRNHNQFIHLKQMNES
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEECCCH
WMGVRDRLGPLSPIGYTRVGPSLRHTNELLKNCGYKQKWIILITDARPNDYDQYEGKYGI
HHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHCCCCCCH
EDVNKAVGECLLNGVQVYTLAIGKEEKPTIPAMMRNASYQMLFHPERLLDSLQEFFRRAI
HHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHCCCCEEEECHHHHHHHHHHHHHHHH
RV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: nitrous oxide; acceptor; H2O

Specific reaction: nitrous oxide + acceptor + H2O = 2 nitric oxide + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA