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The map label for this gene is acdA4 [H]

Identifier: 183222229

GI number: 183222229

Start: 2973257

End: 2974423

Strand: Reverse

Name: acdA4 [H]

Synonym: LEPBI_I2880

Alternate gene names: 183222229

Gene position: 2974423-2973257 (Counterclockwise)

Preceding gene: 183222233

Following gene: 183222228

Centisome position: 82.63

GC content: 44.64

Gene sequence:

>1167_bases
ATGTATAGCCAATTCACAGAGCAACAACTTGAAATCAGAGATTTAGTTCGTAACTTCGTCAAAAAAGAAATCCCGCATGA
AGTAGCCTTGCACTGGGATGAAAAAAACCAACACCCGACAGAACTCATCAACAAAATGCGTTCCGAATTGGGAATCAACG
GTCTTGTGATCCCAGAAGAATACGGTGGATGGGGTCTAGGTGCGATCGAGCAGTGTTTAGCCATTGAGGAATTGTCTCGT
GGATGCCTTGGAATCGCACTAGGATTTGCTTACACTGGCCTTGGGGTACTTCCCATCCTAAAAGGTGCCACTCACGAACA
AAAATTAAAATGGCTTCCTGAAATTGCAGACGGAAAGTTCGGAGTTTCTTTCTGTTTGTCTGAGCCAGGTGCTGGTTCTG
ACGTTCCTGGTATGACCACTCGCGCTGAGAAAAAAGGCGACAAATGGATCATCAACGGTGCAAAACAATGGATCACTGGT
GCCTCCGATGCCCAAGCCTTTACTGTATTTGCTTATACTGATAAAAACCGCGGAACACGCGGAGTTTCTTGTTTCTACGT
TCCACGTAGTGCAAAAGGTCTCACTGTTGGGAAAAAAGAAGACAAACTCGGAATCCGAGCATCTTCCACTCACCAAGTGA
TTTTCGAAGATTGTGAAGTGGGTGAAGACGCACTCGTTGGAAAAGAAAACCTTGGTTTCGTTTACGCACTCCAAACTTTG
AATGCTTCTCGTCCTTTCGTAGCCGTTATGGGTGTGGGTGTGGCGCAGGCCGCTCTTGACCACGCAGCTCGTTACGCACG
TGAGAGAGAACAGTTCGGTGTAAAAATCGGAACCTTCCAAGCAGTGCAACACATGTTAGCTGATATGTCGATCAAAGTAG
AAACTGCAAGAGAAATCACTTACAAAGCAGCTCGTCTTTCTGATGCAAACGATCCTAACCTTCCAAAATACTCTGCGATT
GCAAAAGCATACGCTTCTGAATGTGCTGTTCAGTGTGCTACTGACGCCGTTCAAATTTTTGGTGGATACGGATACACAAA
AGAGTATCCTGTTGAGAAGTTAATGAGAGATTCCAAAATTCTCACGATCTTTGAAGGAACGACACAAATCCAAAAGAACG
AAATTGCAGCTTACGTGATTAAAGAAGCAGCTTCGAAAAAAGACTAA

Upstream 100 bases:

>100_bases
GTGTTTTTGCTTTCTTGTAAAGAGAGAAAAACCCTTGGCACAGGAAGGGTCGTACGAAAAAAGGTAGTAAATACCCCATT
CTCAGAAGGAACATCCCGGA

Downstream 100 bases:

>100_bases
AACTTGAGTCACAACCTGTTTTAGAAAGGGAGCCTCCAGAGATGGGGGCTTTTTTTTTGGGGGTGGTACAGGATTGGAGT
TTGGTATCCCCGCCCTGATT

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MYSQFTEQQLEIRDLVRNFVKKEIPHEVALHWDEKNQHPTELINKMRSELGINGLVIPEEYGGWGLGAIEQCLAIEELSR
GCLGIALGFAYTGLGVLPILKGATHEQKLKWLPEIADGKFGVSFCLSEPGAGSDVPGMTTRAEKKGDKWIINGAKQWITG
ASDAQAFTVFAYTDKNRGTRGVSCFYVPRSAKGLTVGKKEDKLGIRASSTHQVIFEDCEVGEDALVGKENLGFVYALQTL
NASRPFVAVMGVGVAQAALDHAARYAREREQFGVKIGTFQAVQHMLADMSIKVETAREITYKAARLSDANDPNLPKYSAI
AKAYASECAVQCATDAVQIFGGYGYTKEYPVEKLMRDSKILTIFEGTTQIQKNEIAAYVIKEAASKKD

Sequences:

>Translated_388_residues
MYSQFTEQQLEIRDLVRNFVKKEIPHEVALHWDEKNQHPTELINKMRSELGINGLVIPEEYGGWGLGAIEQCLAIEELSR
GCLGIALGFAYTGLGVLPILKGATHEQKLKWLPEIADGKFGVSFCLSEPGAGSDVPGMTTRAEKKGDKWIINGAKQWITG
ASDAQAFTVFAYTDKNRGTRGVSCFYVPRSAKGLTVGKKEDKLGIRASSTHQVIFEDCEVGEDALVGKENLGFVYALQTL
NASRPFVAVMGVGVAQAALDHAARYAREREQFGVKIGTFQAVQHMLADMSIKVETAREITYKAARLSDANDPNLPKYSAI
AKAYASECAVQCATDAVQIFGGYGYTKEYPVEKLMRDSKILTIFEGTTQIQKNEIAAYVIKEAASKKD
>Mature_388_residues
MYSQFTEQQLEIRDLVRNFVKKEIPHEVALHWDEKNQHPTELINKMRSELGINGLVIPEEYGGWGLGAIEQCLAIEELSR
GCLGIALGFAYTGLGVLPILKGATHEQKLKWLPEIADGKFGVSFCLSEPGAGSDVPGMTTRAEKKGDKWIINGAKQWITG
ASDAQAFTVFAYTDKNRGTRGVSCFYVPRSAKGLTVGKKEDKLGIRASSTHQVIFEDCEVGEDALVGKENLGFVYALQTL
NASRPFVAVMGVGVAQAALDHAARYAREREQFGVKIGTFQAVQHMLADMSIKVETAREITYKAARLSDANDPNLPKYSAI
AKAYASECAVQCATDAVQIFGGYGYTKEYPVEKLMRDSKILTIFEGTTQIQKNEIAAYVIKEAASKKD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=366, Percent_Identity=42.3497267759563, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI4557231, Length=372, Percent_Identity=42.741935483871, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI187960098, Length=372, Percent_Identity=42.741935483871, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI4501859, Length=380, Percent_Identity=40, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI226958412, Length=373, Percent_Identity=35.9249329758713, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI226958414, Length=332, Percent_Identity=38.2530120481928, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI21361497, Length=361, Percent_Identity=37.3961218836565, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=32.1899736147757, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI4501857, Length=381, Percent_Identity=30.9711286089239, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI76496475, Length=336, Percent_Identity=34.2261904761905, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI4557235, Length=336, Percent_Identity=34.2261904761905, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI4503943, Length=372, Percent_Identity=30.1075268817204, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=29.7814207650273, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI38505218, Length=292, Percent_Identity=25, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI211971008, Length=291, Percent_Identity=25.4295532646048, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI48976061, Length=291, Percent_Identity=25.4295532646048, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=30.3896103896104, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1786223, Length=350, Percent_Identity=29.7142857142857, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI87082384, Length=268, Percent_Identity=25.7462686567164, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI87081702, Length=348, Percent_Identity=26.7241379310345, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=43.421052631579, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17570075, Length=388, Percent_Identity=42.5257731958763, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=41.4893617021277, Blast_Score=277, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI17508101, Length=377, Percent_Identity=40.5835543766578, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17506239, Length=379, Percent_Identity=39.8416886543536, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17538396, Length=381, Percent_Identity=36.2204724409449, Blast_Score=241, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17533517, Length=363, Percent_Identity=33.0578512396694, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71990804, Length=279, Percent_Identity=38.7096774193548, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=43.0434782608696, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71985184, Length=387, Percent_Identity=31.5245478036176, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=277, Percent_Identity=34.6570397111913, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=245, Percent_Identity=34.2857142857143, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17551932, Length=391, Percent_Identity=27.3657289002558, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17505929, Length=386, Percent_Identity=27.2020725388601, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI71985192, Length=316, Percent_Identity=30.6962025316456, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17534353, Length=374, Percent_Identity=27.0053475935829, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17531913, Length=183, Percent_Identity=31.1475409836066, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562446, Length=342, Percent_Identity=26.0233918128655, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI86563383, Length=266, Percent_Identity=26.3157894736842, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=266, Percent_Identity=26.3157894736842, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24660351, Length=371, Percent_Identity=44.743935309973, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI21356377, Length=384, Percent_Identity=40.8854166666667, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=35.7142857142857, Blast_Score=247, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24666513, Length=339, Percent_Identity=40.7079646017699, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI21355753, Length=376, Percent_Identity=36.7021276595745, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI281363737, Length=346, Percent_Identity=35.8381502890173, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI19920834, Length=382, Percent_Identity=28.5340314136126, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24652780, Length=322, Percent_Identity=25.4658385093168, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42561; Mature: 42561

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSQFTEQQLEIRDLVRNFVKKEIPHEVALHWDEKNQHPTELINKMRSELGINGLVIPEE
CCCCHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCC
YGGWGLGAIEQCLAIEELSRGCLGIALGFAYTGLGVLPILKGATHEQKLKWLPEIADGKF
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCC
GVSFCLSEPGAGSDVPGMTTRAEKKGDKWIINGAKQWITGASDAQAFTVFAYTDKNRGTR
CEEEEECCCCCCCCCCCCCCHHHHCCCEEEECCHHHHHCCCCCCCEEEEEEEECCCCCCC
GVSCFYVPRSAKGLTVGKKEDKLGIRASSTHQVIFEDCEVGEDALVGKENLGFVYALQTL
CEEEEEECCCCCCCCCCCCCCCCCCEECCCCCEEEHHCCCCCCCCCCCCCCCEEEEEEEC
NASRPFVAVMGVGVAQAALDHAARYAREREQFGVKIGTFQAVQHMLADMSIKVETAREIT
CCCCCEEEEHHCHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHCCEEEEEHHHHHH
YKAARLSDANDPNLPKYSAIAKAYASECAVQCATDAVQIFGGYGYTKEYPVEKLMRDSKI
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCE
LTIFEGTTQIQKNEIAAYVIKEAASKKD
EEEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYSQFTEQQLEIRDLVRNFVKKEIPHEVALHWDEKNQHPTELINKMRSELGINGLVIPEE
CCCCHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCC
YGGWGLGAIEQCLAIEELSRGCLGIALGFAYTGLGVLPILKGATHEQKLKWLPEIADGKF
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCC
GVSFCLSEPGAGSDVPGMTTRAEKKGDKWIINGAKQWITGASDAQAFTVFAYTDKNRGTR
CEEEEECCCCCCCCCCCCCCHHHHCCCEEEECCHHHHHCCCCCCCEEEEEEEECCCCCCC
GVSCFYVPRSAKGLTVGKKEDKLGIRASSTHQVIFEDCEVGEDALVGKENLGFVYALQTL
CEEEEEECCCCCCCCCCCCCCCCCCEECCCCCEEEHHCCCCCCCCCCCCCCCEEEEEEEC
NASRPFVAVMGVGVAQAALDHAARYAREREQFGVKIGTFQAVQHMLADMSIKVETAREIT
CCCCCEEEEHHCHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHCCEEEEEHHHHHH
YKAARLSDANDPNLPKYSAIAKAYASECAVQCATDAVQIFGGYGYTKEYPVEKLMRDSKI
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCE
LTIFEGTTQIQKNEIAAYVIKEAASKKD
EEEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]