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The map label for this gene is tlpA [H]

Identifier: 183221805

GI number: 183221805

Start: 2508541

End: 2510613

Strand: Reverse

Name: tlpA [H]

Synonym: LEPBI_I2436

Alternate gene names: 183221805

Gene position: 2510613-2508541 (Counterclockwise)

Preceding gene: 183221806

Following gene: 183221802

Centisome position: 69.75

GC content: 38.54

Gene sequence:

>2073_bases
ATGAGCATTCGTCAGAGGGTTTCTCTTTTTATCGCTGGAATTTTGTTTGTTGGATTTACGATTTTAACCTCGTTTCAAAT
CTATAGAACGATCACCGACCTGAAATCGGAAATCCAAGAAAACGCAAATATTACCTCACAAAAATGGTCCTTCCAAATCC
AGGAACATTTGAATGCGATGATGGGAGTCATTCGTGGGTATCGATTTGCACTCTTTTATGCATCTCCACCTCGTGATGCA
ATGGTGAGTAGCCTCCGCGAAATTTTAGAAAGAAATGATAATATCTTTGGAATATGGCTCTGTTATGAACCGAATGCCTA
TGAAGGACGAGATGCTGCTTTTGTTGGGAAACCAGGCCACGATAAATCGGGAAGGTTTGTTCCTTACCTGCACCACACAC
CTGATGGAAAAATTAATTTTGAGCCTTTAGCTGATTATGATAATCCGAATGGAGCAGGCGATTTTTACCTCCAAGTGAAA
AAAACAAACAAAGCAAAGGTATTTGGTCCGTATGAATACATTGCTGGCGGTAAAAAAATCCAAATGATTTCTCTTGTTGT
TCCGATTTATCCCAAAGGCAAATTTCTCGGAGCAGCGGGGATTGACTTAGATATCGGAACTCTGCAAGAAAAAATCGGAG
ACAACCGACCGTTTCGTGGGCAAGGGTACATTTCCTTTATTTCAGATAACGGAACTTATGTGATGTATGGCCAAGATAAG
GACAAACTTGGAAAAAAAATCCAGAACCCAGAACACCTGAAAATATATTTAGAAAAGTTGAAATTAGGAGAAATGTTTAC
CATTCATCATGATGGATATACCGATTATTTCACTCCATTTCATATTGGAAAGGATCCACAATTTTGGGCCTTACAAGTGA
GTATCCCCGATTCAATTCTTACCGAACAAGTCACAAAAGTTGTCATCAGTTCGATTACGATCTCACTTTTAATTCTTTTT
GTGGTTTTATTCTTTTTGAATTTTGTATTTAAAAATCTCATCAGTACTCGTTTGACCCAAGCCATCACTTTTTCATCACA
AATTGCGAGTGGAAATTTAGCAACAAGTCCTGAAGAAATCAACCAAGATGAAATTGGAAGTTTGTTAGACTCAATGAATC
AAATGAGAAACAGTTTAGTGTCTATCATTGGTGATATCAAACATACTGTTGAAAAATTGGGAAACCAATCCCAACAAATG
GCTTCCACTTCTCAAAATTTATCCGACATATCCCAAACGCAAGCAAGTGCTGCAGAAGAATCATCGGCTGCAGTGGAAGA
ATTATCGGCTTCCGCAGACAATGTTGGGAAATCAATGGAAGAAGCTGTTCTTAAAATGAAAGAAATTGACCAATCTGTTT
TAACCCTTCGTGAAGAAGTGCAAAACATCAATAAAGAAATGGAATACCTTGCCAAGTTTGCATCGGAATCGAGAGAACAC
GCTGTTGTCGGTGAAACGGCGATGAACGATTCCACAAAAGCAATGGAAGACATTGGTGAAAAAGCGGAACGAATCAGCGA
AGTATTAGACATCATCACAGAGATTTCTGAAAAAACCAATTTACTCGCCTTAAATGCGGCCATAGAAGCTGCCAGAGCAG
GGGATGCTGGAAGAGGATTTGCAGTGGTGGCAGAAGAAATTGGAAAACTCGCCTTACAAACAGGAACTTCAGTAAAAGAA
ATTGGTGATCTGGTAATATCAACAAATTCAGCTGTCGAAAATGGAAACAGGAAAGTGACGGAAGCCGCACAAGTTTTAAA
CCTTTTGAACAATCGTGTGAAAGAATTTGAAACTTCAGCAAAACGAGTGTTAAACTCAGTCTTATTGCAAGAAAACAATG
CAAAAGATATTGCTCAAAATTCGAATCTCCTCACGAATCTAAATCTTCAAATTGAAGAAGCAGTCTTTGAACAAAAGCGG
GCCACAGAAGAAATTTCAAAAACAATCATTAGTATTTCGAATGGAACACAAGATGTCGCATCAGGGTCTGACCAACTTAC
AATTGTTTCCGCTGAAATTGCTTCGCAAGCCTCGTATCTATCGACTCAGGTAGAGAAATTCAAATTAAAATAA

Upstream 100 bases:

>100_bases
CCAAAATTTAGTATAAACCACTGATTTCTGGAGAAGAAAATTACCAGATCCAATCGCGAAACAATTTACAAATATTTTAA
AAGGTCTAAGATCGACCCCT

Downstream 100 bases:

>100_bases
AAAAAGGCCCACATGAGTGGGCCTTAGATTCATACGAAAGAATTGATTTTTAAAATCTTATTTTGAAAAAAATCGTTTCT
CTACTTCTTCAGGAAGTTTT

Product: putative methyl-accepting chemotaxis protein McpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 690; Mature: 689

Protein sequence:

>690_residues
MSIRQRVSLFIAGILFVGFTILTSFQIYRTITDLKSEIQENANITSQKWSFQIQEHLNAMMGVIRGYRFALFYASPPRDA
MVSSLREILERNDNIFGIWLCYEPNAYEGRDAAFVGKPGHDKSGRFVPYLHHTPDGKINFEPLADYDNPNGAGDFYLQVK
KTNKAKVFGPYEYIAGGKKIQMISLVVPIYPKGKFLGAAGIDLDIGTLQEKIGDNRPFRGQGYISFISDNGTYVMYGQDK
DKLGKKIQNPEHLKIYLEKLKLGEMFTIHHDGYTDYFTPFHIGKDPQFWALQVSIPDSILTEQVTKVVISSITISLLILF
VVLFFLNFVFKNLISTRLTQAITFSSQIASGNLATSPEEINQDEIGSLLDSMNQMRNSLVSIIGDIKHTVEKLGNQSQQM
ASTSQNLSDISQTQASAAEESSAAVEELSASADNVGKSMEEAVLKMKEIDQSVLTLREEVQNINKEMEYLAKFASESREH
AVVGETAMNDSTKAMEDIGEKAERISEVLDIITEISEKTNLLALNAAIEAARAGDAGRGFAVVAEEIGKLALQTGTSVKE
IGDLVISTNSAVENGNRKVTEAAQVLNLLNNRVKEFETSAKRVLNSVLLQENNAKDIAQNSNLLTNLNLQIEEAVFEQKR
ATEEISKTIISISNGTQDVASGSDQLTIVSAEIASQASYLSTQVEKFKLK

Sequences:

>Translated_690_residues
MSIRQRVSLFIAGILFVGFTILTSFQIYRTITDLKSEIQENANITSQKWSFQIQEHLNAMMGVIRGYRFALFYASPPRDA
MVSSLREILERNDNIFGIWLCYEPNAYEGRDAAFVGKPGHDKSGRFVPYLHHTPDGKINFEPLADYDNPNGAGDFYLQVK
KTNKAKVFGPYEYIAGGKKIQMISLVVPIYPKGKFLGAAGIDLDIGTLQEKIGDNRPFRGQGYISFISDNGTYVMYGQDK
DKLGKKIQNPEHLKIYLEKLKLGEMFTIHHDGYTDYFTPFHIGKDPQFWALQVSIPDSILTEQVTKVVISSITISLLILF
VVLFFLNFVFKNLISTRLTQAITFSSQIASGNLATSPEEINQDEIGSLLDSMNQMRNSLVSIIGDIKHTVEKLGNQSQQM
ASTSQNLSDISQTQASAAEESSAAVEELSASADNVGKSMEEAVLKMKEIDQSVLTLREEVQNINKEMEYLAKFASESREH
AVVGETAMNDSTKAMEDIGEKAERISEVLDIITEISEKTNLLALNAAIEAARAGDAGRGFAVVAEEIGKLALQTGTSVKE
IGDLVISTNSAVENGNRKVTEAAQVLNLLNNRVKEFETSAKRVLNSVLLQENNAKDIAQNSNLLTNLNLQIEEAVFEQKR
ATEEISKTIISISNGTQDVASGSDQLTIVSAEIASQASYLSTQVEKFKLK
>Mature_689_residues
SIRQRVSLFIAGILFVGFTILTSFQIYRTITDLKSEIQENANITSQKWSFQIQEHLNAMMGVIRGYRFALFYASPPRDAM
VSSLREILERNDNIFGIWLCYEPNAYEGRDAAFVGKPGHDKSGRFVPYLHHTPDGKINFEPLADYDNPNGAGDFYLQVKK
TNKAKVFGPYEYIAGGKKIQMISLVVPIYPKGKFLGAAGIDLDIGTLQEKIGDNRPFRGQGYISFISDNGTYVMYGQDKD
KLGKKIQNPEHLKIYLEKLKLGEMFTIHHDGYTDYFTPFHIGKDPQFWALQVSIPDSILTEQVTKVVISSITISLLILFV
VLFFLNFVFKNLISTRLTQAITFSSQIASGNLATSPEEINQDEIGSLLDSMNQMRNSLVSIIGDIKHTVEKLGNQSQQMA
STSQNLSDISQTQASAAEESSAAVEELSASADNVGKSMEEAVLKMKEIDQSVLTLREEVQNINKEMEYLAKFASESREHA
VVGETAMNDSTKAMEDIGEKAERISEVLDIITEISEKTNLLALNAAIEAARAGDAGRGFAVVAEEIGKLALQTGTSVKEI
GDLVISTNSAVENGNRKVTEAAQVLNLLNNRVKEFETSAKRVLNSVLLQENNAKDIAQNSNLLTNLNLQIEEAVFEQKRA
TEEISKTIISISNGTQDVASGSDQLTIVSAEIASQASYLSTQVEKFKLK

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=377, Percent_Identity=26.2599469496021, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI1788195, Length=266, Percent_Identity=30.0751879699248, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI2367378, Length=328, Percent_Identity=26.5243902439024, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1788194, Length=449, Percent_Identity=24.7216035634744, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1789453, Length=329, Percent_Identity=24.6200607902736, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 76323; Mature: 76191

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRQRVSLFIAGILFVGFTILTSFQIYRTITDLKSEIQENANITSQKWSFQIQEHLNAM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
MGVIRGYRFALFYASPPRDAMVSSLREILERNDNIFGIWLCYEPNAYEGRDAAFVGKPGH
HHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEECCCCC
DKSGRFVPYLHHTPDGKINFEPLADYDNPNGAGDFYLQVKKTNKAKVFGPYEYIAGGKKI
CCCCCEEEEEEECCCCCEECCCCCCCCCCCCCCEEEEEEEECCCCEEECCHHHHCCCCEE
QMISLVVPIYPKGKFLGAAGIDLDIGTLQEKIGDNRPFRGQGYISFISDNGTYVMYGQDK
EEEEEEEEECCCCCEEECCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEECCCH
DKLGKKIQNPEHLKIYLEKLKLGEMFTIHHDGYTDYFTPFHIGKDPQFWALQVSIPDSIL
HHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCCCEEEEEEECCHHHH
TEQVTKVVISSITISLLILFVVLFFLNFVFKNLISTRLTQAITFSSQIASGNLATSPEEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHC
NQDEIGSLLDSMNQMRNSLVSIIGDIKHTVEKLGNQSQQMASTSQNLSDISQTQASAAEE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SSAAVEELSASADNVGKSMEEAVLKMKEIDQSVLTLREEVQNINKEMEYLAKFASESREH
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AVVGETAMNDSTKAMEDIGEKAERISEVLDIITEISEKTNLLALNAAIEAARAGDAGRGF
EEECCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCH
AVVAEEIGKLALQTGTSVKEIGDLVISTNSAVENGNRKVTEAAQVLNLLNNRVKEFETSA
HHHHHHHHHHHHHCCCCHHHHHHHEEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
KRVLNSVLLQENNAKDIAQNSNLLTNLNLQIEEAVFEQKRATEEISKTIISISNGTQDVA
HHHHHHHHHCCCCCHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
SGSDQLTIVSAEIASQASYLSTQVEKFKLK
CCCCCEEEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIRQRVSLFIAGILFVGFTILTSFQIYRTITDLKSEIQENANITSQKWSFQIQEHLNAM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
MGVIRGYRFALFYASPPRDAMVSSLREILERNDNIFGIWLCYEPNAYEGRDAAFVGKPGH
HHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEECCCCC
DKSGRFVPYLHHTPDGKINFEPLADYDNPNGAGDFYLQVKKTNKAKVFGPYEYIAGGKKI
CCCCCEEEEEEECCCCCEECCCCCCCCCCCCCCEEEEEEEECCCCEEECCHHHHCCCCEE
QMISLVVPIYPKGKFLGAAGIDLDIGTLQEKIGDNRPFRGQGYISFISDNGTYVMYGQDK
EEEEEEEEECCCCCEEECCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEECCCH
DKLGKKIQNPEHLKIYLEKLKLGEMFTIHHDGYTDYFTPFHIGKDPQFWALQVSIPDSIL
HHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCCCEEEEEEECCHHHH
TEQVTKVVISSITISLLILFVVLFFLNFVFKNLISTRLTQAITFSSQIASGNLATSPEEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHC
NQDEIGSLLDSMNQMRNSLVSIIGDIKHTVEKLGNQSQQMASTSQNLSDISQTQASAAEE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SSAAVEELSASADNVGKSMEEAVLKMKEIDQSVLTLREEVQNINKEMEYLAKFASESREH
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AVVGETAMNDSTKAMEDIGEKAERISEVLDIITEISEKTNLLALNAAIEAARAGDAGRGF
EEECCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCH
AVVAEEIGKLALQTGTSVKEIGDLVISTNSAVENGNRKVTEAAQVLNLLNNRVKEFETSA
HHHHHHHHHHHHHCCCCHHHHHHHEEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
KRVLNSVLLQENNAKDIAQNSNLLTNLNLQIEEAVFEQKRATEEISKTIISISNGTQDVA
HHHHHHHHHCCCCCHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
SGSDQLTIVSAEIASQASYLSTQVEKFKLK
CCCCCEEEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]