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The map label for this gene is nadC [H]

Identifier: 183221699

GI number: 183221699

Start: 2397650

End: 2398513

Strand: Reverse

Name: nadC [H]

Synonym: LEPBI_I2326

Alternate gene names: 183221699

Gene position: 2398513-2397650 (Counterclockwise)

Preceding gene: 183221700

Following gene: 183221697

Centisome position: 66.63

GC content: 40.62

Gene sequence:

>864_bases
ATGAACCGAGGCTATACTTCTCCCGTCACTGAAATCTCAGAAAAAGACTTCGAAACCCTTGTGCAAATGGCACTGGATGA
GGATTTACCAGCAGGGGATATCACAACCGACACATTGTTTGCCAAAGAAGAAACCTGCACGGCAGTTTTACTGGCTAAAG
AAGAAGGGATTTTGTGTGGAACGGCGGTCATTCCCTGTCTCATCCAAAAAACCAAAGCAGATGTCACTTGGAATGGAATC
TTATCCGATGGAGCGACACTTTCCAAAGGAACAGTGGTAGGGGAATTAAAGGGATCCCTTGTTGGGATTCTTAAAATGGA
ACGAATTTTACTGAATTTTATCCAATACCTTTCCGGGATTGCAACGAACGCCAATAAAGTAGCAAAACAGTTTCCAAACC
TACTCATTCTTGATACAAGGAAAACACTTCCTGGTTACCGAAAACTAGCCAAGTATGCGGTGTATATGGGAGGAGGTGCC
AACCACCGATTGAATTTGTCCGAGATGGCAATGTTAAAAGACAATCATATTGCGCGTGCTGGTTCCATCCAAACTGCCGT
ACAATTAGTACGAGAAAAAAATCCCGGCAAAAAAATTGAATTGGAGATTGATGGGATTTTTCAATTGAATGACGCGATCC
TTGCCAAACCTGATATCATTTTACTCGATAATTTTTCAGATACAGATACCGAAAAAGCGATTCAAATCTTAAAGGAAACA
GCTCCAATGATTCGGATCGAATGTTCAGGTGGGATCACACCTGAAAAATTAAACTTTTTGTCCAAGTTTGATGGGATTGG
AGTGAGTATGGGTTATCTCACACATACGGTTAAATTTTTAGACATTAGTTTGGATATAAAGTAA

Upstream 100 bases:

>100_bases
AAAAATTGGAAAAGCACCTAAGGAATAAACAAGACTTAGGTGAAACGAAGAAAAGCTGTCGTAAAGGCAGCTTTTTTTTT
GTCTAAACCATAGGACCTAT

Downstream 100 bases:

>100_bases
TGGGACTGTATCAGGATATAAAAGACAAACAGGAGTTATTTGACGCTGTCCAAAAAAGACTTGGTCCTGAAAAAGCACAA
CTGATTCAAAAAGCATATCA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MNRGYTSPVTEISEKDFETLVQMALDEDLPAGDITTDTLFAKEETCTAVLLAKEEGILCGTAVIPCLIQKTKADVTWNGI
LSDGATLSKGTVVGELKGSLVGILKMERILLNFIQYLSGIATNANKVAKQFPNLLILDTRKTLPGYRKLAKYAVYMGGGA
NHRLNLSEMAMLKDNHIARAGSIQTAVQLVREKNPGKKIELEIDGIFQLNDAILAKPDIILLDNFSDTDTEKAIQILKET
APMIRIECSGGITPEKLNFLSKFDGIGVSMGYLTHTVKFLDISLDIK

Sequences:

>Translated_287_residues
MNRGYTSPVTEISEKDFETLVQMALDEDLPAGDITTDTLFAKEETCTAVLLAKEEGILCGTAVIPCLIQKTKADVTWNGI
LSDGATLSKGTVVGELKGSLVGILKMERILLNFIQYLSGIATNANKVAKQFPNLLILDTRKTLPGYRKLAKYAVYMGGGA
NHRLNLSEMAMLKDNHIARAGSIQTAVQLVREKNPGKKIELEIDGIFQLNDAILAKPDIILLDNFSDTDTEKAIQILKET
APMIRIECSGGITPEKLNFLSKFDGIGVSMGYLTHTVKFLDISLDIK
>Mature_287_residues
MNRGYTSPVTEISEKDFETLVQMALDEDLPAGDITTDTLFAKEETCTAVLLAKEEGILCGTAVIPCLIQKTKADVTWNGI
LSDGATLSKGTVVGELKGSLVGILKMERILLNFIQYLSGIATNANKVAKQFPNLLILDTRKTLPGYRKLAKYAVYMGGGA
NHRLNLSEMAMLKDNHIARAGSIQTAVQLVREKNPGKKIELEIDGIFQLNDAILAKPDIILLDNFSDTDTEKAIQILKET
APMIRIECSGGITPEKLNFLSKFDGIGVSMGYLTHTVKFLDISLDIK

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=276, Percent_Identity=32.6086956521739, Blast_Score=128, Evalue=7e-30,
Organism=Escherichia coli, GI1786299, Length=279, Percent_Identity=35.4838709677419, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321162, Length=264, Percent_Identity=33.7121212121212, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31336; Mature: 31336

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRGYTSPVTEISEKDFETLVQMALDEDLPAGDITTDTLFAKEETCTAVLLAKEEGILCG
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCEEH
TAVIPCLIQKTKADVTWNGILSDGATLSKGTVVGELKGSLVGILKMERILLNFIQYLSGI
HHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ATNANKVAKQFPNLLILDTRKTLPGYRKLAKYAVYMGGGANHRLNLSEMAMLKDNHIARA
CCCHHHHHHHCCCEEEEECCCCCCHHHHHHHHEEEECCCCCCEECHHHHHHHHCCCCCCC
GSIQTAVQLVREKNPGKKIELEIDGIFQLNDAILAKPDIILLDNFSDTDTEKAIQILKET
CHHHHHHHHHHHCCCCCEEEEEECCEEEECCCEECCCCEEEEECCCCCCHHHHHHHHHHC
APMIRIECSGGITPEKLNFLSKFDGIGVSMGYLTHTVKFLDISLDIK
CCEEEEEECCCCCHHHHHHHHHHCCCCEEHHHHHHEEEEEEEEEECC
>Mature Secondary Structure
MNRGYTSPVTEISEKDFETLVQMALDEDLPAGDITTDTLFAKEETCTAVLLAKEEGILCG
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCEEH
TAVIPCLIQKTKADVTWNGILSDGATLSKGTVVGELKGSLVGILKMERILLNFIQYLSGI
HHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ATNANKVAKQFPNLLILDTRKTLPGYRKLAKYAVYMGGGANHRLNLSEMAMLKDNHIARA
CCCHHHHHHHCCCEEEEECCCCCCHHHHHHHHEEEECCCCCCEECHHHHHHHHCCCCCCC
GSIQTAVQLVREKNPGKKIELEIDGIFQLNDAILAKPDIILLDNFSDTDTEKAIQILKET
CHHHHHHHHHHHCCCCCEEEEEECCEEEECCCEECCCCEEEEECCCCCCHHHHHHHHHHC
APMIRIECSGGITPEKLNFLSKFDGIGVSMGYLTHTVKFLDISLDIK
CCEEEEEECCCCCHHHHHHHHHHCCCCEEHHHHHHEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]