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The map label for this gene is purL

Identifier: 183221536

GI number: 183221536

Start: 2242450

End: 2244696

Strand: Direct

Name: purL

Synonym: LEPBI_I2154

Alternate gene names: 183221536

Gene position: 2242450-2244696 (Clockwise)

Preceding gene: 183221535

Following gene: 183221537

Centisome position: 62.3

GC content: 46.42

Gene sequence:

>2247_bases
ATGGAAAAAGAGAAAGTCAGTCTGGCAGATGCGAAAGAACACGGACTCACCGAAACTGAATTTGTTGAAATTCAAAAAAT
CTTAGGAAGGATTCCCAATTCCACTGAACTTGGAATTTTTTCTGCCATGTGGTCAGAACACTGCTCTTATAAAAATTCCA
TCCTAAAATTAAAAACCCTTCCCACAAAATCTGACAAACTCCTCGCAGGAGCTGGTGAAGAAAATGCGGGAGCCATGGAC
ATCGGAGATGGCCTTGCCGTGGTCTTTAAAATTGAAAGCCACAACCACCCAACAGCTGTAGAACCCTACCAAGGTGCTGC
CACAGGCGTTGGTGGGATCATGCGTGATATTTTTACTATGGGAGCGCGACCTATCACTTCTCTCAACTCACTCCGGTTTG
GTGATCCAAAAGAACCACGAAATAAATACCTACTCACTCGTGCCGTCAAAGGCATTGGCGATTATGGGAACTCACTTGGG
ATTGCGGTGGGTGGTGGGGAACTTTTCCTCCATCCAACCTTCACCAAAAATCCACTTGTGAATGCCATGACTGTTGGAAT
CGCCAAACATGATGAAATGGCTTCTGCTTCCACGAAAGGAAAAGTCGGAAACAAAGTTTATATTGTTGGTGCTACAACTG
GCCGTGATGGAATCCATGGAGCAAGTTTCGCCTCCAAAGACCTCACAAAAGAATCCGAAGAAAAACGTTCTGCCGTGCAA
GTGGGAGATCCCTTTATGGAAAAACTCCTGATGGAAGCATCGCTTGAGGCCATCCAAAAGAAACTCCTTGTGGGGATCCA
AGATATGGGAGCCGCAGGAATTTCTTGTGCAACATCGGAGATGAGTGCCAAAGGGAAAACAGGGATGGATGTGGATCTTG
ACAAAGTCCCACTCCGCGAAGCGGACATGAATGCCTATGAAATCATGTTATCCGAATCCCAAGAACGGATGCTCGTCATC
CCAGAAGTGGGCAAAGAAGGAGAACTTGTTTCCATCTTCCACAAATGGGGGTTAAACGCCGTAGAAATTGGAACTGTCAC
TGCTGACGGGATCTTACGCATCCGAAAAAACGGAACCCTCAAAGCGGAAATCCCAGCAGAATCCCTTGTTCTCGGTGGTG
GTGCCCCAAGGTATGTCCGAGAAGAAAAAAGACCGACTTACCTCGATGAGGTGGTGAAGTTTGATCCAAACAAAATCCCT
GACTTAAAACCAGACACTGTCCCTCAAACTTTAAATAGCCTACTCTCTTCCCTCAATATCAGTTCCAGACGACCTCTCTA
CGAACAGTATGACACTGAAGTGGGACTTGTGAAGGTCGTGGAACCTGGGGAGGACGGAGGTCTTGTCCGGATCCCTGGCA
CGAAAAAAGGGATTGCGGTCGCAACAGACTGTAACTCACGTTATACATATCTCAATCCTTATGAAGGGGCACAAATTGCT
GTTTGTGAATCGGCAAGAAACGTGGCCGCTACGGGCGCCGAACCATACGGCGTTACCAACAACCTCAATTTTGGAAATCC
CTACATCCCAGAAAACTATTATGTGTTCAGTGAATGCGTGCGAGGGCTTGGGGATGCTTGTCGTTTCCTTGGACTTCCTG
TCACTGGTGGGAACGTATCCTTTTATAATGAATCCCCAGAAGGACCTGTGTTTCCTACACCTACCATTGGTATGGTGGGA
GTGATTGACGATGTTGCCAAAGGACTACGTACCTACCCGAGAACAAAGGAAGATGTGAAGTATGCCCTTGTTGGAAATTT
CCAACCCACAATCTCAGCTTCTGAGTATTTGTATCGTTCCCAAGGTCTTGATACCGGTGCGATCCCTAACATTTCTTTGG
AAAAGGAAAAACAAACCATGGATGCCCTCATCGAGTGCCGGAAAAACGGACTCCTCACTTCCGCCAAAGACCTGTCACTT
GGTGGCCTCCTTGTGGCTCTCGCTAAAATTGTCATCGCCGGAAAAAAAGGTGTCGAAGTCAATTTGAATGAACTACAAAC
AAAGGTTCCAAGGCTTGATGCATTGTGTTTTGGTGAAACAGGTGCTAGTTTTATCGTAAGTTTTTTACCAAACGACGAAA
CAAAGGTTCGTGAGTCCTTTACGTCAAAGGGTTTGAGTGTTTACACACTGGGATCCTCAAGTGCAAAGGCTTCCCTATCG
GTCAAAGGAGATGGGTTCCATTGGGAGTGGACGACCAAATCTTTGGAAGTTGAGTTTGAATCGGGACTCAAATCTTATTT
CGAATAG

Upstream 100 bases:

>100_bases
TGGATCTTCTTAGGCCAAGTGGAAGCAGTGGTCACAAAAGAAGGGTCTCCCCTCCTCTATTTCAATCGCAATTACCGGGA
ACTCGTTTAAGGAAACACAC

Downstream 100 bases:

>100_bases
ACAAGTTTCAAATCAAGGGAAGGATATGCCAGATGCGTGTCCTTCTCCTCTCTGTTCTCTTTCTTTTTTTCTCCATCCAA
TGCACAAGCCTCGCCAAACG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 748; Mature: 748

Protein sequence:

>748_residues
MEKEKVSLADAKEHGLTETEFVEIQKILGRIPNSTELGIFSAMWSEHCSYKNSILKLKTLPTKSDKLLAGAGEENAGAMD
IGDGLAVVFKIESHNHPTAVEPYQGAATGVGGIMRDIFTMGARPITSLNSLRFGDPKEPRNKYLLTRAVKGIGDYGNSLG
IAVGGGELFLHPTFTKNPLVNAMTVGIAKHDEMASASTKGKVGNKVYIVGATTGRDGIHGASFASKDLTKESEEKRSAVQ
VGDPFMEKLLMEASLEAIQKKLLVGIQDMGAAGISCATSEMSAKGKTGMDVDLDKVPLREADMNAYEIMLSESQERMLVI
PEVGKEGELVSIFHKWGLNAVEIGTVTADGILRIRKNGTLKAEIPAESLVLGGGAPRYVREEKRPTYLDEVVKFDPNKIP
DLKPDTVPQTLNSLLSSLNISSRRPLYEQYDTEVGLVKVVEPGEDGGLVRIPGTKKGIAVATDCNSRYTYLNPYEGAQIA
VCESARNVAATGAEPYGVTNNLNFGNPYIPENYYVFSECVRGLGDACRFLGLPVTGGNVSFYNESPEGPVFPTPTIGMVG
VIDDVAKGLRTYPRTKEDVKYALVGNFQPTISASEYLYRSQGLDTGAIPNISLEKEKQTMDALIECRKNGLLTSAKDLSL
GGLLVALAKIVIAGKKGVEVNLNELQTKVPRLDALCFGETGASFIVSFLPNDETKVRESFTSKGLSVYTLGSSSAKASLS
VKGDGFHWEWTTKSLEVEFESGLKSYFE

Sequences:

>Translated_748_residues
MEKEKVSLADAKEHGLTETEFVEIQKILGRIPNSTELGIFSAMWSEHCSYKNSILKLKTLPTKSDKLLAGAGEENAGAMD
IGDGLAVVFKIESHNHPTAVEPYQGAATGVGGIMRDIFTMGARPITSLNSLRFGDPKEPRNKYLLTRAVKGIGDYGNSLG
IAVGGGELFLHPTFTKNPLVNAMTVGIAKHDEMASASTKGKVGNKVYIVGATTGRDGIHGASFASKDLTKESEEKRSAVQ
VGDPFMEKLLMEASLEAIQKKLLVGIQDMGAAGISCATSEMSAKGKTGMDVDLDKVPLREADMNAYEIMLSESQERMLVI
PEVGKEGELVSIFHKWGLNAVEIGTVTADGILRIRKNGTLKAEIPAESLVLGGGAPRYVREEKRPTYLDEVVKFDPNKIP
DLKPDTVPQTLNSLLSSLNISSRRPLYEQYDTEVGLVKVVEPGEDGGLVRIPGTKKGIAVATDCNSRYTYLNPYEGAQIA
VCESARNVAATGAEPYGVTNNLNFGNPYIPENYYVFSECVRGLGDACRFLGLPVTGGNVSFYNESPEGPVFPTPTIGMVG
VIDDVAKGLRTYPRTKEDVKYALVGNFQPTISASEYLYRSQGLDTGAIPNISLEKEKQTMDALIECRKNGLLTSAKDLSL
GGLLVALAKIVIAGKKGVEVNLNELQTKVPRLDALCFGETGASFIVSFLPNDETKVRESFTSKGLSVYTLGSSSAKASLS
VKGDGFHWEWTTKSLEVEFESGLKSYFE
>Mature_748_residues
MEKEKVSLADAKEHGLTETEFVEIQKILGRIPNSTELGIFSAMWSEHCSYKNSILKLKTLPTKSDKLLAGAGEENAGAMD
IGDGLAVVFKIESHNHPTAVEPYQGAATGVGGIMRDIFTMGARPITSLNSLRFGDPKEPRNKYLLTRAVKGIGDYGNSLG
IAVGGGELFLHPTFTKNPLVNAMTVGIAKHDEMASASTKGKVGNKVYIVGATTGRDGIHGASFASKDLTKESEEKRSAVQ
VGDPFMEKLLMEASLEAIQKKLLVGIQDMGAAGISCATSEMSAKGKTGMDVDLDKVPLREADMNAYEIMLSESQERMLVI
PEVGKEGELVSIFHKWGLNAVEIGTVTADGILRIRKNGTLKAEIPAESLVLGGGAPRYVREEKRPTYLDEVVKFDPNKIP
DLKPDTVPQTLNSLLSSLNISSRRPLYEQYDTEVGLVKVVEPGEDGGLVRIPGTKKGIAVATDCNSRYTYLNPYEGAQIA
VCESARNVAATGAEPYGVTNNLNFGNPYIPENYYVFSECVRGLGDACRFLGLPVTGGNVSFYNESPEGPVFPTPTIGMVG
VIDDVAKGLRTYPRTKEDVKYALVGNFQPTISASEYLYRSQGLDTGAIPNISLEKEKQTMDALIECRKNGLLTSAKDLSL
GGLLVALAKIVIAGKKGVEVNLNELQTKVPRLDALCFGETGASFIVSFLPNDETKVRESFTSKGLSVYTLGSSSAKASLS
VKGDGFHWEWTTKSLEVEFESGLKSYFE

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Escherichia coli, GI48994899, Length=813, Percent_Identity=23.8622386223862, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_LEPBA (B0SB88)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001963172.1
- ProteinModelPortal:   B0SB88
- SMR:   B0SB88
- GeneID:   6387703
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_2099
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   LBIF355278:LBF_2099-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 80637; Mature: 80637

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKEKVSLADAKEHGLTETEFVEIQKILGRIPNSTELGIFSAMWSEHCSYKNSILKLKTL
CCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEC
PTKSDKLLAGAGEENAGAMDIGDGLAVVFKIESHNHPTAVEPYQGAATGVGGIMRDIFTM
CCCCCCEEECCCCCCCCCEECCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
GARPITSLNSLRFGDPKEPRNKYLLTRAVKGIGDYGNSLGIAVGGGELFLHPTFTKNPLV
CCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCCCCC
NAMTVGIAKHDEMASASTKGKVGNKVYIVGATTGRDGIHGASFASKDLTKESEEKRSAVQ
HHEEEEEECCCHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VGDPFMEKLLMEASLEAIQKKLLVGIQDMGAAGISCATSEMSAKGKTGMDVDLDKVPLRE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHCCCCCCCCCCCCCCCCCCC
ADMNAYEIMLSESQERMLVIPEVGKEGELVSIFHKWGLNAVEIGTVTADGILRIRKNGTL
CCCCEEEEEEECCCCCEEEEECCCCCCCEEEEEHHHCCCEEEEEEEECCCEEEEECCCCE
KAEIPAESLVLGGGAPRYVREEKRPTYLDEVVKFDPNKIPDLKPDTVPQTLNSLLSSLNI
EEECCCCCEEECCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
SSRRPLYEQYDTEVGLVKVVEPGEDGGLVRIPGTKKGIAVATDCNSRYTYLNPYEGAQIA
CCCCCCHHHHCCCCCEEEEECCCCCCCEEECCCCCCCEEEEECCCCCCCEECCCCCCEEE
VCESARNVAATGAEPYGVTNNLNFGNPYIPENYYVFSECVRGLGDACRFLGLPVTGGNVS
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCEECCCCEE
FYNESPEGPVFPTPTIGMVGVIDDVAKGLRTYPRTKEDVKYALVGNFQPTISASEYLYRS
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCEEEEEECCCCCCCHHHHHHHH
QGLDTGAIPNISLEKEKQTMDALIECRKNGLLTSAKDLSLGGLLVALAKIVIAGKKGVEV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHCCCCCCEE
NLNELQTKVPRLDALCFGETGASFIVSFLPNDETKVRESFTSKGLSVYTLGSSSAKASLS
EHHHHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCEEEEEECCCCCCEEEE
VKGDGFHWEWTTKSLEVEFESGLKSYFE
EECCCEEEEEECCEEEEEHHHHHHHHCC
>Mature Secondary Structure
MEKEKVSLADAKEHGLTETEFVEIQKILGRIPNSTELGIFSAMWSEHCSYKNSILKLKTL
CCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEC
PTKSDKLLAGAGEENAGAMDIGDGLAVVFKIESHNHPTAVEPYQGAATGVGGIMRDIFTM
CCCCCCEEECCCCCCCCCEECCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
GARPITSLNSLRFGDPKEPRNKYLLTRAVKGIGDYGNSLGIAVGGGELFLHPTFTKNPLV
CCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCCCCC
NAMTVGIAKHDEMASASTKGKVGNKVYIVGATTGRDGIHGASFASKDLTKESEEKRSAVQ
HHEEEEEECCCHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VGDPFMEKLLMEASLEAIQKKLLVGIQDMGAAGISCATSEMSAKGKTGMDVDLDKVPLRE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHCCCCCCCCCCCCCCCCCCC
ADMNAYEIMLSESQERMLVIPEVGKEGELVSIFHKWGLNAVEIGTVTADGILRIRKNGTL
CCCCEEEEEEECCCCCEEEEECCCCCCCEEEEEHHHCCCEEEEEEEECCCEEEEECCCCE
KAEIPAESLVLGGGAPRYVREEKRPTYLDEVVKFDPNKIPDLKPDTVPQTLNSLLSSLNI
EEECCCCCEEECCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
SSRRPLYEQYDTEVGLVKVVEPGEDGGLVRIPGTKKGIAVATDCNSRYTYLNPYEGAQIA
CCCCCCHHHHCCCCCEEEEECCCCCCCEEECCCCCCCEEEEECCCCCCCEECCCCCCEEE
VCESARNVAATGAEPYGVTNNLNFGNPYIPENYYVFSECVRGLGDACRFLGLPVTGGNVS
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCEECCCCEE
FYNESPEGPVFPTPTIGMVGVIDDVAKGLRTYPRTKEDVKYALVGNFQPTISASEYLYRS
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCEEEEEECCCCCCCHHHHHHHH
QGLDTGAIPNISLEKEKQTMDALIECRKNGLLTSAKDLSLGGLLVALAKIVIAGKKGVEV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHCCCCCCEE
NLNELQTKVPRLDALCFGETGASFIVSFLPNDETKVRESFTSKGLSVYTLGSSSAKASLS
EHHHHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCEEEEEECCCCCCEEEE
VKGDGFHWEWTTKSLEVEFESGLKSYFE
EECCCEEEEEECCEEEEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA