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The map label for this gene is hisZ [H]

Identifier: 183221318

GI number: 183221318

Start: 2022503

End: 2023549

Strand: Reverse

Name: hisZ [H]

Synonym: LEPBI_I1935

Alternate gene names: 183221318

Gene position: 2023549-2022503 (Counterclockwise)

Preceding gene: 183221320

Following gene: 183221317

Centisome position: 56.21

GC content: 36.96

Gene sequence:

>1047_bases
TTGGGTGATCGAGATCCCGGTATGAATCATAAAAACAAACCAATTTCCTCGGAACAGAAATGGATACCCGATGGATTTCA
TTTTTTAGGTCCGGAAGAAAGTAAAAACCGGCGAAATTTACTACAATCGTTTTCAGAACTTTTTGAAAAAGAAGGGTATT
CTGAAATCACCTTACCCAGCTTCGATTATTCCAATTCGTTTCGTTCTCAATTACAGGATGGTTTGGAAAGTTTACTCGTC
GCCAAAGATTGGGATGGGAATGAACTTTCGCCTGGTGTGGATTTAACACTCCAAGTGGTAAAAGGGATGGCGGCAAGGTC
TCATTGGGAAGAAAACCAAAACGTCTATTACTTTGCCAAAAAAATTAGAGATCATAAAAAACGGAACGCATCACGGCGAG
AAGTCCTCCAGGTAGGTGTGGAGAGTTTGGGAAATAGTGATACAAATCATTTGATTTCGCAAATTAAAATTCTAAAAAAA
CTTTGGGACAATACATTGCCCAATAAAACCTTTACTCTCGTATTTGGGCATTCTTCCTTTTTTCGTACGATTTTGGAAAT
CCTTGGTTGGAACGAAGAACAAACAAATGTTCTACGACAGTTTTTATACACTAAAAACTTACCAGAACTAGTTTCTTTGG
CTGCTCGGGAGAATACTTCTGAGACTCATATGCAGATCATCCAATTATTACTAAAACCGATCCTATCTTCGGAAATGGGT
GTTTTTAAAAAAACATTAGAAACTGTTTTATCAAAAGATGAATTATTAAAAGTAAAACATGATTTGGAATCCATTACTTC
CTTTTTCGAAGTTTGGAACAAAGAAATGAAAGGGATTTTTTGCATCTTTGATCCTGCTCTCGTCCGAGATCTCTCGTATT
ACACTGGTTTTATGTTCCAGGGATATGTGGAACAAGATCCGGAACCTGTGTTTGCGGGTGGTGTTTATAATGATTTATAT
GCAAGTTTTACTGGAATTCAAAAGGATGCATGTGGTTTTGCACTGCATTTGGATGCAATCGAAGTTATGTTAAATAAGGA
AAAATGA

Upstream 100 bases:

>100_bases
TATCCCTCTAAACCGACATCAGCGTACTGAAAAGTTTCGATTTGTCTATTCGATTTTTACAATTGATTGCGTAAATCTAG
GATTTCTCTAAACTGACTTC

Downstream 100 bases:

>100_bases
GGGATTTATGCCTGCAAATTTAGTCGTTGGAGCCCAGTGGGGTGATGAAGGAAAGGCAAAAGTAATTGATTACCTTTCAA
AAGATACAGATATCATTGTA

Product: ATP phosphoribosyltransferase regulatory subunit

Products: AMP; diphosphate; L-histidyl-tRNA(His)

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MGDRDPGMNHKNKPISSEQKWIPDGFHFLGPEESKNRRNLLQSFSELFEKEGYSEITLPSFDYSNSFRSQLQDGLESLLV
AKDWDGNELSPGVDLTLQVVKGMAARSHWEENQNVYYFAKKIRDHKKRNASRREVLQVGVESLGNSDTNHLISQIKILKK
LWDNTLPNKTFTLVFGHSSFFRTILEILGWNEEQTNVLRQFLYTKNLPELVSLAARENTSETHMQIIQLLLKPILSSEMG
VFKKTLETVLSKDELLKVKHDLESITSFFEVWNKEMKGIFCIFDPALVRDLSYYTGFMFQGYVEQDPEPVFAGGVYNDLY
ASFTGIQKDACGFALHLDAIEVMLNKEK

Sequences:

>Translated_348_residues
MGDRDPGMNHKNKPISSEQKWIPDGFHFLGPEESKNRRNLLQSFSELFEKEGYSEITLPSFDYSNSFRSQLQDGLESLLV
AKDWDGNELSPGVDLTLQVVKGMAARSHWEENQNVYYFAKKIRDHKKRNASRREVLQVGVESLGNSDTNHLISQIKILKK
LWDNTLPNKTFTLVFGHSSFFRTILEILGWNEEQTNVLRQFLYTKNLPELVSLAARENTSETHMQIIQLLLKPILSSEMG
VFKKTLETVLSKDELLKVKHDLESITSFFEVWNKEMKGIFCIFDPALVRDLSYYTGFMFQGYVEQDPEPVFAGGVYNDLY
ASFTGIQKDACGFALHLDAIEVMLNKEK
>Mature_347_residues
GDRDPGMNHKNKPISSEQKWIPDGFHFLGPEESKNRRNLLQSFSELFEKEGYSEITLPSFDYSNSFRSQLQDGLESLLVA
KDWDGNELSPGVDLTLQVVKGMAARSHWEENQNVYYFAKKIRDHKKRNASRREVLQVGVESLGNSDTNHLISQIKILKKL
WDNTLPNKTFTLVFGHSSFFRTILEILGWNEEQTNVLRQFLYTKNLPELVSLAARENTSETHMQIIQLLLKPILSSEMGV
FKKTLETVLSKDELLKVKHDLESITSFFEVWNKEMKGIFCIFDPALVRDLSYYTGFMFQGYVEQDPEPVFAGGVYNDLYA
SFTGIQKDACGFALHLDAIEVMLNKEK

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004516 [H]

Pfam domain/function: NA

EC number: 6.1.1.21

Molecular weight: Translated: 40011; Mature: 39880

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDRDPGMNHKNKPISSEQKWIPDGFHFLGPEESKNRRNLLQSFSELFEKEGYSEITLPS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCC
FDYSNSFRSQLQDGLESLLVAKDWDGNELSPGVDLTLQVVKGMAARSHWEENQNVYYFAK
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
KIRDHKKRNASRREVLQVGVESLGNSDTNHLISQIKILKKLWDNTLPNKTFTLVFGHSSF
HHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHH
FRTILEILGWNEEQTNVLRQFLYTKNLPELVSLAARENTSETHMQIIQLLLKPILSSEMG
HHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VFKKTLETVLSKDELLKVKHDLESITSFFEVWNKEMKGIFCIFDPALVRDLSYYTGFMFQ
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHC
GYVEQDPEPVFAGGVYNDLYASFTGIQKDACGFALHLDAIEVMLNKEK
CCCCCCCCCEEECCHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GDRDPGMNHKNKPISSEQKWIPDGFHFLGPEESKNRRNLLQSFSELFEKEGYSEITLPS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCC
FDYSNSFRSQLQDGLESLLVAKDWDGNELSPGVDLTLQVVKGMAARSHWEENQNVYYFAK
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
KIRDHKKRNASRREVLQVGVESLGNSDTNHLISQIKILKKLWDNTLPNKTFTLVFGHSSF
HHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHH
FRTILEILGWNEEQTNVLRQFLYTKNLPELVSLAARENTSETHMQIIQLLLKPILSSEMG
HHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VFKKTLETVLSKDELLKVKHDLESITSFFEVWNKEMKGIFCIFDPALVRDLSYYTGFMFQ
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHC
GYVEQDPEPVFAGGVYNDLYASFTGIQKDACGFALHLDAIEVMLNKEK
CCCCCCCCCEEECCHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine; tRNA(His)

Specific reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA