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The map label for this gene is sufS [H]

Identifier: 183221300

GI number: 183221300

Start: 2006245

End: 2007489

Strand: Reverse

Name: sufS [H]

Synonym: LEPBI_I1917

Alternate gene names: 183221300

Gene position: 2007489-2006245 (Counterclockwise)

Preceding gene: 183221301

Following gene: 183221299

Centisome position: 55.77

GC content: 40.64

Gene sequence:

>1245_bases
ATGAGTTTAGATCCATACAATTTACGCAAAGATTTCCCAATCCTTTCTCAAACCATGCCCAATGGGAAAGAACTTGTTTA
TTTAGACAATGGAGCTACTTCCCAAAAACCACTCTCGGTGATCCAGGCAACAAACGATTATTATGTGAAAGAAAATGCGA
ACATCCATCGGGGTGTGTATTATCTTTCACAACATGCAACAGAACTCTTTGAAAGGACGAGGATTAAAACATCCCATTTT
TTCCAAGCACAGTGTGCAAAGGCCATTATATTTACACGTGGAACAACGGATGCCATCAACTTAGTGGCACAAACTTATGG
ACGCACCAATGTTTCTGAAGGTGATGAAATTGTTTTATCTGTCCAGGAACATCATTCCAATTTGGTTCCTTGGCAAATGT
TGGCCCGTGAAAAAAAAGCATTTTTAAAATTCATTCCTATCCTTGATGACACAACATACGATTTATCGAAGTTAAATGAA
ATCATCACCAAACGCACAAAAATTGTTGCGATTAGCCAAATGTCGAACGTCACAGGAACTATCCATGACCTAACCAAAAT
CATTGATCGGGCGCGCCAAGTGGGTGCCAAAGTACTTGTAGATGGAGCGCAGGCTGCTTGCCATATGCCAATCCATCTAG
TGGATATGGATGTTGATTTTTATGCCTTTTCCGCTCACAAAATGCTTGGGCCAACGGGAGTAGGTGTCCTTTTCGGTAAA
GAAGAAATATTAGAAGCCATGCCGCCTTGGTTAGGTGGTGGAGATATGATTGAGTCTGTCGAATTAGAAAGTTCCACATA
TGCAGCCTTACCTGCGAAATTAGAAGCCGGAACTCCTAATATTGCGGGTGTCATTGGTTTTTCACATGCACTTGATTATC
TACAAAAAGTGGGAATGAAAAACATCAAAGAGCATGAACGAATGTTAACCGAATATGCATTGGAACGAATGCAAAAAATA
GGTGGACTTACGATTTTTGGTACAGAGGATTTAGAAAAACGTGGAGGAGTGGTTTCCTTTACTATGGAAGGGATCCATCC
GCATGATGTAGGATCCATACTCGACGAAGAAGGTGTTGCCATCCGTGTGGGACATCATTGTTGCCAACCTTTGATGAAAC
AATTACAAATCCCTGGAACCTGTCGCGCTTCCTTCTATTTGTACAATACAAAAGAAGACATCGATGTATTAGTCCATTCA
ATCGAAAAAGTGAAATCGATATTTGGTCGTGTCGTCAGAAAATAA

Upstream 100 bases:

>100_bases
TTCGTGATGGAAGTGTACTGGCATTGCCCGCGACAGAACCATTGACGATGTTTCCTACAAAAGTGAATGGGGATGATTTG
GAAGTGGATTTGGAGTCCGT

Downstream 100 bases:

>100_bases
ATCTTATGAGGATTTTCTGAAATGGAAATCCTACGCCAATTGGATCATCCCGAGTGAACCACTACTGGAAGTAAAAAGTT
TAAATCCTTTATGTGGGGAT

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSLDPYNLRKDFPILSQTMPNGKELVYLDNGATSQKPLSVIQATNDYYVKENANIHRGVYYLSQHATELFERTRIKTSHF
FQAQCAKAIIFTRGTTDAINLVAQTYGRTNVSEGDEIVLSVQEHHSNLVPWQMLAREKKAFLKFIPILDDTTYDLSKLNE
IITKRTKIVAISQMSNVTGTIHDLTKIIDRARQVGAKVLVDGAQAACHMPIHLVDMDVDFYAFSAHKMLGPTGVGVLFGK
EEILEAMPPWLGGGDMIESVELESSTYAALPAKLEAGTPNIAGVIGFSHALDYLQKVGMKNIKEHERMLTEYALERMQKI
GGLTIFGTEDLEKRGGVVSFTMEGIHPHDVGSILDEEGVAIRVGHHCCQPLMKQLQIPGTCRASFYLYNTKEDIDVLVHS
IEKVKSIFGRVVRK

Sequences:

>Translated_414_residues
MSLDPYNLRKDFPILSQTMPNGKELVYLDNGATSQKPLSVIQATNDYYVKENANIHRGVYYLSQHATELFERTRIKTSHF
FQAQCAKAIIFTRGTTDAINLVAQTYGRTNVSEGDEIVLSVQEHHSNLVPWQMLAREKKAFLKFIPILDDTTYDLSKLNE
IITKRTKIVAISQMSNVTGTIHDLTKIIDRARQVGAKVLVDGAQAACHMPIHLVDMDVDFYAFSAHKMLGPTGVGVLFGK
EEILEAMPPWLGGGDMIESVELESSTYAALPAKLEAGTPNIAGVIGFSHALDYLQKVGMKNIKEHERMLTEYALERMQKI
GGLTIFGTEDLEKRGGVVSFTMEGIHPHDVGSILDEEGVAIRVGHHCCQPLMKQLQIPGTCRASFYLYNTKEDIDVLVHS
IEKVKSIFGRVVRK
>Mature_413_residues
SLDPYNLRKDFPILSQTMPNGKELVYLDNGATSQKPLSVIQATNDYYVKENANIHRGVYYLSQHATELFERTRIKTSHFF
QAQCAKAIIFTRGTTDAINLVAQTYGRTNVSEGDEIVLSVQEHHSNLVPWQMLAREKKAFLKFIPILDDTTYDLSKLNEI
ITKRTKIVAISQMSNVTGTIHDLTKIIDRARQVGAKVLVDGAQAACHMPIHLVDMDVDFYAFSAHKMLGPTGVGVLFGKE
EILEAMPPWLGGGDMIESVELESSTYAALPAKLEAGTPNIAGVIGFSHALDYLQKVGMKNIKEHERMLTEYALERMQKIG
GLTIFGTEDLEKRGGVVSFTMEGIHPHDVGSILDEEGVAIRVGHHCCQPLMKQLQIPGTCRASFYLYNTKEDIDVLVHSI
EKVKSIFGRVVRK

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=216, Percent_Identity=26.3888888888889, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1787970, Length=403, Percent_Identity=45.6575682382134, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1789175, Length=401, Percent_Identity=43.3915211970075, Blast_Score=355, Evalue=2e-99,
Organism=Escherichia coli, GI48994898, Length=215, Percent_Identity=26.5116279069767, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI193211090, Length=375, Percent_Identity=25.8666666666667, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=254, Percent_Identity=25.5905511811024, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319831, Length=321, Percent_Identity=24.6105919003115, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI20129463, Length=253, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 46153; Mature: 46022

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDPYNLRKDFPILSQTMPNGKELVYLDNGATSQKPLSVIQATNDYYVKENANIHRGVY
CCCCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCHHHEEECCCEEEECCCCHHHHHH
YLSQHATELFERTRIKTSHFFQAQCAKAIIFTRGTTDAINLVAQTYGRTNVSEGDEIVLS
HHHHHHHHHHHHHHCCHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEE
VQEHHSNLVPWQMLAREKKAFLKFIPILDDTTYDLSKLNEIITKRTKIVAISQMSNVTGT
EHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEHHCCCCHH
IHDLTKIIDRARQVGAKVLVDGAQAACHMPIHLVDMDVDFYAFSAHKMLGPTGVGVLFGK
HHHHHHHHHHHHHCCHHEEECCCHHHEECCEEEEEECCCEEEEEHHHHCCCCCCEEEECH
EEILEAMPPWLGGGDMIESVELESSTYAALPAKLEAGTPNIAGVIGFSHALDYLQKVGMK
HHHHHHCCCCCCCCCHHHEEEECCCCEEECCCEECCCCCCHHHHHHHHHHHHHHHHHCHH
NIKEHERMLTEYALERMQKIGGLTIFGTEDLEKRGGVVSFTMEGIHPHDVGSILDEEGVA
HHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHCCCEEEEEECCCCCHHHHHHHCCCCCE
IRVGHHCCQPLMKQLQIPGTCRASFYLYNTKEDIDVLVHSIEKVKSIFGRVVRK
EEECHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLDPYNLRKDFPILSQTMPNGKELVYLDNGATSQKPLSVIQATNDYYVKENANIHRGVY
CCCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCHHHEEECCCEEEECCCCHHHHHH
YLSQHATELFERTRIKTSHFFQAQCAKAIIFTRGTTDAINLVAQTYGRTNVSEGDEIVLS
HHHHHHHHHHHHHHCCHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEE
VQEHHSNLVPWQMLAREKKAFLKFIPILDDTTYDLSKLNEIITKRTKIVAISQMSNVTGT
EHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEHHCCCCHH
IHDLTKIIDRARQVGAKVLVDGAQAACHMPIHLVDMDVDFYAFSAHKMLGPTGVGVLFGK
HHHHHHHHHHHHHCCHHEEECCCHHHEECCEEEEEECCCEEEEEHHHHCCCCCCEEEECH
EEILEAMPPWLGGGDMIESVELESSTYAALPAKLEAGTPNIAGVIGFSHALDYLQKVGMK
HHHHHHCCCCCCCCCHHHEEEECCCCEEECCCEECCCCCCHHHHHHHHHHHHHHHHHCHH
NIKEHERMLTEYALERMQKIGGLTIFGTEDLEKRGGVVSFTMEGIHPHDVGSILDEEGVA
HHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHCCCEEEEEECCCCCHHHHHHHCCCCCE
IRVGHHCCQPLMKQLQIPGTCRASFYLYNTKEDIDVLVHSIEKVKSIFGRVVRK
EEECHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]