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The map label for this gene is kdsA [H]

Identifier: 183221033

GI number: 183221033

Start: 1721599

End: 1722444

Strand: Direct

Name: kdsA [H]

Synonym: LEPBI_I1646

Alternate gene names: 183221033

Gene position: 1721599-1722444 (Clockwise)

Preceding gene: 183221032

Following gene: 183221034

Centisome position: 47.83

GC content: 42.08

Gene sequence:

>846_bases
ATGTACGATTTAATTGAAGAAAGAGAATTTTTTGGAAAAAAAATCGGAGGTCGTCAGCCGTTTTTTCTTATCTCAGGGCC
TTGTGTGATGGAGAACAAGGACTTACTCGATCGAGTTTGTGGAGAAATGAAAGCAATTTGTGATGATTTAGGGATCGTAT
ATATTTTTAAATCTTCCTTTGATAAAGCAAATCGATCCTCCATCAATTCCTACCGGGGACCAGGTCTCGAGGAAGGTCGA
AAGTTACTCGATTTTATCAAAAATAAATACAATGTTCCTGTACTCACTGACATCCATGAAACCATCCAAGTGGATCCTTT
AAAAGACACTGTCGATATTTTTCAAATCCCTGCCTTTTTAAGCCGCCAAACTGATTTGATCGCCAAAGCCGCAGAAACCG
GAAAATGGGTGAATGTCAAAAAGGGACAGTTTATGGCTCCCGATGATACGAGGCATATCAAAACCAAGATCCAAGAATCT
GGTTCTGAAAAATACATGGTAACGGAGCGCGGTGCCAGTTTCGGATATGGAAATCTTGTGTTTGACCTACGTGGCATACC
CATGATGCACAAACATGGGATTCCCATTGTGTTTGATGGCACTCACTCTGCCCAACTTCCTGGAGCAGCAGGGAATATCA
CAGGTGGATTACGAGAATTCATTCCCCATATGATGCGAGGTGCCGTTTCTGTGGGAGTGGAGGGACTTTTTATGGAAGTC
CACCCAGACCCAGAAAAAGCCTTATCGGATGCGACCACACAGTTTCCCTTAGCAAAAGCAAAATCATTACTCACACAACT
TTTAGAACTCGATCGTTTGGTCAAAACGAAGTTCTTAGAAGATTAA

Upstream 100 bases:

>100_bases
TTCCATCCAGAATTCCAATCGAAACCAACAGACCCACATCCACTCTTTGCAGGTTTTATCAAAGCTGCATCGAAATTAGC
AAAAAAAACAGAGGATTAGT

Downstream 100 bases:

>100_bases
GACAAGTTCCAAATGAAAGCGAAGGGATGTACATTGTGTTTACTTTTGGTTTTGGCCTCGTGTAAAGACAAAGAATACCT
TCGTATCGAAGTGGAAAAAG

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MYDLIEEREFFGKKIGGRQPFFLISGPCVMENKDLLDRVCGEMKAICDDLGIVYIFKSSFDKANRSSINSYRGPGLEEGR
KLLDFIKNKYNVPVLTDIHETIQVDPLKDTVDIFQIPAFLSRQTDLIAKAAETGKWVNVKKGQFMAPDDTRHIKTKIQES
GSEKYMVTERGASFGYGNLVFDLRGIPMMHKHGIPIVFDGTHSAQLPGAAGNITGGLREFIPHMMRGAVSVGVEGLFMEV
HPDPEKALSDATTQFPLAKAKSLLTQLLELDRLVKTKFLED

Sequences:

>Translated_281_residues
MYDLIEEREFFGKKIGGRQPFFLISGPCVMENKDLLDRVCGEMKAICDDLGIVYIFKSSFDKANRSSINSYRGPGLEEGR
KLLDFIKNKYNVPVLTDIHETIQVDPLKDTVDIFQIPAFLSRQTDLIAKAAETGKWVNVKKGQFMAPDDTRHIKTKIQES
GSEKYMVTERGASFGYGNLVFDLRGIPMMHKHGIPIVFDGTHSAQLPGAAGNITGGLREFIPHMMRGAVSVGVEGLFMEV
HPDPEKALSDATTQFPLAKAKSLLTQLLELDRLVKTKFLED
>Mature_281_residues
MYDLIEEREFFGKKIGGRQPFFLISGPCVMENKDLLDRVCGEMKAICDDLGIVYIFKSSFDKANRSSINSYRGPGLEEGR
KLLDFIKNKYNVPVLTDIHETIQVDPLKDTVDIFQIPAFLSRQTDLIAKAAETGKWVNVKKGQFMAPDDTRHIKTKIQES
GSEKYMVTERGASFGYGNLVFDLRGIPMMHKHGIPIVFDGTHSAQLPGAAGNITGGLREFIPHMMRGAVSVGVEGLFMEV
HPDPEKALSDATTQFPLAKAKSLLTQLLELDRLVKTKFLED

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=258, Percent_Identity=46.8992248062016, Blast_Score=246, Evalue=8e-67,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 31386; Mature: 31386

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDLIEEREFFGKKIGGRQPFFLISGPCVMENKDLLDRVCGEMKAICDDLGIVYIFKSSF
CCCHHHHHHHHHHHCCCCCCEEEEECCEEECCHHHHHHHHHHHHHHHHHCCEEEEEECCC
DKANRSSINSYRGPGLEEGRKLLDFIKNKYNVPVLTDIHETIQVDPLKDTVDIFQIPAFL
CCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCHHHEECCCCHHHHHHHHHHHHH
SRQTDLIAKAAETGKWVNVKKGQFMAPDDTRHIKTKIQESGSEKYMVTERGASFGYGNLV
HHHHHHHHHHHHCCCEEEECCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEE
FDLRGIPMMHKHGIPIVFDGTHSAQLPGAAGNITGGLREFIPHMMRGAVSVGVEGLFMEV
EEECCCCCHHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEE
HPDPEKALSDATTQFPLAKAKSLLTQLLELDRLVKTKFLED
CCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYDLIEEREFFGKKIGGRQPFFLISGPCVMENKDLLDRVCGEMKAICDDLGIVYIFKSSF
CCCHHHHHHHHHHHCCCCCCEEEEECCEEECCHHHHHHHHHHHHHHHHHCCEEEEEECCC
DKANRSSINSYRGPGLEEGRKLLDFIKNKYNVPVLTDIHETIQVDPLKDTVDIFQIPAFL
CCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCHHHEECCCCHHHHHHHHHHHHH
SRQTDLIAKAAETGKWVNVKKGQFMAPDDTRHIKTKIQESGSEKYMVTERGASFGYGNLV
HHHHHHHHHHHHCCCEEEECCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEE
FDLRGIPMMHKHGIPIVFDGTHSAQLPGAAGNITGGLREFIPHMMRGAVSVGVEGLFMEV
EEECCCCCHHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEE
HPDPEKALSDATTQFPLAKAKSLLTQLLELDRLVKTKFLED
CCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA