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The map label for this gene is accA [H]

Identifier: 183220964

GI number: 183220964

Start: 1648741

End: 1650387

Strand: Direct

Name: accA [H]

Synonym: LEPBI_I1577

Alternate gene names: 183220964

Gene position: 1648741-1650387 (Clockwise)

Preceding gene: 183220963

Following gene: 183220965

Centisome position: 45.8

GC content: 45.72

Gene sequence:

>1647_bases
ATGGAAACCATGCAGTATTCCCTAAACAACCCGTTCAAAGAATCCAAAGCGCCGGAGACACAAACCGGCATTTATGACGA
TGCTCTCAAACTCGGAAAGGAATTGATTGAAAAACCATTCCTTGGTGGTGGTGAAGATCGTATCCGTGTCCAACATTCCA
AAAACAGGATGACTGTTTGGGAAAGGATCAAAGTCCTCACAGACGAAGAACCAAACATCACCTACCAAAACTGGGGACCG
AATTTAGATGGTGCCTCGATTGTTACAGGAATTTTAAATATCAAAGGCCGTGATGTGGCGGTGTATGGGCATGATTTTAC
CCTACGTGCCGGTTCCATGGATGCAACAAACGGTAGCAAACTCGCTCGCCTCATCCAAATGGCAGGAACTCATGGAATCC
CTCTCATTGGGATGAACGATTCCGCAGGTGCTTATGTGCCAGCGGGTGTGGGTGGCCTTGACGGATATTCGGAGGCATTC
ACAGCCCTTCGTAAAATCAGTGGGGTGGTTCCGTCAGTCATGCTCATGTTTGGGTTTAACGCTGGTGGTGGGGCTTACCT
CCCTCGCCAAGGATCCTTTATGATCCAATGTGATGGAACCTTCTTTGGTCTCACGGGACCAGGTGTTGTGAAATCGGTAC
TTGGGGAAGATATCTCTGCCGAAGACTTAGGTGGCCCAAAAGTCCACGGACAATCTGGTGTGGTGGACCTTGTTACAGGT
GACGAGTTAGGATCCCTTAGAACCGCAATTCGATTGTTATCGTATCTTCCAGACAATAACCATAGTTTTGCGCCTTTTTA
CCCTACCTCTGACCCAGTGGACAGATTCATTTACGAAGAGGACATCCTTTTCCGTAAAACTTTTAACTCCCCAACCGGGA
TGAACACTCCTTTTGACATCACACTCTACTTACAACAAATCTGTGACCATGGTGAGTTTTTTGAACTCCAACCACAAAGA
GCCCGGAACATAGTCACGGCGTTTGGAAGGATTGGTGGCCATGTGGTGGGTTTTCTTGCAAATAACTCTGCCGTATCTTC
TGGCCAGATTGATATTGGAGCATCTCGAAAGGGAACTCGTTTTGTCAGGTTTTGTAACCTATACAATATCCCTATGGTGT
TTGTAGAAGATACCACTGGATTTTTACCAGGCCGCGACCAAGAACATAATGGAATTGTACTCGAAGGAAGAAAACTCCTC
GATTCCATCATTGACCTTCGCACTCCAAGACTCACCCTCATCATCCGTAACGCGTTTGGTGGTGCTTACGCTACATTTAA
CTCGTATTTTACGGGAGCATCGATGGTATTTGCCCTTCCAACTGCAAGGATTGCCGTGATGGGTCCTGCTGGAAAAGAGT
ATGTTTACAAAGATGAGATCACTAGTGTTCAAAAGGAATTTTTGGCAAATGTCAAAAAAGGTATGAGTGACAAAGAAGCT
GCTGCCACTCGCGATGCAAAACTCTTTGAGATTGGCCAACGTTATGAAAAAGAACTCATGAATCCAAAAGAAGCACTTTC
TCTTGGTTCTGTTTCCTCCATCATTCTACCAGGTTTCACTCGTAACGTGCTTTCCAAAAACTTGAGTTTTCTCATGTCCA
AATACAAACCGGCGGAAATGTCCGGTCCTCAAAGGGAGTTTGAATAA

Upstream 100 bases:

>100_bases
GGATGCAGCAGTTATTCACGATTTATCCTGATTTAGATGCAGCTTTAAAGTAAAAATCACTTTTCTAAGTGATCCTAACC
AAAACATTGGAAAAAAACTT

Downstream 100 bases:

>100_bases
TTTCCATGTTAGATAAGAATTTAAAACGCATTCAATTCCAAGAATCCGAGTCTGCATGGATTCGTTCCTTTACAGTGGAA
TCCATCAAATGCCTCATTGT

Product: acetyl-CoA carboxylase subunit alpha

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
METMQYSLNNPFKESKAPETQTGIYDDALKLGKELIEKPFLGGGEDRIRVQHSKNRMTVWERIKVLTDEEPNITYQNWGP
NLDGASIVTGILNIKGRDVAVYGHDFTLRAGSMDATNGSKLARLIQMAGTHGIPLIGMNDSAGAYVPAGVGGLDGYSEAF
TALRKISGVVPSVMLMFGFNAGGGAYLPRQGSFMIQCDGTFFGLTGPGVVKSVLGEDISAEDLGGPKVHGQSGVVDLVTG
DELGSLRTAIRLLSYLPDNNHSFAPFYPTSDPVDRFIYEEDILFRKTFNSPTGMNTPFDITLYLQQICDHGEFFELQPQR
ARNIVTAFGRIGGHVVGFLANNSAVSSGQIDIGASRKGTRFVRFCNLYNIPMVFVEDTTGFLPGRDQEHNGIVLEGRKLL
DSIIDLRTPRLTLIIRNAFGGAYATFNSYFTGASMVFALPTARIAVMGPAGKEYVYKDEITSVQKEFLANVKKGMSDKEA
AATRDAKLFEIGQRYEKELMNPKEALSLGSVSSIILPGFTRNVLSKNLSFLMSKYKPAEMSGPQREFE

Sequences:

>Translated_548_residues
METMQYSLNNPFKESKAPETQTGIYDDALKLGKELIEKPFLGGGEDRIRVQHSKNRMTVWERIKVLTDEEPNITYQNWGP
NLDGASIVTGILNIKGRDVAVYGHDFTLRAGSMDATNGSKLARLIQMAGTHGIPLIGMNDSAGAYVPAGVGGLDGYSEAF
TALRKISGVVPSVMLMFGFNAGGGAYLPRQGSFMIQCDGTFFGLTGPGVVKSVLGEDISAEDLGGPKVHGQSGVVDLVTG
DELGSLRTAIRLLSYLPDNNHSFAPFYPTSDPVDRFIYEEDILFRKTFNSPTGMNTPFDITLYLQQICDHGEFFELQPQR
ARNIVTAFGRIGGHVVGFLANNSAVSSGQIDIGASRKGTRFVRFCNLYNIPMVFVEDTTGFLPGRDQEHNGIVLEGRKLL
DSIIDLRTPRLTLIIRNAFGGAYATFNSYFTGASMVFALPTARIAVMGPAGKEYVYKDEITSVQKEFLANVKKGMSDKEA
AATRDAKLFEIGQRYEKELMNPKEALSLGSVSSIILPGFTRNVLSKNLSFLMSKYKPAEMSGPQREFE
>Mature_548_residues
METMQYSLNNPFKESKAPETQTGIYDDALKLGKELIEKPFLGGGEDRIRVQHSKNRMTVWERIKVLTDEEPNITYQNWGP
NLDGASIVTGILNIKGRDVAVYGHDFTLRAGSMDATNGSKLARLIQMAGTHGIPLIGMNDSAGAYVPAGVGGLDGYSEAF
TALRKISGVVPSVMLMFGFNAGGGAYLPRQGSFMIQCDGTFFGLTGPGVVKSVLGEDISAEDLGGPKVHGQSGVVDLVTG
DELGSLRTAIRLLSYLPDNNHSFAPFYPTSDPVDRFIYEEDILFRKTFNSPTGMNTPFDITLYLQQICDHGEFFELQPQR
ARNIVTAFGRIGGHVVGFLANNSAVSSGQIDIGASRKGTRFVRFCNLYNIPMVFVEDTTGFLPGRDQEHNGIVLEGRKLL
DSIIDLRTPRLTLIIRNAFGGAYATFNSYFTGASMVFALPTARIAVMGPAGKEYVYKDEITSVQKEFLANVKKGMSDKEA
AATRDAKLFEIGQRYEKELMNPKEALSLGSVSSIILPGFTRNVLSKNLSFLMSKYKPAEMSGPQREFE

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=35.6164383561644, Blast_Score=288, Evalue=9e-78,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=34.2749529190207, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI11545863, Length=557, Percent_Identity=28.7253141831239, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI134142062, Length=365, Percent_Identity=25.2054794520548, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI38679971, Length=348, Percent_Identity=25.5747126436782, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38679960, Length=348, Percent_Identity=25.5747126436782, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38679974, Length=348, Percent_Identity=25.5747126436782, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38679977, Length=348, Percent_Identity=25.5747126436782, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38679967, Length=348, Percent_Identity=25.5747126436782, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147362, Length=538, Percent_Identity=34.2007434944238, Blast_Score=294, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI25147359, Length=515, Percent_Identity=34.9514563106796, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17552936, Length=560, Percent_Identity=27.6785714285714, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71997163, Length=298, Percent_Identity=22.8187919463087, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324343, Length=359, Percent_Identity=24.7910863509749, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323863, Length=356, Percent_Identity=23.314606741573, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24586065, Length=528, Percent_Identity=27.8409090909091, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI161076407, Length=365, Percent_Identity=23.5616438356164, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24586460, Length=365, Percent_Identity=23.5616438356164, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161076409, Length=365, Percent_Identity=23.5616438356164, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24586458, Length=365, Percent_Identity=23.5616438356164, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 59916; Mature: 59916

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00639 THIOL_PROTEASE_HIS ; PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METMQYSLNNPFKESKAPETQTGIYDDALKLGKELIEKPFLGGGEDRIRVQHSKNRMTVW
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHH
ERIKVLTDEEPNITYQNWGPNLDGASIVTGILNIKGRDVAVYGHDFTLRAGSMDATNGSK
HHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCCHHH
LARLIQMAGTHGIPLIGMNDSAGAYVPAGVGGLDGYSEAFTALRKISGVVPSVMLMFGFN
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AGGGAYLPRQGSFMIQCDGTFFGLTGPGVVKSVLGEDISAEDLGGPKVHGQSGVVDLVTG
CCCCCCCCCCCCEEEEECCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEC
DELGSLRTAIRLLSYLPDNNHSFAPFYPTSDPVDRFIYEEDILFRKTFNSPTGMNTPFDI
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEECCCCCCCCCCEEH
TLYLQQICDHGEFFELQPQRARNIVTAFGRIGGHVVGFLANNSAVSSGQIDIGASRKGTR
HHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCCCCCCE
FVRFCNLYNIPMVFVEDTTGFLPGRDQEHNGIVLEGRKLLDSIIDLRTPRLTLIIRNAFG
EEEEECCCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHHCCCCEEEEEEEECCC
GAYATFNSYFTGASMVFALPTARIAVMGPAGKEYVYKDEITSVQKEFLANVKKGMSDKEA
CHHHHHHHHHCCCEEEEEECCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHH
AATRDAKLFEIGQRYEKELMNPKEALSLGSVSSIILPGFTRNVLSKNLSFLMSKYKPAEM
HHHCCHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
SGPQREFE
CCCCCCCC
>Mature Secondary Structure
METMQYSLNNPFKESKAPETQTGIYDDALKLGKELIEKPFLGGGEDRIRVQHSKNRMTVW
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHH
ERIKVLTDEEPNITYQNWGPNLDGASIVTGILNIKGRDVAVYGHDFTLRAGSMDATNGSK
HHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCCHHH
LARLIQMAGTHGIPLIGMNDSAGAYVPAGVGGLDGYSEAFTALRKISGVVPSVMLMFGFN
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AGGGAYLPRQGSFMIQCDGTFFGLTGPGVVKSVLGEDISAEDLGGPKVHGQSGVVDLVTG
CCCCCCCCCCCCEEEEECCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEC
DELGSLRTAIRLLSYLPDNNHSFAPFYPTSDPVDRFIYEEDILFRKTFNSPTGMNTPFDI
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEECCCCCCCCCCEEH
TLYLQQICDHGEFFELQPQRARNIVTAFGRIGGHVVGFLANNSAVSSGQIDIGASRKGTR
HHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEECCCCCCCE
FVRFCNLYNIPMVFVEDTTGFLPGRDQEHNGIVLEGRKLLDSIIDLRTPRLTLIIRNAFG
EEEEECCCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHHCCCCEEEEEEEECCC
GAYATFNSYFTGASMVFALPTARIAVMGPAGKEYVYKDEITSVQKEFLANVKKGMSDKEA
CHHHHHHHHHCCCEEEEEECCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHH
AATRDAKLFEIGQRYEKELMNPKEALSLGSVSSIILPGFTRNVLSKNLSFLMSKYKPAEM
HHHCCHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
SGPQREFE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]