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The map label for this gene is trpC [H]

Identifier: 183220594

GI number: 183220594

Start: 1249054

End: 1249830

Strand: Direct

Name: trpC [H]

Synonym: LEPBI_I1198

Alternate gene names: 183220594

Gene position: 1249054-1249830 (Clockwise)

Preceding gene: 183220593

Following gene: 183220595

Centisome position: 34.7

GC content: 38.22

Gene sequence:

>777_bases
TTGAATCCAATTTTACACAAAATTGTAGAAACAAAACACTCTGAAATCGAATTAAGTCGCGGTAAAACGTTACCCGACCG
AAAGATTCCCATTCGCGATTGGAAATCAAACCTCAAAACCAATTCGGTATCGGTGATTGCTGAATGTAAGAAGGGGAGTC
CAAGTGCTGGGATATTACGACCAGATTATCATCCTGTAGAAATTGCTAAGCTGTACGAAACTTCAGGAGCTGGAGCAATC
TCAGTTCTCACAGACCAATCTTATTTTTTTGGTTCCTTAAACGATTTAGAATCGGTTGCAAATCAAGTTTCTCTCCCCGT
CATACGAAAGGATTTCATCTTAGATCCAATTCAGATTGATGAAGCATACGCTTATGGTGCTTCTGCAATCTTACTCATTG
TCCGTATCCTGTCTCCATCACTTTTAAAATCATTACATGAACATGCCAACCGATTGGGGCTTGCTGTACTAGTTGAAACT
CATAATGAACTCGAAGTGAATCTGGCACTCGATGCAGGTGCCAATACCATCGGTATCAATACACGTGATTTAGATACATT
CCAAATTCATAAAAACCTAATTGAAGAAATTGCGCCAAAATTGGATCCATCCATCATTCGAGTGGCAGAATCGGGTATTG
AAAGTTATGAGGATTGGCAAAAGTATCGTGGAATGATCGATTCAATGTTAGTTGGAACCTTTTTTATGAAAAGTAAAAAT
ATTCAGCATGATTTTTTTAGTCTCCTAAATGGTTCCAAACCAACCAAAACATCATAA

Upstream 100 bases:

>100_bases
ACCAGCAGTAAAAAGAATCTTTGATGTCATCGAACTGACGTCTTTATTTGATATTTATGATTCTGAAGACGCAGCGTTAA
AATCATTTTAACCAATCGAC

Downstream 100 bases:

>100_bases
TTGATTGTTAAATTTCAGAAAACTTTAAATTTAAAATAATTAAATGTTGTCTTTTTTTTAATCTACGATTCCCTATTTTT
TTAAGATTCACTTATGGACT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MNPILHKIVETKHSEIELSRGKTLPDRKIPIRDWKSNLKTNSVSVIAECKKGSPSAGILRPDYHPVEIAKLYETSGAGAI
SVLTDQSYFFGSLNDLESVANQVSLPVIRKDFILDPIQIDEAYAYGASAILLIVRILSPSLLKSLHEHANRLGLAVLVET
HNELEVNLALDAGANTIGINTRDLDTFQIHKNLIEEIAPKLDPSIIRVAESGIESYEDWQKYRGMIDSMLVGTFFMKSKN
IQHDFFSLLNGSKPTKTS

Sequences:

>Translated_258_residues
MNPILHKIVETKHSEIELSRGKTLPDRKIPIRDWKSNLKTNSVSVIAECKKGSPSAGILRPDYHPVEIAKLYETSGAGAI
SVLTDQSYFFGSLNDLESVANQVSLPVIRKDFILDPIQIDEAYAYGASAILLIVRILSPSLLKSLHEHANRLGLAVLVET
HNELEVNLALDAGANTIGINTRDLDTFQIHKNLIEEIAPKLDPSIIRVAESGIESYEDWQKYRGMIDSMLVGTFFMKSKN
IQHDFFSLLNGSKPTKTS
>Mature_258_residues
MNPILHKIVETKHSEIELSRGKTLPDRKIPIRDWKSNLKTNSVSVIAECKKGSPSAGILRPDYHPVEIAKLYETSGAGAI
SVLTDQSYFFGSLNDLESVANQVSLPVIRKDFILDPIQIDEAYAYGASAILLIVRILSPSLLKSLHEHANRLGLAVLVET
HNELEVNLALDAGANTIGINTRDLDTFQIHKNLIEEIAPKLDPSIIRVAESGIESYEDWQKYRGMIDSMLVGTFFMKSKN
IQHDFFSLLNGSKPTKTS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=247, Percent_Identity=36.4372469635627, Blast_Score=144, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6322638, Length=224, Percent_Identity=35.7142857142857, Blast_Score=125, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28652; Mature: 28652

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPILHKIVETKHSEIELSRGKTLPDRKIPIRDWKSNLKTNSVSVIAECKKGSPSAGILR
CCHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHCCCCCCHHEEEECCCCCCCCCCCC
PDYHPVEIAKLYETSGAGAISVLTDQSYFFGSLNDLESVANQVSLPVIRKDFILDPIQID
CCCCHHHHHHHHHCCCCCEEEEEECCCHHCCCHHHHHHHHHHHCCCHHHHHHCCCCHHHH
EAYAYGASAILLIVRILSPSLLKSLHEHANRLGLAVLVETHNELEVNLALDAGANTIGIN
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEECCCCEECCC
TRDLDTFQIHKNLIEEIAPKLDPSIIRVAESGIESYEDWQKYRGMIDSMLVGTFFMKSKN
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IQHDFFSLLNGSKPTKTS
CHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNPILHKIVETKHSEIELSRGKTLPDRKIPIRDWKSNLKTNSVSVIAECKKGSPSAGILR
CCHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHCCCCCCHHEEEECCCCCCCCCCCC
PDYHPVEIAKLYETSGAGAISVLTDQSYFFGSLNDLESVANQVSLPVIRKDFILDPIQID
CCCCHHHHHHHHHCCCCCEEEEEECCCHHCCCHHHHHHHHHHHCCCHHHHHHCCCCHHHH
EAYAYGASAILLIVRILSPSLLKSLHEHANRLGLAVLVETHNELEVNLALDAGANTIGIN
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEECCCCEECCC
TRDLDTFQIHKNLIEEIAPKLDPSIIRVAESGIESYEDWQKYRGMIDSMLVGTFFMKSKN
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IQHDFFSLLNGSKPTKTS
CHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA