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The map label for this gene is cysJ [H]

Identifier: 183220576

GI number: 183220576

Start: 1226690

End: 1228453

Strand: Direct

Name: cysJ [H]

Synonym: LEPBI_I1180

Alternate gene names: 183220576

Gene position: 1226690-1228453 (Clockwise)

Preceding gene: 183220573

Following gene: 183220577

Centisome position: 34.08

GC content: 38.72

Gene sequence:

>1764_bases
ATGTTATCCGATGAGAAACGCAATCGATTTTTACAATTACTGAAAGAATCCACAAAAGATGAATGGGTGTGGATGTCGGG
TTACCTATCAGCGCTCACCCAAGCAAGCATTGGGGGGAGTGTGGATGTTTCCTTGAATGCCCCGGTGAGTATTTCCTCAA
ATGACCCTTCACATGGGAATTTGAAAGCCGCGCCCATCCAGTGCACTGTTGTGTATGGAACAGAAACTGGGAATTCGAAA
AAACTGGCTACAGAACTTGTCAAAAAACTAAAAGAACTCGGTGTCCAAGCAAAACTAAAAAGTACTGACACGTATAAGGC
AAAAGACCTAAAAGAAGAAGAGTATTTGTTTGTGATCGTATCCACACATGGGGACGGCGAACCGCCTCAAGCCGCAAAAC
CCTTCATTCAAATTTTATCAGATGCAAAAGATTCTTTGTCAAAAATGAAGTTCGCCGTGCTTGGATTAGGTGATACTAGT
TACCCACTGTTTTGCCAAACAGGAATTGATGTGGATTCAATGTTGGAAAAATTAGGGGCTGAACGTATCCACGATCTTGG
AAAATGTGACGTAGATTTTGAACTGGTATCAAAACCATGGATAACAGATCTCATTTCTAAACTCAATGCTATATCCAAAA
CGGCAACCACACAAGTCTCTAAACAAACTCAAACGACAGCGTCCAAACCTAATTCAGGTGGAAAAGTAGTATATGAAGGT
ACAATTGTCACAAATCTTGTGTTAAACGATATTGGGGCAACAAAATCCACTCGTCATATTGAAATCAAAAGCTCTCTTCC
TGTTGATTATTTACCAGGTGATAGCGCTGGATTTTTAGCATACAACCGCGAAGATGAAGTGAATCGAATTTTGGGATTAT
TACAAACAGACAGAGAAACAAGGGTCACCTACAAAGGGGAAACTTGGATGTTGTACGATTTACTTCGCAAAAAAGTATCC
ATTCGTTTTTTACCTGACCGAGTGATCCAAAAGTATGTATCACTTTCTAAAAAAGAAATTCCTTCTGGTAAATTGGATTT
AGATGTATTATTGACACTGTATCCAAGTGATACAAAGCTCGAGATTCAATCGATCGTTGATATTTTGGAACCGATAGTTC
CAAGGTATTATTCCATTGCATCTAGTCCATCGGCACATGGAGAAGAGGAAGTCCACCTAACGGTAGCTGAGGTGGAAATC
GAAACCTTCACAGGTATCAAAACAGGTTTTTGTTCTGGGTTTCTTTCTTCATTAAAAGAAGGAGATACAGTTCCATTTTT
CATTCAAAAAAATAATTCCTTTCGCCTTCCTAGTCCCGATACTGATATCATCATGATTGGGCCAGGAACAGGCATTGCTC
CATTTCGCAGTTTTTTATTTGAAAGGGAACAGTCTGGTGGGAATGGGAAAAATTGGTTATTTTTTGGGGAAAGAAATTTT
GTCTCTGATTTTTATTACCAAACAGAACTTCTCGAGCTAATGGACACAGGTGTACTTCATAAATTGAATACAGCATTTTC
TCGTGATACAAAAGAGAAAGTTTATGTCCAAGACCGAATGGGTGAAAATGCAGAAGAACTTTTGAAATGGATTCAAAATG
GTGCTGTCATTTATCTATGTGGGTCAAAGGATCCTATGAGTAAAGACGTAGATCGTAAGTTAATTGAAATTTTATCGGAA
AGAACTTTTGATACTGGAAAAGAAGCTTCTGATTATCTAAAAGAATTGGAAGAAAACGGCCGTTACATCAAGGACGTTTA
CTGA

Upstream 100 bases:

>100_bases
CTCCATTTTTTTGGTTTACTCGTCTCGAACCCCAGGAAAAGATTCAATTTATAAGACTTTTTGGATGTTTTACTGGAATC
CAACACAAGCATAGGTTTTT

Downstream 100 bases:

>100_bases
GGAACCCATGGCAGAAACTAAAAAAGAAACTCTCGCAGAAAAAGTAAAAAGACTAAGCCGGGGCCTTCGAGGATCACTCG
TCGATAGTTTAAAGGATGAA

Product: sulfite reductase flavoprotein subunit alpha

Products: NA

Alternate protein names: SiR-FP [H]

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MLSDEKRNRFLQLLKESTKDEWVWMSGYLSALTQASIGGSVDVSLNAPVSISSNDPSHGNLKAAPIQCTVVYGTETGNSK
KLATELVKKLKELGVQAKLKSTDTYKAKDLKEEEYLFVIVSTHGDGEPPQAAKPFIQILSDAKDSLSKMKFAVLGLGDTS
YPLFCQTGIDVDSMLEKLGAERIHDLGKCDVDFELVSKPWITDLISKLNAISKTATTQVSKQTQTTASKPNSGGKVVYEG
TIVTNLVLNDIGATKSTRHIEIKSSLPVDYLPGDSAGFLAYNREDEVNRILGLLQTDRETRVTYKGETWMLYDLLRKKVS
IRFLPDRVIQKYVSLSKKEIPSGKLDLDVLLTLYPSDTKLEIQSIVDILEPIVPRYYSIASSPSAHGEEEVHLTVAEVEI
ETFTGIKTGFCSGFLSSLKEGDTVPFFIQKNNSFRLPSPDTDIIMIGPGTGIAPFRSFLFEREQSGGNGKNWLFFGERNF
VSDFYYQTELLELMDTGVLHKLNTAFSRDTKEKVYVQDRMGENAEELLKWIQNGAVIYLCGSKDPMSKDVDRKLIEILSE
RTFDTGKEASDYLKELEENGRYIKDVY

Sequences:

>Translated_587_residues
MLSDEKRNRFLQLLKESTKDEWVWMSGYLSALTQASIGGSVDVSLNAPVSISSNDPSHGNLKAAPIQCTVVYGTETGNSK
KLATELVKKLKELGVQAKLKSTDTYKAKDLKEEEYLFVIVSTHGDGEPPQAAKPFIQILSDAKDSLSKMKFAVLGLGDTS
YPLFCQTGIDVDSMLEKLGAERIHDLGKCDVDFELVSKPWITDLISKLNAISKTATTQVSKQTQTTASKPNSGGKVVYEG
TIVTNLVLNDIGATKSTRHIEIKSSLPVDYLPGDSAGFLAYNREDEVNRILGLLQTDRETRVTYKGETWMLYDLLRKKVS
IRFLPDRVIQKYVSLSKKEIPSGKLDLDVLLTLYPSDTKLEIQSIVDILEPIVPRYYSIASSPSAHGEEEVHLTVAEVEI
ETFTGIKTGFCSGFLSSLKEGDTVPFFIQKNNSFRLPSPDTDIIMIGPGTGIAPFRSFLFEREQSGGNGKNWLFFGERNF
VSDFYYQTELLELMDTGVLHKLNTAFSRDTKEKVYVQDRMGENAEELLKWIQNGAVIYLCGSKDPMSKDVDRKLIEILSE
RTFDTGKEASDYLKELEENGRYIKDVY
>Mature_587_residues
MLSDEKRNRFLQLLKESTKDEWVWMSGYLSALTQASIGGSVDVSLNAPVSISSNDPSHGNLKAAPIQCTVVYGTETGNSK
KLATELVKKLKELGVQAKLKSTDTYKAKDLKEEEYLFVIVSTHGDGEPPQAAKPFIQILSDAKDSLSKMKFAVLGLGDTS
YPLFCQTGIDVDSMLEKLGAERIHDLGKCDVDFELVSKPWITDLISKLNAISKTATTQVSKQTQTTASKPNSGGKVVYEG
TIVTNLVLNDIGATKSTRHIEIKSSLPVDYLPGDSAGFLAYNREDEVNRILGLLQTDRETRVTYKGETWMLYDLLRKKVS
IRFLPDRVIQKYVSLSKKEIPSGKLDLDVLLTLYPSDTKLEIQSIVDILEPIVPRYYSIASSPSAHGEEEVHLTVAEVEI
ETFTGIKTGFCSGFLSSLKEGDTVPFFIQKNNSFRLPSPDTDIIMIGPGTGIAPFRSFLFEREQSGGNGKNWLFFGERNF
VSDFYYQTELLELMDTGVLHKLNTAFSRDTKEKVYVQDRMGENAEELLKWIQNGAVIYLCGSKDPMSKDVDRKLIEILSE
RTFDTGKEASDYLKELEENGRYIKDVY

Specific function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow f

COG id: COG0369

COG function: function code P; Sulfite reductase, alpha subunit (flavoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 flavodoxin-like domain [H]

Homologues:

Organism=Homo sapiens, GI127139033, Length=606, Percent_Identity=28.5478547854785, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI24041029, Length=598, Percent_Identity=29.4314381270903, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI10835173, Length=656, Percent_Identity=27.2865853658537, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI7657393, Length=600, Percent_Identity=27.3333333333333, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI221316709, Length=600, Percent_Identity=27.1666666666667, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI221316705, Length=609, Percent_Identity=26.9293924466338, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI221316707, Length=506, Percent_Identity=27.6679841897233, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI169790956, Length=446, Percent_Identity=27.8026905829596, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI169790958, Length=446, Percent_Identity=27.5784753363229, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI40254422, Length=226, Percent_Identity=38.4955752212389, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI50726981, Length=193, Percent_Identity=29.5336787564767, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1789123, Length=539, Percent_Identity=35.4359925788497, Blast_Score=317, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17554134, Length=609, Percent_Identity=27.9146141215107, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17566446, Length=586, Percent_Identity=27.3037542662116, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17531441, Length=263, Percent_Identity=27.7566539923954, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32563863, Length=125, Percent_Identity=28.8, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321143, Length=268, Percent_Identity=33.5820895522388, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321832, Length=179, Percent_Identity=41.8994413407821, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6325305, Length=236, Percent_Identity=33.0508474576271, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17137192, Length=618, Percent_Identity=28.9644012944984, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24582192, Length=518, Percent_Identity=28.7644787644788, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI78706872, Length=524, Percent_Identity=28.0534351145038, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24583543, Length=524, Percent_Identity=28.0534351145038, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI78706876, Length=524, Percent_Identity=28.0534351145038, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24660907, Length=247, Percent_Identity=33.1983805668016, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24660903, Length=247, Percent_Identity=33.1983805668016, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24647438, Length=391, Percent_Identity=23.7851662404092, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010199
- InterPro:   IPR003097
- InterPro:   IPR017927
- InterPro:   IPR001094
- InterPro:   IPR008254
- InterPro:   IPR001709
- InterPro:   IPR023173
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00667 FAD_binding_1; PF00258 Flavodoxin_1; PF00175 NAD_binding_1 [H]

EC number: =1.8.1.2 [H]

Molecular weight: Translated: 65513; Mature: 65513

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50902 FLAVODOXIN_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDEKRNRFLQLLKESTKDEWVWMSGYLSALTQASIGGSVDVSLNAPVSISSNDPSHGN
CCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCC
LKAAPIQCTVVYGTETGNSKKLATELVKKLKELGVQAKLKSTDTYKAKDLKEEEYLFVIV
EEECCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEEEE
STHGDGEPPQAAKPFIQILSDAKDSLSKMKFAVLGLGDTSYPLFCQTGIDVDSMLEKLGA
EECCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCEEEECCCCHHHHHHHHCH
ERIHDLGKCDVDFELVSKPWITDLISKLNAISKTATTQVSKQTQTTASKPNSGGKVVYEG
HHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
TIVTNLVLNDIGATKSTRHIEIKSSLPVDYLPGDSAGFLAYNREDEVNRILGLLQTDRET
EEEEHHHHHHCCCCCCCEEEEEECCCCEEECCCCCCCEEEECCCHHHHHHHHHHHCCCCC
RVTYKGETWMLYDLLRKKVSIRFLPDRVIQKYVSLSKKEIPSGKLDLDVLLTLYPSDTKL
EEEECCCEEHHHHHHHHHHEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCC
EIQSIVDILEPIVPRYYSIASSPSAHGEEEVHLTVAEVEIETFTGIKTGFCSGFLSSLKE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEHHCCCHHHHHHHHHHHHHC
GDTVPFFIQKNNSFRLPSPDTDIIMIGPGTGIAPFRSFLFEREQSGGNGKNWLFFGERNF
CCCCEEEEECCCCEECCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCH
VSDFYYQTELLELMDTGVLHKLNTAFSRDTKEKVYVQDRMGENAEELLKWIQNGAVIYLC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEHHHCCCCHHHHHHHHHCCCEEEEE
GSKDPMSKDVDRKLIEILSERTFDTGKEASDYLKELEENGRYIKDVY
CCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure
MLSDEKRNRFLQLLKESTKDEWVWMSGYLSALTQASIGGSVDVSLNAPVSISSNDPSHGN
CCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCC
LKAAPIQCTVVYGTETGNSKKLATELVKKLKELGVQAKLKSTDTYKAKDLKEEEYLFVIV
EEECCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEEEE
STHGDGEPPQAAKPFIQILSDAKDSLSKMKFAVLGLGDTSYPLFCQTGIDVDSMLEKLGA
EECCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCEEEECCCCHHHHHHHHCH
ERIHDLGKCDVDFELVSKPWITDLISKLNAISKTATTQVSKQTQTTASKPNSGGKVVYEG
HHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
TIVTNLVLNDIGATKSTRHIEIKSSLPVDYLPGDSAGFLAYNREDEVNRILGLLQTDRET
EEEEHHHHHHCCCCCCCEEEEEECCCCEEECCCCCCCEEEECCCHHHHHHHHHHHCCCCC
RVTYKGETWMLYDLLRKKVSIRFLPDRVIQKYVSLSKKEIPSGKLDLDVLLTLYPSDTKL
EEEECCCEEHHHHHHHHHHEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCC
EIQSIVDILEPIVPRYYSIASSPSAHGEEEVHLTVAEVEIETFTGIKTGFCSGFLSSLKE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEHHCCCHHHHHHHHHHHHHC
GDTVPFFIQKNNSFRLPSPDTDIIMIGPGTGIAPFRSFLFEREQSGGNGKNWLFFGERNF
CCCCEEEEECCCCEECCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCH
VSDFYYQTELLELMDTGVLHKLNTAFSRDTKEKVYVQDRMGENAEELLKWIQNGAVIYLC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEHHHCCCCHHHHHHHHHCCCEEEEE
GSKDPMSKDVDRKLIEILSERTFDTGKEASDYLKELEENGRYIKDVY
CCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA