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The map label for this gene is cyaA [H]

Identifier: 183220481

GI number: 183220481

Start: 1127169

End: 1128401

Strand: Direct

Name: cyaA [H]

Synonym: LEPBI_I1080

Alternate gene names: 183220481

Gene position: 1127169-1128401 (Clockwise)

Preceding gene: 183220480

Following gene: 183220486

Centisome position: 31.31

GC content: 34.87

Gene sequence:

>1233_bases
ATGAAACAATCATTAGTTGAAGAAATATTAATTGCCAGAGAAATGAAAAACGAAAAGACGGTGGCTCTTGTTCGATTTGT
TTTATTTTCTGTCACATCCATAATGGATTTTGTATCTTATTTGGGTTGGATCAACTATACAATCGTGACTCCAAGCTTTA
TCACCGTAGCATTAGATTTTGTATTTTTATTGTTTGCAAGTATAGTGTTATTTATCGTAAATTTTTTACCTTATCAACCG
TATCTAAAATTTTTCACAATTACTTTGGATTATTTTATTATTGGGTTAATGATTTTTTTGGATCCGACGATCCAGAAAGG
AAATGGTTTGATATACTTTATTGCTATGACTAGCGCAATTTTCGTTTACCAGTTCAACCAATTGAGACATTCAAAAACGG
GAACAATCTACGGAGCTTTTTTAGCTTTTGTTTATTTTGTGGTAATCTCATTCGGTTTAGGGGAAGAGTATCCATTTGAT
ATTTTGCCAATGATGATTGGACTCGCAATGATCCTAGGAGTTGGTTATGTGACAACTGTTTCGAATATTGAAATGGTGAA
AGAGGCCAATACAAAACAAATGATGGAAAGATATTTACCTTCCCAACTCGTAAGTGAATTTTACAAAAATAAAGTTCAGT
TGGAACCTGGTGGAGAAAATAAGGAAGTCACCATACTTTTTTCCGATATTCGTTCCTTTACTAAATTTTCAGAACAAAGG
ACTGCAGAAGAGGTGGTTCTTTTCTTAAATGAATATTTGTCTCGAATGACCGATGTCATTTTTAAATTTAATGGAACTAT
AGATAAGTTTATCGGTGATGCGATAATGACTGTCTTTGGAGCTCCTTTTAAAAATGAGGATGATGCTCTTCAGGCCGTCA
AAACAGCCGTGGAAATGATTCGTGAACTTACAAAATTAAATCAAAATATGGATCTAGGAAGTGACGATTTAAAAGTTGGT
ATTGGGATTCACACAGGTGAGGCGATTGTGGGAAACATTGGATCCGATCGAAGATTGGATTACACCGTAATCGGTGATAA
TGTGAATTTAGCTTCGAGGATTGAGGGGTTAACAAAACATTACGGGTGTTCGATTCTTATATCGGATACAACCTATCTTC
AAATTGAAGGAAAGTATGGAGATCCGGATGGGTTTGTTGTCCGAGAAATTGATCTAGTGGTCGTGAAAGGAAAATCGAAA
GCCATCACGATCTATGAAGTCGTAGTTTTATAA

Upstream 100 bases:

>100_bases
TTTGAATCTATTTCCATTGGATCAAATGAATCCGTGATTTTAAAAATTCGGTACAGACAAAGAGTTGGTTTTTTTGATCC
TTACCAAGGCGGAGCATTGA

Downstream 100 bases:

>100_bases
TGTCGTAATCAAGTGAACATTAGCTGATACCAAAAACACTTGTAGTCGCAATAAAAATTCCAAAAATCTAAAACCTAAAT
TGATGCGAGTCATAGCTTTG

Product: putative adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKQSLVEEILIAREMKNEKTVALVRFVLFSVTSIMDFVSYLGWINYTIVTPSFITVALDFVFLLFASIVLFIVNFLPYQP
YLKFFTITLDYFIIGLMIFLDPTIQKGNGLIYFIAMTSAIFVYQFNQLRHSKTGTIYGAFLAFVYFVVISFGLGEEYPFD
ILPMMIGLAMILGVGYVTTVSNIEMVKEANTKQMMERYLPSQLVSEFYKNKVQLEPGGENKEVTILFSDIRSFTKFSEQR
TAEEVVLFLNEYLSRMTDVIFKFNGTIDKFIGDAIMTVFGAPFKNEDDALQAVKTAVEMIRELTKLNQNMDLGSDDLKVG
IGIHTGEAIVGNIGSDRRLDYTVIGDNVNLASRIEGLTKHYGCSILISDTTYLQIEGKYGDPDGFVVREIDLVVVKGKSK
AITIYEVVVL

Sequences:

>Translated_410_residues
MKQSLVEEILIAREMKNEKTVALVRFVLFSVTSIMDFVSYLGWINYTIVTPSFITVALDFVFLLFASIVLFIVNFLPYQP
YLKFFTITLDYFIIGLMIFLDPTIQKGNGLIYFIAMTSAIFVYQFNQLRHSKTGTIYGAFLAFVYFVVISFGLGEEYPFD
ILPMMIGLAMILGVGYVTTVSNIEMVKEANTKQMMERYLPSQLVSEFYKNKVQLEPGGENKEVTILFSDIRSFTKFSEQR
TAEEVVLFLNEYLSRMTDVIFKFNGTIDKFIGDAIMTVFGAPFKNEDDALQAVKTAVEMIRELTKLNQNMDLGSDDLKVG
IGIHTGEAIVGNIGSDRRLDYTVIGDNVNLASRIEGLTKHYGCSILISDTTYLQIEGKYGDPDGFVVREIDLVVVKGKSK
AITIYEVVVL
>Mature_410_residues
MKQSLVEEILIAREMKNEKTVALVRFVLFSVTSIMDFVSYLGWINYTIVTPSFITVALDFVFLLFASIVLFIVNFLPYQP
YLKFFTITLDYFIIGLMIFLDPTIQKGNGLIYFIAMTSAIFVYQFNQLRHSKTGTIYGAFLAFVYFVVISFGLGEEYPFD
ILPMMIGLAMILGVGYVTTVSNIEMVKEANTKQMMERYLPSQLVSEFYKNKVQLEPGGENKEVTILFSDIRSFTKFSEQR
TAEEVVLFLNEYLSRMTDVIFKFNGTIDKFIGDAIMTVFGAPFKNEDDALQAVKTAVEMIRELTKLNQNMDLGSDDLKVG
IGIHTGEAIVGNIGSDRRLDYTVIGDNVNLASRIEGLTKHYGCSILISDTTYLQIEGKYGDPDGFVVREIDLVVVKGKSK
AITIYEVVVL

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI10181096, Length=182, Percent_Identity=31.3186813186813, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI10947061, Length=182, Percent_Identity=31.3186813186813, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI50959205, Length=185, Percent_Identity=28.1081081081081, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI148536830, Length=188, Percent_Identity=26.063829787234, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI24497587, Length=138, Percent_Identity=27.536231884058, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI31083193, Length=196, Percent_Identity=29.0816326530612, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4580422, Length=204, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI167830411, Length=238, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71989805, Length=160, Percent_Identity=33.75, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71989822, Length=160, Percent_Identity=33.75, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508769, Length=144, Percent_Identity=34.7222222222222, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551720, Length=205, Percent_Identity=27.8048780487805, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534659, Length=229, Percent_Identity=27.9475982532751, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193208534, Length=172, Percent_Identity=29.0697674418605, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193206632, Length=181, Percent_Identity=32.0441988950276, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561804, Length=238, Percent_Identity=28.1512605042017, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995895, Length=194, Percent_Identity=30.4123711340206, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI281366459, Length=228, Percent_Identity=32.0175438596491, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281366457, Length=228, Percent_Identity=32.0175438596491, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281366455, Length=228, Percent_Identity=32.0175438596491, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI56292422, Length=228, Percent_Identity=32.0175438596491, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI56292424, Length=228, Percent_Identity=32.0175438596491, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24666940, Length=228, Percent_Identity=32.0175438596491, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161078020, Length=220, Percent_Identity=30.4545454545455, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24647268, Length=184, Percent_Identity=32.0652173913043, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24651577, Length=234, Percent_Identity=28.2051282051282, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI62484298, Length=211, Percent_Identity=30.8056872037915, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI62484477, Length=210, Percent_Identity=30.952380952381, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585694, Length=180, Percent_Identity=27.2222222222222, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116008008, Length=210, Percent_Identity=30.952380952381, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574512, Length=234, Percent_Identity=29.9145299145299, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161076872, Length=234, Percent_Identity=29.9145299145299, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281366320, Length=157, Percent_Identity=32.484076433121, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24642014, Length=199, Percent_Identity=27.6381909547739, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI62473752, Length=175, Percent_Identity=30.8571428571429, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137448, Length=175, Percent_Identity=30.8571428571429, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583978, Length=137, Percent_Identity=29.9270072992701, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI161084260, Length=157, Percent_Identity=32.484076433121, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24663839, Length=171, Percent_Identity=30.9941520467836, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24663843, Length=224, Percent_Identity=29.0178571428571, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281365507, Length=371, Percent_Identity=23.989218328841, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281365509, Length=371, Percent_Identity=23.989218328841, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24583976, Length=148, Percent_Identity=28.3783783783784, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221330468, Length=235, Percent_Identity=28.936170212766, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221330470, Length=235, Percent_Identity=28.936170212766, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 46296; Mature: 46296

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSLVEEILIAREMKNEKTVALVRFVLFSVTSIMDFVSYLGWINYTIVTPSFITVALDF
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHH
VFLLFASIVLFIVNFLPYQPYLKFFTITLDYFIIGLMIFLDPTIQKGNGLIYFIAMTSAI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEHHHHHHH
FVYQFNQLRHSKTGTIYGAFLAFVYFVVISFGLGEEYPFDILPMMIGLAMILGVGYVTTV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHH
SNIEMVKEANTKQMMERYLPSQLVSEFYKNKVQLEPGGENKEVTILFSDIRSFTKFSEQR
HHHHHHHHCCHHHHHHHHCHHHHHHHHHHCEEEECCCCCCCEEEEEHHHHHHHHHHHHHH
TAEEVVLFLNEYLSRMTDVIFKFNGTIDKFIGDAIMTVFGAPFKNEDDALQAVKTAVEMI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
RELTKLNQNMDLGSDDLKVGIGIHTGEAIVGNIGSDRRLDYTVIGDNVNLASRIEGLTKH
HHHHHHCCCCCCCCCCEEEEEEEECCCHHEECCCCCCEEEEEEECCCCCHHHHHHHHHHH
YGCSILISDTTYLQIEGKYGDPDGFVVREIDLVVVKGKSKAITIYEVVVL
CCCEEEEECCEEEEEECCCCCCCCEEEEEEEEEEEECCCCEEEEEEEEEC
>Mature Secondary Structure
MKQSLVEEILIAREMKNEKTVALVRFVLFSVTSIMDFVSYLGWINYTIVTPSFITVALDF
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHH
VFLLFASIVLFIVNFLPYQPYLKFFTITLDYFIIGLMIFLDPTIQKGNGLIYFIAMTSAI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEHHHHHHH
FVYQFNQLRHSKTGTIYGAFLAFVYFVVISFGLGEEYPFDILPMMIGLAMILGVGYVTTV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHH
SNIEMVKEANTKQMMERYLPSQLVSEFYKNKVQLEPGGENKEVTILFSDIRSFTKFSEQR
HHHHHHHHCCHHHHHHHHCHHHHHHHHHHCEEEECCCCCCCEEEEEHHHHHHHHHHHHHH
TAEEVVLFLNEYLSRMTDVIFKFNGTIDKFIGDAIMTVFGAPFKNEDDALQAVKTAVEMI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
RELTKLNQNMDLGSDDLKVGIGIHTGEAIVGNIGSDRRLDYTVIGDNVNLASRIEGLTKH
HHHHHHCCCCCCCCCCEEEEEEEECCCHHEECCCCCCEEEEEEECCCCCHHHHHHHHHHH
YGCSILISDTTYLQIEGKYGDPDGFVVREIDLVVVKGKSKAITIYEVVVL
CCCEEEEECCEEEEEECCCCCCCCEEEEEEEEEEEECCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]