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The map label for this gene is pdxA [H]

Identifier: 183220451

GI number: 183220451

Start: 1090276

End: 1091220

Strand: Direct

Name: pdxA [H]

Synonym: LEPBI_I1048

Alternate gene names: 183220451

Gene position: 1090276-1091220 (Clockwise)

Preceding gene: 183220450

Following gene: 183220452

Centisome position: 30.29

GC content: 47.09

Gene sequence:

>945_bases
TTGAAAACCATCCTCATTTCGGAAGGGGATCCCACGAGTATCAATTATGAGCTTTTGGAATCAACCTTCCCTCTCTTACA
ATCCTTAGGAAAAGAGCACCGCATTTATCTCATCCGAGGTTCCCACAACCAAACCCTTCCTTCCCTTCCCAATCTCACTG
CACCCATCGATGCCCCAGGATTCTATTCCATCACTTGGAAGGGAGGTGGGAAATCCAAATCCTTTGTACTGGGAAAACCT
TCTCGAGCTTCCGGGAAAATGGCATATGACTCACTCCTTTCGGCCATCGACCTGCAAAAAGAAACTGGTGCGGACCTCAT
CACCCTCCCACTTTCGAAAGAGTGGGTGGTGAAAGCAGGGATCAACGGATTCCGAGGCCATACAGAAACTTTGGCGGATG
CATACAAGAGACCTACATTTATGATGATGTCAGGAGAGAAACTCAACGTGATCCCACTGACAACCCATGTCCCTTTAAAA
GATGTTGTCCGCGAGTTAACCAAATTCAATTGGAAAGAACTTGGTCGGGCGATCACCCAATCTCCTTATTTACACCATCC
AAAGATTGGGTATTTGGGACTGAACCCCCATGCAGGGGAAGGGGGAAAAATCGGGAAGGAAGAAACGACCCTCCTGAAGC
AGGGAGTTTCCATTTTGCGAAAGGCAAAATTATCCTTGGAAGGACCTCTCTCTGCAGATTCCGCTTTTTTACCAGATGCC
AAACCGTACGATTTGTATTTAGCAGGTTACCATGACCAAGGTCTCATCCCATTTAAATTGCTTGAAGGAAAGAAGGGTGT
GAACATAACCTTAGGTCTGGATTTCACTCGTGTTTCCCCAGACCATGGAACCGCCTTTGGGATTGCGGGGAAGGGATGCG
CAGATCCTACGGGACTCATTTCCTGCTTAGAACGACTTGTGGAGAGAAAAACAAAACCAATATGA

Upstream 100 bases:

>100_bases
CTTAAAACATAGCGCCAAAGACCTGATCGAATTGGAATACTCCAAAGATTCTCTCAGTGTCGAAAAGATTTTTGGGAAAC
AACCAAACGCCAAAGAATAA

Downstream 100 bases:

>100_bases
CACTTCTGGAAACTCTTGCCTTTCCTGTTCTTTTTATTTGGTTTGTGGGACTCCTCCTCACTTTTTTCCGAAGGGATTTA
GAACCTCATTGGAAGTTCTT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKTILISEGDPTSINYELLESTFPLLQSLGKEHRIYLIRGSHNQTLPSLPNLTAPIDAPGFYSITWKGGGKSKSFVLGKP
SRASGKMAYDSLLSAIDLQKETGADLITLPLSKEWVVKAGINGFRGHTETLADAYKRPTFMMMSGEKLNVIPLTTHVPLK
DVVRELTKFNWKELGRAITQSPYLHHPKIGYLGLNPHAGEGGKIGKEETTLLKQGVSILRKAKLSLEGPLSADSAFLPDA
KPYDLYLAGYHDQGLIPFKLLEGKKGVNITLGLDFTRVSPDHGTAFGIAGKGCADPTGLISCLERLVERKTKPI

Sequences:

>Translated_314_residues
MKTILISEGDPTSINYELLESTFPLLQSLGKEHRIYLIRGSHNQTLPSLPNLTAPIDAPGFYSITWKGGGKSKSFVLGKP
SRASGKMAYDSLLSAIDLQKETGADLITLPLSKEWVVKAGINGFRGHTETLADAYKRPTFMMMSGEKLNVIPLTTHVPLK
DVVRELTKFNWKELGRAITQSPYLHHPKIGYLGLNPHAGEGGKIGKEETTLLKQGVSILRKAKLSLEGPLSADSAFLPDA
KPYDLYLAGYHDQGLIPFKLLEGKKGVNITLGLDFTRVSPDHGTAFGIAGKGCADPTGLISCLERLVERKTKPI
>Mature_314_residues
MKTILISEGDPTSINYELLESTFPLLQSLGKEHRIYLIRGSHNQTLPSLPNLTAPIDAPGFYSITWKGGGKSKSFVLGKP
SRASGKMAYDSLLSAIDLQKETGADLITLPLSKEWVVKAGINGFRGHTETLADAYKRPTFMMMSGEKLNVIPLTTHVPLK
DVVRELTKFNWKELGRAITQSPYLHHPKIGYLGLNPHAGEGGKIGKEETTLLKQGVSILRKAKLSLEGPLSADSAFLPDA
KPYDLYLAGYHDQGLIPFKLLEGKKGVNITLGLDFTRVSPDHGTAFGIAGKGCADPTGLISCLERLVERKTKPI

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=241, Percent_Identity=39.4190871369295, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 34204; Mature: 34204

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTILISEGDPTSINYELLESTFPLLQSLGKEHRIYLIRGSHNQTLPSLPNLTAPIDAPG
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
FYSITWKGGGKSKSFVLGKPSRASGKMAYDSLLSAIDLQKETGADLITLPLSKEWVVKAG
EEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECC
INGFRGHTETLADAYKRPTFMMMSGEKLNVIPLTTHVPLKDVVRELTKFNWKELGRAITQ
CCCCCCCHHHHHHHHCCCEEEEECCCEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHC
SPYLHHPKIGYLGLNPHAGEGGKIGKEETTLLKQGVSILRKAKLSLEGPLSADSAFLPDA
CCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KPYDLYLAGYHDQGLIPFKLLEGKKGVNITLGLDFTRVSPDHGTAFGIAGKGCADPTGLI
CCCEEEEEEECCCCCEEEEEECCCCCCEEEEECEEEEECCCCCCEEECCCCCCCCHHHHH
SCLERLVERKTKPI
HHHHHHHHHHCCCC
>Mature Secondary Structure
MKTILISEGDPTSINYELLESTFPLLQSLGKEHRIYLIRGSHNQTLPSLPNLTAPIDAPG
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
FYSITWKGGGKSKSFVLGKPSRASGKMAYDSLLSAIDLQKETGADLITLPLSKEWVVKAG
EEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECC
INGFRGHTETLADAYKRPTFMMMSGEKLNVIPLTTHVPLKDVVRELTKFNWKELGRAITQ
CCCCCCCHHHHHHHHCCCEEEEECCCEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHC
SPYLHHPKIGYLGLNPHAGEGGKIGKEETTLLKQGVSILRKAKLSLEGPLSADSAFLPDA
CCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KPYDLYLAGYHDQGLIPFKLLEGKKGVNITLGLDFTRVSPDHGTAFGIAGKGCADPTGLI
CCCEEEEEEECCCCCEEEEEECCCCCCEEEEECEEEEECCCCCCEEECCCCCCCCHHHHH
SCLERLVERKTKPI
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA