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The map label for this gene is purM [H]

Identifier: 183220318

GI number: 183220318

Start: 944687

End: 945715

Strand: Direct

Name: purM [H]

Synonym: LEPBI_I0914

Alternate gene names: 183220318

Gene position: 944687-945715 (Clockwise)

Preceding gene: 183220317

Following gene: 183220329

Centisome position: 26.24

GC content: 35.76

Gene sequence:

>1029_bases
ATGTCTGACCAAAATAAAATTACATATAAAGATGCAGGAGTTGATACTGAAAAAGGGCAAGAATTTGTCAAAAGAATCAA
AGCAAACGTTGCCTCTACACATAATAAAAATGTTTTAGGTGGGTTAGGTGGATTTGCCGCCTGCTACGATGTTAGTTTTT
TGAAATCTTACCAGGAACCAATTTTACTTTCTGGGACCGACGGTGTTGGAACAAAACTTCAAATTGCAAGGCAACTTGGC
ATTCATAATACTGTTGGTATCGATTTGGTTGCAATGTGTGTGAACGATATTCTTGTGAATGGTGGGAAACCAATATTCTT
TCAAGATTATATTGCATGTGGAAAACTTCATTTACCAACAATGGAAGCAATCGTATCAGGTATTGTAAAAGGATGTAGTT
TGGCAGATTGTTCATTAGTTGGTGGTGAAACTGCGGAACATCCTGGTGTGATGCCTGATGATGAATATGATTTGGCAGGT
TTTGTTGTTGGGGTTGTGGAAAAAGGGAAAATGATTGATGGTAAAACCATTTCACCAGGAGATACGATCATTGGACTAAA
GTCTTCAGGTCCACATAGCAATGGTTTTTCTCTCATTCGAAAATTACTTTTAAAAGACGGCAAATTACCGACTTCACAAG
AACAAATTGATTTTATCAAAGATCATATTTTTGTTCCAACTAACATCTACGTAAAATCGATCTTATCTCTGATCGATAAA
ATTTCGATTAAAGGAATGGTTCATATCACAGGTGGTGGTTTTTATGAAAACATACCACGAGTATTGCCAGAGGGAGTTGG
TGCTGAAATTTTTTCCCTTCCTGAGTCTTACGTATTTTCTAAATTAGAAAAAGATCACTCATTAGACCGAAATGATATGT
ATGGAACATTTAATATGGGGATTGGTTATATATTGGTTGTTGATTCAAGCTTAGTTGATGCCACTATGAATGAACTGCAT
GTCCTTGGTGAAGATTCTTTTGTTATTGGAAAAACCAATGACTCCGGAAAAATTTCCATTACATTGTAA

Upstream 100 bases:

>100_bases
ACTTCGGATTCAGATTATGTTCATCTTGCAAGCCGAATTGCAAAAACAATCACACCCAATCATACATTGTCATTAATTAA
TACTACAATAGGAAAACTCC

Downstream 100 bases:

>100_bases
TTGGGAAACTAACTCTGAATATGGTTCTACCAGGAGCAGATTCAAAACTAATGTTTGCGTTGTGTCGGTTTACGATTTCT
TTCACAAGATAAAGTCCAAG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSDQNKITYKDAGVDTEKGQEFVKRIKANVASTHNKNVLGGLGGFAACYDVSFLKSYQEPILLSGTDGVGTKLQIARQLG
IHNTVGIDLVAMCVNDILVNGGKPIFFQDYIACGKLHLPTMEAIVSGIVKGCSLADCSLVGGETAEHPGVMPDDEYDLAG
FVVGVVEKGKMIDGKTISPGDTIIGLKSSGPHSNGFSLIRKLLLKDGKLPTSQEQIDFIKDHIFVPTNIYVKSILSLIDK
ISIKGMVHITGGGFYENIPRVLPEGVGAEIFSLPESYVFSKLEKDHSLDRNDMYGTFNMGIGYILVVDSSLVDATMNELH
VLGEDSFVIGKTNDSGKISITL

Sequences:

>Translated_342_residues
MSDQNKITYKDAGVDTEKGQEFVKRIKANVASTHNKNVLGGLGGFAACYDVSFLKSYQEPILLSGTDGVGTKLQIARQLG
IHNTVGIDLVAMCVNDILVNGGKPIFFQDYIACGKLHLPTMEAIVSGIVKGCSLADCSLVGGETAEHPGVMPDDEYDLAG
FVVGVVEKGKMIDGKTISPGDTIIGLKSSGPHSNGFSLIRKLLLKDGKLPTSQEQIDFIKDHIFVPTNIYVKSILSLIDK
ISIKGMVHITGGGFYENIPRVLPEGVGAEIFSLPESYVFSKLEKDHSLDRNDMYGTFNMGIGYILVVDSSLVDATMNELH
VLGEDSFVIGKTNDSGKISITL
>Mature_341_residues
SDQNKITYKDAGVDTEKGQEFVKRIKANVASTHNKNVLGGLGGFAACYDVSFLKSYQEPILLSGTDGVGTKLQIARQLGI
HNTVGIDLVAMCVNDILVNGGKPIFFQDYIACGKLHLPTMEAIVSGIVKGCSLADCSLVGGETAEHPGVMPDDEYDLAGF
VVGVVEKGKMIDGKTISPGDTIIGLKSSGPHSNGFSLIRKLLLKDGKLPTSQEQIDFIKDHIFVPTNIYVKSILSLIDKI
SIKGMVHITGGGFYENIPRVLPEGVGAEIFSLPESYVFSKLEKDHSLDRNDMYGTFNMGIGYILVVDSSLVDATMNELHV
LGEDSFVIGKTNDSGKISITL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=340, Percent_Identity=43.8235294117647, Blast_Score=278, Evalue=4e-75,
Organism=Homo sapiens, GI209869995, Length=340, Percent_Identity=43.8235294117647, Blast_Score=278, Evalue=4e-75,
Organism=Homo sapiens, GI209869993, Length=340, Percent_Identity=43.8235294117647, Blast_Score=278, Evalue=4e-75,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=49.8542274052478, Blast_Score=330, Evalue=7e-92,
Organism=Caenorhabditis elegans, GI17567511, Length=341, Percent_Identity=36.6568914956012, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321203, Length=346, Percent_Identity=39.3063583815029, Blast_Score=239, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24582400, Length=275, Percent_Identity=42.5454545454545, Blast_Score=198, Evalue=5e-51,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36750; Mature: 36619

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQNKITYKDAGVDTEKGQEFVKRIKANVASTHNKNVLGGLGGFAACYDVSFLKSYQEP
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCC
ILLSGTDGVGTKLQIARQLGIHNTVGIDLVAMCVNDILVNGGKPIFFQDYIACGKLHLPT
EEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCH
MEAIVSGIVKGCSLADCSLVGGETAEHPGVMPDDEYDLAGFVVGVVEKGKMIDGKTISPG
HHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHEEHHCCCCEECCCEECCC
DTIIGLKSSGPHSNGFSLIRKLLLKDGKLPTSQEQIDFIKDHIFVPTNIYVKSILSLIDK
CCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEECCCHHHHHHHHHHHHH
ISIKGMVHITGGGFYENIPRVLPEGVGAEIFSLPESYVFSKLEKDHSLDRNDMYGTFNMG
HCCCEEEEEECCCHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCEEECCC
IGYILVVDSSLVDATMNELHVLGEDSFVIGKTNDSGKISITL
CEEEEEECCHHHHHHHHHHEEECCCCEEEEECCCCCEEEEEC
>Mature Secondary Structure 
SDQNKITYKDAGVDTEKGQEFVKRIKANVASTHNKNVLGGLGGFAACYDVSFLKSYQEP
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCC
ILLSGTDGVGTKLQIARQLGIHNTVGIDLVAMCVNDILVNGGKPIFFQDYIACGKLHLPT
EEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCH
MEAIVSGIVKGCSLADCSLVGGETAEHPGVMPDDEYDLAGFVVGVVEKGKMIDGKTISPG
HHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHEEHHCCCCEECCCEECCC
DTIIGLKSSGPHSNGFSLIRKLLLKDGKLPTSQEQIDFIKDHIFVPTNIYVKSILSLIDK
CCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEECCCHHHHHHHHHHHHH
ISIKGMVHITGGGFYENIPRVLPEGVGAEIFSLPESYVFSKLEKDHSLDRNDMYGTFNMG
HCCCEEEEEECCCHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCEEECCC
IGYILVVDSSLVDATMNELHVLGEDSFVIGKTNDSGKISITL
CEEEEEECCHHHHHHHHHHEEECCCCEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA