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The map label for this gene is degP [H]

Identifier: 183220315

GI number: 183220315

Start: 941448

End: 942575

Strand: Direct

Name: degP [H]

Synonym: LEPBI_I0911

Alternate gene names: 183220315

Gene position: 941448-942575 (Clockwise)

Preceding gene: 183220313

Following gene: 183220316

Centisome position: 26.15

GC content: 47.61

Gene sequence:

>1128_bases
ATGGAAAGAAAACATTCGATTCCACCTGTCGTCTACATTAACTTTGCCTTAGTCTTTGTACTTTTGTTCGCAATTTTTTT
TCCTGAAATTCGTTCCGCTGTTACTAAACTTTTTTCATCACCCAAACCAATTTCAGCAAGTAAACAAAGCCAAGCCATCC
AAATCCAGTCGAGCTTTCGGAACGTATACCGAGAGGCGCAACAATTTGTTGTCTCGATTCGCACCAAAAAGACGGAGATG
ATTTTCCATCCTTATGCTTTCGGTGAAAGTAGGGAAGATCGGATTTCATCCATTGGAAGTGGCTTCATCATTGATGAACG
AGGGTTTGTGGTCACCAATTACCACGTCATTAAAAATGCGGAGATCATCGAAATCATCATGTCCGATGGTCGGATTTTCC
CTGCTCGGTATGTGGGAAGCCATGAGAGGGCCGACATTGCCCTCTTAAAAATCCCAAGTGAAGATAAGTTCATTCCTGCT
TTCCTTGGCAATTCTGATGAAATCGAAGTCGGAGATTGGGCGATTGCCGTCGGATCCCCTTATGGATTGGAAAAAACGTT
CACTGTGGGGGTGGTCTCCGCCAAATCCCGAGAGGACCTGGATGAAACTGGGCAGACCCATATCCAGACCGATACAGCCA
TCAATCCTGGCTCGAGCGGAGGTCCCCTCCTGAATATTTATGGAGAAGTCGTTGGGATCAACCGGATGATCCGGTCATCG
AGTGGAGCCAGTGCAGGGATTGGGTTTGCCATTCCCATCAATTATGCAAAACGTGTGCTCCGTCAGATTGAACAAAATGT
TGGTCAAAACATAAAACCAGCCACCTTAGGGGTTATGGCAACCACGCCACTCCCTGACCATAGGCGTTCCCTTGGAATTC
CAGGGGATGCCGTCGGCGTCCTTGTCTATGACATCGAGCCCAATTCGGCTGCGGAAAAAGGGGGGTTACGCCGTTACGAC
TTCATTGAAGGGGCCAATGGACTCGTTATCCGTCATATCAATGACCTTCGGGAACAGGTGGGTCTTGTGGGACTTGGGGG
CGTCTTACGGTTGAAGATATTAAGGGATACCCAAGAGATGGAATTATCGATCCCTTTGGTCGAAGCAGCCTACCAAAAGG
GCAAATAA

Upstream 100 bases:

>100_bases
TTAGAACCAAAGGAAAGTACAACAATGTCATCATCGTTTTCATCTTTTTCGTTCGACACGGAAGGGGAATCGGCAAGAGT
GGAAGGGGTTTAGGCATTCT

Downstream 100 bases:

>100_bases
TTTTATGAGAAGAAATATAGTCCATTCGGGTGCCGATGCACTCATTTACGAAATTCGCCAGATTGTGGCACTTGCCAAAC
AAATCGAAGCCATGGGTATC

Product: putative periplasmic trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MERKHSIPPVVYINFALVFVLLFAIFFPEIRSAVTKLFSSPKPISASKQSQAIQIQSSFRNVYREAQQFVVSIRTKKTEM
IFHPYAFGESREDRISSIGSGFIIDERGFVVTNYHVIKNAEIIEIIMSDGRIFPARYVGSHERADIALLKIPSEDKFIPA
FLGNSDEIEVGDWAIAVGSPYGLEKTFTVGVVSAKSREDLDETGQTHIQTDTAINPGSSGGPLLNIYGEVVGINRMIRSS
SGASAGIGFAIPINYAKRVLRQIEQNVGQNIKPATLGVMATTPLPDHRRSLGIPGDAVGVLVYDIEPNSAAEKGGLRRYD
FIEGANGLVIRHINDLREQVGLVGLGGVLRLKILRDTQEMELSIPLVEAAYQKGK

Sequences:

>Translated_375_residues
MERKHSIPPVVYINFALVFVLLFAIFFPEIRSAVTKLFSSPKPISASKQSQAIQIQSSFRNVYREAQQFVVSIRTKKTEM
IFHPYAFGESREDRISSIGSGFIIDERGFVVTNYHVIKNAEIIEIIMSDGRIFPARYVGSHERADIALLKIPSEDKFIPA
FLGNSDEIEVGDWAIAVGSPYGLEKTFTVGVVSAKSREDLDETGQTHIQTDTAINPGSSGGPLLNIYGEVVGINRMIRSS
SGASAGIGFAIPINYAKRVLRQIEQNVGQNIKPATLGVMATTPLPDHRRSLGIPGDAVGVLVYDIEPNSAAEKGGLRRYD
FIEGANGLVIRHINDLREQVGLVGLGGVLRLKILRDTQEMELSIPLVEAAYQKGK
>Mature_375_residues
MERKHSIPPVVYINFALVFVLLFAIFFPEIRSAVTKLFSSPKPISASKQSQAIQIQSSFRNVYREAQQFVVSIRTKKTEM
IFHPYAFGESREDRISSIGSGFIIDERGFVVTNYHVIKNAEIIEIIMSDGRIFPARYVGSHERADIALLKIPSEDKFIPA
FLGNSDEIEVGDWAIAVGSPYGLEKTFTVGVVSAKSREDLDETGQTHIQTDTAINPGSSGGPLLNIYGEVVGINRMIRSS
SGASAGIGFAIPINYAKRVLRQIEQNVGQNIKPATLGVMATTPLPDHRRSLGIPGDAVGVLVYDIEPNSAAEKGGLRRYD
FIEGANGLVIRHINDLREQVGLVGLGGVLRLKILRDTQEMELSIPLVEAAYQKGK

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=296, Percent_Identity=34.4594594594595, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI22129776, Length=259, Percent_Identity=32.8185328185328, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI24308541, Length=317, Percent_Identity=29.3375394321767, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI7019477, Length=271, Percent_Identity=33.5793357933579, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1786356, Length=282, Percent_Identity=39.3617021276596, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1789629, Length=309, Percent_Identity=37.2168284789644, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789630, Length=361, Percent_Identity=29.6398891966759, Blast_Score=150, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24646839, Length=288, Percent_Identity=33.6805555555556, Blast_Score=141, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 41143; Mature: 41143

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERKHSIPPVVYINFALVFVLLFAIFFPEIRSAVTKLFSSPKPISASKQSQAIQIQSSFR
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHH
NVYREAQQFVVSIRTKKTEMIFHPYAFGESREDRISSIGSGFIIDERGFVVTNYHVIKNA
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCCCEEEECCCEEEEEEEEECCC
EIIEIIMSDGRIFPARYVGSHERADIALLKIPSEDKFIPAFLGNSDEIEVGDWAIAVGSP
EEEEEEECCCCEEEHHHCCCCCCCCEEEEEECCCCCEEEHCCCCCCCEEECCEEEEECCC
YGLEKTFTVGVVSAKSREDLDETGQTHIQTDTAINPGSSGGPLLNIYGEVVGINRMIRSS
CCCCCEEEEEEEECCCCCCHHHCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHCC
SGASAGIGFAIPINYAKRVLRQIEQNVGQNIKPATLGVMATTPLPDHRRSLGIPGDAVGV
CCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHCCCCCCCEEEE
LVYDIEPNSAAEKGGLRRYDFIEGANGLVIRHINDLREQVGLVGLGGVLRLKILRDTQEM
EEEEECCCCCHHHCCCEEEHHHCCCCCEEEEEHHHHHHHHCEEECCHHEEEEEECCCCHH
ELSIPLVEAAYQKGK
EEECHHHHHHHHCCC
>Mature Secondary Structure
MERKHSIPPVVYINFALVFVLLFAIFFPEIRSAVTKLFSSPKPISASKQSQAIQIQSSFR
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHH
NVYREAQQFVVSIRTKKTEMIFHPYAFGESREDRISSIGSGFIIDERGFVVTNYHVIKNA
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCCCEEEECCCEEEEEEEEECCC
EIIEIIMSDGRIFPARYVGSHERADIALLKIPSEDKFIPAFLGNSDEIEVGDWAIAVGSP
EEEEEEECCCCEEEHHHCCCCCCCCEEEEEECCCCCEEEHCCCCCCCEEECCEEEEECCC
YGLEKTFTVGVVSAKSREDLDETGQTHIQTDTAINPGSSGGPLLNIYGEVVGINRMIRSS
CCCCCEEEEEEEECCCCCCHHHCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHCC
SGASAGIGFAIPINYAKRVLRQIEQNVGQNIKPATLGVMATTPLPDHRRSLGIPGDAVGV
CCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHCCCCCCCEEEE
LVYDIEPNSAAEKGGLRRYDFIEGANGLVIRHINDLREQVGLVGLGGVLRLKILRDTQEM
EEEEECCCCCHHHCCCEEEHHHCCCCCEEEEEHHHHHHHHCEEECCHHEEEEEECCCCHH
ELSIPLVEAAYQKGK
EEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]