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The map label for this gene is nhaC [H]

Identifier: 183220308

GI number: 183220308

Start: 926104

End: 927477

Strand: Direct

Name: nhaC [H]

Synonym: LEPBI_I0903

Alternate gene names: 183220308

Gene position: 926104-927477 (Clockwise)

Preceding gene: 183220307

Following gene: 183220309

Centisome position: 25.73

GC content: 37.7

Gene sequence:

>1374_bases
ATGGAAAATGAGAAAAGAAACTCACTATTTTTTTCTCTCACTCCCATCATCTATTTGATTCTATCCATTGTGTTCTTTAG
AACTGTTTGGATCGTTGAATATCCTCATCCCTATGCACTATGTTTGTCAGGGATGTTTTCTTTTTTGCAGAGATACAATC
GGAATCTTCTATTTTTAAAATCGGCTTTGCGTAAAAATTTTTTATCAGTTCTCCCCGCAATGGAAATCCTATTTTTTGTT
GGGTTACTCATTGCATCTTGGGCTTATTCTGGAATTTTATTAACGATGATGCAAATTGGAACTTCTTTCATCGAACCAAA
ATACTTTTTGCCATCCATCGCCATTGTATCCGCAATTGCAGCAATGGTTTCAGGGTCTTCTTGGACCACTGCTGGTACAT
TAGGTGTTGCCCTCATGGGAGTTTCTAAGTATTTAGGATTCCCTGATGTGATGTCAGCGGGAGCCATTGTTAGCGGTTGT
TATTTTGGAGATAAACTTTCTCCGCTTTCTGATACAACCAATTTAGCCTCCAGTTTGACTCATGTCCCGATTTGGACTCA
CATACGTCATATGTTAAAAACAACATGTTTTAGTTTTGTTTTGGCAGTCTTTTGTTTTTATTTATTGAATTTATATACTT
GGGATCCTCGCGTGCAGGAGGATATTCCTACGAGTATTGGTTTGTCAGTGTTACTTGGGAAAGGAATTGTTTATTGGAAA
TTGATTCCCGTTTTGATTGTCTTCGGTTCCTCTTTTTTCCATCTACCCGTTCGAGTGTCCTTTCTTTTGGGAATTGTTTC
TGCATTTTTATTTCCGATCTTAGAATCTGGAATCTCGATGGAGATGGGGAAATCTCTCATTTTGGGATTCCATTCTCAAT
CTGGAAATCGCACATGGGATCTTTTTCTCAGCGGTGGAGGCATTGTTTCCATTTTACCAACAGAAATTTTGATTTTAACG
GCAGTTTGGTTCGGTGGTGTTGTAGAAGGTTTTGGTTATTTGAATGAACTTCTCATTAAAATCAAACAATGGGCAAAAAA
TCAATTTGATCTACTTTTGTCGACAATGGGAGTCTCTTTTTTACTCAATTTGATGACAGCTGACCAGTATTTGTCATTAG
TGATCCCTGCCCGTGCGTTTCGTACGCTTGCAGTGGAAAAAAATATCCCTGAAAAAGATGTTTCAAGGGCATTGGGAGAT
TCAGGAACCATCACATCGCCCCTGATTCCTTGGAATAGTTGCGGTGCATTTATGGCATCTTCATTGGGAGTTCCTGTCTT
GGGTTTTTTGCCTTTTGTCTTCTTTAATTTGATCCACGTTGTTTTATCTGTTTCTGTTTTATTCTATCAAAAAATAAAAT
TAAAAAGTTCATAA

Upstream 100 bases:

>100_bases
CCAAAACCTTTGATGAACTTATTATCATGGTTTGGCATTCTATTTTTATTTGGATTTTCCATTTATTACATCAACATCAC
TTTCTTCTAAATCATAAAGA

Downstream 100 bases:

>100_bases
TTTAACATCTAGATTTCGTTATATTCTCATTAACGGATGTTATTAGGCAAATTGTGGTTTCCACATTTTTTTAGGTTGTT
ACAAACTTTTCCTATGTTGC

Product: Na(+)/H(+) antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MENEKRNSLFFSLTPIIYLILSIVFFRTVWIVEYPHPYALCLSGMFSFLQRYNRNLLFLKSALRKNFLSVLPAMEILFFV
GLLIASWAYSGILLTMMQIGTSFIEPKYFLPSIAIVSAIAAMVSGSSWTTAGTLGVALMGVSKYLGFPDVMSAGAIVSGC
YFGDKLSPLSDTTNLASSLTHVPIWTHIRHMLKTTCFSFVLAVFCFYLLNLYTWDPRVQEDIPTSIGLSVLLGKGIVYWK
LIPVLIVFGSSFFHLPVRVSFLLGIVSAFLFPILESGISMEMGKSLILGFHSQSGNRTWDLFLSGGGIVSILPTEILILT
AVWFGGVVEGFGYLNELLIKIKQWAKNQFDLLLSTMGVSFLLNLMTADQYLSLVIPARAFRTLAVEKNIPEKDVSRALGD
SGTITSPLIPWNSCGAFMASSLGVPVLGFLPFVFFNLIHVVLSVSVLFYQKIKLKSS

Sequences:

>Translated_457_residues
MENEKRNSLFFSLTPIIYLILSIVFFRTVWIVEYPHPYALCLSGMFSFLQRYNRNLLFLKSALRKNFLSVLPAMEILFFV
GLLIASWAYSGILLTMMQIGTSFIEPKYFLPSIAIVSAIAAMVSGSSWTTAGTLGVALMGVSKYLGFPDVMSAGAIVSGC
YFGDKLSPLSDTTNLASSLTHVPIWTHIRHMLKTTCFSFVLAVFCFYLLNLYTWDPRVQEDIPTSIGLSVLLGKGIVYWK
LIPVLIVFGSSFFHLPVRVSFLLGIVSAFLFPILESGISMEMGKSLILGFHSQSGNRTWDLFLSGGGIVSILPTEILILT
AVWFGGVVEGFGYLNELLIKIKQWAKNQFDLLLSTMGVSFLLNLMTADQYLSLVIPARAFRTLAVEKNIPEKDVSRALGD
SGTITSPLIPWNSCGAFMASSLGVPVLGFLPFVFFNLIHVVLSVSVLFYQKIKLKSS
>Mature_457_residues
MENEKRNSLFFSLTPIIYLILSIVFFRTVWIVEYPHPYALCLSGMFSFLQRYNRNLLFLKSALRKNFLSVLPAMEILFFV
GLLIASWAYSGILLTMMQIGTSFIEPKYFLPSIAIVSAIAAMVSGSSWTTAGTLGVALMGVSKYLGFPDVMSAGAIVSGC
YFGDKLSPLSDTTNLASSLTHVPIWTHIRHMLKTTCFSFVLAVFCFYLLNLYTWDPRVQEDIPTSIGLSVLLGKGIVYWK
LIPVLIVFGSSFFHLPVRVSFLLGIVSAFLFPILESGISMEMGKSLILGFHSQSGNRTWDLFLSGGGIVSILPTEILILT
AVWFGGVVEGFGYLNELLIKIKQWAKNQFDLLLSTMGVSFLLNLMTADQYLSLVIPARAFRTLAVEKNIPEKDVSRALGD
SGTITSPLIPWNSCGAFMASSLGVPVLGFLPFVFFNLIHVVLSVSVLFYQKIKLKSS

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 50568; Mature: 50568

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]