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The map label for this gene is ubiB [C]

Identifier: 183220286

GI number: 183220286

Start: 899693

End: 900997

Strand: Reverse

Name: ubiB [C]

Synonym: LEPBI_I0881

Alternate gene names: 183220286

Gene position: 900997-899693 (Counterclockwise)

Preceding gene: 183220288

Following gene: 183220285

Centisome position: 25.03

GC content: 40.54

Gene sequence:

>1305_bases
ATGGACTCATTTTCCGAGATTGTCTCTTTTGGTCTCCACTCAAGCCTTCGAGTGGCTCATTCTAGTTTTGTGTTCTCAAC
AAAACTGTTAGGAATCCTGGCAAAACTGGCCAAGGGAGAACCAAACCATAGAGAAATCGCCATCATGTTACGCGAGGCCT
TTTCCCAATTAGGTGCGACGTATATCAAACTGGGCCAATTCATTGCCAGTGCCCCTTCCCTCTTTCCCATCGAATACGTA
GAAGAGATGCAGGCCTGTTTGGACTCAGTAAGGCCTGTTCAGTATCGAGAAATCAAATCCACAGTGGAACGAGAGCTTGG
TGGGAAACTAGAATCCTTATTCCATCGTTTTGAAGAAACTCCTCTAGCGTCCGCATCCATTGCCCAAGTCCATGCGGCAA
TCACAAAAGAAGGTTTGGATGTGGTTGTCAAAGTACAAAGGCCCGATGTCCATCTCACTTTAAAAACCGACATGCAGATT
CTAGGGATCCTAACAAAAGTATTGGAGTTCATCGCACCTGAATTTAAAAAATCTGGTCTCACCGCGATGTTCCAAGAATT
CCAGATCTCCATCTTACAAGAAATCGATTTTATCCAAGAAGCCAAAAACATAGAAGAGTTTGAAGCCTATCTTCTGAAAG
CAAATGAAACGAGAGCCAAAGTCCCTCGAGTCTATCACACTCTTTCCACCAAAAAAGTATTAACAATGGAACGGTTTTAT
GGAGTCCCCATCACCGATGAAAAAGGATTAAAACAATTTACGGACAACCCAAGAAAAGTTTTGAGTGATGCACTTGAGAT
TTGGTTTTCTTCTTTGTCCAACCAAGGTTTTTTTCATGCCGATGTCCATGCGGGGAATTTGATGATCCTAAAAGATGGAT
GTATTGGTTTTATTGATTTTGGAATTGTTGGTAGGATCTCTCCAAAAATTTGGAGCGGGTTAATGCTTTTTACCCAAGGG
ATTGGGATTGGTGAACCAATGTTAGTTGCAAAAGGCCTTGTCGAGATGGATTCTACCGATAGCGGAGTGAATCCAACCTT
ACTTGCCAAAGAATTGGATTCTGTTTTTAATGAATTAGAATCCGTTTATGTCCATTTGACGACAAATGAAATGTTTGATG
AATCCAAGGTGAATCGAATCATGTTCGATATGAAGGAAATTGCTGAAAAAAATGGATTAAAAATTCCAAGGGAGTTTGCC
CTTCTCATGAAACAAATGTTATACTTTGACAGATATGTAAAATCCATGGCTCCTGAAATCAATTTGTTTCGAGACTCTCA
AAATTTTGTAATTGGGAAAACATGA

Upstream 100 bases:

>100_bases
AGTTTTTGGTTGGGACCTAATCCTGCAACTCTATTTCAATTGTAGGTTCGGAGTCCATTTTGTCGTTTCCAATCCCCATT
TGAGTCCCAAATTAGGGTTT

Downstream 100 bases:

>100_bases
CACTTTTAGATTTAAACGAAGGGGAAACTGCTGAAATTGTATCCATCAATTTGGACCAATTACCAAAACCAATGATCACA
GAACTGTTAGAGCTGGGATT

Product: putative ubiquinone biosynthesis protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MDSFSEIVSFGLHSSLRVAHSSFVFSTKLLGILAKLAKGEPNHREIAIMLREAFSQLGATYIKLGQFIASAPSLFPIEYV
EEMQACLDSVRPVQYREIKSTVERELGGKLESLFHRFEETPLASASIAQVHAAITKEGLDVVVKVQRPDVHLTLKTDMQI
LGILTKVLEFIAPEFKKSGLTAMFQEFQISILQEIDFIQEAKNIEEFEAYLLKANETRAKVPRVYHTLSTKKVLTMERFY
GVPITDEKGLKQFTDNPRKVLSDALEIWFSSLSNQGFFHADVHAGNLMILKDGCIGFIDFGIVGRISPKIWSGLMLFTQG
IGIGEPMLVAKGLVEMDSTDSGVNPTLLAKELDSVFNELESVYVHLTTNEMFDESKVNRIMFDMKEIAEKNGLKIPREFA
LLMKQMLYFDRYVKSMAPEINLFRDSQNFVIGKT

Sequences:

>Translated_434_residues
MDSFSEIVSFGLHSSLRVAHSSFVFSTKLLGILAKLAKGEPNHREIAIMLREAFSQLGATYIKLGQFIASAPSLFPIEYV
EEMQACLDSVRPVQYREIKSTVERELGGKLESLFHRFEETPLASASIAQVHAAITKEGLDVVVKVQRPDVHLTLKTDMQI
LGILTKVLEFIAPEFKKSGLTAMFQEFQISILQEIDFIQEAKNIEEFEAYLLKANETRAKVPRVYHTLSTKKVLTMERFY
GVPITDEKGLKQFTDNPRKVLSDALEIWFSSLSNQGFFHADVHAGNLMILKDGCIGFIDFGIVGRISPKIWSGLMLFTQG
IGIGEPMLVAKGLVEMDSTDSGVNPTLLAKELDSVFNELESVYVHLTTNEMFDESKVNRIMFDMKEIAEKNGLKIPREFA
LLMKQMLYFDRYVKSMAPEINLFRDSQNFVIGKT
>Mature_434_residues
MDSFSEIVSFGLHSSLRVAHSSFVFSTKLLGILAKLAKGEPNHREIAIMLREAFSQLGATYIKLGQFIASAPSLFPIEYV
EEMQACLDSVRPVQYREIKSTVERELGGKLESLFHRFEETPLASASIAQVHAAITKEGLDVVVKVQRPDVHLTLKTDMQI
LGILTKVLEFIAPEFKKSGLTAMFQEFQISILQEIDFIQEAKNIEEFEAYLLKANETRAKVPRVYHTLSTKKVLTMERFY
GVPITDEKGLKQFTDNPRKVLSDALEIWFSSLSNQGFFHADVHAGNLMILKDGCIGFIDFGIVGRISPKIWSGLMLFTQG
IGIGEPMLVAKGLVEMDSTDSGVNPTLLAKELDSVFNELESVYVHLTTNEMFDESKVNRIMFDMKEIAEKNGLKIPREFA
LLMKQMLYFDRYVKSMAPEINLFRDSQNFVIGKT

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=328, Percent_Identity=26.219512195122, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI41393593, Length=234, Percent_Identity=29.0598290598291, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI217035081, Length=266, Percent_Identity=26.6917293233083, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI27363457, Length=156, Percent_Identity=34.6153846153846, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI217416386, Length=156, Percent_Identity=34.6153846153846, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI2367309, Length=400, Percent_Identity=26.5, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17559152, Length=282, Percent_Identity=32.6241134751773, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32565180, Length=184, Percent_Identity=29.8913043478261, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323282, Length=277, Percent_Identity=31.7689530685921, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=250, Percent_Identity=25.6, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6325148, Length=262, Percent_Identity=26.7175572519084, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24662575, Length=436, Percent_Identity=24.3119266055046, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI22024280, Length=255, Percent_Identity=29.0196078431373, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI18859849, Length=208, Percent_Identity=27.8846153846154, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 48944; Mature: 48944

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSFSEIVSFGLHSSLRVAHSSFVFSTKLLGILAKLAKGEPNHREIAIMLREAFSQLGAT
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
YIKLGQFIASAPSLFPIEYVEEMQACLDSVRPVQYREIKSTVERELGGKLESLFHRFEET
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCC
PLASASIAQVHAAITKEGLDVVVKVQRPDVHLTLKTDMQILGILTKVLEFIAPEFKKSGL
CCCHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHCHHHHHCCH
TAMFQEFQISILQEIDFIQEAKNIEEFEAYLLKANETRAKVPRVYHTLSTKKVLTMERFY
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GVPITDEKGLKQFTDNPRKVLSDALEIWFSSLSNQGFFHADVHAGNLMILKDGCIGFIDF
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCEEHHHH
GIVGRISPKIWSGLMLFTQGIGIGEPMLVAKGLVEMDSTDSGVNPTLLAKELDSVFNELE
CHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
SVYVHLTTNEMFDESKVNRIMFDMKEIAEKNGLKIPREFALLMKQMLYFDRYVKSMAPEI
HEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
NLFRDSQNFVIGKT
EEEECCCCEEEECC
>Mature Secondary Structure
MDSFSEIVSFGLHSSLRVAHSSFVFSTKLLGILAKLAKGEPNHREIAIMLREAFSQLGAT
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
YIKLGQFIASAPSLFPIEYVEEMQACLDSVRPVQYREIKSTVERELGGKLESLFHRFEET
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCC
PLASASIAQVHAAITKEGLDVVVKVQRPDVHLTLKTDMQILGILTKVLEFIAPEFKKSGL
CCCHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHCHHHHHCCH
TAMFQEFQISILQEIDFIQEAKNIEEFEAYLLKANETRAKVPRVYHTLSTKKVLTMERFY
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GVPITDEKGLKQFTDNPRKVLSDALEIWFSSLSNQGFFHADVHAGNLMILKDGCIGFIDF
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCEEHHHH
GIVGRISPKIWSGLMLFTQGIGIGEPMLVAKGLVEMDSTDSGVNPTLLAKELDSVFNELE
CHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
SVYVHLTTNEMFDESKVNRIMFDMKEIAEKNGLKIPREFALLMKQMLYFDRYVKSMAPEI
HEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
NLFRDSQNFVIGKT
EEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]