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The map label for this gene is ung [H]

Identifier: 183220228

GI number: 183220228

Start: 834571

End: 835227

Strand: Reverse

Name: ung [H]

Synonym: LEPBI_I0821

Alternate gene names: 183220228

Gene position: 835227-834571 (Counterclockwise)

Preceding gene: 183220229

Following gene: 183220227

Centisome position: 23.2

GC content: 37.44

Gene sequence:

>657_bases
GTGCAAATTGAATCTAGCTGGAAAGAGGTTTTAAAAGATGAATTTAAAAAACCATATTTTACAGAATTAAGGGAGTGGGT
GAGAGAAAGATACAAATCAACGATCGTTTACCCTCCCGCCAAACAGATATTTAATGCATTTGATTTATGCCCTTTTGACA
ATGTCAAAGTGGTCATTCTTGGCCAAGACCCATACCATGGTCCTGGACAAGCCCATGGTCTTTGTTTTTCTGTCTTAGAA
GGTGTCCCCTTCCCCCCTTCCTTACAAAACATCTTCAAAGAGATCCAAGATGATTTAAAAAAACCAATTCCAAAATCAGG
GAATTTAAGTTACCTCGCCAAACAAGGTGTTTTTTTACTGAATGCGACCCTCACAGTGGAAAAGGACAAAGCAGGTTCCC
ATCAAAACAAAGGATGGGAAATATTTACCGATGCTGTGATTTCAACCTTAGCGGAAAAAAAATCGAACTTGGTATTTTTA
TTATGGGGTTCGTTTGCAGGTAAAAAAGAAATTTTGATTCCACCAAACAAACATTTGGTATTAAAGTCTGCGCATCCTTC
TCCCCTTTCTGCCTACCGAGGATTTTTGGGAAATAAACATTTTTCAAAAACCAATGAATATTTAATTTCTGCAGGAAAAC
AAAGCATTGACTGGTAA

Upstream 100 bases:

>100_bases
AAAGAATTGCGTAATTTCTCAAAAAAAACAATCCATGTCACACATGGTGGGATCGATTTACGGGTGTTATTTTTTCATTC
GGAGGTTCGTTCTGAAAGAC

Downstream 100 bases:

>100_bases
TGAAAAAAAAGGATACTTTTATGTCTTTTTAACCGGAGTCTTTTTCGCTTTTGAAGTCATCGGATTTAAAGAAGTTTTCC
GAAGGTTTCATTTATCGCCA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MQIESSWKEVLKDEFKKPYFTELREWVRERYKSTIVYPPAKQIFNAFDLCPFDNVKVVILGQDPYHGPGQAHGLCFSVLE
GVPFPPSLQNIFKEIQDDLKKPIPKSGNLSYLAKQGVFLLNATLTVEKDKAGSHQNKGWEIFTDAVISTLAEKKSNLVFL
LWGSFAGKKEILIPPNKHLVLKSAHPSPLSAYRGFLGNKHFSKTNEYLISAGKQSIDW

Sequences:

>Translated_218_residues
MQIESSWKEVLKDEFKKPYFTELREWVRERYKSTIVYPPAKQIFNAFDLCPFDNVKVVILGQDPYHGPGQAHGLCFSVLE
GVPFPPSLQNIFKEIQDDLKKPIPKSGNLSYLAKQGVFLLNATLTVEKDKAGSHQNKGWEIFTDAVISTLAEKKSNLVFL
LWGSFAGKKEILIPPNKHLVLKSAHPSPLSAYRGFLGNKHFSKTNEYLISAGKQSIDW
>Mature_218_residues
MQIESSWKEVLKDEFKKPYFTELREWVRERYKSTIVYPPAKQIFNAFDLCPFDNVKVVILGQDPYHGPGQAHGLCFSVLE
GVPFPPSLQNIFKEIQDDLKKPIPKSGNLSYLAKQGVFLLNATLTVEKDKAGSHQNKGWEIFTDAVISTLAEKKSNLVFL
LWGSFAGKKEILIPPNKHLVLKSAHPSPLSAYRGFLGNKHFSKTNEYLISAGKQSIDW

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=214, Percent_Identity=57.9439252336449, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI6224979, Length=214, Percent_Identity=57.9439252336449, Blast_Score=246, Evalue=2e-65,
Organism=Escherichia coli, GI1788934, Length=220, Percent_Identity=50, Blast_Score=219, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=50.9259259259259, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6323620, Length=234, Percent_Identity=46.5811965811966, Blast_Score=191, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24681; Mature: 24681

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIESSWKEVLKDEFKKPYFTELREWVRERYKSTIVYPPAKQIFNAFDLCPFDNVKVVIL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEEEE
GQDPYHGPGQAHGLCFSVLEGVPFPPSLQNIFKEIQDDLKKPIPKSGNLSYLAKQGVFLL
CCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCEEEE
NATLTVEKDKAGSHQNKGWEIFTDAVISTLAEKKSNLVFLLWGSFAGKKEILIPPNKHLV
EEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEECCCCCEE
LKSAHPSPLSAYRGFLGNKHFSKTNEYLISAGKQSIDW
EECCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQIESSWKEVLKDEFKKPYFTELREWVRERYKSTIVYPPAKQIFNAFDLCPFDNVKVVIL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEEEE
GQDPYHGPGQAHGLCFSVLEGVPFPPSLQNIFKEIQDDLKKPIPKSGNLSYLAKQGVFLL
CCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCEEEE
NATLTVEKDKAGSHQNKGWEIFTDAVISTLAEKKSNLVFLLWGSFAGKKEILIPPNKHLV
EEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEECCCCCEE
LKSAHPSPLSAYRGFLGNKHFSKTNEYLISAGKQSIDW
EECCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA