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The map label for this gene is atpA

Identifier: 183220213

GI number: 183220213

Start: 818914

End: 820428

Strand: Direct

Name: atpA

Synonym: LEPBI_I0805

Alternate gene names: 183220213

Gene position: 818914-820428 (Clockwise)

Preceding gene: 183220212

Following gene: 183220214

Centisome position: 22.75

GC content: 43.43

Gene sequence:

>1515_bases
ATGAAAATTAAAACAGACGAAGTAACGTCGGTACTAAAACAAGAAATTAAAAACTTCAAGAAAGACCTCCAAGTAGAAGA
GGTTGGAACAGTTCTCGAAGTCGGGGACGGGATTGCGCGGGTTTACGGACTCACAAACGTAATGTCAGGAGAGCTCGTTG
AATTCCAAAATGGAGTTCGAGGCCAAGCCTTCAACTTAGAAGAAAATTCAGTTGGGGTTGTTATCTTTGGTGATTATATC
AAAATTGAAGAAGGTTTTTCTGTAAAACGTGTGGGAAAAATCTTCGAAGTTCCAGTAGGACCAGAACTTCTTGGTCGAGT
GCTAAACCCACTTGGGGAAGTGATCGATGGAAAAGGCCCCTTAAACGCAAAAAAAACAAGACCAGTTGAGTCACCAGCTC
CTGGGATTGCGATGAGAAAATCAGTTCACGAACCAATGCAAACAGGGATCAAAGCGATTGACGCAATGATTCCAATCGGT
CGTGGACAACGAGAGCTCATCATTGGGGATCGCGGAACAGGAAAAACTTCCATCGCGATCGACACGATCATCAATCAAAA
AGGAAAAGGGGTCATCTGCGTTTATGTAGCGATCGGTCAAAAAGCATCTACTGTTGCTTCCACCATCGAAATGTTACGCG
AAAAAGGGGCATTAGAATATACGATCATCGTATCGGCTAACGCATCGGAACCTGCTCCTATGTTATACATTGCACCTTAC
TCTGGTGCGACGATGGCTGAATACTTTATGTATGAAGAAGGGAAAGCAACACTTGTTGTGTATGATGACCTTTCGAAACA
AGCAGTAGCATACCGCCAAATGTCACTTTTACTTCGCCGCCCACCAGGTCGTGAAGCATACCCTGGTGACGTATTTTACC
TTCACTCTCGTCTACTTGAAAGAGCAGCGAAACTCGATGATAAATTTGGTGGTGGGTCTATGACTGCACTCCCTATCATT
GAAACACAAGAAGGGGAAGTTTCTGCCTACATTCCAACAAACGTAATCTCCATCACCGATGGTCAGATCTACCTCCAATC
CAACCTGTTTGCATCGGGCCTTCGCCCTGCGGTGGACGTGGGGATTTCTGTATCACGAGTTGGATCTGCTGCACAAATCA
AAGCGATGAAAAAAGTTGCAGGAACTCTGAAGTCAGACCTCGCACAGTTCCGTGACTTGGAAGCGTTTGCACAGTTAGGA
ACAGAACTTGACCCAGTGACACAAGCACAGCTGGATCGTGGTTACCGAGTTCTTGAAATTTTAAAACAACCAAACAACTC
TCCAACGCCTGTAGAAGAACAAGTGATTTCCATCTTCGCTGTAACAAAAGGATTTATGGATGTGGTTCCTACTGCAAAAG
TAAGAGAATTCGAAGCGTTTCTTTTGAAAACAATGAGAGAGCAACACCCAGAAATTTTGGAAGAGATCAGAACTGCTAAA
GAAGTAAAACAAGAAGCAGCTCTGCAAAAAACAATCAAATCGATTGTAGAACATTTTTTAGCAAAGAATAATTAA

Upstream 100 bases:

>100_bases
TCTATATAGACGACTTTTTAATCGATGCCTCAATCCGTGCAAAACTTGCCGGAACCCGTGAGGCTCTCCTCCAAAAGAAA
ATCCCAGTCGGAGCATTTGA

Downstream 100 bases:

>100_bases
GGGGAAAGATCTTGGCGACACCGCGTGAGATAAAAAAGAGGATTAACTCGGTTAAAAACACGAGAAAAATCACTCGAACC
ATGGAGATGGTCTCCACGGC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MKIKTDEVTSVLKQEIKNFKKDLQVEEVGTVLEVGDGIARVYGLTNVMSGELVEFQNGVRGQAFNLEENSVGVVIFGDYI
KIEEGFSVKRVGKIFEVPVGPELLGRVLNPLGEVIDGKGPLNAKKTRPVESPAPGIAMRKSVHEPMQTGIKAIDAMIPIG
RGQRELIIGDRGTGKTSIAIDTIINQKGKGVICVYVAIGQKASTVASTIEMLREKGALEYTIIVSANASEPAPMLYIAPY
SGATMAEYFMYEEGKATLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLDDKFGGGSMTALPII
ETQEGEVSAYIPTNVISITDGQIYLQSNLFASGLRPAVDVGISVSRVGSAAQIKAMKKVAGTLKSDLAQFRDLEAFAQLG
TELDPVTQAQLDRGYRVLEILKQPNNSPTPVEEQVISIFAVTKGFMDVVPTAKVREFEAFLLKTMREQHPEILEEIRTAK
EVKQEAALQKTIKSIVEHFLAKNN

Sequences:

>Translated_504_residues
MKIKTDEVTSVLKQEIKNFKKDLQVEEVGTVLEVGDGIARVYGLTNVMSGELVEFQNGVRGQAFNLEENSVGVVIFGDYI
KIEEGFSVKRVGKIFEVPVGPELLGRVLNPLGEVIDGKGPLNAKKTRPVESPAPGIAMRKSVHEPMQTGIKAIDAMIPIG
RGQRELIIGDRGTGKTSIAIDTIINQKGKGVICVYVAIGQKASTVASTIEMLREKGALEYTIIVSANASEPAPMLYIAPY
SGATMAEYFMYEEGKATLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLDDKFGGGSMTALPII
ETQEGEVSAYIPTNVISITDGQIYLQSNLFASGLRPAVDVGISVSRVGSAAQIKAMKKVAGTLKSDLAQFRDLEAFAQLG
TELDPVTQAQLDRGYRVLEILKQPNNSPTPVEEQVISIFAVTKGFMDVVPTAKVREFEAFLLKTMREQHPEILEEIRTAK
EVKQEAALQKTIKSIVEHFLAKNN
>Mature_504_residues
MKIKTDEVTSVLKQEIKNFKKDLQVEEVGTVLEVGDGIARVYGLTNVMSGELVEFQNGVRGQAFNLEENSVGVVIFGDYI
KIEEGFSVKRVGKIFEVPVGPELLGRVLNPLGEVIDGKGPLNAKKTRPVESPAPGIAMRKSVHEPMQTGIKAIDAMIPIG
RGQRELIIGDRGTGKTSIAIDTIINQKGKGVICVYVAIGQKASTVASTIEMLREKGALEYTIIVSANASEPAPMLYIAPY
SGATMAEYFMYEEGKATLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLDDKFGGGSMTALPII
ETQEGEVSAYIPTNVISITDGQIYLQSNLFASGLRPAVDVGISVSRVGSAAQIKAMKKVAGTLKSDLAQFRDLEAFAQLG
TELDPVTQAQLDRGYRVLEILKQPNNSPTPVEEQVISIFAVTKGFMDVVPTAKVREFEAFLLKTMREQHPEILEEIRTAK
EVKQEAALQKTIKSIVEHFLAKNN

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=508, Percent_Identity=58.8582677165354, Blast_Score=596, Evalue=1e-170,
Organism=Homo sapiens, GI4757810, Length=508, Percent_Identity=58.8582677165354, Blast_Score=596, Evalue=1e-170,
Organism=Homo sapiens, GI19913428, Length=328, Percent_Identity=28.6585365853659, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI19913426, Length=335, Percent_Identity=28.0597014925373, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI32189394, Length=372, Percent_Identity=26.3440860215054, Blast_Score=103, Evalue=6e-22,
Organism=Escherichia coli, GI1790172, Length=515, Percent_Identity=51.4563106796116, Blast_Score=533, Evalue=1e-153,
Organism=Escherichia coli, GI1788251, Length=319, Percent_Identity=28.8401253918495, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790170, Length=356, Percent_Identity=25.561797752809, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=504, Percent_Identity=57.3412698412698, Blast_Score=573, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI71988080, Length=504, Percent_Identity=57.3412698412698, Blast_Score=571, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI71988074, Length=504, Percent_Identity=53.7698412698413, Blast_Score=524, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17510931, Length=403, Percent_Identity=28.5359801488834, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17570191, Length=352, Percent_Identity=28.125, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144756, Length=406, Percent_Identity=24.6305418719212, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71988068, Length=72, Percent_Identity=48.6111111111111, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319370, Length=508, Percent_Identity=56.8897637795276, Blast_Score=578, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6322581, Length=372, Percent_Identity=27.6881720430108, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319603, Length=305, Percent_Identity=28.1967213114754, Blast_Score=112, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24658560, Length=506, Percent_Identity=56.7193675889328, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI281361666, Length=322, Percent_Identity=29.1925465838509, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646341, Length=322, Percent_Identity=29.1925465838509, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17136796, Length=322, Percent_Identity=29.1925465838509, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24638766, Length=408, Percent_Identity=25.7352941176471, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28574560, Length=418, Percent_Identity=25.5980861244019, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_LEPBA (B0SDA3)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001961886.1
- ProteinModelPortal:   B0SDA3
- SMR:   B0SDA3
- GeneID:   6387080
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_0776
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- ProtClustDB:   PRK09281
- BioCyc:   LBIF355278:LBF_0776-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55078; Mature: 55078

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKTDEVTSVLKQEIKNFKKDLQVEEVGTVLEVGDGIARVYGLTNVMSGELVEFQNGVR
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCCC
GQAFNLEENSVGVVIFGDYIKIEEGFSVKRVGKIFEVPVGPELLGRVLNPLGEVIDGKGP
CCEECCCCCCEEEEEEECEEEEECCCCHHHHCHHEECCCCHHHHHHHHHHHHHHHCCCCC
LNAKKTRPVESPAPGIAMRKSVHEPMQTGIKAIDAMIPIGRGQRELIIGDRGTGKTSIAI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEE
DTIINQKGKGVICVYVAIGQKASTVASTIEMLREKGALEYTIIVSANASEPAPMLYIAPY
EHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEECC
SGATMAEYFMYEEGKATLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLE
CCCHHHHHHEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RAAKLDDKFGGGSMTALPIIETQEGEVSAYIPTNVISITDGQIYLQSNLFASGLRPAVDV
HHHHCCCCCCCCCEEEEEEEECCCCCEEEEECCCEEEEECCEEEEECCCHHHCCCHHHHC
GISVSRVGSAAQIKAMKKVAGTLKSDLAQFRDLEAFAQLGTELDPVTQAQLDRGYRVLEI
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHH
LKQPNNSPTPVEEQVISIFAVTKGFMDVVPTAKVREFEAFLLKTMREQHPEILEEIRTAK
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
EVKQEAALQKTIKSIVEHFLAKNN
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIKTDEVTSVLKQEIKNFKKDLQVEEVGTVLEVGDGIARVYGLTNVMSGELVEFQNGVR
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCCC
GQAFNLEENSVGVVIFGDYIKIEEGFSVKRVGKIFEVPVGPELLGRVLNPLGEVIDGKGP
CCEECCCCCCEEEEEEECEEEEECCCCHHHHCHHEECCCCHHHHHHHHHHHHHHHCCCCC
LNAKKTRPVESPAPGIAMRKSVHEPMQTGIKAIDAMIPIGRGQRELIIGDRGTGKTSIAI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEE
DTIINQKGKGVICVYVAIGQKASTVASTIEMLREKGALEYTIIVSANASEPAPMLYIAPY
EHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEECC
SGATMAEYFMYEEGKATLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLE
CCCHHHHHHEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RAAKLDDKFGGGSMTALPIIETQEGEVSAYIPTNVISITDGQIYLQSNLFASGLRPAVDV
HHHHCCCCCCCCCEEEEEEEECCCCCEEEEECCCEEEEECCEEEEECCCHHHCCCHHHHC
GISVSRVGSAAQIKAMKKVAGTLKSDLAQFRDLEAFAQLGTELDPVTQAQLDRGYRVLEI
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHH
LKQPNNSPTPVEEQVISIFAVTKGFMDVVPTAKVREFEAFLLKTMREQHPEILEEIRTAK
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
EVKQEAALQKTIKSIVEHFLAKNN
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA