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The map label for this gene is 183220191

Identifier: 183220191

GI number: 183220191

Start: 798903

End: 799838

Strand: Direct

Name: 183220191

Synonym: LEPBI_I0781

Alternate gene names: NA

Gene position: 798903-799838 (Clockwise)

Preceding gene: 183220190

Following gene: 183220195

Centisome position: 22.19

GC content: 42.84

Gene sequence:

>936_bases
ATGAAAACAGGGATTTCCTTTCATCCTACATTTTTAGAACACAAAACAGGGCCAGGTCATCCAGAGACTCATGTGCGATT
GGAATCCATTTTGGAAAAAATTTCAGATCTTCCTTCCGAGTCTTTTACCTGGGAAAAAACTTTTAAAGAAGCACCCTTAT
CTCTCATTTCTGAGATCCACGATCCGAATTACGTACGTTTGGTGGCAAAAGTTTGTGAAGAAAAAGGATCTGGATACTTA
GATGGTGACACCGTATATTCACCAAACACATTTCAGGCGGCTTCCCTTGCAGTCGGGGCTGGGGTAACACTGGCACAAGA
TATTTTAGATGGGAAGCTAAAAAATGGTATGGCACTTGTTCGCCCACCTGGCCACCATGCGGAATCCGACCACGCAATGG
GATTTTGTTTGTTCAATAATATTGCGATCACAGCCAAGTATTTGCAGAGTCAAGGGATCAAACGAATTTTAATTTTGGAT
TGGGATGTGCATCATGGAAATGGCACCCAACACCAGTTCTACGAAGATGATTCTGTTTATTTTGTTTCGCTCCACCAATA
TCCATTTTATCCAGGCACAGGTTCCGAAAAAGAAAGTGGCCAAGGGAAAGGTTTTGGCACTACCTTAAATTTACCAATGG
CCCGCGGGGCAGAAGAGAAACAATACTTGGATCAGTTCCCTCTCATCCACAAAGAGATGGAAACCTTCCAACCAGAATTT
GTTTTGGTTTCTGCTGGATTTGATGCCCACAGGAATGATCCACTGGCAGGAATGAATTTAAATTCGAGTTCCTATGAAAA
AATGACAAACGAAGTGAAACAAATTGCTCGTGTCCACTCTGGTGGGAAACTGCTCTCGTTTCTGGAAGGTGGGTATGATT
TCCAAGCACTTTCGGAATCCGTAAAAGTACATCTGGAAACACTTGCCTCTGCTTAG

Upstream 100 bases:

>100_bases
TCTCTCCAGAAGAAAAAGTGCAAATCACAAAACAAATTGATCGGATCATTGCAGAGATCATTGAGATGATCGTGTTTATC
GAACGTTTTATGTTATTCCA

Downstream 100 bases:

>100_bases
CTTAGGCCTTTGGTGCCACCCCGAACACTTCTTTCACCCAATGGATGAGGGGACGTGAGCTAATGATAGAAAAATGATTT
TGTTTTTTCAGTTCCAAGGT

Product: putative deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKTGISFHPTFLEHKTGPGHPETHVRLESILEKISDLPSESFTWEKTFKEAPLSLISEIHDPNYVRLVAKVCEEKGSGYL
DGDTVYSPNTFQAASLAVGAGVTLAQDILDGKLKNGMALVRPPGHHAESDHAMGFCLFNNIAITAKYLQSQGIKRILILD
WDVHHGNGTQHQFYEDDSVYFVSLHQYPFYPGTGSEKESGQGKGFGTTLNLPMARGAEEKQYLDQFPLIHKEMETFQPEF
VLVSAGFDAHRNDPLAGMNLNSSSYEKMTNEVKQIARVHSGGKLLSFLEGGYDFQALSESVKVHLETLASA

Sequences:

>Translated_311_residues
MKTGISFHPTFLEHKTGPGHPETHVRLESILEKISDLPSESFTWEKTFKEAPLSLISEIHDPNYVRLVAKVCEEKGSGYL
DGDTVYSPNTFQAASLAVGAGVTLAQDILDGKLKNGMALVRPPGHHAESDHAMGFCLFNNIAITAKYLQSQGIKRILILD
WDVHHGNGTQHQFYEDDSVYFVSLHQYPFYPGTGSEKESGQGKGFGTTLNLPMARGAEEKQYLDQFPLIHKEMETFQPEF
VLVSAGFDAHRNDPLAGMNLNSSSYEKMTNEVKQIARVHSGGKLLSFLEGGYDFQALSESVKVHLETLASA
>Mature_311_residues
MKTGISFHPTFLEHKTGPGHPETHVRLESILEKISDLPSESFTWEKTFKEAPLSLISEIHDPNYVRLVAKVCEEKGSGYL
DGDTVYSPNTFQAASLAVGAGVTLAQDILDGKLKNGMALVRPPGHHAESDHAMGFCLFNNIAITAKYLQSQGIKRILILD
WDVHHGNGTQHQFYEDDSVYFVSLHQYPFYPGTGSEKESGQGKGFGTTLNLPMARGAEEKQYLDQFPLIHKEMETFQPEF
VLVSAGFDAHRNDPLAGMNLNSSSYEKMTNEVKQIARVHSGGKLLSFLEGGYDFQALSESVKVHLETLASA

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI20070354, Length=325, Percent_Identity=36.9230769230769, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI13128864, Length=320, Percent_Identity=36.5625, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI30795202, Length=344, Percent_Identity=35.4651162790698, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI17158039, Length=344, Percent_Identity=35.4651162790698, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI30795204, Length=344, Percent_Identity=35.4651162790698, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI153085395, Length=343, Percent_Identity=35.8600583090379, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI148539870, Length=344, Percent_Identity=34.3023255813954, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI169234807, Length=344, Percent_Identity=34.3023255813954, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI62750347, Length=350, Percent_Identity=34, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI62750349, Length=350, Percent_Identity=34, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI226529806, Length=324, Percent_Identity=33.641975308642, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI293336691, Length=190, Percent_Identity=35.2631578947368, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI8923769, Length=259, Percent_Identity=29.7297297297297, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI13128860, Length=190, Percent_Identity=34.7368421052632, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI13128862, Length=230, Percent_Identity=30, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI262073092, Length=184, Percent_Identity=32.0652173913043, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI262073088, Length=175, Percent_Identity=30.8571428571429, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI209862883, Length=191, Percent_Identity=30.3664921465969, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI217272877, Length=191, Percent_Identity=30.3664921465969, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193209491, Length=339, Percent_Identity=34.5132743362832, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17540334, Length=242, Percent_Identity=39.2561983471074, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17540332, Length=235, Percent_Identity=40, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI193206283, Length=235, Percent_Identity=40, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17537347, Length=303, Percent_Identity=32.3432343234323, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25154022, Length=262, Percent_Identity=32.0610687022901, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI25154020, Length=262, Percent_Identity=32.0610687022901, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17508561, Length=262, Percent_Identity=29.3893129770992, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17561978, Length=138, Percent_Identity=40.5797101449275, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17534739, Length=189, Percent_Identity=30.6878306878307, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324307, Length=230, Percent_Identity=40.8695652173913, Blast_Score=182, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6323999, Length=178, Percent_Identity=33.7078651685393, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321244, Length=248, Percent_Identity=29.0322580645161, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6325325, Length=172, Percent_Identity=27.906976744186, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24641720, Length=343, Percent_Identity=34.402332361516, Blast_Score=184, Evalue=5e-47,
Organism=Drosophila melanogaster, GI281360801, Length=343, Percent_Identity=34.402332361516, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI281360799, Length=343, Percent_Identity=34.402332361516, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24642146, Length=303, Percent_Identity=35.3135313531353, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24642142, Length=303, Percent_Identity=35.3135313531353, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI281360899, Length=303, Percent_Identity=35.3135313531353, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24642144, Length=303, Percent_Identity=35.3135313531353, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24657891, Length=188, Percent_Identity=36.1702127659575, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24644244, Length=154, Percent_Identity=33.7662337662338, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286
- InterPro:   IPR003084 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 34388; Mature: 34388

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTGISFHPTFLEHKTGPGHPETHVRLESILEKISDLPSESFTWEKTFKEAPLSLISEIH
CCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHHHHHC
DPNYVRLVAKVCEEKGSGYLDGDTVYSPNTFQAASLAVGAGVTLAQDILDGKLKNGMALV
CCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHCCCHHHHHHHHHHHHHCCEEEE
RPPGHHAESDHAMGFCLFNNIAITAKYLQSQGIKRILILDWDVHHGNGTQHQFYEDDSVY
CCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCEECCCCEE
FVSLHQYPFYPGTGSEKESGQGKGFGTTLNLPMARGAEEKQYLDQFPLIHKEMETFQPEF
EEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHCCCCE
VLVSAGFDAHRNDPLAGMNLNSSSYEKMTNEVKQIARVHSGGKLLSFLEGGYDFQALSES
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHH
VKVHLETLASA
HHHHHHHHHCC
>Mature Secondary Structure
MKTGISFHPTFLEHKTGPGHPETHVRLESILEKISDLPSESFTWEKTFKEAPLSLISEIH
CCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHHHHHC
DPNYVRLVAKVCEEKGSGYLDGDTVYSPNTFQAASLAVGAGVTLAQDILDGKLKNGMALV
CCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHCCCHHHHHHHHHHHHHCCEEEE
RPPGHHAESDHAMGFCLFNNIAITAKYLQSQGIKRILILDWDVHHGNGTQHQFYEDDSVY
CCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCEECCCCEE
FVSLHQYPFYPGTGSEKESGQGKGFGTTLNLPMARGAEEKQYLDQFPLIHKEMETFQPEF
EEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHCCCCE
VLVSAGFDAHRNDPLAGMNLNSSSYEKMTNEVKQIARVHSGGKLLSFLEGGYDFQALSES
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHH
VKVHLETLASA
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]