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The map label for this gene is lpxD2

Identifier: 183220070

GI number: 183220070

Start: 661934

End: 662992

Strand: Reverse

Name: lpxD2

Synonym: LEPBI_I0657

Alternate gene names: 183220070

Gene position: 662992-661934 (Counterclockwise)

Preceding gene: 183220071

Following gene: 183220066

Centisome position: 18.42

GC content: 42.97

Gene sequence:

>1059_bases
ATGACTCAAATCAAACTATCTACACTCCAAACACTTCTTCCAGACGCTACATTTCAAAATTCCGAAACACTAAAGGATAT
CAATTTCTCTGGCCTCACTTCCTTAACCCTTGCTGGTCCTTCTGACATTTCCTTTGTTGCCTCAAAAACGTTTGTGAACG
AAGCCAAAGCATCCAAAGCTTCCTTACTCGTTGTATCTCAAGAAACGGCAGAAGCTCTAAGCGACAAAGCCATCATCATC
GTTTCAAAAGTGGAACTAACCACAGCAAAAATCATTCGTTTGTTTTTCCCAGAAAAACAACCTTCGGGAAAACGAAGTGC
ACAAGTTGCCATCGACCCAAGTGCTAAAATTGGATCCAATACAGATATCGGACATTTTGTAACCATTGGAAAAGATTCCA
TCATTGGGAATGACTGCATCATCGAAGATGGTGTGAAAATTGGAGACCGAGTGCAAATTGGCGATGGAGCACGCATTGGG
AAAAACTGCGTTTTCTTTGACGATACCATTGTGGGGAAACGATTCATTGCGTTTGGAAACTCTACCTTTGGAGGAGATGG
ATTTGGATTTGTGTATGCGGAAGGCAAACACAACAAAATCCCCCAAGTGGGACGTGTGGTCATTGGTGATGATGTGGAAG
TGGGAAGTAATTGCACCATCGACCGAGGTGCACTCACCGACACAACCATTGGCAATGGGTGTAAATTTGATAACATGGTT
CACGTTGCTCACAACTGTAAGGTGGGAGACCATGTCATCATAGCAGGCCAATCCGGTCTTGCAGGAAGTGTGACACTTGG
AAACAATGTCATCATTGGTGGCGCTTGTGCCATTAGTGACCACTTAACACTGGTAGATGGAACGATCATAGCTGGTGGTT
CAAGCCTACGCACCTCCCCAAAAACAAAAGATGTTTATGTGGGGTGGGACTTAGGCCTTACCTTCCCTGAATTCCAAAAG
TACAGAGTGAACATTAAAAACATTGTGAATCTCAACAAATGGCTCAAACGAATTGAAAACATCGAAAAAAAAGTAGGGAT
TGAAACTAAAGAATCGTAA

Upstream 100 bases:

>100_bases
AGGGTGAACATTACTTTGTTGGTTAAGACTAGCTAATAGTGTTAGCCAAACTTTCACCTCTCTGATTCCTTGTCTTAAAT
CCATTGATAAGGAATCGGAG

Downstream 100 bases:

>100_bases
ACCTTTGATTCTGTTGTTTGAAATACATCACAGCTTACATCTTAGGCTGTGGTTGTAACAAAGATCTTTGACAAACTTCA
TCCTCGTATACAAGTCTACT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTQIKLSTLQTLLPDATFQNSETLKDINFSGLTSLTLAGPSDISFVASKTFVNEAKASKASLLVVSQETAEALSDKAIII
VSKVELTTAKIIRLFFPEKQPSGKRSAQVAIDPSAKIGSNTDIGHFVTIGKDSIIGNDCIIEDGVKIGDRVQIGDGARIG
KNCVFFDDTIVGKRFIAFGNSTFGGDGFGFVYAEGKHNKIPQVGRVVIGDDVEVGSNCTIDRGALTDTTIGNGCKFDNMV
HVAHNCKVGDHVIIAGQSGLAGSVTLGNNVIIGGACAISDHLTLVDGTIIAGGSSLRTSPKTKDVYVGWDLGLTFPEFQK
YRVNIKNIVNLNKWLKRIENIEKKVGIETKES

Sequences:

>Translated_352_residues
MTQIKLSTLQTLLPDATFQNSETLKDINFSGLTSLTLAGPSDISFVASKTFVNEAKASKASLLVVSQETAEALSDKAIII
VSKVELTTAKIIRLFFPEKQPSGKRSAQVAIDPSAKIGSNTDIGHFVTIGKDSIIGNDCIIEDGVKIGDRVQIGDGARIG
KNCVFFDDTIVGKRFIAFGNSTFGGDGFGFVYAEGKHNKIPQVGRVVIGDDVEVGSNCTIDRGALTDTTIGNGCKFDNMV
HVAHNCKVGDHVIIAGQSGLAGSVTLGNNVIIGGACAISDHLTLVDGTIIAGGSSLRTSPKTKDVYVGWDLGLTFPEFQK
YRVNIKNIVNLNKWLKRIENIEKKVGIETKES
>Mature_351_residues
TQIKLSTLQTLLPDATFQNSETLKDINFSGLTSLTLAGPSDISFVASKTFVNEAKASKASLLVVSQETAEALSDKAIIIV
SKVELTTAKIIRLFFPEKQPSGKRSAQVAIDPSAKIGSNTDIGHFVTIGKDSIIGNDCIIEDGVKIGDRVQIGDGARIGK
NCVFFDDTIVGKRFIAFGNSTFGGDGFGFVYAEGKHNKIPQVGRVVIGDDVEVGSNCTIDRGALTDTTIGNGCKFDNMVH
VAHNCKVGDHVIIAGQSGLAGSVTLGNNVIIGGACAISDHLTLVDGTIIAGGSSLRTSPKTKDVYVGWDLGLTFPEFQKY
RVNIKNIVNLNKWLKRIENIEKKVGIETKES

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=345, Percent_Identity=31.304347826087, Blast_Score=172, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_LEPBA (B0SCK5)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001961745.1
- ProteinModelPortal:   B0SCK5
- SMR:   B0SCK5
- GeneID:   6388936
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_0635
- HOGENOM:   HBG469615
- OMA:   IAQAFYP
- BioCyc:   LBIF355278:LBF_0635-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 37492; Mature: 37361

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIKLSTLQTLLPDATFQNSETLKDINFSGLTSLTLAGPSDISFVASKTFVNEAKASKA
CCEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHCCCCE
SLLVVSQETAEALSDKAIIIVSKVELTTAKIIRLFFPEKQPSGKRSAQVAIDPSAKIGSN
EEEEEECHHHHHHCCCEEEEEEEEEHHHHHHHEEECCCCCCCCCCCEEEEECCCCCCCCC
TDIGHFVTIGKDSIIGNDCIIEDGVKIGDRVQIGDGARIGKNCVFFDDTIVGKRFIAFGN
CCCCEEEEECCCCCCCCCEEEECCCCCCCEEEECCCCCCCCEEEEECCCCCCCEEEEECC
STFGGDGFGFVYAEGKHNKIPQVGRVVIGDDVEVGSNCTIDRGALTDTTIGNGCKFDNMV
CCCCCCCEEEEEECCCCCCCCCCCEEEECCCEECCCCCEECCCCCCCCCCCCCCCCCCEE
HVAHNCKVGDHVIIAGQSGLAGSVTLGNNVIIGGACAISDHLTLVDGTIIAGGSSLRTSP
EEEECCCCCCEEEEECCCCCEEEEEECCEEEEEEEEEECCCEEEEECEEEECCCCCCCCC
KTKDVYVGWDLGLTFPEFQKYRVNIKNIVNLNKWLKRIENIEKKVGIETKES
CCCEEEEEEECCCCCCCCHHEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TQIKLSTLQTLLPDATFQNSETLKDINFSGLTSLTLAGPSDISFVASKTFVNEAKASKA
CEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHCCCCE
SLLVVSQETAEALSDKAIIIVSKVELTTAKIIRLFFPEKQPSGKRSAQVAIDPSAKIGSN
EEEEEECHHHHHHCCCEEEEEEEEEHHHHHHHEEECCCCCCCCCCCEEEEECCCCCCCCC
TDIGHFVTIGKDSIIGNDCIIEDGVKIGDRVQIGDGARIGKNCVFFDDTIVGKRFIAFGN
CCCCEEEEECCCCCCCCCEEEECCCCCCCEEEECCCCCCCCEEEEECCCCCCCEEEEECC
STFGGDGFGFVYAEGKHNKIPQVGRVVIGDDVEVGSNCTIDRGALTDTTIGNGCKFDNMV
CCCCCCCEEEEEECCCCCCCCCCCEEEECCCEECCCCCEECCCCCCCCCCCCCCCCCCEE
HVAHNCKVGDHVIIAGQSGLAGSVTLGNNVIIGGACAISDHLTLVDGTIIAGGSSLRTSP
EEEECCCCCCEEEEECCCCCEEEEEECCEEEEEEEEEECCCEEEEECEEEECCCCCCCCC
KTKDVYVGWDLGLTFPEFQKYRVNIKNIVNLNKWLKRIENIEKKVGIETKES
CCCEEEEEEECCCCCCCCHHEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA