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The map label for this gene is cya [H]

Identifier: 183219964

GI number: 183219964

Start: 543771

End: 545624

Strand: Reverse

Name: cya [H]

Synonym: LEPBI_I0546

Alternate gene names: 183219964

Gene position: 545624-543771 (Counterclockwise)

Preceding gene: 183219965

Following gene: 183219963

Centisome position: 15.16

GC content: 36.46

Gene sequence:

>1854_bases
ATGAAAACGATTTTGTTCAAATTAAAAAACTTTCTCAGCAGAAACAGAGAAGTCACTAGTGACTTTCAATTTCCTATTAG
ATACAAACTGCTGTTAATCACCTCAATCGTTTTACTTTTCTCCATGTCAGGAGTGATCTTTCTTGCTTCCTATTTTTTTC
GAAAAGATAGTGAAGTGCGAGTCAAAGAAAATAATATCAAAATTAATGAAATTTTATCTTTAAAGGTAAAATCCGATTTA
CATTCCATTAGACAAGATGTTCACATCACTGCTTCTGCTATTTTTAGGAATAACCAATCGGCAAATCAAATAGCAAAGGA
ATTGTTTGAAGAAGATCAAAACTTTGTTTTTATTGGTGCCTATGACTCCGGATTTAATGCAAAGTTTGAAGCAGTCAATG
AAGACTTTTTACAAAAATATGATTATCAAAAATCAGAAGTCAAAAGTATTTTAAAAAACATCCAACCTAAACTTAAAAAA
TCATTTAGCGGAACGACCGTTATCTGGAACATCAGCCCACATTTTCGTAACCCCATCCTATGCATTAGTTTTCCATTATC
GGAAACAAAAGATACTCATACAATTCTTGTGACACTTGTCAAACTTGATACTTTGTTAGATGCATTCCAAACATCTGGTC
CTGTTGAAACATTTTTGGTGAGTGAAGATGGGAGCGTCCTTGCTCACCCCGACGCTAAGGTAGTCCTTTCAGGTATCAAT
TTAAATGATTTAGCGATCGTTGACCGCATGAAAAAATCAACGGTTGATAATGGCCAATTTCGGTATGAAAACAAAGATGG
GGAATTTTACCTGGCTGCCTTCAAAAAATTAGGATTTGGAGGTGTCGGTGTGATCTCACAAGTCCGAGAAGTTAAAATTT
TCGAAGAGGTCAATAATATCCAAAAAAGAAATGTATACCTACTCATCATTTCTTTATCACTTTCTTTTATTGTAGTTTAT
ATCTTTGCCAAATCACTTTCTACACCTATTCTCAAATTGGTGGACGCTTCAGAAGAAATCAGAAGAGGTAATTTCCATAT
CAATCTACATGCGACAACTCATGATGAAATTGGAACTCTAACCAAATCGTTTGTGAGCATGGGGCGAGGCCTCGAGGAAC
GCGAAAAACTAAAAGATTCTTTTGGGAAATTTGTAAACCAAGAGATCGCGGAACTTGCCGCGAAGGGTAAGTTATCGATC
GGTGGGAAACGTAAATATTGTACGATCTTCTTTTCCGACATCCGAAGTTTTACAGCCATTTCAGAAAAACTACAACCGGA
AGAAGTGGTTGAGTTTCTAAACTTGTACATGACGGAAATGGTAAAATGTGTGCAAGAAACAGGTGGAACTGTGGATAAAT
TCATTGGAGATGCCATCATGGCCACTTGGGGAGCCTTACGTGACCACAAAGAACATGCAAAAGCATCTGTTGAAACAGCC
CTCAGTATGAGAGAAAAATTGATCGAGTTCAATAAAACTAGAGGAACAGTCAAAAAACCAATCATTAAAATCGGATGCGG
AATTAATACTGGTTATGTGATTGCAGGTCAAATTGGAAGCTCAGATAAAATGGAATACACTGTCATCGGAGATTCAGTGA
ATCTCGCATCAAGAGTCGAGTCGTTTAACAAAGAAACGCATACAGACATTTTGATTACTGAAACGACATACCAAGAAGTG
AAATCAGAATTTCATGTTGTGAGTATGGGCGAAATTGAATTTAAGGGAAAATCCAAAGCCCAAAAAGTATATGCCGTTCT
TGGCAAAAAATCAGACCCGAATGCTCCGAAAAATCTATCCGAGTTACAAAAGTTAGTTGGAATAGAAATAGCAGCTAAAA
AGGCAAAAAGATGA

Upstream 100 bases:

>100_bases
ACGTTGATTTGGCATGCCCTTAGGAAAAAAATAGTTTCATACTTCATTTTTACTTTTTTTTCATAGAGTTTTGGTTTGAA
TTGGTAAAAGTACCAATCAT

Downstream 100 bases:

>100_bases
ATTTAGATAAACGAGATCGATTTGTTCTCATTGGCCTGACAAGCATTGCAATCTTCTTTAGTATTCTTTTTTATTTAGAT
TTAAATCGTAAAATAGACAT

Product: adenylate/guanylate cyclase family protein 3

Products: NA

Alternate protein names: ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MKTILFKLKNFLSRNREVTSDFQFPIRYKLLLITSIVLLFSMSGVIFLASYFFRKDSEVRVKENNIKINEILSLKVKSDL
HSIRQDVHITASAIFRNNQSANQIAKELFEEDQNFVFIGAYDSGFNAKFEAVNEDFLQKYDYQKSEVKSILKNIQPKLKK
SFSGTTVIWNISPHFRNPILCISFPLSETKDTHTILVTLVKLDTLLDAFQTSGPVETFLVSEDGSVLAHPDAKVVLSGIN
LNDLAIVDRMKKSTVDNGQFRYENKDGEFYLAAFKKLGFGGVGVISQVREVKIFEEVNNIQKRNVYLLIISLSLSFIVVY
IFAKSLSTPILKLVDASEEIRRGNFHINLHATTHDEIGTLTKSFVSMGRGLEEREKLKDSFGKFVNQEIAELAAKGKLSI
GGKRKYCTIFFSDIRSFTAISEKLQPEEVVEFLNLYMTEMVKCVQETGGTVDKFIGDAIMATWGALRDHKEHAKASVETA
LSMREKLIEFNKTRGTVKKPIIKIGCGINTGYVIAGQIGSSDKMEYTVIGDSVNLASRVESFNKETHTDILITETTYQEV
KSEFHVVSMGEIEFKGKSKAQKVYAVLGKKSDPNAPKNLSELQKLVGIEIAAKKAKR

Sequences:

>Translated_617_residues
MKTILFKLKNFLSRNREVTSDFQFPIRYKLLLITSIVLLFSMSGVIFLASYFFRKDSEVRVKENNIKINEILSLKVKSDL
HSIRQDVHITASAIFRNNQSANQIAKELFEEDQNFVFIGAYDSGFNAKFEAVNEDFLQKYDYQKSEVKSILKNIQPKLKK
SFSGTTVIWNISPHFRNPILCISFPLSETKDTHTILVTLVKLDTLLDAFQTSGPVETFLVSEDGSVLAHPDAKVVLSGIN
LNDLAIVDRMKKSTVDNGQFRYENKDGEFYLAAFKKLGFGGVGVISQVREVKIFEEVNNIQKRNVYLLIISLSLSFIVVY
IFAKSLSTPILKLVDASEEIRRGNFHINLHATTHDEIGTLTKSFVSMGRGLEEREKLKDSFGKFVNQEIAELAAKGKLSI
GGKRKYCTIFFSDIRSFTAISEKLQPEEVVEFLNLYMTEMVKCVQETGGTVDKFIGDAIMATWGALRDHKEHAKASVETA
LSMREKLIEFNKTRGTVKKPIIKIGCGINTGYVIAGQIGSSDKMEYTVIGDSVNLASRVESFNKETHTDILITETTYQEV
KSEFHVVSMGEIEFKGKSKAQKVYAVLGKKSDPNAPKNLSELQKLVGIEIAAKKAKR
>Mature_617_residues
MKTILFKLKNFLSRNREVTSDFQFPIRYKLLLITSIVLLFSMSGVIFLASYFFRKDSEVRVKENNIKINEILSLKVKSDL
HSIRQDVHITASAIFRNNQSANQIAKELFEEDQNFVFIGAYDSGFNAKFEAVNEDFLQKYDYQKSEVKSILKNIQPKLKK
SFSGTTVIWNISPHFRNPILCISFPLSETKDTHTILVTLVKLDTLLDAFQTSGPVETFLVSEDGSVLAHPDAKVVLSGIN
LNDLAIVDRMKKSTVDNGQFRYENKDGEFYLAAFKKLGFGGVGVISQVREVKIFEEVNNIQKRNVYLLIISLSLSFIVVY
IFAKSLSTPILKLVDASEEIRRGNFHINLHATTHDEIGTLTKSFVSMGRGLEEREKLKDSFGKFVNQEIAELAAKGKLSI
GGKRKYCTIFFSDIRSFTAISEKLQPEEVVEFLNLYMTEMVKCVQETGGTVDKFIGDAIMATWGALRDHKEHAKASVETA
LSMREKLIEFNKTRGTVKKPIIKIGCGINTGYVIAGQIGSSDKMEYTVIGDSVNLASRVESFNKETHTDILITETTYQEV
KSEFHVVSMGEIEFKGKSKAQKVYAVLGKKSDPNAPKNLSELQKLVGIEIAAKKAKR

Specific function: May function as a membrane-localized receptor protein [H]

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

Organism=Homo sapiens, GI4580422, Length=229, Percent_Identity=29.2576419213974, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI167830411, Length=230, Percent_Identity=31.7391304347826, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI134152694, Length=261, Percent_Identity=29.5019157088123, Blast_Score=76, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71989822, Length=231, Percent_Identity=30.7359307359307, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71989805, Length=231, Percent_Identity=30.7359307359307, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI212659371, Length=183, Percent_Identity=31.1475409836066, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193207841, Length=248, Percent_Identity=29.4354838709677, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534655, Length=230, Percent_Identity=28.695652173913, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193206632, Length=205, Percent_Identity=32.6829268292683, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508769, Length=180, Percent_Identity=31.6666666666667, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71982300, Length=216, Percent_Identity=26.8518518518519, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17561804, Length=213, Percent_Identity=29.5774647887324, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI212645052, Length=253, Percent_Identity=28.0632411067194, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534653, Length=225, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568383, Length=226, Percent_Identity=30.0884955752212, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561800, Length=188, Percent_Identity=32.4468085106383, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17534651, Length=238, Percent_Identity=26.0504201680672, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71995893, Length=249, Percent_Identity=26.5060240963855, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17534657, Length=224, Percent_Identity=27.2321428571429, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17561802, Length=191, Percent_Identity=29.8429319371728, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995895, Length=249, Percent_Identity=26.5060240963855, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17534649, Length=210, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17534665, Length=188, Percent_Identity=30.3191489361702, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561794, Length=225, Percent_Identity=27.5555555555556, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995899, Length=249, Percent_Identity=26.5060240963855, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71990146, Length=183, Percent_Identity=29.5081967213115, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534659, Length=172, Percent_Identity=30.2325581395349, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI212645647, Length=199, Percent_Identity=30.1507537688442, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI62484477, Length=209, Percent_Identity=29.6650717703349, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI62484298, Length=209, Percent_Identity=29.6650717703349, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI116008008, Length=209, Percent_Identity=29.6650717703349, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24663843, Length=239, Percent_Identity=28.4518828451883, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24663839, Length=224, Percent_Identity=29.9107142857143, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24647268, Length=232, Percent_Identity=31.4655172413793, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161076872, Length=241, Percent_Identity=30.7053941908714, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574512, Length=241, Percent_Identity=30.7053941908714, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281366459, Length=174, Percent_Identity=32.183908045977, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281366457, Length=174, Percent_Identity=32.183908045977, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281366455, Length=174, Percent_Identity=32.183908045977, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI56292422, Length=174, Percent_Identity=32.183908045977, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI56292424, Length=174, Percent_Identity=32.183908045977, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666940, Length=174, Percent_Identity=32.183908045977, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI85725044, Length=181, Percent_Identity=34.2541436464088, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI161078020, Length=218, Percent_Identity=26.605504587156, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 69435; Mature: 69435

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS50885 HAMP ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTILFKLKNFLSRNREVTSDFQFPIRYKLLLITSIVLLFSMSGVIFLASYFFRKDSEVR
CCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEE
VKENNIKINEILSLKVKSDLHSIRQDVHITASAIFRNNQSANQIAKELFEEDQNFVFIGA
EECCCEEEEHHEEEHHHHHHHHHHHHHHEEEHHHHCCCCCHHHHHHHHHHCCCCEEEEEE
YDSGFNAKFEAVNEDFLQKYDYQKSEVKSILKNIQPKLKKSFSGTTVIWNISPHFRNPIL
ECCCCCCCHHHCCHHHHHHCCCCHHHHHHHHHHHCHHHHHCCCCCEEEEECCCCCCCCEE
CISFPLSETKDTHTILVTLVKLDTLLDAFQTSGPVETFLVSEDGSVLAHPDAKVVLSGIN
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCEEEEECCC
LNDLAIVDRMKKSTVDNGQFRYENKDGEFYLAAFKKLGFGGVGVISQVREVKIFEEVNNI
CCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHCH
QKRNVYLLIISLSLSFIVVYIFAKSLSTPILKLVDASEEIRRGNFHINLHATTHDEIGTL
HHCCEEEEEEHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHCCCEEEEEEECCCHHHHHH
TKSFVSMGRGLEEREKLKDSFGKFVNQEIAELAAKGKLSIGGKRKYCTIFFSDIRSFTAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEHHHHHHHHHH
SEKLQPEEVVEFLNLYMTEMVKCVQETGGTVDKFIGDAIMATWGALRDHKEHAKASVETA
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSMREKLIEFNKTRGTVKKPIIKIGCGINTGYVIAGQIGSSDKMEYTVIGDSVNLASRVE
HHHHHHHHHHHCCCCCHHCCEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCHHHHHHH
SFNKETHTDILITETTYQEVKSEFHVVSMGEIEFKGKSKAQKVYAVLGKKSDPNAPKNLS
HHCCCCCCEEEEECCHHHHHHHCEEEEEECCEEECCCHHHHHHHHHHCCCCCCCCCCCHH
ELQKLVGIEIAAKKAKR
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTILFKLKNFLSRNREVTSDFQFPIRYKLLLITSIVLLFSMSGVIFLASYFFRKDSEVR
CCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEE
VKENNIKINEILSLKVKSDLHSIRQDVHITASAIFRNNQSANQIAKELFEEDQNFVFIGA
EECCCEEEEHHEEEHHHHHHHHHHHHHHEEEHHHHCCCCCHHHHHHHHHHCCCCEEEEEE
YDSGFNAKFEAVNEDFLQKYDYQKSEVKSILKNIQPKLKKSFSGTTVIWNISPHFRNPIL
ECCCCCCCHHHCCHHHHHHCCCCHHHHHHHHHHHCHHHHHCCCCCEEEEECCCCCCCCEE
CISFPLSETKDTHTILVTLVKLDTLLDAFQTSGPVETFLVSEDGSVLAHPDAKVVLSGIN
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCEEEEECCC
LNDLAIVDRMKKSTVDNGQFRYENKDGEFYLAAFKKLGFGGVGVISQVREVKIFEEVNNI
CCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHCH
QKRNVYLLIISLSLSFIVVYIFAKSLSTPILKLVDASEEIRRGNFHINLHATTHDEIGTL
HHCCEEEEEEHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHCCCEEEEEEECCCHHHHHH
TKSFVSMGRGLEEREKLKDSFGKFVNQEIAELAAKGKLSIGGKRKYCTIFFSDIRSFTAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEHHHHHHHHHH
SEKLQPEEVVEFLNLYMTEMVKCVQETGGTVDKFIGDAIMATWGALRDHKEHAKASVETA
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSMREKLIEFNKTRGTVKKPIIKIGCGINTGYVIAGQIGSSDKMEYTVIGDSVNLASRVE
HHHHHHHHHHHCCCCCHHCCEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCHHHHHHH
SFNKETHTDILITETTYQEVKSEFHVVSMGEIEFKGKSKAQKVYAVLGKKSDPNAPKNLS
HHCCCCCCEEEEECCHHHHHHHCEEEEEECCEEECCCHHHHHHHHHHCCCCCCCCCCCHH
ELQKLVGIEIAAKKAKR
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7601856 [H]